Fengjiao Wang

Chenyuan Bian, Nan Xia, Xia Yang et al.

Deep learning, particularly convolutional neural networks (CNNs) and Transformers, has significantly advanced 3D medical image segmentation. While CNNs are highly effective at capturing local features, their limited receptive fields may hinder performance in complex clinical scenarios. In contrast, Transformers excel at modeling long-range dependencies but are computationally intensive, making them expensive to train and deploy. Recently, the Mamba architecture, based on the State Space Model (SSM), has been proposed to efficiently model long-range dependencies while maintaining linear computational complexity. However, its application in medical image segmentation reveals shortcomings, particularly in capturing critical local features essential for accurate delineation of clinical regions. In this study, we propose MambaClinix, a novel U-shaped architecture for medical image segmentation that integrates a hierarchical gated convolutional network(HGCN) with Mamba in an adaptive stage-wise framework. This design significantly enhances computational efficiency and high-order spatial interactions, enabling the model to effectively capture both proximal and distal relationships in medical images. Specifically, our HGCN is designed to mimic the attention mechanism of Transformers by a purely convolutional structure, facilitating high-order spatial interactions in feature maps while avoiding the computational complexity typically associated with Transformer-based methods. Additionally, we introduce a region-specific Tversky loss, which emphasizes specific pixel regions to improve auto-segmentation performance, thereby optimizing the model's decision-making process. Experimental results on five benchmark datasets demonstrate that the proposed MambaClinix achieves high segmentation accuracy while maintaining low model complexity.

Khoa D. Doan, Saurav Manchanda, Fengjiao Wang et al.

For a given image generation problem, the intrinsic image manifold is often low dimensional. We use the intuition that it is much better to train the GAN generator by minimizing the distributional distance between real and generated images in a small dimensional feature space representing such a manifold than on the original pixel-space. We use the feature space of the GAN discriminator for such a representation. For distributional distance, we employ one of two choices: the Fréchet distance or direct optimal transport (OT); these respectively lead us to two new GAN methods: Fréchet-GAN and OT-GAN. The idea of employing Fréchet distance comes from the success of Fréchet Inception Distance as a solid evaluation metric in image generation. Fréchet-GAN is attractive in several ways. We propose an efficient, numerically stable approach to calculate the Fréchet distance and its gradient. The Fréchet distance estimation requires a significantly less computation time than OT; this allows Fréchet-GAN to use much larger mini-batch size in training than OT. More importantly, we conduct experiments on a number of benchmark datasets and show that Fréchet-GAN (in particular) and OT-GAN have significantly better image generation capabilities than the existing representative primal and dual GAN approaches based on the Wasserstein distance.