Aaron Franklin

Ethan Li, Anders Boesen Lindbo Larsen, Chen Zhang et al. · apple-ml, cmu

We introduce two multilingual, multimodal foundation language models that power Apple Intelligence features across Apple devices and services: i a 3B-parameter on-device model optimized for Apple silicon through architectural innovations such as KV-cache sharing and 2-bit quantization-aware training; and ii a scalable server model built on a novel Parallel-Track Mixture-of-Experts PT-MoE transformer that combines track parallelism, mixture-of-experts sparse computation, and interleaved global-local attention to deliver high quality with competitive cost on Apple's Private Cloud Compute platform. Both models are trained on large-scale multilingual and multimodal datasets sourced via responsible web crawling, licensed corpora, and high-quality synthetic data, then further refined with supervised fine-tuning and reinforcement learning on a new asynchronous platform. The resulting models support several additional languages while understanding images and executing tool calls. In public benchmarks and human evaluations, both the server model and the on-device model match or surpass comparably sized open baselines. A new Swift-centric Foundation Models framework exposes guided generation, constrained tool calling, and LoRA adapter fine-tuning, allowing developers to integrate these capabilities with a few lines of code. The latest advancements in Apple Intelligence models are grounded in our Responsible AI approach with safeguards like content filtering and locale-specific evaluation, as well as our commitment to protecting our users' privacy with innovations like Private Cloud Compute.

Anish Karpurapu, Adam Krekorian, Ye Tian et al.

Warfarin, a commonly prescribed drug to prevent blood clots, has a highly variable individual response. Determining a maintenance warfarin dose that achieves a therapeutic blood clotting time, as measured by the international normalized ratio (INR), is crucial in preventing complications. Machine learning algorithms are increasingly being used for warfarin dosing; usually, an initial dose is predicted with clinical and genotype factors, and this dose is revised after a few days based on previous doses and current INR. Since a sequence of prior doses and INR better capture the variability in individual warfarin response, we hypothesized that longitudinal dose response data will improve maintenance dose predictions. To test this hypothesis, we analyzed a dataset from the COAG warfarin dosing study, which includes clinical data, warfarin doses and INR measurements over the study period, and maintenance dose when therapeutic INR was achieved. Various machine learning regression models to predict maintenance warfarin dose were trained with clinical factors and dosing history and INR data as features. Overall, dose revision algorithms with a single dose and INR achieved comparable performance as the baseline dose revision algorithm. In contrast, dose revision algorithms with longitudinal dose and INR data provided maintenance dose predictions that were statistically significantly much closer to the true maintenance dose. Focusing on the best performing model, gradient boosting (GB), the proportion of ideal estimated dose, i.e., defined as within $\pm$20% of the true dose, increased from the baseline (54.92%) to the GB model with the single (63.11%) and longitudinal (75.41%) INR. More accurate maintenance dose predictions with longitudinal dose response data can potentially achieve therapeutic INR faster, reduce drug-related complications and improve patient outcomes with warfarin therapy.