Lei Liu

Yuxian Gu, Jiaxin Wen, Hao Sun et al. · tsinghua

Large-scale pre-training has shown remarkable performance in building open-domain dialogue systems. However, previous works mainly focus on showing and evaluating the conversational performance of the released dialogue model, ignoring the discussion of some key factors towards a powerful human-like chatbot, especially in Chinese scenarios. In this paper, we conduct extensive experiments to investigate these under-explored factors, including data quality control, model architecture designs, training approaches, and decoding strategies. We propose EVA2.0, a large-scale pre-trained open-domain Chinese dialogue model with 2.8 billion parameters, and will make our models and codes publicly available. Automatic and human evaluations show that EVA2.0 significantly outperforms other open-source counterparts. We also discuss the limitations of this work by presenting some failure cases and pose some future research directions on large-scale Chinese open-domain dialogue systems.

Zechen Bai, Tong He, Haiyang Mei et al.

We introduce VideoLISA, a video-based multimodal large language model designed to tackle the problem of language-instructed reasoning segmentation in videos. Leveraging the reasoning capabilities and world knowledge of large language models, and augmented by the Segment Anything Model, VideoLISA generates temporally consistent segmentation masks in videos based on language instructions. Existing image-based methods, such as LISA, struggle with video tasks due to the additional temporal dimension, which requires temporal dynamic understanding and consistent segmentation across frames. VideoLISA addresses these challenges by integrating a Sparse Dense Sampling strategy into the video-LLM, which balances temporal context and spatial detail within computational constraints. Additionally, we propose a One-Token-Seg-All approach using a specially designed <TRK> token, enabling the model to segment and track objects across multiple frames. Extensive evaluations on diverse benchmarks, including our newly introduced ReasonVOS benchmark, demonstrate VideoLISA's superior performance in video object segmentation tasks involving complex reasoning, temporal understanding, and object tracking. While optimized for videos, VideoLISA also shows promising generalization to image segmentation, revealing its potential as a unified foundation model for language-instructed object segmentation. Code and model will be available at: https://github.com/showlab/VideoLISA.

Ying Liu, Lei Liu, Wei-Peng Chen

The combination of Artificial Intelligence (AI) and Internet-of-Things (IoT), which is denoted as AI-powered Internet-of-Things (AIoT), is capable of processing huge amount of data generated from a large number of devices and handling complex problems in social infrastructures. As AI and IoT technologies are becoming mature, in this paper, we propose to apply AIoT technologies for traffic light control, which is an essential component for intelligent transportation system, to improve the efficiency of smart city's road system. Specifically, various sensors such as surveillance cameras provide real-time information for intelligent traffic light control system to observe the states of both motorized traffic and non-motorized traffic. In this paper, we propose an intelligent traffic light control solution by using distributed multi-agent Q learning, considering the traffic information at the neighboring intersections as well as local motorized and non-motorized traffic, to improve the overall performance of the entire control system. By using the proposed multi-agent Q learning algorithm, our solution is targeting to optimize both the motorized and non-motorized traffic. In addition, we considered many constraints/rules for traffic light control in the real world, and integrate these constraints in the learning algorithm, which can facilitate the proposed solution to be deployed in real operational scenarios. We conducted numerical simulations for a real-world map with real-world traffic data. The simulation results show that our proposed solution outperforms existing solutions in terms of vehicle and pedestrian queue lengths, waiting time at intersections, and many other key performance metrics.

Zhiyuan Yan, Peng Sun, Yubo Lang et al.

Existing deepfake detectors face several challenges in achieving robustness and generalization. One of the primary reasons is their limited ability to extract relevant information from forgery videos, especially in the presence of various artifacts such as spatial, frequency, temporal, and landmark mismatches. Current detectors rely on pixel-level features that are easily affected by unknown disturbances or facial landmarks that do not provide sufficient information. Furthermore, most detectors cannot utilize information from multiple domains for detection, leading to limited effectiveness in identifying deepfake videos. To address these limitations, we propose a novel framework, namely Multimodal Graph Learning (MGL) that leverages information from multiple modalities using two GNNs and several multimodal fusion modules. At the frame level, we employ a bi-directional cross-modal transformer and an adaptive gating mechanism to combine the features from the spatial and frequency domains with the geometric-enhanced landmark features captured by a GNN. At the video level, we use a Graph Attention Network (GAT) to represent each frame in a video as a node in a graph and encode temporal information into the edges of the graph to extract temporal inconsistency between frames. Our proposed method aims to effectively identify and utilize distinguishing features for deepfake detection. We evaluate the effectiveness of our method through extensive experiments on widely-used benchmarks and demonstrate that our method outperforms the state-of-the-art detectors in terms of generalization ability and robustness against unknown disturbances.

Zheheng Luo, Lei Liu, Qianqian Xie et al.

Existing NTMs with contrastive learning suffer from the sample bias problem owing to the word frequency-based sampling strategy, which may result in false negative samples with similar semantics to the prototypes. In this paper, we aim to explore the efficient sampling strategy and contrastive learning in NTMs to address the aforementioned issue. We propose a new sampling assumption that negative samples should contain words that are semantically irrelevant to the prototype. Based on it, we propose the graph contrastive topic model (GCTM), which conducts graph contrastive learning (GCL) using informative positive and negative samples that are generated by the graph-based sampling strategy leveraging in-depth correlation and irrelevance among documents and words. In GCTM, we first model the input document as the document word bipartite graph (DWBG), and construct positive and negative word co-occurrence graphs (WCGs), encoded by graph neural networks, to express in-depth semantic correlation and irrelevance among words. Based on the DWBG and WCGs, we design the document-word information propagation (DWIP) process to perform the edge perturbation of DWBG, based on multi-hop correlations/irrelevance among documents and words. This yields the desired negative and positive samples, which will be utilized for GCL together with the prototypes to improve learning document topic representations and latent topics. We further show that GCL can be interpreted as the structured variational graph auto-encoder which maximizes the mutual information of latent topic representations of different perspectives on DWBG. Experiments on several benchmark datasets demonstrate the effectiveness of our method for topic coherence and document representation learning compared with existing SOTA methods.

Lei Liu, Shansuo Liang, Li Ping

This paper investigates a large unitarily invariant system (LUIS) involving a unitarily invariant sensing matrix, an arbitrary fixed signal distribution, and forward error control (FEC) coding. Several area properties are established based on the state evolution of orthogonal approximate message passing (OAMP) in an un-coded LUIS. Under the assumptions that the state evolution for joint OAMP and FEC decoding is correct and the replica method is reliable, we analyze the achievable rate of OAMP. We prove that OAMP reaches the constrained capacity predicted by the replica method of the LUIS with an arbitrary signal distribution based on matched FEC coding. Meanwhile, we elaborate a constrained capacity-achieving coding principle for LUIS, based on which irregular low-density parity-check (LDPC) codes are optimized for binary signaling in the simulation results. We show that OAMP with the optimized codes has significant performance improvement over the un-optimized ones and the well-known Turbo linear MMSE algorithm. For quadrature phase-shift keying (QPSK) modulation, constrained capacity-approaching bit error rate (BER) performances are observed under various channel conditions.

Xiaoqiong Xia, Chaoyu Zhu, Yuqi Shan et al.

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR), their performances can be improved by addressing issues such as insufficient data modality, suboptimal fusion algorithms, and poor generalizability for novel drugs or cell lines. We introduce TransCDR, which uses transfer learning to learn drug representations and fuses multi-modality features of drugs and cell lines by a self-attention mechanism, to predict the IC50 values or sensitive states of drugs on cell lines. We are the first to systematically evaluate the generalization of the CDR prediction model to novel (i.e., never-before-seen) compound scaffolds and cell line clusters. TransCDR shows better generalizability than 8 state-of-the-art models. TransCDR outperforms its 5 variants that train drug encoders (i.e., RNN and AttentiveFP) from scratch under various scenarios. The most critical contributors among multiple drug notations and omics profiles are Extended Connectivity Fingerprint and genetic mutation. Additionally, the attention-based fusion module further enhances the predictive performance of TransCDR. TransCDR, trained on the GDSC dataset, demonstrates strong predictive performance on the external testing set CCLE. It is also utilized to predict missing CDRs on GDSC. Moreover, we investigate the biological mechanisms underlying drug response by classifying 7,675 patients from TCGA into drug-sensitive or drug-resistant groups, followed by a Gene Set Enrichment Analysis. TransCDR emerges as a potent tool with significant potential in drug response prediction. The source code and data can be accessed at https://github.com/XiaoqiongXia/TransCDR.

Zhengliang Liu, Xinyu He, Lei Liu et al.

This study aims at improving the performance of scoring student responses in science education automatically. BERT-based language models have shown significant superiority over traditional NLP models in various language-related tasks. However, science writing of students, including argumentation and explanation, is domain-specific. In addition, the language used by students is different from the language in journals and Wikipedia, which are training sources of BERT and its existing variants. All these suggest that a domain-specific model pre-trained using science education data may improve model performance. However, the ideal type of data to contextualize pre-trained language model and improve the performance in automatically scoring student written responses remains unclear. Therefore, we employ different data in this study to contextualize both BERT and SciBERT models and compare their performance on automatic scoring of assessment tasks for scientific argumentation. We use three datasets to pre-train the model: 1) journal articles in science education, 2) a large dataset of students' written responses (sample size over 50,000), and 3) a small dataset of students' written responses of scientific argumentation tasks. Our experimental results show that in-domain training corpora constructed from science questions and responses improve language model performance on a wide variety of downstream tasks. Our study confirms the effectiveness of continual pre-training on domain-specific data in the education domain and demonstrates a generalizable strategy for automating science education tasks with high accuracy. We plan to release our data and SciEdBERT models for public use and community engagement.

Yunpeng Wang, Kang Wang, Yaoyao Zhuo et al.

Rapid and accurate diagnosis of pneumothorax, utilizing chest X-ray and computed tomography (CT), is crucial for assisted diagnosis. Chest X-ray is commonly used for initial localization of pneumothorax, while CT ensures accurate quantification. However, CT scans involve high radiation doses and can be costly. To achieve precise quantitative diagnosis while minimizing radiation exposure, we proposed X-Recon, a CT ultra-sparse reconstruction network based on ortho-lateral chest X-ray images. X-Recon integrates generative adversarial networks (GANs), including a generator with a multi-scale fusion rendering module and a discriminator enhanced by 3D coordinate convolutional layers, designed to facilitate CT reconstruction. To improve precision, a projective spatial transformer is utilized to incorporate multi-angle projection loss. Additionally, we proposed PTX-Seg, a zero-shot pneumothorax segmentation algorithm, combining image processing techniques with deep-learning models for the segmentation of air-accumulated regions and lung structures. Experiments on a large-scale dataset demonstrate its superiority over existing approaches. X-Recon achieved a significantly higher reconstruction resolution with a higher average spatial resolution and a lower average slice thickness. The reconstruction metrics achieved state-of-the-art performance in terms of several metrics including peak signal-to-noise ratio. The zero-shot segmentation algorithm, PTX-Seg, also demonstrated high segmentation precision for the air-accumulated region, the left lung, and the right lung. Moreover, the consistency analysis for the pneumothorax chest occupancy ratio between reconstructed CT and original CT obtained a high correlation coefficient. Code will be available at: https://github.com/wangyunpengbio/X-Recon

Lei Liu, Xiaoyan Yang, Yue Shen et al.

Memory-augmented Large Language Models (LLMs) have demonstrated remarkable performance in long-term human-machine interactions, which basically relies on iterative recalling and reasoning of history to generate high-quality responses. However, such repeated recall-reason steps easily produce biased thoughts, \textit{i.e.}, inconsistent reasoning results when recalling the same history for different questions. On the contrary, humans can keep thoughts in the memory and recall them without repeated reasoning. Motivated by this human capability, we propose a novel memory mechanism called TiM (Think-in-Memory) that enables LLMs to maintain an evolved memory for storing historical thoughts along the conversation stream. The TiM framework consists of two crucial stages: (1) before generating a response, a LLM agent recalls relevant thoughts from memory, and (2) after generating a response, the LLM agent post-thinks and incorporates both historical and new thoughts to update the memory. Thus, TiM can eliminate the issue of repeated reasoning by saving the post-thinking thoughts as the history. Besides, we formulate the basic principles to organize the thoughts in memory based on the well-established operations, (\textit{i.e.}, insert, forget, and merge operations), allowing for dynamic updates and evolution of the thoughts. Furthermore, we introduce Locality-Sensitive Hashing into TiM to achieve efficient retrieval for the long-term conversations. We conduct qualitative and quantitative experiments on real-world and simulated dialogues covering a wide range of topics, demonstrating that equipping existing LLMs with TiM significantly enhances their performance in generating responses for long-term interactions.

Lei Liu, Shunqi Huang, Brian M. Kurkoski

Approximate message passing (AMP) type algorithms have been widely used in the signal reconstruction of certain large random linear systems. A key feature of the AMP-type algorithms is that their dynamics can be correctly described by state evolution. However, state evolution does not necessarily guarantee the convergence of iterative algorithms. To solve the convergence problem of AMP-type algorithms in principle, this paper proposes a memory AMP (MAMP) under a sufficient statistic condition, named sufficient statistic MAMP (SS-MAMP). We show that the covariance matrices of SS-MAMP are L-banded and convergent. Given an arbitrary MAMP, we can construct the SS-MAMP by damping, which not only ensures the convergence, but also preserves the orthogonality, i.e., its dynamics can be correctly described by state evolution.

Guangrong Zhao, Yiran Shen, Ning Chen et al.

Rotational speed is one of the important metrics to be measured for calibrating the electric motors in manufacturing, monitoring engine during car repairing, faults detection on electrical appliance and etc. However, existing measurement techniques either require prohibitive hardware (e.g., high-speed camera) or are inconvenient to use in real-world application scenarios. In this paper, we propose, EV-Tach, an event-based tachometer via efficient dynamic vision sensing on mobile devices. EV-Tach is designed as a high-fidelity and convenient tachometer by introducing dynamic vision sensor as a new sensing modality to capture the high-speed rotation precisely under various real-world scenarios. By designing a series of signal processing algorithms bespoke for dynamic vision sensing on mobile devices, EV-Tach is able to extract the rotational speed accurately from the event stream produced by dynamic vision sensing on rotary targets. According to our extensive evaluations, the Relative Mean Absolute Error (RMAE) of EV-Tach is as low as 0.03% which is comparable to the state-of-the-art laser tachometer under fixed measurement mode. Moreover, EV-Tach is robust to subtle movement of user's hand, therefore, can be used as a handheld device, where the laser tachometer fails to produce reasonable results.

Lei Liu, Javier E. Santos, Maša Prodanović et al.

Spatial nonstationarity, the location variance of features' statistical distributions, is ubiquitous in many natural settings. For example, in geological reservoirs rock matrix porosity varies vertically due to geomechanical compaction trends, in mineral deposits grades vary due to sedimentation and concentration processes, in hydrology rainfall varies due to the atmosphere and topography interactions, and in metallurgy crystalline structures vary due to differential cooling. Conventional geostatistical modeling workflows rely on the assumption of stationarity to be able to model spatial features for the geostatistical inference. Nevertheless, this is often not a realistic assumption when dealing with nonstationary spatial data and this has motivated a variety of nonstationary spatial modeling workflows such as trend and residual decomposition, cosimulation with secondary features, and spatial segmentation and independent modeling over stationary subdomains. The advent of deep learning technologies has enabled new workflows for modeling spatial relationships. However, there is a paucity of demonstrated best practice and general guidance on mitigation of spatial nonstationarity with deep learning in the geospatial context. We demonstrate the impact of two common types of geostatistical spatial nonstationarity on deep learning model prediction performance and propose the mitigation of such impacts using self-attention (vision transformer) models. We demonstrate the utility of vision transformers for the mitigation of nonstationarity with relative errors as low as 10%, exceeding the performance of alternative deep learning methods such as convolutional neural networks. We establish best practice by demonstrating the ability of self-attention networks for modeling large-scale spatial relationships in the presence of commonly observed geospatial nonstationarity.

Liang Cheng, Peiyuan Guan, Amir Taherkordi et al.

Variational Autoencoders (VAEs), as a form of deep generative model, have been widely used in recent years, and shown great great peformance in a number of different domains, including image generation and anomaly detection, etc.. This paper aims to explore neural network model compression method based on VAE. The experiment uses different neural network models for MNIST recognition as compression targets, including Feedforward Neural Network (FNN), Convolutional Neural Network (CNN), Recurrent Neural Network (RNN) and Long Short-Term Memory (LSTM). These models are the most basic models in deep learning, and other more complex and advanced models are based on them or inherit their features and evolve. In the experiment, the first step is to train the models mentioned above, each trained model will have different accuracy and number of total parameters. And then the variants of parameters for each model are processed as training data in VAEs separately, and the trained VAEs are tested by the true model parameters. The experimental results show that using the latent space as a representation of the model compression can improve the compression rate compared to some traditional methods such as pruning and quantization, meanwhile the accuracy is not greatly affected using the model parameters reconstructed based on the latent space. In the future, a variety of different large-scale deep learning models will be used more widely, so exploring different ways to save time and space on saving or transferring models will become necessary, and the use of VAE in this paper can provide a basis for these further explorations.

Yuxue Cao, Shengjie Wang, Xiang Zheng et al.

Reinforcement learning methods as a promising technique have achieved superior results in the motion planning of free-floating space robots. However, due to the increase in planning dimension and the intensification of system dynamics coupling, the motion planning of dual-arm free-floating space robots remains an open challenge. In particular, the current study cannot handle the task of capturing a non-cooperative object due to the lack of the pose constraint of the end-effectors. To address the problem, we propose a novel algorithm, EfficientLPT, to facilitate RL-based methods to improve planning accuracy efficiently. Our core contributions are constructing a mixed policy with prior knowledge guidance and introducing infinite norm to build a more reasonable reward function. Furthermore, our method successfully captures a rotating object with different spinning speeds.

Xianhao Wang, Xiaojian Ma, Haozhe Hu et al.

Generalist embodied agents must perform interactive, causally-dependent reasoning, continually interacting with the environment, acquiring information, and updating plans to solve long-horizon tasks before they could be adopted in real-life scenarios. For instance, retrieving an apple from a cabinet may require opening multiple doors and drawers before the apple becomes visible and reachable, demanding sequential interaction under partial observability. However, existing benchmarks fail to systematically evaluate this essential capability. We introduce COIN, a benchmark designed to assess interactive reasoning in realistic robotic manipulation through three key contributions. First, we construct COIN-50: 50 interactive tasks in daily scenarios, and create COIN-Primitive required by causally-dependent tasks, and COIN-Composition with mid-term complexity for skill learning and generalization evaluation. Second, we develop a low-cost mobile AR teleoperation system and collect the COIN-Primitive Dataset with 50 demonstrations per primitive task (1,000 in total). Third, we develop systematic evaluation metrics about execution stability and generalization robustness to evaluate CodeAsPolicy, VLA, and language-conditioned H-VLA approaches. Our comprehensive evaluation reveals critical limitations in current methods: models struggle with interactive reasoning tasks due to significant gaps between visual understanding and motor execution. We provide fine-grained analysis of these limitations.

Lei Liu, Li Liu

Automatic Cued Speech Recognition (ACSR) provides an intelligent human-machine interface for visual communications, where the Cued Speech (CS) system utilizes lip movements and hand gestures to code spoken language for hearing-impaired people. Previous ACSR approaches often utilize direct feature concatenation as the main fusion paradigm. However, the asynchronous modalities i.e., lip, hand shape and hand position) in CS may cause interference for feature concatenation. To address this challenge, we propose a transformer based cross-modal mutual learning framework to prompt multi-modal interaction. Compared with the vanilla self-attention, our model forces modality-specific information of different modalities to pass through a modality-invariant codebook, collating linguistic representations for tokens of each modality. Then the shared linguistic knowledge is used to re-synchronize multi-modal sequences. Moreover, we establish a novel large-scale multi-speaker CS dataset for Mandarin Chinese. To our knowledge, this is the first work on ACSR for Mandarin Chinese. Extensive experiments are conducted for different languages i.e., Chinese, French, and British English). Results demonstrate that our model exhibits superior recognition performance to the state-of-the-art by a large margin.

Guoqing Ma, Haoyang Huang, Kun Yan et al.

We present Step-Video-T2V, a state-of-the-art text-to-video pre-trained model with 30B parameters and the ability to generate videos up to 204 frames in length. A deep compression Variational Autoencoder, Video-VAE, is designed for video generation tasks, achieving 16x16 spatial and 8x temporal compression ratios, while maintaining exceptional video reconstruction quality. User prompts are encoded using two bilingual text encoders to handle both English and Chinese. A DiT with 3D full attention is trained using Flow Matching and is employed to denoise input noise into latent frames. A video-based DPO approach, Video-DPO, is applied to reduce artifacts and improve the visual quality of the generated videos. We also detail our training strategies and share key observations and insights. Step-Video-T2V's performance is evaluated on a novel video generation benchmark, Step-Video-T2V-Eval, demonstrating its state-of-the-art text-to-video quality when compared with both open-source and commercial engines. Additionally, we discuss the limitations of current diffusion-based model paradigm and outline future directions for video foundation models. We make both Step-Video-T2V and Step-Video-T2V-Eval available at https://github.com/stepfun-ai/Step-Video-T2V. The online version can be accessed from https://yuewen.cn/videos as well. Our goal is to accelerate the innovation of video foundation models and empower video content creators.

Yueqi Zeng, Ziqiang Li, Pengfei Xia et al.

With the boom in the natural language processing (NLP) field these years, backdoor attacks pose immense threats against deep neural network models. However, previous works hardly consider the effect of the poisoning rate. In this paper, our main objective is to reduce the number of poisoned samples while still achieving a satisfactory Attack Success Rate (ASR) in text backdoor attacks. To accomplish this, we propose an efficient trigger word insertion strategy in terms of trigger word optimization and poisoned sample selection. Extensive experiments on different datasets and models demonstrate that our proposed method can significantly improve attack effectiveness in text classification tasks. Remarkably, our approach achieves an ASR of over 90% with only 10 poisoned samples in the dirty-label setting and requires merely 1.5% of the training data in the clean-label setting.

Ziqiang Li, Yueqi Zeng, Pengfei Xia et al.

With the burgeoning advancements in the field of natural language processing (NLP), the demand for training data has increased significantly. To save costs, it has become common for users and businesses to outsource the labor-intensive task of data collection to third-party entities. Unfortunately, recent research has unveiled the inherent risk associated with this practice, particularly in exposing NLP systems to potential backdoor attacks. Specifically, these attacks enable malicious control over the behavior of a trained model by poisoning a small portion of the training data. Unlike backdoor attacks in computer vision, textual backdoor attacks impose stringent requirements for attack stealthiness. However, existing attack methods meet significant trade-off between effectiveness and stealthiness, largely due to the high information entropy inherent in textual data. In this paper, we introduce the Efficient and Stealthy Textual backdoor attack method, EST-Bad, leveraging Large Language Models (LLMs). Our EST-Bad encompasses three core strategies: optimizing the inherent flaw of models as the trigger, stealthily injecting triggers with LLMs, and meticulously selecting the most impactful samples for backdoor injection. Through the integration of these techniques, EST-Bad demonstrates an efficient achievement of competitive attack performance while maintaining superior stealthiness compared to prior methods across various text classifier datasets.

Jian Zhu, Xin Zou, Jun Sun et al.

In recent years, the advancement of Graph Neural Networks (GNNs) has significantly propelled progress in Multi-View Clustering (MVC). However, existing methods face the problem of coarse-grained graph fusion. Specifically, current approaches typically generate a separate graph structure for each view and then perform weighted fusion of graph structures at the view level, which is a relatively rough strategy. To address this limitation, we present a novel Mixture of Ego-Graphs Contrastive Representation Learning (MoEGCL). It mainly consists of two modules. In particular, we propose an innovative Mixture of Ego-Graphs Fusion (MoEGF), which constructs ego graphs and utilizes a Mixture-of-Experts network to implement fine-grained fusion of ego graphs at the sample level, rather than the conventional view-level fusion. Additionally, we present the Ego Graph Contrastive Learning (EGCL) module to align the fused representation with the view-specific representation. The EGCL module enhances the representation similarity of samples from the same cluster, not merely from the same sample, further boosting fine-grained graph representation. Extensive experiments demonstrate that MoEGCL achieves state-of-the-art results in deep multi-view clustering tasks. The source code is publicly available at https://github.com/HackerHyper/MoEGCL.

Yeqiu Chen, Ziyan Liu, Zhenxin Huang et al.

Recent progress in LLM reasoning has increasingly shifted from single-pass generation to explicit search over intermediate reasoning states. Tree-of-Thoughts (ToT) organizes inference to tree-structured search with branching and backtracking, but it substantially amplifies the Key--Value (KV) cache: retaining KV states for a frontier of partial trajectories quickly becomes a memory bottleneck that limits throughput and constrains search depth and width under fixed hardware budgets. We address this challenge by observing that KV reuse in ToT-style inference is governed by search dynamics: near-term decoding depends primarily on the active branch and its ancestors, whereas inactive subtrees have low short-term reuse probability yet must remain recoverable for backtracking. Motivated by this, we propose ArborKV, a structure-aware eviction framework that couples a lightweight value estimator with a tree-aware allocation policy, and performs purely token-extractive eviction with lazy rehydration to support revisits. Experiments on ToT-style reasoning benchmarks show that ArborKV achieves up to ~4x peak KV-memory reduction while preserving near-full-retention accuracy, enabling larger search configurations under fixed device budgets that would otherwise run out of memory.

Ziyi Yang, Zitong Tian, Yinjun Jia et al.

D-peptide binders targeting L-proteins have promising therapeutic potential. Despite rapid advances in machine learning-based target-conditioned peptide design, generating D-peptide binders remains largely unexplored. In this work, we show that by injecting axial features to $E(3)$-equivariant (polar) vector features,it is feasible to achieve cross-chirality generalization from homo-chiral (L--L) training data to hetero-chiral (D--L) design tasks. By implementing this method within a latent diffusion model, we achieved D-peptide binder design that not only outperforms existing tools in in silico benchmarks, but also demonstrates efficacy in wet-lab validation. To our knowledge, our approach represents the first wet-lab validated generative AI for the de novo design of D-peptide binders, offering new perspectives on handling chirality in protein design.

Wentao Lei, Lei Liu, Li Liu

Intelligent medical diagnosis has shown remarkable progress based on the large-scale datasets with precise annotations. However, fewer labeled images are available due to significantly expensive cost for annotating data by experts. To fully exploit the easily available unlabeled data, we propose a novel Spatio-Temporal Structure Consistent (STSC) learning framework. Specifically, a gram matrix is derived to combine the spatial structure consistency and temporal structure consistency together. This gram matrix captures the structural similarity among the representations of different training samples. At the spatial level, our framework explicitly enforces the consistency of structural similarity among different samples under perturbations. At the temporal level, we consider the consistency of the structural similarity in different training iterations by digging out the stable sub-structures in a relation graph. Experiments on two medical image datasets (i.e., ISIC 2018 challenge and ChestX-ray14) show that our method outperforms state-of-the-art SSL methods. Furthermore, extensive qualitative analysis on the Gram matrices and heatmaps by Grad-CAM are presented to validate the effectiveness of our method.

Lei Liu, Li Liu, Yawen Cui

Even in the era of large models, one of the well-known issues in continual learning (CL) is catastrophic forgetting, which is significantly challenging when the continual data stream exhibits a long-tailed distribution, termed as Long-Tailed Continual Learning (LTCL). Existing LTCL solutions generally require the label distribution of the data stream to achieve re-balance training. However, obtaining such prior information is often infeasible in real scenarios since the model should learn without pre-identifying the majority and minority classes. To this end, we propose a novel Prior-free Balanced Replay (PBR) framework to learn from long-tailed data stream with less forgetting. Concretely, motivated by our experimental finding that the minority classes are more likely to be forgotten due to the higher uncertainty, we newly design an uncertainty-guided reservoir sampling strategy to prioritize rehearsing minority data without using any prior information, which is based on the mutual dependence between the model and samples. Additionally, we incorporate two prior-free components to further reduce the forgetting issue: (1) Boundary constraint is to preserve uncertain boundary supporting samples for continually re-estimating task boundaries. (2) Prototype constraint is to maintain the consistency of learned class prototypes along with training. Our approach is evaluated on three standard long-tailed benchmarks, demonstrating superior performance to existing CL methods and previous SOTA LTCL approach in both task- and class-incremental learning settings, as well as ordered- and shuffled-LTCL settings.

Jian Zhu, Yu Cui, Zhangmin Huang et al.

The multi-view hash method converts heterogeneous data from multiple views into binary hash codes, which is one of the critical technologies in multimedia retrieval. However, the current methods mainly explore the complementarity among multiple views while lacking confidence learning and fusion. Moreover, in practical application scenarios, the single-view data contain redundant noise. To conduct the confidence learning and eliminate unnecessary noise, we propose a novel Adaptive Confidence Multi-View Hashing (ACMVH) method. First, a confidence network is developed to extract useful information from various single-view features and remove noise information. Furthermore, an adaptive confidence multi-view network is employed to measure the confidence of each view and then fuse multi-view features through a weighted summation. Lastly, a dilation network is designed to further enhance the feature representation of the fused features. To the best of our knowledge, we pioneer the application of confidence learning into the field of multimedia retrieval. Extensive experiments on two public datasets show that the proposed ACMVH performs better than state-of-the-art methods (maximum increase of 3.24%). The source code is available at https://github.com/HackerHyper/ACMVH.

Yiyue Hu, Lei Zhang, Nan Mu et al.

Transformers have achieved remarkable success in medical image analysis owing to their powerful capability to use flexible self-attention mechanism. However, due to lacking intrinsic inductive bias in modeling visual structural information, they generally require a large-scale pre-training schedule, limiting the clinical applications over expensive small-scale medical data. To this end, we propose a parameter-efficient transformer to explore intrinsic inductive bias via position information for medical image segmentation. Specifically, we empirically investigate how different position encoding strategies affect the prediction quality of the region of interest (ROI), and observe that ROIs are sensitive to the position encoding strategies. Motivated by this, we present a novel Hybrid Axial-Attention (HAA), a form of position self-attention that can be equipped with spatial pixel-wise information and relative position information as inductive bias. Moreover, we introduce a gating mechanism to alleviate the burden of training schedule, resulting in efficient feature selection over small-scale datasets. Experiments on the BraTS and Covid19 datasets prove the superiority of our method over the baseline and previous works. Internal workflow visualization with interpretability is conducted to better validate our success.

Lei Liu, Yuhao Chi, Shunqi Huang et al.

As wireless communication applications evolve from traditional multipath environments to high-mobility scenarios like unmanned aerial vehicles, multiplexing techniques have advanced accordingly. Traditional single-carrier frequency-domain equalization (SC-FDE) and orthogonal frequency-division multiplexing (OFDM) have given way to emerging orthogonal time-frequency space (OTFS) and affine frequency-division multiplexing (AFDM). These approaches exploit specific channel structures to diagonalize or sparsify the effective channel, thereby enabling low-complexity detection. However, their reliance on these structures significantly limits their robustness in dynamic, real-world environments. To address these challenges, this paper studies a random multiplexing technique that is decoupled from the physical channels, enabling its application to arbitrary norm-bounded and spectrally convergent channel matrices. Random multiplexing achieves statistical fading-channel ergodicity for transmitted signals by constructing an equivalent input-isotropic channel matrix in the random transform domain. It guarantees the asymptotic replica MAP bit-error rate (BER) optimality of AMP-type detectors for linear systems with arbitrary norm-bounded, spectrally convergent channel matrices and signaling configurations, under the unique fixed point assumption. A low-complexity cross-domain memory AMP (CD-MAMP) detector is considered, leveraging the sparsity of the time-domain channel and the randomness of the equivalent channel. Optimal power allocations are derived to minimize the replica MAP BER and maximize the replica constrained capacity of random multiplexing systems. The optimal coding principle and replica constrained-capacity optimality of CD-MAMP detector are investigated for random multiplexing systems. Additionally, the versatility of random multiplexing in diverse wireless applications is explored.

Chengting Yu, Lei Liu, Gaoang Wang et al.

Recent insights have revealed that rate-coding is a primary form of information representation captured by surrogate-gradient-based Backpropagation Through Time (BPTT) in training deep Spiking Neural Networks (SNNs). Motivated by these findings, we propose rate-based backpropagation, a training strategy specifically designed to exploit rate-based representations to reduce the complexity of BPTT. Our method minimizes reliance on detailed temporal derivatives by focusing on averaged dynamics, streamlining the computational graph to reduce memory and computational demands of SNNs training. We substantiate the rationality of the gradient approximation between BPTT and the proposed method through both theoretical analysis and empirical observations. Comprehensive experiments on CIFAR-10, CIFAR-100, ImageNet, and CIFAR10-DVS validate that our method achieves comparable performance to BPTT counterparts, and surpasses state-of-the-art efficient training techniques. By leveraging the inherent benefits of rate-coding, this work sets the stage for more scalable and efficient SNNs training within resource-constrained environments. Our code is available at https://github.com/Tab-ct/rate-based-backpropagation.

Lei Liu, Haonan Zhang, Huahang Xu et al.

Spinning flexible objects, exemplified by traditional Chinese handkerchief performances, demands periodic steady-state motions under nonlinear dynamics with frictional contacts and boundary constraints. To address these challenges, we first design an intuitive dexterous wrist based on a parallel anti-parallelogram tendon-driven structure, which achieves 90 degrees omnidirectional rotation with low inertia and decoupled roll-pitch sensing, and implement a high-low level hierarchical control scheme. We then develop a particle-spring model of the handkerchief for control-oriented abstraction and strategy evaluation. Hardware experiments validate this framework, achieving an unfolding ratio of approximately 99% and fingertip tracking error of RMSE = 2.88 mm in high-dynamic spinning. These results demonstrate that integrating control-oriented modeling with a task-tailored dexterous wrist enables robust rest-to-steady-state transitions and precise periodic manipulation of highly flexible objects. More visualizations: https://slowly1113.github.io/icra2026-handkerchief/

Mehran Taghian, Yunke Peng, Xing Huang et al.

Large foundation models have become central to modern machine learning, with performance scaling predictably with model size and data. However, training and deploying such models incur substantial computational and memory costs, motivating the development of low-precision training techniques. Recent work has demonstrated that 4-bit floating-point (FP4) formats--such as MXFP4 and NVFP4--can be successfully applied to linear GEMM operations in large language models (LLMs), achieving up to 4x improvements in compute throughput and memory efficiency compared to higher-precision baselines. In this work, we investigate the recently proposed HiFloat4 FP4 format for Huawei Ascend NPUs and systematically compare it with MXFP4 in large-scale training settings. All experiments are conducted on Ascend NPU clusters, with linear and expert GEMM operations performed entirely in FP4 precision. We evaluate both dense architectures (e.g., Pangu and LLaMA-style models) and mixture-of-experts (MoE) models, where both standard linear layers and expert-specific GEMMs operate in FP4. Furthermore, we explore stabilization techniques tailored to FP4 training that significantly reduce numerical degradation, maintaining relative error within 1% of full-precision baselines while preserving the efficiency benefits of 4-bit computation. Our results provide a comprehensive empirical study of FP4 training on NPUs and highlight the practical trade-offs between FP4 formats in large-scale dense and MoE models.

Lei Liu, Hao Zhu, Yue Shen et al.

Continual Pre-training (CPT) serves as a fundamental approach for adapting foundation models to domain-specific applications. Scaling laws for pre-training define a power-law relationship between dataset size and the test loss of an LLM. However, the marginal gains from simply increasing data for CPT diminish rapidly, yielding suboptimal data utilization and inefficient training. To address this challenge, we propose a novel perplexity-aware data scaling law to establish a predictive relationship between the perplexity landscape of domain-specific data and the test loss. Our approach leverages the perplexity derived from the pre-trained model on domain data as a proxy for estimating the knowledge gap, effectively quantifying the informational perplexity landscape of candidate training samples. By fitting this scaling law across diverse perplexity regimes, we enable adaptive selection of high-utility data subsets, prioritizing content that maximizes knowledge absorption while minimizing redundancy and noise. Extensive experiments demonstrate that our method consistently identifies near-optimal training subsets and achieves superior performance on both medical and general-domain benchmarks.

Shiwei Lyu, Xidong Wang, Lei Liu et al.

Although large language models (LLMs) demonstrate expert-level medical knowledge, aligning their open-ended outputs with fine-grained clinician preferences remains challenging. Existing methods often rely on coarse objectives or unreliable automated judges that are weakly grounded in professional guidelines. We propose a two-stage framework to address this gap. First, we introduce HealthRubrics, a dataset of 7,034 physician-verified preference examples in which clinicians refine LLM-drafted rubrics to meet rigorous medical standards. Second, we distill these rubrics into HealthPrinciples: 119 broadly reusable, clinically grounded principles organized by clinical dimensions, enabling scalable supervision beyond manual annotation. We use HealthPrinciples for (1) offline alignment by synthesizing rubrics for unlabeled queries and (2) an inference-time tool for guided self-revision. A 30B-A3B model trained with our framework achieves 33.4% on HealthBench-Hard, outperforming much larger models including Deepseek-R1 and o3, establishing a resource-efficient baseline for clinical alignment.

Shiwei Lyu, Chenfei Chi, Hongbo Cai et al.

We introduce RJUA-QA, a novel medical dataset for question answering (QA) and reasoning with clinical evidence, contributing to bridge the gap between general large language models (LLMs) and medical-specific LLM applications. RJUA-QA is derived from realistic clinical scenarios and aims to facilitate LLMs in generating reliable diagnostic and advice. The dataset contains 2,132 curated Question-Context-Answer pairs, corresponding about 25,000 diagnostic records and clinical cases. The dataset covers 67 common urological disease categories, where the disease coverage exceeds 97.6\% of the population seeking medical services in urology. Each data instance in RJUA-QA comprises: (1) a question mirroring real patient to inquiry about clinical symptoms and medical conditions, (2) a context including comprehensive expert knowledge, serving as a reference for medical examination and diagnosis, (3) a doctor response offering the diagnostic conclusion and suggested examination guidance, (4) a diagnosed clinical disease as the recommended diagnostic outcome, and (5) clinical advice providing recommendations for medical examination. RJUA-QA is the first medical QA dataset for clinical reasoning over the patient inquiries, where expert-level knowledge and experience are required for yielding diagnostic conclusions and medical examination advice. A comprehensive evaluation is conducted to evaluate the performance of both medical-specific and general LLMs on the RJUA-QA dataset. Our data is are publicly available at \url{https://github.com/alipay/RJU_Ant_QA}.

Lei Liu, Jialin Chen, Kathy Macropol

Causal inference from electronic health records (EHR) is fundamentally limited by unmeasured confounding: critical clinical states such as frailty, goals of care, and mental status are documented in free-text notes but absent from structured data. Large language models can extract these latent confounders as interpretable, structured covariates, yet how to effectively integrate them into causal estimation pipelines has not been systematically studied. Using the MIMIC-IV database with 21,859 sepsis patients, we compare seven covariate-integration strategies for estimating the effect of early vasopressor initiation on 28-day mortality, spanning tabular-only baselines, traditional NLP representations, and three LLM-augmented approaches. A central finding is that not all integration strategies are equally effective: directly augmenting the propensity score model with LLM covariates achieves the best performance, while dual-caliper matching on text-derived categorical distances restricts the donor pool and degrades estimation. In semi-synthetic experiments with known ground-truth effects, LLM-augmented propensity scores reduce estimation bias from 0.0143 to 0.0003 relative to tabular-only methods, and this advantage persists under substantial simulated extraction error. On real data, incorporating LLM-extracted covariates reduces the estimated treatment effect from 0.055 to 0.027, directionally consistent with the CLOVERS randomized trial, and a doubly robust estimator yielding 0.019 confirms the robustness of this finding. Our results offer practical guidance on when and how text-derived covariates improve causal estimation in critical care.

Pan Yin, Kaiyu Li, Xiangyong Cao et al.

Recently, road graph extraction has garnered increasing attention due to its crucial role in autonomous driving, navigation, etc. However, accurately and efficiently extracting road graphs remains a persistent challenge, primarily due to the severe scarcity of labeled data. To address this limitation, we collect a global-scale satellite road graph extraction dataset, i.e. Global-Scale dataset. Specifically, the Global-Scale dataset is $\sim20 \times$ larger than the largest existing public road extraction dataset and spans over 13,800 $km^2$ globally. Additionally, we develop a novel road graph extraction model, i.e. SAM-Road++, which adopts a node-guided resampling method to alleviate the mismatch issue between training and inference in SAM-Road, a pioneering state-of-the-art road graph extraction model. Furthermore, we propose a simple yet effective ``extended-line'' strategy in SAM-Road++ to mitigate the occlusion issue on the road. Extensive experiments demonstrate the validity of the collected Global-Scale dataset and the proposed SAM-Road++ method, particularly highlighting its superior predictive power in unseen regions. The dataset and code are available at \url{https://github.com/earth-insights/samroadplus}.

Haoran Sun, Yankai Jiang, Wenjie Lou et al.

Multimodal large language models (MLLMs) have begun to demonstrate robust reasoning capabilities on general tasks, yet their application in the medical domain remains in its early stages. Constructing chain-of-thought (CoT) training data is essential for bolstering the reasoning abilities of medical MLLMs. However, existing approaches exhibit a deficiency in offering a comprehensive framework for searching and evaluating effective reasoning paths towards critical diagnosis. To address this challenge, we propose Mentor-Intern Collaborative Search (MICS), a novel reasoning-path searching scheme to generate rigorous and effective medical CoT data. MICS first leverages mentor models to initialize the reasoning, one step at a time, then prompts each intern model to continue the thinking along those initiated paths, and finally selects the optimal reasoning path according to the overall reasoning performance of multiple intern models. The reasoning performance is determined by an MICS-Score, which assesses the quality of generated reasoning paths. Eventually, we construct MMRP, a multi-task medical reasoning dataset with ranked difficulty, and Chiron-o1, a new medical MLLM devised via a curriculum learning strategy, with robust visual question-answering and generalizable reasoning capabilities. Extensive experiments demonstrate that Chiron-o1, trained on our CoT dataset constructed using MICS, achieves state-of-the-art performance across a list of medical visual question answering and reasoning benchmarks. Codes are available at https://github.com/manglu097/Chiron-o1

Chengting Yu, Xiaochen Zhao, Lei Liu et al.

Spiking Neural Networks (SNNs) are emerging as a brain-inspired alternative to traditional Artificial Neural Networks (ANNs), prized for their potential energy efficiency on neuromorphic hardware. Despite this, SNNs often suffer from accuracy degradation compared to ANNs and face deployment challenges due to fixed inference timesteps, which require retraining for adjustments, limiting operational flexibility. To address these issues, our work considers the spatio-temporal property inherent in SNNs, and proposes a novel distillation framework for deep SNNs that optimizes performance across full-range timesteps without specific retraining, enhancing both efficacy and deployment adaptability. We provide both theoretical analysis and empirical validations to illustrate that training guarantees the convergence of all implicit models across full-range timesteps. Experimental results on CIFAR-10, CIFAR-100, CIFAR10-DVS, and ImageNet demonstrate state-of-the-art performance among distillation-based SNNs training methods. Our code is available at https://github.com/Intelli-Chip-Lab/snn\_temporal\_decoupling\_distillation.

Xinhui Liu, Can Wang, Lei Liu et al.

Free-Viewpoint Video (FVV) reconstruction enables photorealistic and interactive 3D scene visualization; however, real-time streaming is often bottlenecked by sparse-view inputs, prohibitive training costs, and bandwidth constraints. While recent 3D Gaussian Splatting (3DGS) has advanced FVV due to its superior rendering speed, Streaming Free-Viewpoint Video (SFVV) introduces additional demands for rapid optimization, high-fidelity reconstruction under sparse constraints, and minimal storage footprints. To bridge this gap, we propose StreamLoD-GS, an LoD-based Gaussian Splatting framework designed specifically for SFVV. Our approach integrates three core innovations: 1) an Anchor- and Octree-based LoD-structured 3DGS with a hierarchical Gaussian dropout technique to ensure efficient and stable optimization while maintaining high-quality rendering; 2) a GMM-based motion partitioning mechanism that separates dynamic and static content, refining dynamic regions while preserving background stability; and 3) a quantized residual refinement framework that significantly reduces storage requirements without compromising visual fidelity. Extensive experiments demonstrate that StreamLoD-GS achieves competitive or state-of-the-art performance in terms of quality, efficiency, and storage.

Hao Yan, Lei Liu, Yuhao Liu et al.

This paper proposes a coding framework for capacity-region-achieving sparse regression (SR) codes over MIMO multiple-access channels (MIMO-MAC), where a single SR code is used for each user at the transmitter. With random semi-unitary dictionary matrices applied for encoding, multiple-access OAMP (MA-OAMP) enables reliable parallel interference cancellation (PIC) at the receiver. Theoretically, an optimal coding principle with the MA-OAMP receiver, which achieves the sum capacity and, in combination with time sharing, achieves the entire capacity region, is established as the guiding principle for designing capacity-region-achieving codes. Accordingly, a coding scheme for capacity-region-achieving SR codes is proposed via proper power allocation over the position-modulated signals.

Zhehao Tan, Yihan Jiao, Dan Yang et al.

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge, where the LLM's ability to generate responses based on the combination of a given query and retrieved documents is crucial. However, most benchmarks focus on overall RAG system performance, rarely assessing LLM-specific capabilities. Current benchmarks emphasize broad aspects such as noise robustness, but lack a systematic and granular evaluation framework on document utilization. To this end, we introduce \textit{Placeholder-RAG-Benchmark}, a multi-level fine-grained benchmark, emphasizing the following progressive dimensions: (1) multi-level filtering abilities, (2) combination abilities, and (3) reference reasoning. To provide a more nuanced understanding of LLMs' roles in RAG systems, we formulate an innovative placeholder-based approach to decouple the contributions of the LLM's parametric knowledge and the external knowledge. Experiments demonstrate the limitations of representative LLMs in the RAG system's generation capabilities, particularly in error resilience and context faithfulness. Our benchmark provides a reproducible framework for developing more reliable and efficient RAG systems. Our code is available in https://github.com/Alipay-Med/PRGB.

Jian Zhu, Xin Zou, Lei Liu et al.

Multi-view clustering can partition data samples into their categories by learning a consensus representation in an unsupervised way and has received more and more attention in recent years. However, there is an untrusted fusion problem. The reasons for this problem are as follows: 1) The current methods ignore the presence of noise or redundant information in the view; 2) The similarity of contrastive learning comes from the same sample rather than the same cluster in deep multi-view clustering. It causes multi-view fusion in the wrong direction. This paper proposes a novel multi-view clustering network to address this problem, termed as Trusted Mamba Contrastive Network (TMCN). Specifically, we present a new Trusted Mamba Fusion Network (TMFN), which achieves a trusted fusion of multi-view data through a selective mechanism. Moreover, we align the fused representation and the view-specific representation using the Average-similarity Contrastive Learning (AsCL) module. AsCL increases the similarity of view presentation from the same cluster, not merely from the same sample. Extensive experiments show that the proposed method achieves state-of-the-art results in deep multi-view clustering tasks. The source code is available at https://github.com/HackerHyper/TMCN.

Can Wang, Lei Liu, Wei Jiang et al.

Recent advances in 3D Gaussian Splatting (3DGS) have enabled significant progress in photorealistic novel view synthesis. However, traditional 3DGS relies on a slow, iterative optimization process, which limits its use in scenarios demanding real-time results. To overcome this bottleneck, recent feed-forward methods aim to predict Gaussian attributes directly from images, but they often struggle with the redundancy of Gaussian primitives and rendering quality. In this work, we introduce a transformer-based architecture specifically designed for feed-forward Gaussian Splatting. Our key insight is that spatial and semantic relationships among Gaussians can be effectively captured through a sparse attention mechanism, enabled by a Z-order strategy that organizes the unstructured Gaussian set into a spatially coherent sequence. Furthermore, we incorporate this Z-order strategy to adaptively suppress redundancy while preserving critical structural details. This allows the transformer to efficiently model context, compress Gaussian primitives, and predict Gaussian attributes in a single forward pass. Comprehensive experiments demonstrate that our method achieves fast and high-quality novel view synthesis with fewer Gaussian primitives.

Xidong Wang, Shuqi Guo, Yue Shen et al.

The reliability of medical LLM evaluation is critically undermined by data contamination and knowledge obsolescence, leading to inflated scores on static benchmarks. To address these challenges, we introduce LiveClin, a live benchmark designed for approximating real-world clinical practice. Built from contemporary, peer-reviewed case reports and updated biannually, LiveClin ensures clinical currency and resists data contamination. Using a verified AI-human workflow involving 239 physicians, we transform authentic patient cases into complex, multimodal evaluation scenarios that span the entire clinical pathway. The benchmark currently comprises 1,407 case reports and 6,605 questions. Our evaluation of 26 models on LiveClin reveals the profound difficulty of these real-world scenarios, with the top-performing model achieving a Case Accuracy of just 35.7%. In benchmarking against human experts, Chief Physicians achieved the highest accuracy, followed closely by Attending Physicians, with both surpassing most models. LiveClin thus provides a continuously evolving, clinically grounded framework to guide the development of medical LLMs towards closing this gap and achieving greater reliability and real-world utility. Our data and code are publicly available at https://github.com/AQ-MedAI/LiveClin.

Jiadong Hong, Lei Liu, Xinyu Bian et al.

Flow matching has emerged as a powerful framework for generative modeling, with recent empirical successes highlighting the effectiveness of signal-space prediction ($x$-prediction). In this work, we investigate the transfer of this paradigm to binary manifolds, a fundamental setting for generative modeling of discrete data. While $x$-prediction remains effective, we identify a latent structural mismatch that arises when it is coupled with velocity-based objectives ($v$-loss), leading to a time-dependent singular weighting that amplifies gradient sensitivity to approximation errors. Motivated by this observation, we formalize prediction-loss alignment as a necessary condition for flow matching training. We prove that re-aligning the objective to the signal space ($x$-loss) eliminates the singular weighting, yielding uniformly bounded gradients and enabling robust training under uniform timestep sampling without reliance on heuristic schedules. Finally, with alignment secured, we examine design choices specific to binary data, revealing a topology-dependent distinction between probabilistic objectives (e.g., cross-entropy) and geometric losses (e.g., mean squared error). Together, these results provide theoretical foundations and practical guidelines for robust flow matching on binary -- and related discrete -- domains, positioning signal-space alignment as a key principle for robust diffusion learning.

Fuhao Zhang, Lei Liu, Jialin Zhang et al.

Accurate medical image segmentation requires effective modeling of both global anatomical structures and fine-grained boundary details. Recent state space models (e.g., Vision Mamba) offer efficient long-range dependency modeling. However, their one-dimensional serialization weakens local spatial continuity and high-frequency representation. To this end, we propose SpectralMamba-UNet, a novel frequency-disentangled framework to decouple the learning of structural and textural information in the spectral domain. Our Spectral Decomposition and Modeling (SDM) module applies discrete cosine transform to decompose low- and high-frequency features, where low frequency contributes to global contextual modeling via a frequency-domain Mamba and high frequency preserves boundary-sensitive details. To balance spectral contributions, we introduce a Spectral Channel Reweighting (SCR) mechanism to form channel-wise frequency-aware attention, and a Spectral-Guided Fusion (SGF) module to achieve adaptively multi-scale fusion in the decoder. Experiments on five public benchmarks demonstrate consistent improvements across diverse modalities and segmentation targets, validating the effectiveness and generalizability of our approach.

Kailin Jiang, Ning Jiang, Yuntao Du et al.

Large Multimodal Models (LMMs) encode rich factual knowledge via cross-modal pre-training, yet their static representations struggle to maintain an accurate understanding of time-sensitive factual knowledge. Existing benchmarks remain constrained by static designs, inadequately evaluating LMMs' ability to understand time-sensitive knowledge. To address this gap, we propose MINED, a comprehensive benchmark that evaluates temporal awareness along 6 key dimensions and 11 challenging tasks: cognition, awareness, trustworthiness, understanding, reasoning, and robustness. MINED is constructed from Wikipedia by two professional annotators, containing 2,104 time-sensitive knowledge samples spanning six knowledge types. Evaluating 15 widely used LMMs on MINED shows that Gemini-2.5-Pro achieves the highest average CEM score of 63.07, while most open-source LMMs still lack time understanding ability. Meanwhile, LMMs perform best on organization knowledge, whereas their performance is weakest on sport. To address these challenges, we investigate the feasibility of updating time-sensitive knowledge in LMMs through knowledge editing methods and observe that LMMs can effectively update knowledge via knowledge editing methods in single editing scenarios.

Haoran Sun, Yankai Jiang, Zhenyu Tang et al.

The foundation of reproducible science lies in protocols that are precise, logically ordered, and executable. The autonomous generation of these protocols through natural language queries could greatly improve the efficiency of the reproduction process. However, current leading large language models (LLMs) often generate incomplete or inconsistent protocols, limiting their utility. To address this limitation, we first introduce SciRecipe, a large-scale dataset of over 12K structured protocols spanning 27 biological subfields and encompassing both comprehension and problem-solving tasks. To further improve protocol generation, we propose the "Sketch-and-Fill" paradigm, which separates analysis, structuring, and expression to ensure each step is explicit and verifiable. Complementing this, the structured component-based reward mechanism evaluates step granularity, action order, and semantic fidelity, aligning model optimization with experimental reliability. Building on these components, we develop Thoth, trained through a staged Knowledge-to-Action process that progresses from knowledge acquisition to operational reasoning and ultimately to robust, executable protocol generation. Across multiple benchmarks, Thoth consistently surpasses both proprietary and open-source LLMs, achieving significant improvements in step alignment, logical sequencing, and semantic accuracy. Our approach paves the way for reliable scientific assistants that bridge knowledge with experimental execution. All data, code, and models will be released publicly.

Xiaochen Zhao, Chengting Yu, Kairong Yu et al.

Spiking Neural Networks (SNNs) exhibit exceptional energy efficiency on neuromorphic hardware due to their sparse activation patterns. However, conventional training methods based on surrogate gradients and Backpropagation Through Time (BPTT) not only lag behind Artificial Neural Networks (ANNs) in performance, but also incur significant computational and memory overheads that grow linearly with the temporal dimension. To enable high-performance SNN training under limited computational resources, we propose an enhanced self-distillation framework, jointly optimized with rate-based backpropagation. Specifically, the firing rates of intermediate SNN layers are projected onto lightweight ANN branches, and high-quality knowledge generated by the model itself is used to optimize substructures through the ANN pathways. Unlike traditional self-distillation paradigms, we observe that low-quality self-generated knowledge may hinder convergence. To address this, we decouple the teacher signal into reliable and unreliable components, ensuring that only reliable knowledge is used to guide the optimization of the model. Extensive experiments on CIFAR-10, CIFAR-100, CIFAR10-DVS, and ImageNet demonstrate that our method reduces training complexity while achieving high-performance SNN training. Our code is available at https://github.com/Intelli-Chip-Lab/enhanced-self-distillation-framework-for-snn.

Lei Liu, Can Wang, Zhenghao Chen et al.

Recent advances in 4D Gaussian Splatting (4DGS) editing still face challenges with view, temporal, and non-editing region consistency, as well as with handling complex text instructions. To address these issues, we propose 4DGS-Craft, a consistent and interactive 4DGS editing framework. We first introduce a 4D-aware InstructPix2Pix model to ensure both view and temporal consistency. This model incorporates 4D VGGT geometry features extracted from the initial scene, enabling it to capture underlying 4D geometric structures during editing. We further enhance this model with a multi-view grid module that enforces consistency by iteratively refining multi-view input images while jointly optimizing the underlying 4D scene. Furthermore, we preserve the consistency of non-edited regions through a novel Gaussian selection mechanism, which identifies and optimizes only the Gaussians within the edited regions. Beyond consistency, facilitating user interaction is also crucial for effective 4DGS editing. Therefore, we design an LLM-based module for user intent understanding. This module employs a user instruction template to define atomic editing operations and leverages an LLM for reasoning. As a result, our framework can interpret user intent and decompose complex instructions into a logical sequence of atomic operations, enabling it to handle intricate user commands and further enhance editing performance. Compared to related works, our approach enables more consistent and controllable 4D scene editing. Our code will be made available upon acceptance.