Ayelet Akselrod-Ballin

David Chettrit, Tomer Meir, Hila Lebel et al. · mila

An osteoporosis-related fracture occurs every three seconds worldwide, affecting one in three women and one in five men aged over 50. The early detection of at-risk patients facilitates effective and well-evidenced preventative interventions, reducing the incidence of major osteoporotic fractures. In this study, we present an automatic system for identification of vertebral compression fractures on Computed Tomography images, which are often an undiagnosed precursor to major osteoporosis-related fractures. The system integrates a compact 3D representation of the spine, utilizing a Convolutional Neural Network (CNN) for spinal cord detection and a novel end-to-end sequence to sequence 3D architecture. We evaluate several model variants that exploit different representation and classification approaches and present a framework combining an ensemble of models that achieves state of the art results, validated on a large data set, with a patient-level fracture identification of 0.955 Area Under the Curve (AUC). The system proposed has the potential to support osteoporosis clinical management, improve treatment pathways, and to change the course of one of the most burdensome diseases of our generation.

Muhamedrahimov Raouf, Bar Amir, Akselrod-Ballin Ayelet

In standard classification, we typically treat class categories as independent of one-another. In many problems, however, we would be neglecting the natural relations that exist between categories, which are often dictated by an underlying biological or physical process. In this work, we propose novel formulations of the classification problem, based on a realization that the assumption of class-independence is a limiting factor that leads to the requirement of more training data. First, we propose manual ways to reduce our data needs by reintroducing knowledge about problem-specific interclass relations into the training process. Second, we propose a general approach to jointly learn categorical label representations that can implicitly encode natural interclass relations, alleviating the need for strong prior assumptions, which are not always available. We demonstrate this in the domain of medical images, where access to large amounts of labelled data is not trivial. Specifically, our experiments show the advantages of this approach in the classification of Intravenous Contrast enhancement phases in CT images, which encapsulate multiple interesting inter-class relations.

Shaked Perek, Alon Hazan, Ella Barkan et al.

Standard breast cancer screening involves the acquisition of two mammography X-ray projections for each breast. Typically, a comparison of both views supports the challenging task of tumor detection and localization. We introduce a deep learning, patch-based Siamese network for lesion matching in dual-view mammography. Our locally-fitted approach generates a joint patch pair representation and comparison with a shared configuration between the two views. We performed a comprehensive set of experiments with the network on standard datasets, among them the large Digital Database for Screening Mammography (DDSM). We analyzed the effect of transfer learning with the network between different types of datasets and compared the network-based matching to using Euclidean distance by template matching. Finally, we evaluated the contribution of the matching network in a full detection pipeline. Experimental results demonstrate the promise of improved detection accuracy using our approach.