Christiaan Boerkamp

Zaid Al-Ars, Obinna Agba, Zhuoran Guo et al.

This paper offers a systematic method for creating medical knowledge-grounded patient records for use in activities involving differential diagnosis. Additionally, an assessment of machine learning models that can differentiate between various conditions based on given symptoms is also provided. We use a public disease-symptom data source called SymCat in combination with Synthea to construct the patients records. In order to increase the expressive nature of the synthetic data, we use a medically-standardized symptom modeling method called NLICE to augment the synthetic data with additional contextual information for each condition. In addition, Naive Bayes and Random Forest models are evaluated and compared on the synthetic data. The paper shows how to successfully construct SymCat-based and NLICE-based datasets. We also show results for the effectiveness of using the datasets to train predictive disease models. The SymCat-based dataset is able to train a Naive Bayes and Random Forest model yielding a 58.8% and 57.1% Top-1 accuracy score, respectively. In contrast, the NLICE-based dataset improves the results, with a Top-1 accuracy of 82.0% and Top-5 accuracy values of more than 90% for both models. Our proposed data generation approach solves a major barrier to the application of artificial intelligence methods in the healthcare domain. Our novel NLICE symptom modeling approach addresses the incomplete and insufficient information problem in the current binary symptom representation approach. The NLICE code is open sourced at https://github.com/guozhuoran918/NLICE.

Christiaan Boerkamp, Akhil John Thomas

Medical image segmentation, particularly tumor segmentation, is a critical task in medical imaging, with U-Net being a widely adopted convolutional neural network (CNN) architecture for this purpose. However, U-Net's high computational and memory requirements pose challenges for deployment on resource-constrained devices such as wearable medical systems. This paper addresses these challenges by introducing QuantU-Net, a quantized version of U-Net optimized for efficient deployment on low-power devices like Field-Programmable Gate Arrays (FPGAs). Using Brevitas, a PyTorch library for quantization-aware training, we quantize the U-Net model, reducing its precision to an average of 4.24 bits while maintaining a validation accuracy of 94.25%, only 1.89% lower than the floating-point baseline. The quantized model achieves an approximately 8x reduction in size, making it suitable for real-time applications in wearable medical devices. We employ a custom loss function that combines Binary Cross-Entropy (BCE) Loss, Dice Loss, and a bitwidth loss function to optimize both segmentation accuracy and the size of the model. Using this custom loss function, we have significantly reduced the training time required to find an optimal combination of bitwidth and accuracy from a hypothetical 6^23 number of training sessions to a single training session. The model's usage of integer arithmetic highlights its potential for deployment on FPGAs and other designated AI accelerator hardware. This work advances the field of medical image segmentation by enabling the deployment of deep learning models on resource-constrained devices, paving the way for real-time, low-power diagnostic solutions in wearable healthcare applications.

Akhil John Thomas, Christiaan Boerkamp

Nerve segmentation is crucial in medical imaging for precise identification of nerve structures. This study presents an optimized DeepLabV3-based segmentation pipeline that incorporates automated threshold fine-tuning to improve segmentation accuracy. By refining preprocessing steps and implementing parameter optimization, we achieved a Dice Score of 0.78, an IoU of 0.70, and a Pixel Accuracy of 0.95 on ultrasound nerve imaging. The results demonstrate significant improvements over baseline models and highlight the importance of tailored parameter selection in automated nerve detection.