Zongliang Yue

Zongliang Yue, Qi Li, Terry Heiman-Patterson et al.

Amyotrophic lateral sclerosis (ALS) is a progressive and heterogeneous neurodegenerative disease in which predicting clinically meaningful milestones, such as assistive device use, remains challenging. We developed a time-to-event, digital-twin-inspired framework that integrates longitudinal ALS Functional Rating Scale-Revised (ALSFRS-R) trajectories with survival modeling to support individualized prediction of functional decline and assistive device utilization. We constructed a harmonized longitudinal dataset by integrating diagnosis records, ALSFRS-R assessments, activities of daily living, and demographic information, followed by preprocessing to ensure data quality, temporal alignment, and cohort consistency. Correlation-based clustering identified coherent functional domains spanning bulbar, upper limb, axial, lower limb, and respiratory systems. Generalized additive mixed models characterized nonlinear, domain-specific functional decline across all domains. In addition, a temporal machine learning model was developed to predict longitudinal functional decline and capture stage-dependent disease progression. Cox proportional hazards modeling further identified lower limb function, particularly walking and stair climbing, as the strongest predictors of earlier wheelchair access. Building on these results, we implemented a digital twin-inspired temporal machine learning-based time-to-event (TTE) model that generates individualized survival curves and dynamically predicts wheelchair-free survival. This framework provides a scalable, interpretable, and clinically actionable approach for linking ALS progression with personalized decision support, with applications in proactive care planning, clinical trial stratification, and precision medicine.

Quang-Huy Nguyen, Jiaqi Wang, Wei-Shinn Ku

Single-cell integration workflows often construct low-dimensional cell embeddings and then refine them with post-hoc methods to reduce batch effects. This refinement process can become unstable when cell-type compositions vary across batches, with some populations underrepresented or absent in particular batches. The problem becomes more consequential in dynamic single-cell data systems, where newly acquired batches can change both technical conditions and cell-type composition. Such instability can reduce downstream cell-type classification performance and weaken stability under imbalance perturbations. We introduce scBatchProx, a lightweight post-hoc refinement method for stabilizing single-cell latent embeddings in these heterogeneous and evolving settings. scBatchProx operates directly on precomputed embeddings and treats each batch or study as a client in a federated-inspired optimization procedure. A batch-conditioned FiLM adapter learns local latent updates, while proximal and identity-preserving regularization keep these updates conservative. Experiments on multi-batch and cross-study single-cell datasets show that scBatchProx improves downstream cell-type classification across different upstream embeddings. In controlled imbalance perturbations, scBatchProx maintains more stable affected-cell-type F1 when selected populations are downsampled or ablated from one batch. In cumulative retraining and continual integration settings, scBatchProx remains effective as new datasets arrive over time. Together, these results suggest that conservative, federated-inspired refinement can help maintain stable single-cell embeddings as batch compositions change across datasets and over time.

Vasileios Alevizos, Sabrina Edralin, Akebu Simasiku et al.

Dyslexia and dysgraphia are learning disabilities that profoundly impact reading, writing, and language processing capabilities. Dyslexia primarily affects reading, manifesting as difficulties in word recognition and phonological processing, where individuals struggle to connect sounds with their corresponding letters. Dysgraphia, on the other hand, affects writing skills, resulting in difficulties with letter formation, spacing, and alignment. The coexistence of dyslexia and dysgraphia complicates diagnosis, requiring a nuanced approach capable of adapting to these complexities while accurately identifying and differentiating between the disorders. This study utilizes advanced geometrical patterns and recurrent neural networks (RNN) to identify handwriting anomalies indicative of dyslexia and dysgraphia. Handwriting is first standardized, followed by feature extraction that focuses on baseline deviations, letter connectivity, stroke thickness, and other anomalies. These features are then fed into an RNN-based autoencoder to identify irregularities. Initial results demonstrate the ability of this RNN model to achieve state-of-art performance on combined dyslexia and dysgraphia detection, while showing the challenges associated with complex pattern adaptation of deep-learning to a diverse corpus of about 33,000 writing samples.

Vasileios Alevizos, George A Papakostas, Akebu Simasiku et al.

While new technologies emerge, human errors always looming. Software supply chain is increasingly complex and intertwined, the security of a service has become paramount to ensuring the integrity of products, safeguarding data privacy, and maintaining operational continuity. In this work, we conducted experiments on the promising open Large Language Models (LLMs) into two main software security challenges: source code language errors and deprecated code, with a focus on their potential to replace conventional static and dynamic security scanners that rely on predefined rules and patterns. Our findings suggest that while LLMs present some unexpected results, they also encounter significant limitations, particularly in memory complexity and the management of new and unfamiliar data patterns. Despite these challenges, the proactive application of LLMs, coupled with extensive security databases and continuous updates, holds the potential to fortify Software Supply Chain (SSC) processes against emerging threats.