Nancy M Young

Yanlin Wang, Di Yuan, Shani Dettman et al.

Cochlear implants (CI) significantly improve spoken language in children with severe-to-profound sensorineural hearing loss (SNHL), yet outcomes remain more variable than in children with normal hearing. This variability cannot be reliably predicted for individual children using age at implantation or residual hearing. This study aims to compare the accuracy of traditional machine learning (ML) to deep transfer learning (DTL) algorithms to predict post-CI spoken language development of children with bilateral SNHL using a binary classification model of high versus low language improvers. A total of 278 implanted children enrolled from three centers. The accuracy, sensitivity and specificity of prediction models based upon brain neuroanatomic features using traditional ML and DTL learning. DTL prediction models using bilinear attention-based fusion strategy achieved: accuracy of 92.39% (95% CI, 90.70%-94.07%), sensitivity of 91.22% (95% CI, 89.98%-92.47%), specificity of 93.56% (95% CI, 90.91%-96.21%), and area under the curve (AUC) of 0.977 (95% CI, 0.969-0.986). DTL outperformed traditional ML models in all outcome measures. DTL was significantly improved by direct capture of discriminative and task-specific information that are advantages of representation learning enabled by this approach over ML. The results support the feasibility of a single DTL prediction model for language prediction of children served by CI programs worldwide.

Yanlin Wang, Nancy M Young, Patrick C M Wong

Neural prediction offers a promising approach to forecasting the individual variability of neurocognitive functions and disorders and providing prognostic indicators for personalized invention. However, it is challenging to translate neural predictive models into medical artificial intelligent applications due to the limitations of domain shift and label scarcity. Here, we propose the directed evolution model (DEM), a novel computational model that mimics the trial-and-error processes of biological directed evolution to approximate optimal solutions for predictive modeling tasks. We demonstrated that the directed evolution algorithm is an effective strategy for uncertainty exploration, enhancing generalization in reinforcement learning. Furthermore, by incorporating replay buffer and continual backpropagate methods into DEM, we provide evidence of achieving better trade-off between exploitation and exploration in continuous learning settings. We conducted experiments on four different datasets for children with cochlear implants whose spoken language developmental outcomes vary considerably on the individual-child level. Preoperative neural MRI data has shown to accurately predict the post-operative outcome of these children within but not across datasets. Our results show that DEM can efficiently improve the performance of cross-domain pre-implantation neural predictions while addressing the challenge of label scarcity in target domain.