Ben Sherwood

Ben Sherwood, Bradley S. Price

Modern multivariate machine learning and statistical methodologies estimate parameters of interest while leveraging prior knowledge of the association between outcome variables. The methods that do allow for estimation of relationships do so typically through an error covariance matrix in multivariate regression which does not scale to other types of models. In this article we proposed the MinPEN framework to simultaneously estimate regression coefficients associated with the multivariate regression model and the relationships between outcome variables using mild assumptions. The MinPen framework utilizes a novel penalty based on the minimum function to exploit detected relationships between responses. An iterative algorithm that generalizes current state of the art methods is proposed as a solution to the non-convex optimization that is required to obtain estimates. Theoretical results such as high dimensional convergence rates, model selection consistency, and a framework for post selection inference are provided. We extend the proposed MinPen framework to other exponential family loss functions, with a specific focus on multiple binomial responses. Tuning parameter selection is also addressed. Finally, simulations and two data examples are presented to show the finite sample properties of this framework.

Bradley S. Price, Aaron J. Molstad, Ben Sherwood

We propose a penalized likelihood framework for estimating multiple precision matrices from different classes. Most existing methods either incorporate no information on relationships between the precision matrices, or require this information be known a priori. The framework proposed in this article allows for simultaneous estimation of the precision matrices and relationships between the precision matrices, jointly. Sparse and non-sparse estimators are proposed, both of which require solving a non-convex optimization problem. To compute our proposed estimators, we use an iterative algorithm which alternates between a convex optimization problem solved by blockwise coordinate descent and a k-means clustering problem. Blockwise updates for computing the sparse estimator require solving an elastic net penalized precision matrix estimation problem, which we solve using a proximal gradient descent algorithm. We prove that this subalgorithm has a linear rate of convergence. In simulation studies and two real data applications, we show that our method can outperform competitors that ignore relevant relationships between precision matrices and performs similarly to methods which use prior information often uknown in practice.

Bradley S. Price, Ben Sherwood

We propose a method for estimating coefficients in multivariate regression when there is a clustering structure to the response variables. The proposed method includes a fusion penalty, to shrink the difference in fitted values from responses in the same cluster, and an L1 penalty for simultaneous variable selection and estimation. The method can be used when the grouping structure of the response variables is known or unknown. When the clustering structure is unknown the method will simultaneously estimate the clusters of the response and the regression coefficients. Theoretical results are presented for the penalized least squares case, including asymptotic results allowing for p >> n. We extend our method to the setting where the responses are binomial variables. We propose a coordinate descent algorithm for both the normal and binomial likelihood, which can easily be extended to other generalized linear model (GLM) settings. Simulations and data examples from business operations and genomics are presented to show the merits of both the least squares and binomial methods.