Vasileios Magoulianitis

Vasileios Magoulianitis, Yijing Yang, C. -C. Jay Kuo

A high-performance unsupervised nuclei instance segmentation (HUNIS) method is proposed in this work. HUNIS consists of two-stage block-wise operations. The first stage includes: 1) adaptive thresholding of pixel intensities, 2) incorporation of nuclei size/shape priors and 3) removal of false positive nuclei instances. Then, HUNIS conducts the second stage segmentation by receiving guidance from the first one. The second stage exploits the segmentation masks obtained in the first stage and leverages color and shape distributions for a more accurate segmentation. The main purpose of the two-stage design is to provide pixel-wise pseudo-labels from the first to the second stage. This self-supervision mechanism is novel and effective. Experimental results on the MoNuSeg dataset show that HUNIS outperforms all other unsupervised methods by a substantial margin. It also has a competitive standing among state-of-the-art supervised methods.

Yijing Yang, Vasileios Magoulianitis, Xinyu Wang et al.

A statistical attention localization (SAL) method is proposed to facilitate the object classification task in this work. SAL consists of three steps: 1) preliminary attention window selection via decision statistics, 2) attention map refinement, and 3) rectangular attention region finalization. SAL computes soft-decision scores of local squared windows and uses them to identify salient regions in Step 1. To accommodate object of various sizes and shapes, SAL refines the preliminary result and obtain an attention map of more flexible shape in Step 2. Finally, SAL yields a rectangular attention region using the refined attention map and bounding box regularization in Step 3. As an application, we adopt E-PixelHop, which is an object classification solution based on successive subspace learning (SSL), as the baseline. We apply SAL so as to obtain a cropped-out and resized attention region as an alternative input. Classification results of the whole image as well as the attention region are ensembled to achieve the highest classification accuracy. Experiments on the CIFAR-10 dataset are given to demonstrate the advantage of the SAL-assisted object classification method.

Vasileios Magoulianitis, Athanasios Psaltis

Among the existing modalities for 3D action recognition, 3D flow has been poorly examined, although conveying rich motion information cues for human actions. Presumably, its susceptibility to noise renders it intractable, thus challenging the learning process within deep models. This work demonstrates the use of 3D flow sequence by a deep spatiotemporal model and further proposes an incremental two-level spatial attention mechanism, guided from skeleton domain, for emphasizing motion features close to the body joint areas and according to their informativeness. Towards this end, an extended deep skeleton model is also introduced to learn the most discriminant action motion dynamics, so as to estimate an informativeness score for each joint. Subsequently, a late fusion scheme is adopted between the two models for learning the high level cross-modal correlations. Experimental results on the currently largest and most challenging dataset NTU RGB+D, demonstrate the effectiveness of the proposed approach, achieving state-of-the-art results.

Vasileios Magoulianitis, Catherine A. Alexander, Jiaxin Yang et al.

Nuclei segmentation is the cornerstone task in histology image reading, shedding light on the underlying molecular patterns and leading to disease or cancer diagnosis. Yet, it is a laborious task that requires expertise from trained physicians. The large nuclei variability across different organ tissues and acquisition processes challenges the automation of this task. On the other hand, data annotations are expensive to obtain, and thus, Deep Learning (DL) models are challenged to generalize to unseen organs or different domains. This work proposes Local-to-Global NuSegHop (LG-NuSegHop), a self-supervised pipeline developed on prior knowledge of the problem and molecular biology. There are three distinct modules: (1) a set of local processing operations to generate a pseudolabel, (2) NuSegHop a novel data-driven feature extraction model and (3) a set of global operations to post-process the predictions of NuSegHop. Notably, even though the proposed pipeline uses { no manually annotated training data} or domain adaptation, it maintains a good generalization performance on other datasets. Experiments in three publicly available datasets show that our method outperforms other self-supervised and weakly supervised methods while having a competitive standing among fully supervised methods. Remarkably, every module within LG-NuSegHop is transparent and explainable to physicians.

Vasileios Magoulianitis, Jiaxin Yang, Catherine A. Alexander et al.

Clinically significant prostate cancer (csPCa) is a leading cause of cancer death in men, yet it has a high survival rate if diagnosed early. Bi-parametric MRI (bpMRI) reading has become a prominent screening test for csPCa. However, this process has a high false positive (FP) rate, incurring higher diagnostic costs and patient discomfort. This paper introduces RadHop-Net, a novel and lightweight CNN for FP reduction. The pipeline consists of two stages: Stage 1 employs data driven radiomics to extract candidate ROIs. In contrast, Stage 2 expands the receptive field about each ROI using RadHop-Net to compensate for the predicted error from Stage 1. Moreover, a novel loss function for regression problems is introduced to balance the influence between FPs and true positives (TPs). RadHop-Net is trained in a radiomics-to-error manner, thus decoupling from the common voxel-to-label approach. The proposed Stage 2 improves the average precision (AP) in lesion detection from 0.407 to 0.468 in the publicly available pi-cai dataset, also maintaining a significantly smaller model size than the state-of-the-art.

Vasileios Magoulianitis, Peida Han, Yijing Yang et al.

An unsupervised data-driven nuclei segmentation method for histology images, called CBM, is proposed in this work. CBM consists of three modules applied in a block-wise manner: 1) data-driven color transform for energy compaction and dimension reduction, 2) data-driven binarization, and 3) incorporation of geometric priors with morphological processing. CBM comes from the first letter of the three modules - "Color transform", "Binarization" and "Morphological processing". Experiments on the MoNuSeg dataset validate the effectiveness of the proposed CBM method. CBM outperforms all other unsupervised methods and offers a competitive standing among supervised models based on the Aggregated Jaccard Index (AJI) metric.

Yijing Yang, Vasileios Magoulianitis, C. -C. Jay Kuo

Based on PixelHop and PixelHop++, which are recently developed using the successive subspace learning (SSL) framework, we propose an enhanced solution for object classification, called E-PixelHop, in this work. E-PixelHop consists of the following steps. First, to decouple the color channels for a color image, we apply principle component analysis and project RGB three color channels onto two principle subspaces which are processed separately for classification. Second, to address the importance of multi-scale features, we conduct pixel-level classification at each hop with various receptive fields. Third, to further improve pixel-level classification accuracy, we develop a supervised label smoothing (SLS) scheme to ensure prediction consistency. Forth, pixel-level decisions from each hop and from each color subspace are fused together for image-level decision. Fifth, to resolve confusing classes for further performance boosting, we formulate E-PixelHop as a two-stage pipeline. In the first stage, multi-class classification is performed to get a soft decision for each class, where the top 2 classes with the highest probabilities are called confusing classes. Then,we conduct a binary classification in the second stage. The main contributions lie in Steps 1, 3 and 5.We use the classification of the CIFAR-10 dataset as an example to demonstrate the effectiveness of the above-mentioned key components of E-PixelHop.