Mayank Daswani

Gheorghe Comanici, Eric Bieber, Mike Schaekermann et al. · amazon-science, baidu

In this report, we introduce the Gemini 2.X model family: Gemini 2.5 Pro and Gemini 2.5 Flash, as well as our earlier Gemini 2.0 Flash and Flash-Lite models. Gemini 2.5 Pro is our most capable model yet, achieving SoTA performance on frontier coding and reasoning benchmarks. In addition to its incredible coding and reasoning skills, Gemini 2.5 Pro is a thinking model that excels at multimodal understanding and it is now able to process up to 3 hours of video content. Its unique combination of long context, multimodal and reasoning capabilities can be combined to unlock new agentic workflows. Gemini 2.5 Flash provides excellent reasoning abilities at a fraction of the compute and latency requirements and Gemini 2.0 Flash and Flash-Lite provide high performance at low latency and cost. Taken together, the Gemini 2.X model generation spans the full Pareto frontier of model capability vs cost, allowing users to explore the boundaries of what is possible with complex agentic problem solving.

Harsha Nori, Mayank Daswani, Christopher Kelly et al.

Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the complexity and nuance of evidence-based medicine in real-world settings. In clinical practice, physicians iteratively formulate and revise diagnostic hypotheses, adapting each subsequent question and test to what they've just learned, and weigh the evolving evidence before committing to a final diagnosis. To emulate this iterative process, we introduce the Sequential Diagnosis Benchmark, which transforms 304 diagnostically challenging New England Journal of Medicine clinicopathological conference (NEJM-CPC) cases into stepwise diagnostic encounters. A physician or AI begins with a short case abstract and must iteratively request additional details from a gatekeeper model that reveals findings only when explicitly queried. Performance is assessed not just by diagnostic accuracy but also by the cost of physician visits and tests performed. We also present the MAI Diagnostic Orchestrator (MAI-DxO), a model-agnostic orchestrator that simulates a panel of physicians, proposes likely differential diagnoses and strategically selects high-value, cost-effective tests. When paired with OpenAI's o3 model, MAI-DxO achieves 80% diagnostic accuracy--four times higher than the 20% average of generalist physicians. MAI-DxO also reduces diagnostic costs by 20% compared to physicians, and 70% compared to off-the-shelf o3. When configured for maximum accuracy, MAI-DxO achieves 85.5% accuracy. These performance gains with MAI-DxO generalize across models from the OpenAI, Gemini, Claude, Grok, DeepSeek, and Llama families. We highlight how AI systems, when guided to think iteratively and act judiciously, can advance diagnostic precision and cost-effectiveness in clinical care.

Elzbieta Gruzewska, Pooja Rao, Sebastien Baur et al.

Radar technology presents untapped potential for continuous, contactless, and passive heart rate monitoring via consumer electronics like mobile phones. However the variety of available radar systems and lack of standardization means that a large new paired dataset collection is required for each radar system. This study demonstrates transfer learning between frequency-modulated continuous wave (FMCW) and impulse-radio ultra-wideband (IR-UWB) radar systems, both increasingly integrated into consumer devices. FMCW radar utilizes a continuous chirp, while IR-UWB radar employs short pulses. Our mm-wave FMCW radar operated at 60 GHz with a 5.5 GHz bandwidth (2.7 cm resolution, 3 receiving antennas [Rx]), and our IR-UWB radar at 8 GHz with a 500 MHz bandwidth (30 cm resolution, 2 Rx). Using a novel 2D+1D ResNet architecture we achieved a mean absolute error (MAE) of 0.85 bpm and a mean absolute percentage error (MAPE) of 1.42% for heart rate monitoring with FMCW radar (N=119 participants, an average of 8 hours per participant). This model maintained performance (under 5 MAE/10% MAPE) across various body positions and heart rate ranges, with a 98.9% recall. We then fine-tuned a variant of this model, trained on single-antenna and single-range bin FMCW data, using a small (N=376, avg 6 minutes per participant) IR-UWB dataset. This transfer learning approach yielded a model with MAE 4.1 bpm and MAPE 6.3% (97.5% recall), a 25% MAE reduction over the IR-UWB baseline. This demonstration of transfer learning between radar systems for heart rate monitoring has the potential to accelerate its introduction into existing consumer devices.

Wei-Hung Weng, Sebastien Baur, Mayank Daswani et al.

Cardiovascular diseases (CVDs) are responsible for a large proportion of premature deaths in low- and middle-income countries. Early CVD detection and intervention is critical in these populations, yet many existing CVD risk scores require a physical examination or lab measurements, which can be challenging in such health systems due to limited accessibility. Here we investigated the potential to use photoplethysmography (PPG), a sensing technology available on most smartphones that can potentially enable large-scale screening at low cost, for CVD risk prediction. We developed a deep learning PPG-based CVD risk score (DLS) to predict the probability of having major adverse cardiovascular events (MACE: non-fatal myocardial infarction, stroke, and cardiovascular death) within ten years, given only age, sex, smoking status and PPG as predictors. We compared the DLS with the office-based refit-WHO score, which adopts the shared predictors from WHO and Globorisk scores (age, sex, smoking status, height, weight and systolic blood pressure) but refitted on the UK Biobank (UKB) cohort. In UKB cohort, DLS's C-statistic (71.1%, 95% CI 69.9-72.4) was non-inferior to office-based refit-WHO score (70.9%, 95% CI 69.7-72.2; non-inferiority margin of 2.5%, p<0.01). The calibration of the DLS was satisfactory, with a 1.8% mean absolute calibration error. Adding DLS features to the office-based score increased the C-statistic by 1.0% (95% CI 0.6-1.4). DLS predicts ten-year MACE risk comparable with the office-based refit-WHO score. It provides a proof-of-concept and suggests the potential of a PPG-based approach strategies for community-based primary prevention in resource-limited regions.

Tom Everitt, Daniel Filan, Mayank Daswani et al.

Any agent that is part of the environment it interacts with and has versatile actuators (such as arms and fingers), will in principle have the ability to self-modify -- for example by changing its own source code. As we continue to create more and more intelligent agents, chances increase that they will learn about this ability. The question is: will they want to use it? For example, highly intelligent systems may find ways to change their goals to something more easily achievable, thereby `escaping' the control of their designers. In an important paper, Omohundro (2008) argued that goal preservation is a fundamental drive of any intelligent system, since a goal is more likely to be achieved if future versions of the agent strive towards the same goal. In this paper, we formalise this argument in general reinforcement learning, and explore situations where it fails. Our conclusion is that the self-modification possibility is harmless if and only if the value function of the agent anticipates the consequences of self-modifications and use the current utility function when evaluating the future.

Mayank Daswani, Jan Leike

What is happiness for reinforcement learning agents? We seek a formal definition satisfying a list of desiderata. Our proposed definition of happiness is the temporal difference error, i.e. the difference between the value of the obtained reward and observation and the agent's expectation of this value. This definition satisfies most of our desiderata and is compatible with empirical research on humans. We state several implications and discuss examples.