Hongjian Zhou

Fenglin Liu, Zheng Li, Hongjian Zhou et al.

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical decisions involve answering open-ended questions without pre-set options. To better understand LLMs in the clinic, we construct a benchmark ClinicBench. We first collect eleven existing datasets covering diverse clinical language generation, understanding, and reasoning tasks. Furthermore, we construct six novel datasets and clinical tasks that are complex but common in real-world practice, e.g., open-ended decision-making, long document processing, and emerging drug analysis. We conduct an extensive evaluation of twenty-two LLMs under both zero-shot and few-shot settings. Finally, we invite medical experts to evaluate the clinical usefulness of LLMs. The benchmark data is available at https://github.com/AI-in-Health/ClinicBench.

Fenglin Liu, Jinge Wu, Hongjian Zhou et al. · oxford

The application of Large Language Models (LLMs) to various clinical applications has attracted growing research attention. However, real-world clinical decision-making differs significantly from the standardized, exam-style scenarios commonly used in current efforts. In this paper, we present the RiskAgent system to perform a broad range of medical risk predictions, covering over 387 risk scenarios across diverse complex diseases, e.g., cardiovascular disease and cancer. RiskAgent is designed to collaborate with hundreds of clinical decision tools, i.e., risk calculators and scoring systems that are supported by evidence-based medicine. To evaluate our method, we have built the first benchmark MedRisk specialized for risk prediction, including 12,352 questions spanning 154 diseases, 86 symptoms, 50 specialties, and 24 organ systems. The results show that our RiskAgent, with 8 billion model parameters, achieves 76.33% accuracy, outperforming the most recent commercial LLMs, o1, o3-mini, and GPT-4.5, and doubling the 38.39% accuracy of GPT-4o. On rare diseases, e.g., Idiopathic Pulmonary Fibrosis (IPF), RiskAgent outperforms o1 and GPT-4.5 by 27.27% and 45.46% accuracy, respectively. Finally, we further conduct a generalization evaluation on an external evidence-based diagnosis benchmark and show that our RiskAgent achieves the best results. These encouraging results demonstrate the great potential of our solution for diverse diagnosis domains. To improve the adaptability of our model in different scenarios, we have built and open-sourced a family of models ranging from 1 billion to 70 billion parameters. Our code, data, and models are all available at https://github.com/AI-in-Health/RiskAgent.

Hongjian Zhou, Boyang Gu, Chenghao Jin

Scheduling plays an important role in automated production. Its impact can be found in various fields such as the manufacturing industry, the service industry and the technology industry. A scheduling problem (NP-hard) is a task of finding a sequence of job assignments on a given set of machines with the goal of optimizing the objective defined. Methods such as Operation Research, Dispatching Rules, and Combinatorial Optimization have been applied to scheduling problems but no solution guarantees to find the optimal solution. The recent development of Reinforcement Learning has shown success in sequential decision-making problems. This research presents a Reinforcement Learning approach for scheduling problems. In particular, this study delivers an OpenAI gym environment with search-space reduction for Job Shop Scheduling Problems and provides a heuristic-guided Q-Learning solution with state-of-the-art performance for Multi-agent Flexible Job Shop Problems.

Ziang Yin, Hongjian Zhou, Chetan Choppali Sudarshan et al.

The relentless growth of large-scale artificial intelligence (AI) has created unprecedented demand for computational power, straining the energy, bandwidth, and scaling limits of conventional electronic platforms. Electronic-photonic integrated circuits (EPICs) have emerged as a compelling platform for next-generation AI systems, offering inherent advantages in ultra-high bandwidth, low latency, and energy efficiency for computing and interconnection. Beyond performance, EPICs also hold unique promises for sustainability. Fabricated in relaxed process nodes with fewer metal layers and lower defect densities, photonic devices naturally reduce embodied carbon footprint (CFP) compared to advanced digital electronic integrated circuits, while delivering orders-of-magnitude higher computing performance and interconnect bandwidth. To further advance the sustainability of photonic AI systems, we explore how electronic-photonic design automation (EPDA) and cross-layer co-design methodologies can amplify these inherent benefits. We present how advanced EPDA tools enable more compact layout generation, reducing both chip area and metal layer usage. We will also demonstrate how cross-layer device-circuit-architecture co-design unlocks new sustainability gains for photonic hardware: ultra-compact photonic circuit designs that minimize chip area cost, reconfigurable hardware topology that adapts to evolving AI workloads, and intelligent resilience mechanisms that prolong lifetime by tolerating variations and faults. By uniting intrinsic photonic efficiency with EPDA- and co-design-driven gains in area efficiency, reconfigurability, and robustness, we outline a vision for lifelong-sustainable electronic-photonic AI systems. This perspective highlights how EPIC AI systems can simultaneously meet the performance demands of modern AI and the urgent imperative for sustainable computing.