Matti Hamalainen

Silvia Mura, Elisabetta Marini, Maurizio Magarini et al.

Sub-terahertz (sub-THz) and terahertz (THz) radiation offer unique opportunities for non-invasive diagnostics and imaging due to their sensitivity to water content and molecular dynamics in biological tissues. In this work, a comprehensive dielectric model of human skin and its cellular constituents is developed across these frequency ranges. The model combines multi-Debye relaxation theory with effective medium formulations to account for intracellular water dynamics and macromolecular relaxation processes. Key cellular parameters, including water content, protein and lipid fractions, and ionic conductivity, are integrated from experimentally validated sources. The proposed framework enables realistic predictions of frequency-dependent permittivity for different skin layers and cell types, providing a physically interpretable description of sub-THz and THz tissue interactions. This approach establishes a foundation for the design and optimization of next-generation diagnostic and imaging techniques operating in these frequency bands.

Elisabetta Marini, Silvia Mura, Marco Hernandez et al.

Terahertz (THz) radiation provides a non-ionizing, highly sensitive probe of the dielectric properties of biological tissues. In this study, we present a comprehensive experimental characterization of dielectric properties using pork skin tissue, a widely used surrogate for human tissue, as a biological sample. Measurements are conducted employing THz time-domain spectroscopy in the 0.1-11 THz frequency range with photoconductive antennas for both signal generation and detection. Frequency-dependent refractive indices, absorption, and complex permittivity are extracted from transmitted time-domain signals. Our results confirm strong absorption and low transmittance at low THz frequencies due to water content, while highlighting frequency-dependent dispersion and narrowband transmission features at higher frequencies. This work provides one of the first extended-frequency datasets of biological tissue dielectric properties, supporting realistic channel modeling for the design and development of intra-body nanosensor networks in the THz band.

Sheraz Khan, Javeria Hashmi, Fahimeh Mamashli et al.

The functional significance of resting state networks and their abnormal manifestations in psychiatric disorders are firmly established, as is the importance of the cortical rhythms in mediating these networks. Resting state networks are known to undergo substantial reorganization from childhood to adulthood, but whether distinct cortical rhythms, which are generated by separable neural mechanisms and are often manifested abnormally in psychiatric conditions, mediate maturation differentially, remains unknown. Using magnetoencephalography (MEG) to map frequency band specific maturation of resting state networks from age 7 to 29 in 162 participants (31 independent), we found significant changes with age in networks mediated by the beta (13-30Hz) and gamma (31-80Hz) bands. More specifically, gamma band mediated networks followed an expected asymptotic trajectory, but beta band mediated networks followed a linear trajectory. Network integration increased with age in gamma band mediated networks, while local segregation increased with age in beta band mediated networks. Spatially, the hubs that changed in importance with age in the beta band mediated networks had relatively little overlap with those that showed the greatest changes in the gamma band mediated networks. These findings are relevant for our understanding of the neural mechanisms of cortical maturation, in both typical and atypical development.