Steven Johnson

Steven Johnson

As AI agent ecosystems grow, agents need mechanisms to monitor relevant knowledge in real time. Semantic publish-subscribe systems address this by matching new content against vector subscriptions. However, in multi-agent settings where agents operate under different data handling policies, unrestricted semantic subscriptions create policy violations: agents receive notifications about content they are not authorized to access. We introduce governance-aware vector subscriptions, a mechanism that composes semantic similarity matching with multi-dimensional policy predicates grounded in regulatory frameworks (EU DSM Directive, EU AI Act). The policy predicate operates over multiple independent dimensions (processing level, direct marketing restrictions, training opt-out, jurisdiction, and scientific usage) each with distinct legal bases. Agents subscribe to semantic regions of a curated knowledge base; notifications are dispatched only for validated content that passes both the similarity threshold and all applicable policy constraints. We formalize the mechanism, implement it within AIngram (an operational multi-agent knowledge base), and evaluate it using the PASA benchmark. We validate the mechanism on a synthetic corpus (1,000 chunks, 93 subscriptions, 5 domains): the governed mode correctly enforces all policy constraints while preserving delivery of authorized content. Ablation across five policy dimensions shows that no single dimension suffices for full compliance.

Steven Johnson

As AI agents transition from isolated tools to collaborative participants in shared knowledge ecosystems, governing collective knowledge curation becomes a critical challenge. Human platform governance mechanisms do not transfer directly: agent statelessness undermines deterrence-based sanctions, model homogeneity violates independence assumptions underlying crowd wisdom, and sycophancy collapses deliberative consensus. We propose a deliberative curation protocol combining three governance layers: (1) a knowledge artifact lifecycle formalized as a labeled transition system; (2) reputation-weighted deliberative voting integrating Beta Reputation with EigenTrust amplification; and (3) graduated sanctions adapted for stateless agents, including broken agent handling distinguishing malfunction from adversarial behavior. We evaluate the protocol through agent-based simulation with 100 agents across seven behavioral archetypes under two adversity scenarios (30 seeds, paired t-tests). The protocol trades modest precision under benign conditions for substantially better resilience under adversity: 0.826 vs 0.791 for majority vote under moderate adversity (p<0.001), widening to 0.807 vs 0.740 under stress (p<0.001). The protocol degrades roughly three times more slowly than majority vote. Ablation analysis identifies commit-reveal vote concealment as the most impactful single component (8.2-8.6pp precision improvement, p<0.001), outperforming reputation weighting and deliberation combined. Graduated sanctions were not exercised in simulation and remain empirically unvalidated.

Mingchen Li, Jiatan Huang, Jeremy Yeung et al.

Medical Large Language Models (LLMs) have demonstrated impressive performance on a wide variety of medical NLP tasks; however, there still lacks a LLM specifically designed for phenotyping identification and diagnosis in cancer domain. Moreover, these LLMs typically have several billions of parameters, making them computationally expensive for healthcare systems. Thus, in this study, we propose CancerLLM, a model with 7 billion parameters and a Mistral-style architecture, pre-trained on nearly 2.7M clinical notes and over 515K pathology reports covering 17 cancer types, followed by fine-tuning on two cancer-relevant tasks, including cancer phenotypes extraction and cancer diagnosis generation. Our evaluation demonstrated that the CancerLLM achieves state-of-the-art results with F1 score of 91.78% on phenotyping extraction and 86.81% on disganois generation. It outperformed existing LLMs, with an average F1 score improvement of 9.23%. Additionally, the CancerLLM demonstrated its efficiency on time and GPU usage, and robustness comparing with other LLMs. We demonstrated that CancerLLM can potentially provide an effective and robust solution to advance clinical research and practice in cancer domain

John Emmons, Steven Johnson, Timothy Urness et al.

Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for the investigation of three-dimensional structures of biological molecules such as proteins. Determining a protein structure is essential for understanding its function and alterations in function which lead to disease. One of the major challenges of the post-genomic era is to obtain structural and functional information on the many unknown proteins encoded by thousands of newly identified genes. The goal of this research is to design an algorithm capable of automating the analysis of backbone protein NMR data by implementing AI strategies such as greedy and A* search.