Guangyu Wang

Guangyu Wang, Jingkun Yue, Siqi Zhang et al.

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

Xiaobao Wei, Jiajun Cao, Yizhu Jin et al.

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent methods have been proposed to adapt the foundational Segment Anything Model (SAM) to medical image segmentation. However, they still focus on discrete representations to generate pixel-wise predictions, which are spatially inflexible and scale poorly to higher resolution. In contrast, implicit methods learn continuous representations for segmentation, which is crucial for medical image segmentation. In this paper, we propose I-MedSAM, which leverages the benefits of both continuous representations and SAM, to obtain better cross-domain ability and accurate boundary delineation. Since medical image segmentation needs to predict detailed segmentation boundaries, we designed a novel adapter to enhance the SAM features with high-frequency information during Parameter-Efficient Fine-Tuning (PEFT). To convert the SAM features and coordinates into continuous segmentation output, we utilize Implicit Neural Representation (INR) to learn an implicit segmentation decoder. We also propose an uncertainty-guided sampling strategy for efficient learning of INR. Extensive evaluations on 2D medical image segmentation tasks have shown that our proposed method with only 1.6M trainable parameters outperforms existing methods including discrete and implicit methods. The code will be available at: https://github.com/ucwxb/I-MedSAM.

Xiaohong Liu, Guoxing Yang, Yulin Luo et al.

Radiology is a vital and complex component of modern clinical workflow and covers many tasks. Recently, vision-language (VL) foundation models in medicine have shown potential in processing multimodal information, offering a unified solution for various radiology tasks. However, existing studies either pre-trained VL models on natural data or did not fully integrate vision-language architecture and pretraining, often neglecting the unique multimodal complexity in radiology images and their textual contexts. Additionally, their practical applicability in real-world scenarios remains underexplored. Here, we present RadFound, a large and open-source vision-language foundation model tailored for radiology, that is trained on the most extensive dataset of over 8.1 million images and 250,000 image-text pairs, covering 19 major organ systems and 10 imaging modalities. To establish expert-level multimodal perception and generation capabilities, RadFound introduces an enhanced vision encoder to capture intra-image local features and inter-image contextual information, and a unified cross-modal learning design tailored to radiology. To fully assess the models' capability, we construct a benchmark, RadVLBench, including radiology interpretation tasks like medical vision-language question-answering, as well as text generation tasks ranging from captioning to report generation. We also propose a human evaluation framework. When evaluated on the real-world benchmark involving three representative modalities, 2D images (chest X-rays), multi-view images (mammograms), and 3D images (thyroid CT scans), RadFound significantly outperforms other VL foundation models on both quantitative metrics and human evaluation. In summary, the development of RadFound represents an advancement in radiology generalists, demonstrating broad applicability potential for integration into clinical workflows.

Zijian Wu, Lingkai Kong, Wenwei Zhang et al.

Large language models (LLMs) have achieved significant progress in solving complex reasoning tasks by Reinforcement Learning with Verifiable Rewards (RLVR). This advancement is also inseparable from the oversight automated by reliable verifiers. However, current outcome-based verifiers (OVs) are unable to inspect the unreliable intermediate steps in the long reasoning chains of thought (CoTs). Meanwhile, current process-based verifiers (PVs) have difficulties in reliably detecting errors in the complex long CoTs, limited by the scarcity of high-quality annotations due to the prohibitive costs of human annotations. Therefore, we propose the Outcome-based Process Verifier (OPV), which verifies the rationale process of summarized outcomes from long CoTs to achieve both accurate and efficient verification and enable large-scale annotation. To empower the proposed verifier, we adopt an iterative active learning framework with expert annotations to progressively improve the verification capability of OPV with fewer annotation costs. Specifically, in each iteration, the most uncertain cases of the current best OPV are annotated and then subsequently used to train a new OPV through Rejection Fine-Tuning (RFT) and RLVR for the next round. Extensive experiments demonstrate OPV's superior performance and broad applicability. It achieves new state-of-the-art results on our held-out OPV-Bench, outperforming much larger open-source models such as Qwen3-Max-Preview with an F1 score of 83.1 compared to 76.3. Furthermore, OPV effectively detects false positives within synthetic dataset, closely align with expert assessment. When collaborating with policy models, OPV consistently yields performance gains, e.g., raising the accuracy of DeepSeek-R1-Distill-Qwen-32B from 55.2% to 73.3% on AIME2025 as the compute budget scales.

Qing Wang, Tianshi Liu, Minghao Zhou et al.

Systematic characterization of drug-disease relationships is essential for drug discovery and repurposing, yet is hindered by the heterogeneity and rapid growth of biomedical literature. Existing datasets rely on labor-intensive curation and are often incomplete, while LLM-only approaches suffer from hallucination and weak evidence grounding. We introduce UniD$^3$, a unified framework that integrates Large Language Models with Knowledge Graph-enhanced Retrieval-Augmented Generation (KG-RAG) to extract, organize, and validate drug-disease knowledge across Drug-Disease Matching (DDM), Drug Effectiveness Assessment (DEA), and Drug-Target Analysis (DTA). UniD$^3$ processes 157,849 PubMed articles with Llama 3.3-70B and constructs knowledge graphs via a dual-stage strategy combining paper-level extraction with KG-level consolidation centered on drug and disease entities. These graphs support KG-RAG-based generation of structured datasets, evaluated through external benchmarks, fuzzy matching with curated resources, and clinician review. UniD$^3$ produces six knowledge graphs and large-scale datasets, including 28,915 DDM, 15,042 DEA, and over 4,000 DTA QA pairs. External validation shows strong performance (F1: 0.85-0.87 for DDM/DEA; 0.82 for DTA), with clinician review confirming high reliability (AUROC = 0.90). KG-RAG-augmented models outperform standalone LLMs, and the UniD$^3$ chatbot enables interpretable, citation-supported exploration of drug-disease relationships. UniD$^3$ provides a scalable, extensible framework for transforming unstructured biomedical literature into high-quality, structured drug-disease knowledge, supporting AI-driven discovery, repurposing, and precision medicine.

Yuhe Wu, Guangyu Wang, Yuran Chen et al.

As large language models (LLMs) evolve from conversational assistants into agents capable of handling complex tasks, they are increasingly deployed in high-risk domains. However, existing benchmarks largely rely on mixed queries and posterior evaluation, output-level scoring, which quantifies hallucination severity but offers limited insight into where and why hallucinations arise in the generation pipeline. We therefore reformulate hallucination evaluation as a diagnostic problem and propose PRISM, a controlled benchmark that disentangles hallucinations into four dimensions: knowledge missing, knowledge errors, reasoning errors, and instruction-following errors, grounded in three stages of generation (memory, instruction, and reasoning). PRISM contains 9,448 instances across 65 tasks and supports fine-grained, stage-aware diagnostic evaluation. Evaluating 24 mainstream open-source and proprietary LLMs, we uncover consistent trade-offs across instruction following, memory retrieval, and logical reasoning, showing that mitigation strategies often improve specific dimensions at the expense of others. We hope PRISM provides a framework for understanding the specific mechanisms behind LLMs hallucinations, ultimately accelerating the development of trustworthy large language models.

Leyan Xue, Changqing Zhang, Kecheng Xue et al.

Although multimodal fusion has made significant progress, its advancement is severely hindered by the lack of adequate evaluation benchmarks. Current fusion methods are typically evaluated on a small selection of public datasets, a limited scope that inadequately represents the complexity and diversity of real-world scenarios, potentially leading to biased evaluations. This issue presents a twofold challenge. On one hand, models may overfit to the biases of specific datasets, hindering their generalization to broader practical applications. On the other hand, the absence of a unified evaluation standard makes fair and objective comparisons between different fusion methods difficult. Consequently, a truly universal and high-performance fusion model has yet to emerge. To address these challenges, we have developed a large-scale, domain-adaptive benchmark for multimodal evaluation. This benchmark integrates over 30 datasets, encompassing 15 modalities and 20 predictive tasks across key application domains. To complement this, we have also developed an open-source, unified, and automated evaluation pipeline that includes standardized implementations of state-of-the-art models and diverse fusion paradigms. Leveraging this platform, we have conducted large-scale experiments, successfully establishing new performance baselines across multiple tasks. This work provides the academic community with a crucial platform for rigorous and reproducible assessment of multimodal models, aiming to propel the field of multimodal artificial intelligence to new heights.

Guangyu Wang, Yujie Chen, Ming Gao et al.

Accurate traffic prediction faces significant challenges, necessitating a deep understanding of both temporal and spatial cues and their complex interactions across multiple variables. Recent advancements in traffic prediction systems are primarily due to the development of complex sequence-centric models. However, existing approaches often embed multiple variables and spatial relationships at each time step, which may hinder effective variable-centric learning, ultimately leading to performance degradation in traditional traffic prediction tasks. To overcome these limitations, we introduce variable-centric and prior knowledge-centric modeling techniques. Specifically, we propose a Heterogeneous Mixture of Experts (TITAN) model for traffic flow prediction. TITAN initially consists of three experts focused on sequence-centric modeling. Then, designed a low-rank adaptive method, TITAN simultaneously enables variable-centric modeling. Furthermore, we supervise the gating process using a prior knowledge-centric modeling strategy to ensure accurate routing. Experiments on two public traffic network datasets, METR-LA and PEMS-BAY, demonstrate that TITAN effectively captures variable-centric dependencies while ensuring accurate routing. Consequently, it achieves improvements in all evaluation metrics, ranging from approximately 4.37\% to 11.53\%, compared to previous state-of-the-art (SOTA) models. The code is open at \href{https://github.com/sqlcow/TITAN}{https://github.com/sqlcow/TITAN}.

Guoxing Yang, Jianyu Shi, Zan Wang et al.

Pre-training and fine-tuning have emerged as a promising paradigm across various natural language processing (NLP) tasks. The effectiveness of pretrained large language models (LLM) has witnessed further enhancement, holding potential for applications in the field of medicine, particularly in the context of Traditional Chinese Medicine (TCM). However, the application of these general models to specific domains often yields suboptimal results, primarily due to challenges like lack of domain knowledge, unique objectives, and computational efficiency. Furthermore, their effectiveness in specialized domains, such as Traditional Chinese Medicine, requires comprehensive evaluation. To address the above issues, we propose a novel domain specific TCMDA (TCM Domain Adaptation) approach, efficient pre-training with domain-specific corpus. Specifically, we first construct a large TCM-specific corpus, TCM-Corpus-1B, by identifying domain keywords and retreving from general corpus. Then, our TCMDA leverages the LoRA which freezes the pretrained model's weights and uses rank decomposition matrices to efficiently train specific dense layers for pre-training and fine-tuning, efficiently aligning the model with TCM-related tasks, namely TCM-GPT-7B. We further conducted extensive experiments on two TCM tasks, including TCM examination and TCM diagnosis. TCM-GPT-7B archived the best performance across both datasets, outperforming other models by relative increments of 17% and 12% in accuracy, respectively. To the best of our knowledge, our study represents the pioneering validation of domain adaptation of a large language model with 7 billion parameters in TCM domain. We will release both TCMCorpus-1B and TCM-GPT-7B model once accepted to facilitate interdisciplinary development in TCM and NLP, serving as the foundation for further study.

Guangyu Wang, Guoxing Yang, Zongxin Du et al.

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in medical applications is limited, due to challenges such as factual inaccuracies, reasoning abilities, and lack grounding in real-world experience. In this study, we present ClinicalGPT, a language model explicitly designed and optimized for clinical scenarios. By incorporating extensive and diverse real-world data, such as medical records, domain-specific knowledge, and multi-round dialogue consultations in the training process, ClinicalGPT is better prepared to handle multiple clinical task. Furthermore, we introduce a comprehensive evaluation framework that includes medical knowledge question-answering, medical exams, patient consultations, and diagnostic analysis of medical records. Our results demonstrate that ClinicalGPT significantly outperforms other models in these tasks, highlighting the effectiveness of our approach in adapting large language models to the critical domain of healthcare.

Yuhao Wang, Kai Wang, Xiaohong Liu et al.

Automated radiology report generation aims at automatically generating a detailed description of medical images, which can greatly alleviate the workload of radiologists and provide better medical services to remote areas. Most existing works pay attention to the holistic impression of medical images, failing to utilize important anatomy information. However, in actual clinical practice, radiologists usually locate important anatomical structures, and then look for signs of abnormalities in certain structures and reason the underlying disease. In this paper, we propose a novel framework AGFNet to dynamically fuse the global and anatomy region feature to generate multi-grained radiology report. Firstly, we extract important anatomy region features and global features of input Chest X-ray (CXR). Then, with the region features and the global features as input, our proposed self-adaptive fusion gate module could dynamically fuse multi-granularity information. Finally, the captioning generator generates the radiology reports through multi-granularity features. Experiment results illustrate that our model achieved the state-of-the-art performance on two benchmark datasets including the IU X-Ray and MIMIC-CXR. Further analyses also prove that our model is able to leverage the multi-grained information from radiology images and texts so as to help generate more accurate reports.

Rong Han, Xiaohong Liu, Tong Pan et al.

Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to capture the binding mechanisms comprehensively. The recent emerging pre-trained language models trained on massive unsupervised sequences of protein and RNA have shown strong representation ability for various in-domain downstream tasks, including binding site prediction. However, applying different-domain language models collaboratively for complex-level tasks remains unexplored. In this paper, we propose CoPRA to bridge pre-trained language models from different biological domains via Complex structure for Protein-RNA binding Affinity prediction. We demonstrate for the first time that cross-biological modal language models can collaborate to improve binding affinity prediction. We propose a Co-Former to combine the cross-modal sequence and structure information and a bi-scope pre-training strategy for improving Co-Former's interaction understanding. Meanwhile, we build the largest protein-RNA binding affinity dataset PRA310 for performance evaluation. We also test our model on a public dataset for mutation effect prediction. CoPRA reaches state-of-the-art performance on all the datasets. We provide extensive analyses and verify that CoPRA can (1) accurately predict the protein-RNA binding affinity; (2) understand the binding affinity change caused by mutations; and (3) benefit from scaling data and model size.

Zongbo Han, Jialong Yang, Guangyu Wang et al.

Vision-language foundation models (VLMs), such as CLIP, exhibit remarkable performance across a wide range of tasks. However, deploying these models can be unreliable when significant distribution gaps exist between training and test data, while fine-tuning for diverse scenarios is often costly. Cache-based test-time adapters offer an efficient alternative by storing representative test samples to guide subsequent classifications. Yet, these methods typically employ naive cache management with limited capacity, leading to severe catastrophic forgetting when samples are inevitably dropped during updates. In this paper, we propose DOTA (DistributiOnal Test-time Adaptation), a simple yet effective method addressing this limitation. Crucially, instead of merely memorizing individual test samples, DOTA continuously estimates the underlying distribution of the test data stream. Test-time posterior probabilities are then computed using these dynamically estimated distributions via Bayes' theorem for adaptation. This distribution-centric approach enables the model to continually learn and adapt to the deployment environment. Extensive experiments validate that DOTA significantly mitigates forgetting and achieves state-of-the-art performance compared to existing methods.

Yufei Jia, Heng Zhang, Ziheng Zhang et al.

Embodied AI research is undergoing a shift toward vision-centric perceptual paradigms. While massively parallel simulators have catalyzed breakthroughs in proprioception-based locomotion, their potential remains largely untapped for vision-informed tasks due to the prohibitive computational overhead of large-scale photorealistic rendering. Furthermore, the creation of simulation-ready 3D assets heavily relies on labor-intensive manual modeling, while the significant sim-to-real physical gap hinders the transfer of contact-rich manipulation policies. To address these bottlenecks, we propose GS-Playground, a multi-modal simulation framework designed to accelerate end-to-end perceptual learning. We develop a novel high-performance parallel physics engine, specifically designed to integrate with a batch 3D Gaussian Splatting (3DGS) rendering pipeline to ensure high-fidelity synchronization. Our system achieves a breakthrough throughput of 10^4 FPS at 640x480 resolution, significantly lowering the barrier for large-scale visual RL. Additionally, we introduce an automated Real2Sim workflow that reconstructs photorealistic, physically consistent, and memory-efficient environments, streamlining the generation of complex simulation-ready scenes. Extensive experiments on locomotion, navigation, and manipulation demonstrate that GS-Playground effectively bridges the perceptual and physical gaps across diverse embodied tasks. Project homepage: https://gsplayground.github.io.

Wuyang Lan, Wenzheng Wang, Changwei Ji et al.

Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce ClinicalGPT-R1, a reasoning enhanced generalist large language model for disease diagnosis. Trained on a dataset of 20,000 real-world clinical records, ClinicalGPT-R1 leverages diverse training strategies to enhance diagnostic reasoning. To benchmark performance, we curated MedBench-Hard, a challenging dataset spanning seven major medical specialties and representative diseases. Experimental results demonstrate that ClinicalGPT-R1 outperforms GPT-4o in Chinese diagnostic tasks and achieves comparable performance to GPT-4 in English settings. This comparative study effectively validates the superior performance of ClinicalGPT-R1 in disease diagnosis tasks. Resources are available at https://github.com/medfound/medfound.

Guangyu Wang, Xiaodong Ma, Xinming Wu

Borehole breakouts are stress-induced spalling on the borehole wall, which are identifiable in acoustic image logs as paired zones with near-symmetry azimuths, low acoustic amplitudes, and increased borehole radius. Accurate breakout characterization is crucial for in-situ stress analysis. In recent years, deep learning has been introduced to automate the time-consuming and labor-intensive breakout picking process. However, existing approaches often suffer from misclassification of non-breakout features, leading to high false positive rates. To address this limitation, this study develops a deep learning framework, termed Breakout-picker, with a specific focus on reducing false positives in automatic breakout characterization. Breakout-picker reduces false positives through two strategies. First, the training of Breakout-picker incorporates negative samples of non-breakout features, including natural fractures, keyseats, and logging artifacts. They share similar characteristics with breakouts, such as low acoustic amplitude or locally enlarged borehole radius. These negative training samples enables Breakout-picker to better discriminate true breakouts and similar non-breakout features. Second, candidate breakouts identified by Breakout-picker are further validated by azimuthal symmetry criteria, whereby detections that do not exhibit the near-symmetry characteristics of breakout azimuth are excluded. The performance of Breakout-picker is evaluated using three acoustic image log datasets from different regions. The results demonstrate that Breakout-picker outperforms other automatic methods with higher accuracy and substantially lower false positive rates. By reducing false positives, Breakout-picker enhances the reliability of automatic breakout characterization from acoustic image logs, which in turn benefits in-situ stress analysis based on borehole breakouts.

Jingkun Yue, Siqi Zhang, Zinan Jia et al.

Visual grounding is essential for precise perception and reasoning in multimodal large language models (MLLMs), especially in medical imaging domains. While existing medical visual grounding benchmarks primarily focus on single-image scenarios, real-world clinical applications often involve sequential images, where accurate lesion localization across different modalities and temporal tracking of disease progression (e.g., pre- vs. post-treatment comparison) require fine-grained cross-image semantic alignment and context-aware reasoning. To remedy the underrepresentation of image sequences in existing medical visual grounding benchmarks, we propose MedSG-Bench, the first benchmark tailored for Medical Image Sequences Grounding. It comprises eight VQA-style tasks, formulated into two paradigms of the grounding tasks, including 1) Image Difference Grounding, which focuses on detecting change regions across images, and 2) Image Consistency Grounding, which emphasizes detection of consistent or shared semantics across sequential images. MedSG-Bench covers 76 public datasets, 10 medical imaging modalities, and a wide spectrum of anatomical structures and diseases, totaling 9,630 question-answer pairs. We benchmark both general-purpose MLLMs (e.g., Qwen2.5-VL) and medical-domain specialized MLLMs (e.g., HuatuoGPT-vision), observing that even the advanced models exhibit substantial limitations in medical sequential grounding tasks. To advance this field, we construct MedSG-188K, a large-scale instruction-tuning dataset tailored for sequential visual grounding, and further develop MedSeq-Grounder, an MLLM designed to facilitate future research on fine-grained understanding across medical sequential images. The benchmark, dataset, and model are available at https://huggingface.co/MedSG-Bench

Linxi Zhao, Jiankai Tang, Dongyu Chen et al.

Nailfold capillaroscopy is widely used in assessing health conditions, highlighting the pressing need for an automated nailfold capillary analysis system. In this study, we present a pioneering effort in constructing a comprehensive nailfold capillary dataset-321 images, 219 videos from 68 subjects, with clinic reports and expert annotations-that serves as a crucial resource for training deep-learning models. Leveraging this dataset, we finetuned three deep learning models with expert annotations as supervised labels and integrated them into a novel end-to-end nailfold capillary analysis pipeline. This pipeline excels in automatically detecting and measuring a wide range of size factors, morphological features, and dynamic aspects of nailfold capillaries. We compared our outcomes with clinical reports. Experiment results showed that our automated pipeline achieves an average of sub-pixel level precision in measurements and 89.9% accuracy in identifying morphological abnormalities. These results underscore its potential for advancing quantitative medical research and enabling pervasive computing in healthcare. Our data and code are available at https://github.com/THU-CS-PI-LAB/ANFC-Automated-Nailfold-Capillary.

Huan Ma, Jingdong Chen, Joey Tianyi Zhou et al.

Over the past few years, Large Language Models (LLMs) have developed rapidly and are widely applied in various domains. However, LLMs face the issue of hallucinations, generating responses that may be unreliable when the models lack relevant knowledge. To be aware of potential hallucinations, uncertainty estimation methods have been introduced, and most of them have confirmed that reliability lies in critical tokens. However, probability-based methods perform poorly in identifying token reliability, limiting their practical utility. In this paper, we reveal that the probability-based method fails to estimate token reliability due to the loss of evidence strength information which is accumulated in the training stage. Therefore, we present Logits-induced token uncertainty (LogTokU), a framework for estimating decoupled token uncertainty in LLMs, enabling real-time uncertainty estimation without requiring multiple sampling processes. We employ evidence modeling to implement LogTokU and use the estimated uncertainty to guide downstream tasks. The experimental results demonstrate that LogTokU has significant effectiveness and promise.

Yuning Yang, Han Yu, Chuan Sun et al.

Federated Learning (FL) is a collaborative machine learning paradigm for training models on local sensitive data with privacy protection. Pre-trained transformer-based models have emerged as useful foundation models (FMs) to be fine-tuned for a wide range of downstream tasks. However, large-scale pre-trained models make it challenging for traditional FL due to high communication overhead in the resource-constrained IoT. This has inspired the field of parameter-efficient fine-tuning (PEFT) research. Existing PEFT methods attempt to optimize model performance at the given dropout level. Such an approach places the burden on human users to find a dropout rate that provides a satisfactory level of performance through trial-and-error, which is time consuming and resource intensive. To address this limitation, we propose the Step-wise Parameter Dropout for Continual Federated Learning (SPD-CFL) approach. Instead of pre-defining a desired dropout rate, it allows users to specify the target level of performance and then attempts to find the most suitable dropout rate for the given FL model. Specifically, on the server side, SPD-CFL drops trainable parameters in a stepwise manner to improve communication efficiency by reducing the rank of low-rank adaptation (LoRA). The sensitivity-based gradient consistency (SGC) measure is designed to facilitate the adaptive adjustment of parameter dropout. In addition, SPD-CFL introduces continual learning (CL) on the client side to mitigate performance degradation due to the inconsistent optima with distinct parameter dropout rates under heterogeneous FL. Extensive experiments on the public benchmark dataset CIFAR-10 and a real-world medical Face dataset demonstrate significant superiority of SPD-CFL over state-of-the-art methods. Compared to the best-performing baseline, it achieves a 2.07% higher test AUC while reducing communication overhead by 29.53%.

Guangyu Wang, Jinzhi Zhang, Fan Wang et al.

We propose XScale-NVS for high-fidelity cross-scale novel view synthesis of real-world large-scale scenes. Existing representations based on explicit surface suffer from discretization resolution or UV distortion, while implicit volumetric representations lack scalability for large scenes due to the dispersed weight distribution and surface ambiguity. In light of the above challenges, we introduce hash featurized manifold, a novel hash-based featurization coupled with a deferred neural rendering framework. This approach fully unlocks the expressivity of the representation by explicitly concentrating the hash entries on the 2D manifold, thus effectively representing highly detailed contents independent of the discretization resolution. We also introduce a novel dataset, namely GigaNVS, to benchmark cross-scale, high-resolution novel view synthesis of realworld large-scale scenes. Our method significantly outperforms competing baselines on various real-world scenes, yielding an average LPIPS that is 40% lower than prior state-of-the-art on the challenging GigaNVS benchmark. Please see our project page at: xscalenvs.github.io.

Junbo Niu, Zheng Liu, Zhuangcheng Gu et al.

We introduce MinerU2.5, a 1.2B-parameter document parsing vision-language model that achieves state-of-the-art recognition accuracy while maintaining exceptional computational efficiency. Our approach employs a coarse-to-fine, two-stage parsing strategy that decouples global layout analysis from local content recognition. In the first stage, the model performs efficient layout analysis on downsampled images to identify structural elements, circumventing the computational overhead of processing high-resolution inputs. In the second stage, guided by the global layout, it performs targeted content recognition on native-resolution crops extracted from the original image, preserving fine-grained details in dense text, complex formulas, and tables. To support this strategy, we developed a comprehensive data engine that generates diverse, large-scale training corpora for both pretraining and fine-tuning. Ultimately, MinerU2.5 demonstrates strong document parsing ability, achieving state-of-the-art performance on multiple benchmarks, surpassing both general-purpose and domain-specific models across various recognition tasks, while maintaining significantly lower computational overhead.

Yuncheng Jiang, Chun-Mei Feng, Jinke Ren et al.

Ultrasound imaging is widely used in clinical diagnosis due to its non-invasive nature and real-time capabilities. However, conventional ultrasound diagnostics face several limitations, including high dependence on physician expertise and suboptimal image quality, which complicates interpretation and increases the likelihood of diagnostic errors. Artificial intelligence (AI) has emerged as a promising solution to enhance clinical diagnosis, particularly in detecting abnormalities across various biomedical imaging modalities. Nonetheless, current AI models for ultrasound imaging face critical challenges. First, these models often require large volumes of labeled medical data, raising concerns over patient privacy breaches. Second, most existing models are task-specific, which restricts their broader clinical utility. To overcome these challenges, we present UltraFedFM, an innovative privacy-preserving ultrasound foundation model. UltraFedFM is collaboratively pre-trained using federated learning across 16 distributed medical institutions in 9 countries, leveraging a dataset of over 1 million ultrasound images covering 19 organs and 10 ultrasound modalities. This extensive and diverse data, combined with a secure training framework, enables UltraFedFM to exhibit strong generalization and diagnostic capabilities. It achieves an average area under the receiver operating characteristic curve of 0.927 for disease diagnosis and a dice similarity coefficient of 0.878 for lesion segmentation. Notably, UltraFedFM surpasses the diagnostic accuracy of mid-level ultrasonographers and matches the performance of expert-level sonographers in the joint diagnosis of 8 common systemic diseases. These findings indicate that UltraFedFM can significantly enhance clinical diagnostics while safeguarding patient privacy, marking an advancement in AI-driven ultrasound imaging for future clinical applications.

Huan Ma, Jiadong Pan, Jing Liu et al.

Large Language Models (LLMs) are being increasingly deployed in real-world applications, but they remain susceptible to hallucinations, which produce fluent yet incorrect responses and lead to erroneous decision-making. Uncertainty estimation is a feasible approach to detect such hallucinations. For example, semantic entropy estimates uncertainty by considering the semantic diversity across multiple sampled responses, thus identifying hallucinations. However, semantic entropy relies on post-softmax probabilities and fails to capture the model's inherent uncertainty, causing it to be ineffective in certain scenarios. To address this issue, we introduce Semantic Energy, a novel uncertainty estimation framework that leverages the inherent confidence of LLMs by operating directly on logits of penultimate layer. By combining semantic clustering with a Boltzmann-inspired energy distribution, our method better captures uncertainty in cases where semantic entropy fails. Experiments across multiple benchmarks show that Semantic Energy significantly improves hallucination detection and uncertainty estimation, offering more reliable signals for downstream applications such as hallucination detection.

Haijiang Tian, Jingkun Yue, Xiaohong Liu et al.

Medical images are often more difficult to acquire than natural images due to the specialism of the equipment and technology, which leads to less medical image datasets. So it is hard to train a strong pretrained medical vision model. How to make the best of natural pretrained vision model and adapt in medical domain still pends. For image classification, a popular method is linear probe (LP). However, LP only considers the output after feature extraction. Yet, there exists a gap between input medical images and natural pretrained vision model. We introduce visual prompting (VP) to fill in the gap, and analyze the strategies of coupling between LP and VP. We design a joint learning loss function containing categorisation loss and discrepancy loss, which describe the variance of prompted and plain images, naming this joint training strategy MoVL (Mixture of Visual Prompting and Linear Probe). We experiment on 4 medical image classification datasets, with two mainstream architectures, ResNet and CLIP. Results shows that without changing the parameters and architecture of backbone model and with less parameters, there is potential for MoVL to achieve full finetune (FF) accuracy (on four medical datasets, average 90.91% for MoVL and 91.13% for FF). On out of distribution medical dataset, our method(90.33%) can outperform FF (85.15%) with absolute 5.18 % lead.

Leyan Xue, Zongbo Han, Guangyu Wang et al.

Vision-Language Models (VLMs) like CLIP achieve cross-modal semantic alignment through contrastive learning, exhibiting robust zero-shot generalization. Traditional prompt engineering, however, predominantly relies on coarse-grained category labels, neglecting fine-grained local semantics. Existing approaches assume that VLMs inherently recognize localized visual details and attempt to enhance classification by augmenting text prompts with attribute descriptors generated by large language models. However, our systematic experiments reveal critical limitations: CLIP's strong bias toward global image patterns hinders its ability to process localized visual descriptors. To address this fundamental constraint, we propose a simple, effective, and plug-and-play solution that enables CLIP to ``See Both the Forest and the Trees." Specifically, we employ stochastic multi-crop augmentation to activate CLIP's latent capacity for localized feature analysis. By cropping only partial regions, the approach effectively constrains the model's receptive field and recalibrates its attention mechanism, thereby mitigating its inherent bias. We evaluate the proposed method under zero-shot, few-shot, and test-time adaptation settings, and extensive experiments demonstrate that D&D achieves promising performance.

Yuning Yang, Han Yu, Tianrun Gao et al.

The deep integration of foundation models (FM) with federated learning (FL) enhances personalization and scalability for diverse downstream tasks, making it crucial in sensitive domains like healthcare. Achieving group fairness has become an increasingly prominent issue in the era of federated foundation models (FFMs), since biases in sensitive attributes might lead to inequitable treatment for under-represented demographic groups. Existing studies mostly focus on achieving fairness with respect to a single sensitive attribute. This renders them unable to provide clear interpretability of dependencies among multiple sensitive attributes which is required to achieve group fairness. Our paper takes the first attempt towards a causal analysis of the relationship between group fairness across various sensitive attributes in the FFM. We extend the FFM structure to trade off multiple sensitive attributes simultaneously and quantify the causal effect behind the group fairness through causal discovery and inference. Extensive experiments validate its effectiveness, offering insights into interpretability towards building trustworthy and fair FFM systems.

Qing Wang, Yining Pan, Minghao Zhou et al.

Drug resistance presents a major challenge in cancer therapy. Single cell profiling offers insights into cellular heterogeneity, yet the application of large-scale foundation models for predicting drug response in single cell data remains underexplored. To address this, we developed scDrugMap, an integrated framework featuring both a Python command-line interface and a web server for drug response prediction. scDrugMap evaluates a wide range of foundation models, including eight single-cell models and two large language models, using a curated dataset of over 326,000 cells in the primary collection and 18,800 cells in the validation set, spanning 36 datasets and diverse tissue and cancer types. We benchmarked model performance under pooled-data and cross-data evaluation settings, employing both layer freezing and Low-Rank Adaptation (LoRA) fine-tuning strategies. In the pooled-data scenario, scFoundation achieved the best performance, with mean F1 scores of 0.971 (layer freezing) and 0.947 (fine-tuning), outperforming the lowest-performing model by over 50%. In the cross-data setting, UCE excelled post fine-tuning (mean F1: 0.774), while scGPT led in zero-shot learning (mean F1: 0.858). Overall, scDrugMap provides the first large-scale benchmark of foundation models for drug response prediction in single-cell data and serves as a user-friendly, flexible platform for advancing drug discovery and translational research.