Janarthanam Jothi Balaji

Rishav Bhardwaj, Janarthanam Jothi Balaji, Vasudevan Lakshminarayanan

There has been considerable progress in implicit neural representation to upscale an image to any arbitrary resolution. However, existing methods are based on defining a function to predict the Red, Green and Blue (RGB) value from just four specific loci. Relying on just four loci is insufficient as it leads to losing fine details from the neighboring region(s). We show that by taking into account the semi-local region leads to an improvement in performance. In this paper, we propose applying a new technique called Overlapping Windows on Semi-Local Region (OW-SLR) to an image to obtain any arbitrary resolution by taking the coordinates of the semi-local region around a point in the latent space. This extracted detail is used to predict the RGB value of a point. We illustrate the technique by applying the algorithm to the Optical Coherence Tomography-Angiography (OCT-A) images and show that it can upscale them to random resolution. This technique outperforms the existing state-of-the-art methods when applied to the OCT500 dataset. OW-SLR provides better results for classifying healthy and diseased retinal images such as diabetic retinopathy and normals from the given set of OCT-A images. The project page is available at https://rishavbb.github.io/ow-slr/index.html

V. K. Viekash, Janarthanam Jothi Balaji, Vasudevan Lakshminarayanan

Various ocular diseases and high myopia influence the anatomical reference point Foveal Avascular Zone (FAZ) dimensions. Therefore, it is important to segment and quantify the FAZs dimensions accurately. To the best of our knowledge, there is no automated tool or algorithms available to segment the FAZ's deep retinal layer. The paper describes a new open-access software with a user-friendly Graphical User Interface (GUI) and compares the results with the ground truth (manual segmentation).

Vasudevan Lakshminarayanan, Hoda Kherdfallah, Arya Sarkar et al.

Diabetic Retinopathy (DR) is a leading cause of vision loss in the world,. In the past few Diabetic Retinopathy (DR) is a leading cause of vision loss in the world. In the past few years, Artificial Intelligence (AI) based approaches have been used to detect and grade DR. Early detection enables appropriate treatment and thus prevents vision loss, Both fundus and optical coherence tomography (OCT) images are used to image the retina. With deep learning/machine learning apprroaches it is possible to extract features from the images and detect the presence of DR. Multiple strategies are implemented to detect and grade the presence of DR using classification, segmentation, and hybrid techniques. This review covers the literature dealing with AI approaches to DR that have been published in the open literature over a five year span (2016-2021). In addition a comprehensive list of available DR datasets is reported. Both the PICO (P-patient, I-intervention, C-control O-outcome) and Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA)2009 search strategies were employed. We summarize a total of 114 published articles which conformed to the scope of the review. In addition a list of 43 major datasets is presented.

Amitojdeep Singh, J. Jothi Balaji, Mohammed Abdul Rasheed et al.

Background: The lack of explanations for the decisions made by algorithms such as deep learning has hampered their acceptance by the clinical community despite highly accurate results on multiple problems. Recently, attribution methods have emerged for explaining deep learning models, and they have been tested on medical imaging problems. The performance of attribution methods is compared on standard machine learning datasets and not on medical images. In this study, we perform a comparative analysis to determine the most suitable explainability method for retinal OCT diagnosis. Methods: A commonly used deep learning model known as Inception v3 was trained to diagnose 3 retinal diseases - choroidal neovascularization (CNV), diabetic macular edema (DME), and drusen. The explanations from 13 different attribution methods were rated by a panel of 14 clinicians for clinical significance. Feedback was obtained from the clinicians regarding the current and future scope of such methods. Results: An attribution method based on a Taylor series expansion, called Deep Taylor was rated the highest by clinicians with a median rating of 3.85/5. It was followed by two other attribution methods, Guided backpropagation and SHAP (SHapley Additive exPlanations). Conclusion: Explanations of deep learning models can make them more transparent for clinical diagnosis. This study compared different explanations methods in the context of retinal OCT diagnosis and found that the best performing method may not be the one considered best for other deep learning tasks. Overall, there was a high degree of acceptance from the clinicians surveyed in the study. Keywords: explainable AI, deep learning, machine learning, image processing, Optical coherence tomography, retina, Diabetic macular edema, Choroidal Neovascularization, Drusen