Zhenxi Song

Xiongri Shen, Jiaqi Wang, Zhenxi Song et al.

Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are closely associated with the early Alzheimer's disease continuum, where accurate and explainable diagnosis is important for early risk assessment and intervention. Existing connectome-based deep learning models can improve classification performance but often provide limited insight into disease-related functional and structural connectivity changes. This paper proposes an atlas-knowledge-guided Generative Counterfactual Attention-guided Network (GCAN) for explainable cognitive decline diagnosis using multimodal brain connectomes. GCAN formulates diagnosis as a source-to-target counterfactual generation problem, where target-label connectomes are generated from source-label inputs and their differences are used to construct counterfactual attention maps. To preserve connectome topology, an Atlas-aware Bidirectional Transformer (AABT) performs network-level token encoding and decoding under brain-atlas constraints. The framework is further extended from functional connectivity (FC) to joint functional and structural connectivity (SC) modeling, enabling counterfactual analysis of complementary functional reorganization and structural topology changes. Experiments on hospital-collected and ADNI datasets show that GCAN achieves competitive performance across HC vs. SCD, HC vs. MCI, and SCD vs. MCI classification tasks. Visualization, circular connectome analysis, CAM-based comparison, ablation studies, and confidence interval analysis further support the interpretability and reliability of the proposed framework. Modality-specific FC and SC pre-trained classifiers are used to provide target-state priors for counterfactual generation while being separated from the downstream diagnostic classifier to prevent data leakage.

Xiongri Shen, Jiaqi Wang, Yi Zhong et al.

Functional and structural connectivity (FC/SC) are key multimodal biomarkers for brain analysis, yet their clinical utility is hindered by costly acquisition, complex preprocessing, and frequent missing modalities. Existing foundation models either process single modalities or lack explicit mechanisms for cross-modal and cross-scale consistency. We propose BrainCSD, a hierarchical mixture-of-experts (MoE) foundation model that jointly synthesizes FC/SC biomarkers and supports downstream decoding tasks (diagnosis and prediction). BrainCSD features three neuroanatomically grounded components: (1) a ROI-specific MoE that aligns regional activations from canonical networks (e.g., DMN, FPN) with a global atlas via contrastive consistency; (2) a Encoding-Activation MOE that models dynamic cross-time/gradient dependencies in fMRI/dMRI; and (3) a network-aware refinement MoE that enforces structural priors and symmetry at individual and population levels. Evaluated on the datasets under complete and missing-modality settings, BrainCSD achieves SOTA results: 95.6\% accuracy for MCI vs. CN classification without FC, low synthesis error (FC RMSE: 0.038; SC RMSE: 0.006), brain age prediction (MAE: 4.04 years), and MMSE score estimation (MAE: 1.72 points). Code is available in \href{https://github.com/SXR3015/BrainCSD}{BrainCSD}

Xiongri Shen, Jiaqi Wang, Yi Zhong et al.

Magnetic resonance imaging (MRI), especially functional MRI (fMRI) and diffusion MRI (dMRI), is essential for studying neurodegenerative diseases. However, missing modalities pose a major barrier to their clinical use. Although GAN- and diffusion model-based approaches have shown some promise in modality completion, they remain limited in fMRI-dMRI synthesis due to (1) significant BOLD vs. diffusion-weighted signal differences between fMRI and dMRI in time/gradient axis, and (2) inadequate integration of disease-related neuroanatomical patterns during generation. To address these challenges, we propose PDS, introducing two key innovations: (1) a pattern-aware dual-modal 3D diffusion framework for cross-modality learning, and (2) a tissue refinement network integrated with a efficient microstructure refinement to maintain structural fidelity and fine details. Evaluated on OASIS-3, ADNI, and in-house datasets, our method achieves state-of-the-art results, with PSNR/SSIM scores of 29.83 dB/90.84\% for fMRI synthesis (+1.54 dB/+4.12\% over baselines) and 30.00 dB/77.55\% for dMRI synthesis (+1.02 dB/+2.2\%). In clinical validation, the synthesized data show strong diagnostic performance, achieving 67.92\%/66.02\%/64.15\% accuracy (NC vs. MCI vs. AD) in hybrid real-synthetic experiments. Code is available in \href{https://github.com/SXR3015/PDS}{PDS GitHub Repository}

Zhexuan Wang, Xuebo Liu, Li Wang et al.

Large language model (LLM)-based Multi-agent systems (MAS) have shown promise in tackling complex collaborative tasks, where agents are typically orchestrated via role-specific prompts. While the quality of these prompts is pivotal, jointly optimizing them across interacting agents remains a non-trivial challenge, primarily due to the misalignment between local agent objectives and holistic system goals. To address this, we introduce MASPO, a novel framework designed to automatically and iteratively refine prompts across the entire system. A core innovation of MASPO is its joint evaluation mechanism, which assesses prompts not merely by their local validity, but by their capacity to facilitate downstream success for successor agents. This effectively bridges the gap between local interactions and global outcomes without relying on ground-truth labels. Furthermore, MASPO employs a data-driven evolutionary beam search to efficiently navigate the high-dimensional prompt space. Extensive empirical evaluations across 6 diverse tasks demonstrate that MASPO consistently outperforms state-of-the-art prompt optimization methods, achieving an average accuracy improvement of 2.9. We release our code at https://github.com/wangzx1219/MASPO.

Xiongri Shen, Zhenxi Song, Zhiguo Zhang

Diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) from fMRI functional connectivity (FC) has gained popularity, but most FC-based diagnostic models are black boxes lacking casual reasoning so they contribute little to the knowledge about FC-based neural biomarkers of cognitive decline.To enhance the explainability of diagnostic models, we propose a generative counterfactual attention-guided network (GCAN), which introduces counterfactual reasoning to recognize cognitive decline-related brain regions and then uses these regions as attention maps to boost the prediction performance of diagnostic models. Furthermore, to tackle the difficulty in the generation of highly-structured and brain-atlas-constrained FC, which is essential in counterfactual reasoning, an Atlas-Aware Bidirectional Transformer (AABT) method is developed. AABT employs a bidirectional strategy to encode and decode the tokens from each network of brain atlas, thereby enhancing the generation of high-quality target label FC. In the experiments of hospital-collected and ADNI datasets, the generated attention maps closely resemble FC abnormalities in the literature on SCD and MCI. The diagnostic performance is also superior to baseline models. The code is available at https://github.com/SXR3015/GCAN

Xiongri Shen, Zhenxi Song, Linling Li et al.

Early diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) utilizing multi-modal magnetic resonance imaging (MRI) is a pivotal area of research. While various regional and connectivity features from functional MRI (fMRI) and diffusion tensor imaging (DTI) have been employed to develop diagnosis models, most studies integrate these features without adequately addressing their alignment and interactions. This limits the potential to fully exploit the synergistic contributions of combined features and modalities. To solve this gap, our study introduces a novel Hierarchical Alignments and Hierarchical Interactions (HA-HI) method for MCI and SCD classification, leveraging the combined strengths of fMRI and DTI. HA-HI efficiently learns significant MCI- or SCD- related regional and connectivity features by aligning various feature types and hierarchically maximizing their interactions. Furthermore, to enhance the interpretability of our approach, we have developed the Synergistic Activation Map (SAM) technique, revealing the critical brain regions and connections that are indicative of MCI/SCD. Comprehensive evaluations on the ADNI dataset and our self-collected data demonstrate that HA-HI outperforms other existing methods in diagnosing MCI and SCD, making it a potentially vital and interpretable tool for early detection. The implementation of this method is publicly accessible at https://github.com/ICI-BCI/Dual-MRI-HA-HI.git.

Fengcheng Wu, Zhenxi Song, Guoyang Xu et al.

Robust and interpretable dementia diagnosis from noisy, non-stationary electroencephalography (EEG) is clinically essential yet remains challenging. To this end, we propose SeeGraph, a Sparse-Explanatory dynamic EEG-graph network that models time-evolving functional connectivity and employs a node-guided sparse edge mask to reveal the connections that drive diagnostic decisions, while remaining robust to noise and cross-site variability. SeeGraph comprises four components: (1) a dual-trajectory temporal encoder that models dynamic EEG with two streams, where node signals capture regional oscillations and edge signals capture interregional coupling; (2) a topology-aware positional encoder that derives graph-spectral Laplacian coordinates from the fused connectivity and augments node embeddings; (3) a node-guided sparse explanatory edge mask that gates the connectivity into a compact subgraph; and (4) a gated graph predictor that operates on the sparsified graph. The framework is trained using cross-entropy loss together with a sparsity regularizer on the mask, yielding noise-robust and interpretable diagnoses. The effectiveness of SeeGraph is validated on public and in-house EEG cohorts, including patients with neurodegenerative dementias and healthy controls, under both raw and noise-perturbed conditions. Its sparse, node-guided explanations highlight disease-relevant connections and align with established clinical findings on functional connectivity alterations, thereby offering transparent cues for neurological evaluation.

Xiaopeng Ke, Hexuan Deng, Xuebo Liu et al.

Despite the impressive performance of large language models (LLMs) in general domains, they often underperform in specialized domains. Existing approaches typically rely on data synthesis methods and yield promising results by using unlabeled data to capture domain-specific features. However, these methods either incur high computational costs or suffer from performance limitations, while also demonstrating insufficient generalization across different tasks. To address these challenges, we propose AQuilt, a framework for constructing instruction-tuning data for any specialized domains from corresponding unlabeled data, including Answer, Question, Unlabeled data, Inspection, Logic, and Task type. By incorporating logic and inspection, we encourage reasoning processes and self-inspection to enhance model performance. Moreover, customizable task instructions enable high-quality data generation for any task. As a result, we construct a dataset of 703k examples to train a powerful data synthesis model. Experiments show that AQuilt is comparable to DeepSeek-V3 while utilizing just 17% of the production cost. Further analysis demonstrates that our generated data exhibits higher relevance to downstream tasks. Source code, models, and scripts are available at https://github.com/Krueske/AQuilt.

Guoyang Xu, Zhenxi Song, Junqi Xue et al.

Achieving consistent sentiment representation across diverse modalities remains a key challenge in multimodal sentiment analysis. However, rapid emotional fluctuations over time often introduce instability, leading to compromised prediction performance. To address this challenge, we propose a robust sentiment representation dual enhancement strategy that simultaneously enhances the temporal and modality dimensions, guided by targeted mechanisms in both forward and backward propagation. Specifically, in the modality dimension, we introduce a modality invariant fusion mechanism that fosters stable cross-modal representations, which aim to capture the common and stable representations shared across different modalities. In the temporal dimension, we impose a specialized sequential variation regularization term that regulates the model's learning trajectory during backward propagation, which is essentially total variation regularization degenerated into one-dimensional linear differences. Extensive experiments on three standard public datasets validate the effectiveness of our proposed approach.

Zihui Zhou, Yong Feng, Yanying Chen et al.

Multimodal large language models (MLLMs) are increasingly adopted in remote sensing (RS) and have shown strong performance on tasks such as RS visual grounding (RSVG), RS visual question answering (RSVQA), and multimodal dialogue. However, hallucinations, which are responses inconsistent with the input RS images, severely hinder their deployment in high-stakes scenarios (e.g., emergency management and agricultural monitoring) and remain under-explored in RS. In this work, we present RSHallu, a systematic study with three deliverables: (1) we formalize RS hallucinations with an RS-oriented taxonomy and introduce image-level hallucination to capture RS-specific inconsistencies beyond object-centric errors (e.g., modality, resolution, and scene-level semantics); (2) we build a hallucination benchmark RSHalluEval (2,023 QA pairs) and enable dual-mode checking, supporting high-precision cloud auditing and low-cost reproducible local checking via a compact checker fine-tuned on RSHalluCheck dataset (15,396 QA pairs); and (3) we introduce a domain-tailored dataset RSHalluShield (30k QA pairs) for training-friendly mitigation and further propose training-free plug-and-play strategies, including decoding-time logit correction and RS-aware prompting. Across representative RS-MLLMs, our mitigation improves the hallucination-free rate by up to 21.63 percentage points under a unified protocol, while maintaining competitive performance on downstream RS tasks (RSVQA/RSVG). Code and datasets will be released.

Jiaqi Wang, Zhengyu Ma, Xiongri Shen et al.

Auditory attention detection (AAD) aims to decode listeners' focus in complex auditory environments from electroencephalography (EEG) recordings, which is crucial for developing neuro-steered hearing devices. Despite recent advancements, EEG-based AAD remains hindered by the absence of synergistic frameworks that can fully leverage complementary EEG features under energy-efficiency constraints. We propose S$^2$M-Former, a novel spiking symmetric mixing framework to address this limitation through two key innovations: i) Presenting a spike-driven symmetric architecture composed of parallel spatial and frequency branches with mirrored modular design, leveraging biologically plausible token-channel mixers to enhance complementary learning across branches; ii) Introducing lightweight 1D token sequences to replace conventional 3D operations, reducing parameters by 14.7$\times$. The brain-inspired spiking architecture further reduces power consumption, achieving a 5.8$\times$ energy reduction compared to recent ANN methods, while also surpassing existing SNN baselines in terms of parameter efficiency and performance. Comprehensive experiments on three AAD benchmarks (KUL, DTU and AV-GC-AAD) across three settings (within-trial, cross-trial and cross-subject) demonstrate that S$^2$M-Former achieves comparable state-of-the-art (SOTA) decoding accuracy, making it a promising low-power, high-performance solution for AAD tasks. Code is available at https://github.com/JackieWang9811/S2M-Former.

Jiaqi Wang, Zhenxi Song, Zhengyu Ma et al.

Reconstructing natural language from non-invasive electroencephalography (EEG) holds great promise as a language decoding technology for brain-computer interfaces (BCIs). However, EEG-based language decoding is still in its nascent stages, facing several technical issues such as: 1) Absence of a hybrid strategy that can effectively integrate cross-modality (between EEG and text) self-learning with intra-modality self-reconstruction of EEG features or textual sequences; 2) Under-utilization of large language models (LLMs) to enhance EEG-based language decoding. To address above issues, we propose the Contrastive EEG-Text Masked Autoencoder (CET-MAE), a novel model that orchestrates compound self-supervised learning across and within EEG and text through a dedicated multi-stream encoder. Furthermore, we develop a framework called E2T-PTR (EEG-to-Text decoding using Pretrained Transferable Representations), which leverages pre-trained modules alongside the EEG stream from CET-MAE and further enables an LLM (specifically BART) to decode text from EEG sequences. Comprehensive experiments conducted on the popular text-evoked EEG database, ZuCo, demonstrate the superiority of E2T-PTR, which outperforms the state-of-the-art in ROUGE-1 F1 and BLEU-4 scores by 8.34% and 32.21%, respectively. These results indicate significant advancements in the field and underscores the proposed framework's potential to enable more powerful and widespread BCI applications.

Jilong Li, Zhenxi Song, Jiaqi Wang et al.

Current EEG/MEG-to-text decoding systems suffer from three key limitations: (1) reliance on teacher-forcing methods, which compromises robustness during inference, (2) sensitivity to session-specific noise, hindering generalization across subjects, and (3) misalignment between brain signals and linguistic representations due to pre-trained language model over-dominance. To overcome these challenges, we propose BrainECHO (Brain signal decoding via vEctor-quantized speCtrogram reconstruction for WHisper-enhanced text generatiOn), a multi-stage framework that employs decoupled representation learning to achieve state-of-the-art performance on both EEG and MEG datasets. Specifically, BrainECHO consists of three stages: (1) Discrete autoencoding, which transforms continuous Mel spectrograms into a finite set of high-quality discrete representations for subsequent stages. (2) Frozen alignment, where brain signal embeddings are mapped to corresponding Mel spectrogram embeddings in a frozen latent space, effectively filtering session-specific noise through vector-quantized reconstruction, yielding a 3.65% improvement in BLEU-4 score. (3) Constrained decoding fine-tuning, which leverages the pre-trained Whisper model for audio-to-text translation, balancing signal adaptation with knowledge preservation, and achieving 74%-89% decoding BLEU scores without excessive reliance on teacher forcing. BrainECHO demonstrates robustness across sentence, session, and subject-independent conditions, passing Gaussian noise tests and showcasing its potential for enhancing language-based brain-computer interfaces.

Zhenxi Song, Ruihan Qin, Huixia Ren et al.

Cross-center data heterogeneity and annotation unreliability significantly challenge the intelligent diagnosis of diseases using brain signals. A notable example is the EEG-based diagnosis of neurodegenerative diseases, which features subtler abnormal neural dynamics typically observed in small-group settings. To advance this area, in this work, we introduce a transferable framework employing Manifold Attention and Confidence Stratification (MACS) to diagnose neurodegenerative disorders based on EEG signals sourced from four centers with unreliable annotations. The MACS framework's effectiveness stems from these features: 1) The Augmentor generates various EEG-represented brain variants to enrich the data space; 2) The Switcher enhances the feature space for trusted samples and reduces overfitting on incorrectly labeled samples; 3) The Encoder uses the Riemannian manifold and Euclidean metrics to capture spatiotemporal variations and dynamic synchronization in EEG; 4) The Projector, equipped with dual heads, monitors consistency across multiple brain variants and ensures diagnostic accuracy; 5) The Stratifier adaptively stratifies learned samples by confidence levels throughout the training process; 6) Forward and backpropagation in MACS are constrained by confidence stratification to stabilize the learning system amid unreliable annotations. Our subject-independent experiments, conducted on both neurocognitive and movement disorders using cross-center corpora, have demonstrated superior performance compared to existing related algorithms. This work not only improves EEG-based diagnostics for cross-center and small-setting brain diseases but also offers insights into extending MACS techniques to other data analyses, tackling data heterogeneity and annotation unreliability in multimedia and multimodal content understanding.

Jiaqi Wang, Liutao Yu, Liwei Huang et al.

The intrinsic dynamics and event-driven nature of spiking neural networks (SNNs) make them excel in processing temporal information by naturally utilizing embedded time sequences as time steps. Recent studies adopting this approach have demonstrated SNNs' effectiveness in speech command recognition, achieving high performance by employing large time steps for long time sequences. However, the large time steps lead to increased deployment burdens for edge computing applications. Thus, it is important to balance high performance and low energy consumption when detecting temporal patterns in edge devices. Our solution comprises two key components. 1). We propose a high-performance fully spike-driven framework termed SpikeSCR, characterized by a global-local hybrid structure for efficient representation learning, which exhibits long-term learning capabilities with extended time steps. 2). To further fully embrace low energy consumption, we propose an effective knowledge distillation method based on curriculum learning (KDCL), where valuable representations learned from the easy curriculum are progressively transferred to the hard curriculum with minor loss, striking a trade-off between power efficiency and high performance. We evaluate our method on three benchmark datasets: the Spiking Heidelberg Dataset (SHD), the Spiking Speech Commands (SSC), and the Google Speech Commands (GSC) V2. Our experimental results demonstrate that SpikeSCR outperforms current state-of-the-art (SOTA) methods across these three datasets with the same time steps. Furthermore, by executing KDCL, we reduce the number of time steps by 60% and decrease energy consumption by 54.8% while maintaining comparable performance to recent SOTA results. Therefore, this work offers valuable insights for tackling temporal processing challenges with long time sequences in edge neuromorphic computing systems.

Yuxin Liu, Zhenxi Song, Guoyang Xu et al.

Brain-computer interface (BCI) based on steady-state visual evoked potentials (SSVEP) is a popular paradigm for its simplicity and high information transfer rate (ITR). Accurate and fast SSVEP decoding is crucial for reliable BCI performance. However, conventional decoding methods demand longer time windows, and deep learning models typically require subject-specific fine-tuning, leaving challenges in achieving optimal performance in cross-subject settings. This paper proposed a biofocal masking attention-based method (SSVEP-BiMA) that synergistically leverages the native and symmetric-antisymmetric components for decoding SSVEP. By utilizing multiple signal representations, the network is able to integrate features from a wider range of sample perspectives, leading to more generalized and comprehensive feature learning, which enhances both prediction accuracy and robustness. We performed experiments on two public datasets, and the results demonstrate that our proposed method surpasses baseline approaches in both accuracy and ITR. We believe that this work will contribute to the development of more efficient SSVEP-based BCI systems.

Zirui Wang, Zhenxi Song, Yi Guo et al.

The development of EEG decoding algorithms confronts challenges such as data sparsity, subject variability, and the need for precise annotations, all of which are vital for advancing brain-computer interfaces and enhancing the diagnosis of diseases. To address these issues, we propose a novel two-stage approach named Self-Supervised State Reconstruction-Primed Riemannian Dynamics (EEG-ReMinD) , which mitigates reliance on supervised learning and integrates inherent geometric features. This approach efficiently handles EEG data corruptions and reduces the dependency on labels. EEG-ReMinD utilizes self-supervised and geometric learning techniques, along with an attention mechanism, to analyze the temporal dynamics of EEG features within the framework of Riemannian geometry, referred to as Riemannian dynamics. Comparative analyses on both intact and corrupted datasets from two different neurodegenerative disorders underscore the enhanced performance of EEG-ReMinD.