Christoph Dehner

Christoph Dehner, Guillaume Zahnd

Clinical adoption of multispectral optoacoustic tomography necessitates improvements of the image quality available in real-time, as well as a reduction in the scanner financial cost. Deep learning approaches have recently unlocked the reconstruction of high-quality optoacoustic images in real-time. However, currently used deep neural network architectures require powerful graphics processing units to infer images at sufficiently high frame-rates, consequently greatly increasing the price tag. Herein we propose EfficientDeepMB, a relatively lightweight (17M parameters) network architecture achieving high frame-rates on medium-sized graphics cards with no noticeable downgrade in image quality. EfficientDeepMB is built upon DeepMB, a previously established deep learning framework to reconstruct high-quality images in real-time, and upon EfficientNet, a network architectures designed to operate of mobile devices. We demonstrate the performance of EfficientDeepMB in terms of reconstruction speed and accuracy using a large and diverse dataset of in vivo optoacoustic scans. EfficientDeepMB is about three to five times faster than DeepMB: deployed on a medium-sized NVIDIA RTX A2000 Ada, EfficientDeepMB reconstructs images at speeds enabling live image feedback (59Hz) while DeepMB fails to meets the real-time inference threshold (14Hz). The quantitative difference between the reconstruction accuracy of EfficientDeepMB and DeepMB is marginal (data residual norms of 0.1560 vs. 0.1487, mean absolute error of 0.642 vs. 0.745). There are no perceptible qualitative differences between images inferred with the two reconstruction methods.

Christoph Dehner, Ivan Olefir, Kaushik Basak Chowdhury et al.

Image contrast in multispectral optoacoustic tomography (MSOT) can be severely reduced by electrical noise and interference in the acquired optoacoustic signals. Signal processing techniques have proven insufficient to remove the effects of electrical noise because they typically rely on simplified models and fail to capture complex characteristics of signal and noise. Moreover, they often involve time-consuming processing steps that are unsuited for real-time imaging applications. In this work, we develop and demonstrate a discriminative deep learning (DL) approach to separate electrical noise from optoacoustic signals prior to image reconstruction. The proposed DL algorithm is based on two key features. First, it learns spatiotemporal correlations in both noise and signal by using the entire optoacoustic sinogram as input. Second, it employs training based on a large dataset of experimentally acquired pure noise and synthetic optoacoustic signals. We validated the ability of the trained model to accurately remove electrical noise on synthetic data and on optoacoustic images of a phantom and the human breast. We demonstrate significant enhancements of morphological and spectral optoacoustic images reaching 19% higher blood vessel contrast and localized spectral contrast at depths of more than 2 cm for images acquired in vivo. We discuss how the proposed denoising framework is applicable to clinical multispectral optoacoustic tomography and suitable for real-time operation.