Puria Azadi

Philip Fradkin, Puria Azadi, Karush Suri et al.

Predicting molecular impact on cellular function is a core challenge in therapeutic design. Phenomic experiments, designed to capture cellular morphology, utilize microscopy based techniques and demonstrate a high throughput solution for uncovering molecular impact on the cell. In this work, we learn a joint latent space between molecular structures and microscopy phenomic experiments, aligning paired samples with contrastive learning. Specifically, we study the problem ofContrastive PhenoMolecular Retrieval, which consists of zero-shot molecular structure identification conditioned on phenomic experiments. We assess challenges in multi-modal learning of phenomics and molecular modalities such as experimental batch effect, inactive molecule perturbations, and encoding perturbation concentration. We demonstrate improved multi-modal learner retrieval through (1) a uni-modal pre-trained phenomics model, (2) a novel inter sample similarity aware loss, and (3) models conditioned on a representation of molecular concentration. Following this recipe, we propose MolPhenix, a molecular phenomics model. MolPhenix leverages a pre-trained phenomics model to demonstrate significant performance gains across perturbation concentrations, molecular scaffolds, and activity thresholds. In particular, we demonstrate an 8.1x improvement in zero shot molecular retrieval of active molecules over the previous state-of-the-art, reaching 77.33% in top-1% accuracy. These results open the door for machine learning to be applied in virtual phenomics screening, which can significantly benefit drug discovery applications.

Ailar Mahdizadeh, Puria Azadi, Muchen Li et al.

Streaming video understanding with large vision-language models (VLMs) requires a compact memory that can support future reasoning over an ever-growing visual history. A common solution is to compress the key-value (KV) cache, but existing streaming methods typically rely on local token-wise heuristics, such as recency, temporal redundancy, or saliency, which do not explicitly optimize whether the retained cache is representative of the accumulated history. We propose to view KV-cache compression as a coreset selection problem: rather than scoring tokens independently for retention, we select a small subset that covers the geometry of the accumulated visual cache. Our method operates in a joint KV representation and introduces a bicriteria objective that balances coverage in key and value spaces, preserving both retrieval structure and output-relevant information. To encourage a more diverse retained subset, we further introduce an orthogonality-driven diversity criterion that favors candidates contributing new directions beyond the current selection, and connect this criterion to log-determinant subset selection. Across four open-source VLMs and five long-video and streaming-video benchmarks, our method improves over heuristic streaming compression baselines under a fixed cache budget. These results highlight that representative coreset selection offers a more effective principle, than token-wise pruning, for memory-constrained streaming video understanding.