Tobias Geimer

Siming Bayer, Ute Spiske, Jie Luo et al.

For a wide range of clinical applications, such as adaptive treatment planning or intraoperative image update, feature-based deformable registration (FDR) approaches are widely employed because of their simplicity and low computational complexity. FDR algorithms estimate a dense displacement field by interpolating a sparse field, which is given by the established correspondence between selected features. In this paper, we consider the deformation field as a Gaussian Process (GP), whereas the selected features are regarded as prior information on the valid deformations. Using GP, we are able to estimate the both dense displacement field and a corresponding uncertainty map at once. Furthermore, we evaluated the performance of different hyperparameter settings for squared exponential kernels with synthetic, phantom and clinical data respectively. The quantitative comparison shows, GP-based interpolation has performance on par with state-of-the-art B-spline interpolation. The greatest clinical benefit of GP-based interpolation is that it gives a reliable estimate of the mathematical uncertainty of the calculated dense displacement map.

Tobias Geimer, Paul Keall, Katharina Breininger et al.

Data-driven respiratory signal extraction from rotational X-ray scans is a challenge as angular effects overlap with respiration-induced change in the scene. In this paper, we use the linearity of the X-ray transform to propose a bilinear model based on a prior 4D scan to separate angular and respiratory variation. The bilinear estimation process is supported by a B-spline interpolation using prior knowledge about the trajectory angle. Consequently, extraction of respiratory features simplifies to a linear problem. Though the need for a prior 4D CT seems steep, our proposed use-case of driving a respiratory motion model in radiation therapy usually meets this requirement. We evaluate on DRRs of 5 patient 4D CTs in a leave-one-phase-out manner and achieve a mean estimation error of 3.01 % in the gray values for unseen viewing angles. We further demonstrate suitability of the extracted weights to drive a motion model for treatments with a continuously rotating gantry.

Gerd Häusler, Aleksandra Milczarek, Markus Schreiter et al.

This document contains the results obtained by the Innovation Management Seminar in winter term 2017. In total 11 ideas have been developed by the team. In the document all 11 ideas show improvements for future applications in ophthalmology. The 11 ideas are AR/VR Glasses with Medical Applications, Augmented Reality Eye Surgery, Game Diagnosis, Intelligent Adapting Glasses, MD Facebook, Medical Crowd Segmentation, Personalized 3D Model of the Human Eye, Photoacoustic Contact Lens, Power Supply Smart Contact Lens, VR-Cornea and Head Mount for Fundus Imaging