Manikanta Srikar Yellapragada

Luyao Shi, Deepta Rajan, Shafiq Abedin et al.

Pulmonary Embolism (PE) is a life-threatening disorder associated with high mortality and morbidity. Prompt diagnosis and immediate initiation of therapeutic action is important. We explored a deep learning model to detect PE on volumetric contrast-enhanced chest CT scans using a 2-stage training strategy. First, a residual convolutional neural network (ResNet) was trained using annotated 2D images. In addition to the classification loss, an attention loss was added during training to help the network focus attention on PE. Next, a recurrent network was used to scan sequentially through the features provided by the pre-trained ResNet to detect PE. This combination allows the network to be trained using both a limited and sparse set of pixel-level annotated images and a large number of easily obtainable patient-level image-label pairs. We used 1,670 sparsely annotated studies and more than 10,000 labeled studies in our training. On a test set with 2,160 patient studies, the proposed method achieved an area under the ROC curve (AUC) of 0.812. The proposed framework is also able to provide localized attention maps that indicate possible PE lesions, which could potentially help radiologists accelerate the diagnostic process.

Manikanta Srikar Yellapragada, Yiting Xie, Benedikt Graf et al.

Acute aortic syndrome (AAS) is a group of life threatening conditions of the aorta. We have developed an end-to-end automatic approach to detect AAS in computed tomography (CT) images. Our approach consists of two steps. At first, we extract N cross sections along the segmented aorta centerline for each CT scan. These cross sections are stacked together to form a new volume which is then classified using two different classifiers, a 3D convolutional neural network (3D CNN) and a multiple instance learning (MIL). We trained, validated, and compared two models on 2291 contrast CT volumes. We tested on a set aside cohort of 230 normal and 50 positive CT volumes. Our models detected AAS with an Area under Receiver Operating Characteristic curve (AUC) of 0.965 and 0.985 using 3DCNN and MIL, respectively.

Manikanta Srikar Yellapragada, Chandra Prakash Konkimalla

Deep neural networks have achieved impressive results on a wide variety of tasks. However, quantifying uncertainty in the network's output is a challenging task. Bayesian models offer a mathematical framework to reason about model uncertainty. Variational methods have been used for approximating intractable integrals that arise in Bayesian inference for neural networks. In this report, we review the major variational inference concepts pertinent to Bayesian neural networks and compare various approximation methods used in literature. We also talk about the applications of variational bayes in Reinforcement learning and continual learning.

Chandra Prakash Konkimalla, Manikanta Srikar Yellapragada, Trishal Gayam et al.

Telugu is a Dravidian language spoken by more than 80 million people worldwide. The optical character recognition (OCR) of the Telugu script has wide ranging applications including education, health-care, administration etc. The beautiful Telugu script however is very different from Germanic scripts like English and German. This makes the use of transfer learning of Germanic OCR solutions to Telugu a non-trivial task. To address the challenge of OCR for Telugu, we make three contributions in this work: (i) a database of Telugu characters, (ii) a deep learning based OCR algorithm, and (iii) a client server solution for the online deployment of the algorithm. For the benefit of the Telugu people and the research community, we will make our code freely available at https://gayamtrishal.github.io/OCR_Telugu.github.io/