Christian Simon

Christian Simon, Masoud Faraki, Yi-Hsuan Tsai et al.

Humans have the ability to accumulate knowledge of new tasks in varying conditions, but deep neural networks often suffer from catastrophic forgetting of previously learned knowledge after learning a new task. Many recent methods focus on preventing catastrophic forgetting under the assumption of train and test data following similar distributions. In this work, we consider a more realistic scenario of continual learning under domain shifts where the model must generalize its inference to an unseen domain. To this end, we encourage learning semantically meaningful features by equipping the classifier with class similarity metrics as learning parameters which are obtained through Mahalanobis similarity computations. Learning of the backbone representation along with these extra parameters is done seamlessly in an end-to-end manner. In addition, we propose an approach based on the exponential moving average of the parameters for better knowledge distillation. We demonstrate that, to a great extent, existing continual learning algorithms fail to handle the forgetting issue under multiple distributions, while our proposed approach learns new tasks under domain shift with accuracy boosts up to 10% on challenging datasets such as DomainNet and OfficeHome.

Abdelmalek Mouazer, Sophie Dubois, Romain Léguillon et al.

Background: Medication review is a structured interview of the patient, performed by the pharmacist and aimed at optimizing drug treatments. In practice, medication review is a long and cognitively-demanding task that requires specific knowledge. Clinical practice guidelines have been proposed, but their application is tedious. Methods: We designed ABiMed, a clinical decision support system for medication reviews, based on the implementation of the STOPP/START v2 guidelines and on the visual presentation of aggregated drug knowledge using tables, graphs and flower glyphs. We evaluated ABiMed with 39 community pharmacists during a randomized simulation trial, each pharmacist performing a medication review for two fictitious patients without ABiMed, and two others with ABiMed. We recorded the problems identified by the pharmacists, the interventions proposed, the response time, the perceived usability and the comments. Pharmacists' medication reviews were compared to an expert-designed gold standard. Results: With ABiMed, pharmacists found 1.6 times more relevant drug-related problems during the medication review (p=1.1e-12) and proposed better interventions (p=9.8e-9), without needing more time (p=0.56). The System Usability Scale score is 82.7, which is ranked "excellent". In their comments, pharmacists appreciated the visual aspect of ABiMed and its ability to compare the current treatment with the proposed one. A multifactor analysis showed no difference in the support offered by ABiMed according to the pharmacist's age or sex, in terms of percentage of problems identified or quality of the proposed interventions. Conclusions: The use of an intelligent and visual clinical decision support system can help pharmacists when they perform medication reviews. Our main perspective is the validation of the system in clinical conditions.

Yuanhong Chen, Kazuki Shimada, Christian Simon et al.

Binaural audio generation (BAG) aims to convert monaural audio to stereo audio using visual prompts, requiring a deep understanding of spatial and semantic information. However, current models risk overfitting to room environments and lose fine-grained spatial details. In this paper, we propose a new audio-visual binaural generation model incorporating an audio-visual conditional normalisation layer that dynamically aligns the mean and variance of the target difference audio features using visual context, along with a new contrastive learning method to enhance spatial sensitivity by mining negative samples from shuffled visual features. We also introduce a cost-efficient way to utilise test-time augmentation in video data to enhance performance. Our approach achieves state-of-the-art generation accuracy on the FAIR-Play and MUSIC-Stereo benchmarks.

Abdelmalek Mouazer, Romain Léguillon, Nada Boudegzdame et al.

Background: Polypharmacy, i.e. taking five drugs or more, is both a public health and an economic issue. Medication reviews are structured interviews of the patient by the community pharmacist, aiming at optimizing the drug treatment and deprescribing useless, redundant or dangerous drugs. However, they remain difficult to perform and time-consuming. Several clinical decision support systems were developed for helping clinicians to manage polypharmacy. However, most were limited to the implementation of clinical practice guidelines. In this work, our objective is to design an innovative clinical decision support system for medication reviews and polypharmacy management, named ABiMed. Methods: ABiMed associates several approaches: guidelines implementation, but the automatic extraction of patient data from the GP's electronic health record and its transfer to the pharmacist, and the visual presentation of contextualized drug knowledge using visual analytics. We performed an ergonomic assessment and qualitative evaluations involving pharmacists and GPs during focus groups and workshops. Results: We describe the proposed architecture, which allows a collaborative multi-user usage. We present the various screens of ABiMed for entering or verifying patient data, for accessing drug knowledge (posology, adverse effects, interactions), for viewing STOPP/START rules and for suggesting modification to the treatment. Qualitative evaluations showed that health professionals were highly interested by our approach, associating the automatic guidelines execution with the visual presentation of drug knowledge. Conclusions: The association of guidelines implementation with visual presentation of knowledge is a promising approach for managing polypharmacy. Future works will focus on the improvement and the evaluation of ABiMed.

Koichi Saito, Julian Tanke, Christian Simon et al.

Prevailing Video-to-Audio (V2A) generation models operate offline, assuming an entire video sequence or chunks of frames are available beforehand. This critically limits their use in interactive applications such as live content creation and emerging generative world models. To address this gap, we introduce the novel task of frame-level online V2A generation, where a model autoregressively generates audio from video without access to future video frames. Furthermore, we propose SoundReactor, which, to the best of our knowledge, is the first simple yet effective framework explicitly tailored for this task. Our design enforces end-to-end causality and targets low per-frame latency with audio-visual synchronization. Our model's backbone is a decoder-only causal transformer over continuous audio latents. For vision conditioning, it leverages grid (patch) features extracted from the smallest variant of the DINOv2 vision encoder, which are aggregated into a single token per frame to maintain end-to-end causality and efficiency. The model is trained through a diffusion pre-training followed by consistency fine-tuning to accelerate the diffusion head decoding. On a benchmark of diverse gameplay videos from AAA titles, our model successfully generates semantically and temporally aligned, high-quality full-band stereo audio, validated by both objective and human evaluations. Furthermore, our model achieves low per-frame waveform-level latency (26.3ms with the head NFE=1, 31.5ms with NFE=4) on 30FPS, 480p videos using a single H100. Demo samples are available at https://koichi-saito-sony.github.io/soundreactor/.

Christian Simon, Masato Ishii, Akio Hayakawa et al.

In the recent development of conditional diffusion models still require heavy supervised fine-tuning for performing control on a category of tasks. Training-free conditioning via guidance with off-the-shelf models is a favorable alternative to avoid further fine-tuning on the base model. However, the existing training-free guidance frameworks either have heavy memory requirements or offer sub-optimal control due to rough estimation. These shortcomings limit the applicability to control diffusion models that require intense computation, such as Text-to-Video (T2V) diffusion models. In this work, we propose Taming Inference Time Alignment for Guided Text-to-Video Diffusion Model, so-called TITAN-Guide, which overcomes memory space issues, and provides more optimal control in the guidance process compared to the counterparts. In particular, we develop an efficient method for optimizing diffusion latents without backpropagation from a discriminative guiding model. In particular, we study forward gradient descents for guided diffusion tasks with various options on directional directives. In our experiments, we demonstrate the effectiveness of our approach in efficiently managing memory during latent optimization, while previous methods fall short. Our proposed approach not only minimizes memory requirements but also significantly enhances T2V performance across a range of diffusion guidance benchmarks. Code, models, and demo are available at https://titanguide.github.io.

Christian Simon, Piotr Koniusz, Lars Petersson et al.

Neural Architecture Search (NAS) is the game changer in designing robust neural architectures. Architectures designed by NAS outperform or compete with the best manual network designs in terms of accuracy, size, memory footprint and FLOPs. That said, previous studies focus on developing NAS algorithms for clean high quality data, a restrictive and somewhat unrealistic assumption. In this paper, focusing on the differentiable NAS algorithms, we show that vanilla NAS algorithms suffer from a performance loss if class labels are noisy. To combat this issue, we make use of the principle of information bottleneck as a regularizer. This leads us to develop a noise injecting operation that is included during the learning process, preventing the network from learning from noisy samples. Our empirical evaluations show that the noise injecting operation does not degrade the performance of the NAS algorithm if the data is indeed clean. In contrast, if the data is noisy, the architecture learned by our algorithm comfortably outperforms algorithms specifically equipped with sophisticated mechanisms to learn in the presence of label noise. In contrast to many algorithms designed to work in the presence of noisy labels, prior knowledge about the properties of the noise and its characteristics are not required for our algorithm.