Xiangjian Hou

Shahad Hardan, Hussain Alasmawi, Xiangjian Hou et al.

Vestibular schwannoma (VS) is a non-cancerous tumor located next to the ear that can cause hearing loss. Most brain MRI images acquired from patients are contrast-enhanced T1 (ceT1), with a growing interest in high-resolution T2 images (hrT2) to replace ceT1, which involves the use of a contrast agent. As hrT2 images are currently scarce, it is less likely to train robust machine learning models to segment VS or other brain structures. In this work, we propose a weakly supervised machine learning approach that learns from only ceT1 scans and adapts to segment two structures from hrT2 scans: the VS and the cochlea from the crossMoDA dataset. Our model 1) generates fake hrT2 scans from ceT1 images and segmentation masks, 2) is trained using the fake hrT2 scans, 3) predicts the augmented real hrT2 scans, and 4) is retrained again using both the fake and real hrT2. The final result of this model has been computed on an unseen testing dataset provided by the 2022 crossMoDA challenge organizers. The mean dice score and average symmetric surface distance (ASSD) are 0.78 and 0.46, respectively. The predicted segmentation masks achieved a dice score of 0.83 and an ASSD of 0.56 on the VS, and a dice score of 0.74 and an ASSD of 0.35 on the cochleas.

Xiangjian Hou, Sarit Khirirat, Mohammad Yaqub et al.

Federated learning (FL) is a distributed machine learning (ML) framework where multiple clients collaborate to train a model without exposing their private data. FL involves cycles of local computations and bi-directional communications between the clients and server. To bolster data security during this process, FL algorithms frequently employ a differential privacy (DP) mechanism that introduces noise into each client's model updates before sharing. However, while enhancing privacy, the DP mechanism often hampers convergence performance. In this paper, we posit that an optimal balance exists between the number of local steps and communication rounds, one that maximizes the convergence performance within a given privacy budget. Specifically, we present a proof for the optimal number of local steps and communication rounds that enhance the convergence bounds of the DP version of the ScaffNew algorithm. Our findings reveal a direct correlation between the optimal number of local steps, communication rounds, and a set of variables, e.g the DP privacy budget and other problem parameters, specifically in the context of strongly convex optimization. We furthermore provide empirical evidence to validate our theoretical findings.

Xiangjian Hou, Chao Qin, Chang Ni et al.

Global token mixing, implemented via self-attention or state-space sequence models, has become a popular model design choice for MRI restoration. However, MRI restoration tasks differ substantially in how their degradations vary over image and k-space domains, and in the degree to which global coupling is already imposed by physics-driven data consistency terms. In this work, we ask the question whether global token mixing is actually beneficial in each individual task across three representative settings: accelerated MRI reconstruction with explicit data consistency, MRI super-resolution with k-space center cropping, and denoising of clinical carotid MRI data with spatially heteroscedastic noise. To reduce confounding factors, we establish a controlled testbed comparing a minimal local gated CNN and its large-field variant, benchmarking them directly against state-of-the-art global models under aligned training and evaluation protocols. For accelerated MRI reconstruction, the minimal unrolled gated-CNN baseline is already highly competitive compared to recent token-mixing approaches in public reconstruction benchmarks, suggesting limited additional benefits when the forward model and data-consistency steps provide strong global constraints. For super-resolution, where low-frequency k-space data are largely preserved by the controlled low-pass degradation, local gated models remain competitive, and a lightweight large-field variant yields only modest improvements. In contrast, for denoising with pronounced spatially heteroscedastic noise, token-mixing models achieve the strongest overall performance, consistent with the need to estimate spatially varying reliability. In conclusion, our results demonstrate that the utility of global token mixing in MRI restoration is task-dependent, and it should be tailored to the underlying imaging physics and degradation structure.

Xiangjian Hou, Ebru Yaman Akcicek, Xin Wang et al.

While total intracranial carotid artery calcification (ICAC) volume is an established stroke biomarker, growing evidence shows this aggregate metric ignores the critical influence of plaque location, since calcification in different segments carries distinct prognostic and procedural risks. However, a finer-grained, segment-specific quantification has remained technically infeasible. Conventional 3D models are forced to process downsampled volumes or isolated patches, sacrificing the global context required to resolve anatomical ambiguity and render reliable landmark localization. To overcome this, we reformulate the 3D challenge as a \textbf{Parallel Probabilistic Landmark Localization} task along the 1D axial dimension. We propose the \textbf{Depth-Sequence Transformer (DST)}, a framework that processes full-resolution CT volumes as sequences of 2D slices, learning to predict $N=6$ independent probability distributions that pinpoint key anatomical landmarks. Our DST framework demonstrates exceptional accuracy and robustness. Evaluated on a 100-patient clinical cohort with rigorous 5-fold cross-validation, it achieves a Mean Absolute Error (MAE) of \textbf{0.1 slices}, with \textbf{96\%} of predictions falling within a $\pm1$ slice tolerance. Furthermore, to validate its architectural power, the DST backbone establishes the best result on the public Clean-CC-CCII classification benchmark under an end-to-end evaluation protocol. Our work delivers the first practical tool for automated segment-specific ICAC analysis. The proposed framework provides a foundation for further studies on the role of location-specific biomarkers in diagnosis, prognosis, and procedural planning.