Mao chen

Yajing Yang, Zeyu Zeng, Mao Chen et al.

Both knowledge graphs and user-item interaction graphs are frequently used in recommender systems due to their ability to provide rich information for modeling users and items. However, existing studies often focused on one of these sources (either the knowledge graph or the user-item interaction graph), resulting in underutilization of the benefits that can be obtained by integrating both sources of information. In this paper, we propose DEKGCI, a novel double-sided recommendation model. In DEKGCI, we use the high-order collaborative signals from the user-item interaction graph to enrich the user representations on the user side. Additionally, we utilize the high-order structural and semantic information from the knowledge graph to enrich the item representations on the item side. DEKGCI simultaneously learns the user and item representations to effectively capture the joint interactions between users and items. Three real-world datasets are adopted in the experiments to evaluate DEKGCI's performance, and experimental results demonstrate its high effectiveness compared to seven state-of-the-art baselines in terms of AUC and ACC.

Ruihao Zhang, Mao chen, Fei Ye et al.

T cell receptor (TCR) repertoires encode critical immunological signatures for autoimmune diseases, yet their clinical application remains limited by sequence sparsity and low witness rates. We developed EAMil, a multi-instance deep learning framework that leverages TCR sequencing data to diagnose systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) with exceptional accuracy. By integrating PrimeSeq feature extraction with ESMonehot encoding and enhanced gate attention mechanisms, our model achieved state-of-the-art performance with AUCs of 98.95% for SLE and 97.76% for RA. EAMil successfully identified disease-associated genes with over 90% concordance with established differential analyses and effectively distinguished disease-specific TCR genes. The model demonstrated robustness in classifying multiple disease categories, utilizing the SLEDAI score to stratify SLE patients by disease severity as well as to diagnose the site of damage in SLE patients, and effectively controlling for confounding factors such as age and gender. This interpretable framework for immune receptor analysis provides new insights for autoimmune disease detection and classification with broad potential clinical applications across immune-mediated conditions.

Xiangkai Zhang, Xiang Zhou, Mao Chen et al.

Absolute localization, aiming to determine an agent's location with respect to a global reference, is crucial for unmanned aerial vehicles (UAVs) in various applications, but it becomes challenging when global navigation satellite system (GNSS) signals are unavailable. Vision-based absolute localization methods, which locate the current view of the UAV in a reference satellite map to estimate its position, have become popular in GNSS-denied scenarios. However, existing methods mostly rely on traditional and low-level image matching, suffering from difficulties due to significant differences introduced by cross-source discrepancies and temporal variations. To overcome these limitations, in this paper, we introduce a hierarchical cross-source image matching method designed for UAV absolute localization, which integrates a semantic-aware and structure-constrained coarse matching module with a lightweight fine-grained matching module. Specifically, in the coarse matching module, semantic features derived from a vision foundation model first establish region-level correspondences under semantic and structural constraints. Then, the fine-grained matching module is applied to extract fine features and establish pixel-level correspondences. Building upon this, a UAV absolute visual localization pipeline is constructed without any reliance on relative localization techniques, mainly by employing an image retrieval module before the proposed hierarchical image matching modules. Experimental evaluations on public benchmark datasets and a newly introduced CS-UAV dataset demonstrate superior accuracy and robustness of the proposed method under various challenging conditions, confirming its effectiveness.