Ben Cardoen

Ivan R. Nabi, Ben Cardoen, Ismail M. Khater et al.

Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell, bridging the mesoscale gap to classical structural biology methodologies. Analysis of super-resolution data by artificial intelligence (AI), such as machine learning, offers tremendous potential for discovery of new biology, that, by definition, is not known and lacks ground truth. Herein, we describe the application of weakly supervised paradigms to super-resolution microscopy and its potential to enable the accelerated exploration of the nanoscale architecture of subcellular macromolecules and organelles.

Hanene Ben Yedder, Ben Cardoen, Ghassan Hamarneh

Medical imaging is an invaluable resource in medicine as it enables to peer inside the human body and provides scientists and physicians with a wealth of information indispensable for understanding, modelling, diagnosis, and treatment of diseases. Reconstruction algorithms entail transforming signals collected by acquisition hardware into interpretable images. Reconstruction is a challenging task given the ill-posed of the problem and the absence of exact analytic inverse transforms in practical cases. While the last decades witnessed impressive advancements in terms of new modalities, improved temporal and spatial resolution, reduced cost, and wider applicability, several improvements can still be envisioned such as reducing acquisition and reconstruction time to reduce patient's exposure to radiation and discomfort while increasing clinics throughput and reconstruction accuracy. Furthermore, the deployment of biomedical imaging in handheld devices with small power requires a fine balance between accuracy and latency.