Peiwu Qin

Ruitao Zhang, Xueying Han, Ijaz Gul et al.

Acute leukemia is a type of blood cancer with a high mortality rate. Current therapeutic methods include bone marrow transplantation, supportive therapy, and chemotherapy. Although a satisfactory remission of the disease can be achieved, the risk of recurrence is still high. Therefore, novel treatments are demanding. Chimeric antigen receptor-T (CAR-T) therapy has emerged as a promising approach to treat and cure acute leukemia. To harness the therapeutic potential of CAR-T cell therapy for blood diseases, reliable cell morphological identification is crucial. Nevertheless, the identification of CAR-T cells is a big challenge posed by their phenotypic similarity with other blood cells. To address this substantial clinical challenge, herein we first construct a CAR-T dataset with 500 original microscopy images after staining. Following that, we create a novel integrated model called RCMNet (ResNet18 with CBAM and MHSA) that combines the convolutional neural network (CNN) and Transformer. The model shows 99.63% top-1 accuracy on the public dataset. Compared with previous reports, our model obtains satisfactory results for image classification. Although testing on the CAR-T cells dataset, a decent performance is observed, which is attributed to the limited size of the dataset. Transfer learning is adapted for RCMNet and a maximum of 83.36% accuracy has been achieved, which is higher than other SOTA models. The study evaluates the effectiveness of RCMNet on a big public dataset and translates it to a clinical dataset for diagnostic applications.

Yang Liu, Ersi Zhang, Lulu Xu et al.

Deep learning techniques have shown great potential in medical image processing, particularly through accurate and reliable image segmentation on magnetic resonance imaging (MRI) scans or computed tomography (CT) scans, which allow the localization and diagnosis of lesions. However, training these segmentation models requires a large number of manually annotated pixel-level labels, which are time-consuming and labor-intensive, in contrast to image-level labels that are easier to obtain. It is imperative to resolve this problem through weakly-supervised semantic segmentation models using image-level labels as supervision since it can significantly reduce human annotation efforts. Most of the advanced solutions exploit class activation mapping (CAM). However, the original CAMs rarely capture the precise boundaries of lesions. In this study, we propose the strategy of multi-scale inference to refine CAMs by reducing the detail loss in single-scale reasoning. For segmentation, we develop a novel model named Mixed-UNet, which has two parallel branches in the decoding phase. The results can be obtained after fusing the extracted features from two branches. We evaluate the designed Mixed-UNet against several prevalent deep learning-based segmentation approaches on our dataset collected from the local hospital and public datasets. The validation results demonstrate that our model surpasses available methods under the same supervision level in the segmentation of various lesions from brain imaging.

Muhammad Hassan, Haifei Guan, Aikaterini Melliou et al.

Neural networks have been rapidly expanding in recent years, with novel strategies and applications. However, challenges such as interpretability, explainability, robustness, safety, trust, and sensibility remain unsolved in neural network technologies, despite the fact that they will unavoidably be addressed for critical applications. Attempts have been made to overcome the challenges in neural network computing by representing and embedding domain knowledge in terms of symbolic representations. Thus, the neuro-symbolic learning (NeSyL) notion emerged, which incorporates aspects of symbolic representation and bringing common sense into neural networks (NeSyL). In domains where interpretability, reasoning, and explainability are crucial, such as video and image captioning, question-answering and reasoning, health informatics, and genomics, NeSyL has shown promising outcomes. This review presents a comprehensive survey on the state-of-the-art NeSyL approaches, their principles, advances in machine and deep learning algorithms, applications such as opthalmology, and most importantly, future perspectives of this emerging field.

Zhicheng Du, Chenyao Jiang, Xi Yuan et al.

The timely identification of mental disorders in adolescents is a global public health challenge.Single factor is difficult to detect the abnormality due to its complex and subtle nature. Additionally, the generalized multimodal Computer-Aided Screening (CAS) systems with interactive robots for adolescent mental disorders are not available. Here, we design an android application with mini-games and chat recording deployed in a portable robot to screen 3,783 middle school students and construct the multimodal screening dataset, including facial images, physiological signs, voice recordings, and textual transcripts.We develop a model called GAME (Generalized Model with Attention and Multimodal EmbraceNet) with novel attention mechanism that integrates cross-modal features into the model. GAME evaluates adolescent mental conditions with high accuracy (73.34%-92.77%) and F1-Score (71.32%-91.06%).We find each modality contributes dynamically to the mental disorders screening and comorbidities among various mental disorders, indicating the feasibility of explainable model. This study provides a system capable of acquiring multimodal information and constructs a generalized multimodal integration algorithm with novel attention mechanisms for the early screening of adolescent mental disorders.

Joongwon Chae, Lihui Luo, Yang Liu et al.

Feature-based anomaly detection is widely adopted in industrial inspection due to the strong representational power of large pre-trained vision encoders. While most existing methods focus on improving within-category anomaly scoring, practical deployments increasingly require task-agnostic operation under continual category expansion, where the category identity is unknown at test time. In this setting, overall performance is often dominated by expert selection, namely routing an input to an appropriate normality model before any head-specific scoring is applied. However, routing rules that compare head-specific anomaly scores across independently constructed heads are unreliable in practice, as score distributions can differ substantially across categories in scale and tail behavior. We propose GCR, a lightweight mixture-of-experts framework for stabilizing task-agnostic continual anomaly detection through geometry-consistent routing. GCR routes each test image directly in a shared frozen patch-embedding space by minimizing an accumulated nearest-prototype distance to category-specific prototype banks, and then computes anomaly maps only within the routed expert using a standard prototype-based scoring rule. By separating cross-head decision making from within-head anomaly scoring, GCR avoids cross-head score comparability issues without requiring end-to-end representation learning. Experiments on MVTec AD and VisA show that geometry-consistent routing substantially improves routing stability and mitigates continual performance collapse, achieving near-zero forgetting while maintaining competitive detection and localization performance. These results indicate that many failures previously attributed to representation forgetting can instead be explained by decision-rule instability in cross-head routing. Code is available at https://github.com/jw-chae/GCR

Yang Liu, Xiaoyun Zhong, Shiyao Zhai et al.

The vast majority of people who suffer unexpected cardiac arrest are performed cardiopulmonary resuscitation (CPR) by passersby in a desperate attempt to restore life, but endeavors turn out to be fruitless on account of disqualification. Fortunately, many pieces of research manifest that disciplined training will help to elevate the success rate of resuscitation, which constantly desires a seamless combination of novel techniques to yield further advancement. To this end, we collect a custom CPR video dataset in which trainees make efforts to behave resuscitation on mannequins independently in adherence to approved guidelines, thereby devising an auxiliary toolbox to assist supervision and rectification of intermediate potential issues via modern deep learning methodologies. Our research empirically views this problem as a temporal action segmentation (TAS) task in computer vision, which aims to segment an untrimmed video at a frame-wise level. Here, we propose a Prompt-enhanced hierarchical Transformer (PhiTrans) that integrates three indispensable modules, including a textual prompt-based Video Features Extractor (VFE), a transformer-based Action Segmentation Executor (ASE), and a regression-based Prediction Refinement Calibrator (PRC). The backbone of the model preferentially derives from applications in three approved public datasets (GTEA, 50Salads, and Breakfast) collected for TAS tasks, which accounts for the excavation of the segmentation pipeline on the CPR dataset. In general, we unprecedentedly probe into a feasible pipeline that genuinely elevates the CPR instruction qualification via action segmentation in conjunction with cutting-edge deep learning techniques. Associated experiments advocate our implementation with multiple metrics surpassing 91.0%.

Chenyao Jiang, Shiyao Zhai, Hengrui Song et al.

Dental caries is one of the most common oral diseases that, if left untreated, can lead to a variety of oral problems. It mainly occurs inside the pits and fissures on the occlusal/buccal/palatal surfaces of molars and children are a high-risk group for pit and fissure caries in permanent molars. Pit and fissure sealing is one of the most effective methods that is widely used in prevention of pit and fissure caries. However, current detection of pits and fissures or caries depends primarily on the experienced dentists, which ordinary parents do not have, and children may miss the remedial treatment without timely detection. To address this issue, we present a method to autodetect caries and pit and fissure sealing requirements using oral photos taken by smartphones. We use the YOLOv5 and YOLOX models and adopt a tiling strategy to reduce information loss during image pre-processing. The best result for YOLOXs model with tiling strategy is 72.3 mAP.5, while the best result without tiling strategy is 71.2. YOLOv5s6 model with/without tiling attains 70.9/67.9 mAP.5, respectively. We deploy the pre-trained network to mobile devices as a WeChat applet, allowing in-home detection by parents or children guardian.

Joongwon Chae, Zhenyu Wang, Ijaz Gul et al.

Recent advancements in protein structure prediction, particularly AlphaFold2, have revolutionized structural biology by achieving near-experimental accuracy ($\text{average RMSD} < 1.5\textÅ$). However, the computational demands of these models (approximately 30 minutes per protein on an RTX 4090) significantly limit their application in high-throughput protein screening. While large language models like ESM (Evolutionary Scale Modeling) have shown promise in extracting structural information directly from protein sequences, rapid assessment of protein structure quality for large-scale analyses remains a major challenge. We introduce pLDDT-Predictor, a high-speed protein screening tool that achieves a $250,000\times$ speedup compared to AlphaFold2 by leveraging pre-trained ESM2 protein embeddings and a Transformer architecture. Our model predicts AlphaFold2's pLDDT (predicted Local Distance Difference Test) scores with a Pearson correlation of 0.7891 and processes proteins in just 0.007 seconds on average. Using a comprehensive dataset of 1.5 million diverse protein sequences (ranging from 50 to 2048 amino acids), we demonstrate that pLDDT-Predictor accurately classifies high-confidence structures (pLDDT $>$ 70) with 91.2\% accuracy and achieves an MSE of 84.8142 compared to AlphaFold2's predictions. The source code and pre-trained models are freely available at https://github.com/jw-chae/pLDDT_Predictor, enabling the research community to perform rapid, large-scale protein structure quality assessments.

Haoxuan Li, Wei song, Peiwu Qin et al.

Breast cancer lesion segmentation in DCE-MRI remains challenging due to heterogeneous tumor morphology and indistinct boundaries. To address these challenges, this study proposes a novel hybrid segmentation network, HCMA-UNet, for lesion segmentation of breast cancer. Our network consists of a lightweight CNN backbone and a Multi-view Axial Self-Attention Mamba (MISM) module. The MISM module integrates Visual State Space Block (VSSB) and Axial Self-Attention (ASA) mechanism, effectively reducing parameters through Asymmetric Split Channel (ASC) strategy to achieve efficient tri-directional feature extraction. Our lightweight model achieves superior performance with 2.87M parameters and 126.44 GFLOPs. A Feature-guided Region-aware loss function (FRLoss) is proposed to enhance segmentation accuracy. Extensive experiments on one private and two public DCE-MRI breast cancer datasets demonstrate that our approach achieves state-of-the-art performance while maintaining computational efficiency. FRLoss also exhibits good cross-architecture generalization capabilities. The source code is available at https://github.com/Haoxuanli-Thu/HCMA-UNet.

Joongwon Chae, Lihui Luo, Yang Liu et al.

Max pooling is the de facto standard for converting anomaly score maps into image-level decisions in memory-bank-based unsupervised anomaly detection (UAD). However, because it relies on a single extreme response, it discards most information about how anomaly evidence is distributed and structured across the image, often causing normal and anomalous scores to overlap. We propose StructCore, a training-free, structure-aware image-level scoring method that goes beyond max pooling. Given an anomaly score map, StructCore computes a low-dimensional structural descriptor phi(S) that captures distributional and spatial characteristics, and refines image-level scoring via a diagonal Mahalanobis calibration estimated from train-good samples, without modifying pixel-level localization. StructCore achieves image-level AUROC scores of 99.6% on MVTec AD and 98.4% on VisA, demonstrating robust image-level anomaly detection by exploiting structural signatures missed by max pooling.

Joongwon Chae, Runming Wang, Chen Xiong et al.

Effective surveillance of hand, foot and mouth disease (HFMD) requires forecasts accounting for epidemiological patterns and contextual drivers like school calendars and weather. While classical models and recent foundation models (e.g., Chronos, TimesFM) incorporate covariates, they often lack the semantic reasoning to interpret the causal interplay between conflicting drivers. In this work, we propose a two-agent framework decoupling contextual interpretation from probabilistic forecasting. An LLM "event interpreter" processes heterogeneous signals-including school schedules, meteorological summaries, and reports-into a scalar transmission-impact signal. A neuro-symbolic core then combines this with historical case counts to produce calibrated probabilistic forecasts. We evaluate the framework on real-world HFMD datasets from Hong Kong (2023-2024) and Lishui, China (2024). Compared to traditional and foundation-model baselines, our approach achieves competitive point forecasting accuracy while providing robust 90% prediction intervals (coverage 0.85-1.00) and human-interpretable rationales. Our results suggest that structurally integrating domain knowledge through LLMs can match state-of-the-art performance while yielding context-aware forecasts that align with public health workflows. Code is available at https://github.com/jw-chae/forecast_MED .

Joongwon Chae, Lihui Luo, Xi Yuan et al.

Accurate tongue segmentation is crucial for reliable TCM analysis. Supervised models require large annotated datasets, while SAM-family models remain prompt-driven. We present Memory-SAM, a training-free, human-prompt-free pipeline that automatically generates effective prompts from a small memory of prior cases via dense DINOv3 features and FAISS retrieval. Given a query image, mask-constrained correspondences to the retrieved exemplar are distilled into foreground/background point prompts that guide SAM2 without manual clicks or model fine-tuning. We evaluate on 600 expert-annotated images (300 controlled, 300 in-the-wild). On the mixed test split, Memory-SAM achieves mIoU 0.9863, surpassing FCN (0.8188) and a detector-to-box SAM baseline (0.1839). On controlled data, ceiling effects above 0.98 make small differences less meaningful given annotation variability, while our method shows clear gains under real-world conditions. Results indicate that retrieval-to-prompt enables data-efficient, robust segmentation of irregular boundaries in tongue imaging. The code is publicly available at https://github.com/jw-chae/memory-sam.

Haoxuan Li, Wei Song, Aofan Liu et al.

Document Visual Question Answering (Document VQA) faces significant challenges when processing long documents in low-resource environments due to context limitations and insufficient training data. This paper presents AdaDocVQA, a unified adaptive framework addressing these challenges through three core innovations: a hybrid text retrieval architecture for effective document segmentation, an intelligent data augmentation pipeline that automatically generates high-quality reasoning question-answer pairs with multi-level verification, and adaptive ensemble inference with dynamic configuration generation and early stopping mechanisms. Experiments on Japanese document VQA benchmarks demonstrate substantial improvements with 83.04\% accuracy on Yes/No questions, 52.66\% on factual questions, and 44.12\% on numerical questions in JDocQA, and 59\% accuracy on LAVA dataset. Ablation studies confirm meaningful contributions from each component, and our framework establishes new state-of-the-art results for Japanese document VQA while providing a scalable foundation for other low-resource languages and specialized domains. Our code available at: https://github.com/Haoxuanli-Thu/AdaDocVQA.

Yingshan Liang, Keyu Fan, Zhicheng Du et al.

Video-to-audio (V2A) generation shows great potential in fields such as film production. Despite significant advances, current V2A methods relying on global video information struggle with complex scenes and generating audio tailored to specific objects. To address these limitations, we introduce Hear-Your-Click, an interactive V2A framework enabling users to generate sounds for specific objects by clicking on the frame. To achieve this, we propose Object-aware Contrastive Audio-Visual Fine-tuning (OCAV) with a Mask-guided Visual Encoder (MVE) to obtain object-level visual features aligned with audio. Furthermore, we tailor two data augmentation strategies, Random Video Stitching (RVS) and Mask-guided Loudness Modulation (MLM), to enhance the model's sensitivity to segmented objects. To measure audio-visual correspondence, we designed a new evaluation metric, the CAV score. Extensive experiments demonstrate that our framework offers more precise control and improves generation performance across various metrics. Project Page: https://github.com/SynapGrid/Hear-Your-Click

Haoxuan Li, Wei Song, Aofan Liu et al.

Medical image analysis faces significant challenges due to limited annotation data, particularly in three-dimensional carotid artery segmentation tasks, where existing datasets exhibit spatially discontinuous slice annotations with only a small portion of expert-labeled slices in complete 3D volumetric data. To address this challenge, we propose a two-stage segmentation framework. First, we construct continuous vessel centerlines by interpolating between annotated slice centroids and propagate labels along these centerlines to generate interpolated annotations for unlabeled slices. The slices with expert annotations are used for fine-tuning SAM-Med2D, while the interpolated labels on unlabeled slices serve as prompts to guide segmentation during inference. In the second stage, we propose a novel Dense Bidirectional Feature Fusion UNet (DBF-UNet). This lightweight architecture achieves precise segmentation of complete 3D vascular structures. The network incorporates bidirectional feature fusion in the encoder and integrates multi-scale feature aggregation with dense connectivity for effective feature reuse. Experimental validation on public datasets demonstrates that our proposed method effectively addresses the sparse annotation challenge in carotid artery segmentation while achieving superior performance compared to existing approaches. The source code is available at https://github.com/Haoxuanli-Thu/DBF-UNet.

Joongwon Chae, Zhenyu Wang, Peiwu Qin

Despite significant advances in vision-language understanding, implementing image segmentation within multimodal architectures remains a fundamental challenge in modern artificial intelligence systems. Existing vision-language models, which primarily rely on backbone architectures or CLIP-based embedding learning, demonstrate inherent limitations in fine-grained spatial localization and operational capabilities. This paper introduces SJTU: Spatial Judgments in Multimodal Models - Towards Unified Segmentation through Coordinate Detection, a framework that leverages spatial coordinate understanding to bridge vision-language interaction and precise segmentation, enabling accurate target identification through natural language instructions. The framework presents an approach for integrating segmentation techniques with vision-language models through spatial inference in multimodal space. By utilizing normalized coordinate detection for bounding boxes and transforming them into actionable segmentation outputs, we establish a connection between spatial and language representations in multimodal architectures. Experimental results demonstrate superior performance across benchmark datasets, achieving IoU scores of 0.5958 on COCO 2017 and 0.6758 on Pascal VOC. Testing on a single NVIDIA RTX 3090 GPU with 512x512 resolution images yields an average inference time of 7 seconds per image, demonstrating the framework's effectiveness in both accuracy and practical deployability. The project code is available at https://github.com/jw-chae/SJTU

Boyuan Peng, Jiaju Chen, P. Bilha Githinji et al.

Cell segmentation is essential in biomedical research for analyzing cellular morphology and behavior. Deep learning methods, particularly convolutional neural networks (CNNs), have revolutionized cell segmentation by extracting intricate features from images. However, the robustness of these methods under microscope optical aberrations remains a critical challenge. This study evaluates cell image segmentation models under optical aberrations from fluorescence and bright field microscopy. By simulating different types of aberrations, including astigmatism, coma, spherical aberration, trefoil, and mixed aberrations, we conduct a thorough evaluation of various cell instance segmentation models using the DynamicNuclearNet (DNN) and LIVECell datasets, representing fluorescence and bright field microscopy cell datasets, respectively. We train and test several segmentation models, including the Otsu threshold method and Mask R-CNN with different network heads (FPN, C3) and backbones (ResNet, VGG, Swin Transformer), under aberrated conditions. Additionally, we provide usage recommendations for the Cellpose 2.0 Toolbox on complex cell degradation images. The results indicate that the combination of FPN and SwinS demonstrates superior robustness in handling simple cell images affected by minor aberrations. In contrast, Cellpose 2.0 proves effective for complex cell images under similar conditions. Furthermore, we innovatively propose the Point Spread Function Image Label Classification Model (PLCM). This model can quickly and accurately identify aberration types and amplitudes from PSF images, assisting researchers without optical training. Through PLCM, researchers can better apply our proposed cell segmentation guidelines.

P. Bilha Githinji, Aikaterini Meilliou, Peiwu Qin

The increasing health-seeking behavior and digital consumption of biomedical information by the general public necessitate scalable solutions for automatically adapting complex scientific and technical documents into plain language. Automatic text simplification solutions, including advanced large language models, however, continue to face challenges in reliably arbitrating the tension between optimizing readability performance and ensuring preservation of discourse fidelity. This report empirically assesses the performance of two major classes of general-purpose LLMs, demonstrating their linguistic capabilities and foundational readiness for the task compared to a human benchmark. Using a comparative analysis of the instruction-tuned Mistral 24B and the reasoning-augmented QWen2.5 32B, we identify a potential architectural advantage in the instruction-tuned LLM. Mistral exhibits a tempered lexical simplification strategy that enhances readability across a suite of metrics and the simplification-specific formula SARI (mean 42.46), while preserving human-level discourse with a BERTScore of 0.91. QWen also attains enhanced readability performance, but its operational strategy shows a disconnect in balancing between readability and accuracy, reaching a statistically significantly lower BERTScore of 0.89. Additionally, a comprehensive correlation analysis of 21 metrics spanning readability, discourse fidelity, content safety, and underlying distributional measures for mechanistic insights, confirms strong functional redundancies among five readability indices. This empirical evidence tracks baseline performance of the evolving LLMs for the task of text simplification, identifies the instruction-tuned Mistral 24B for simplification, provides necessary heuristics for metric selection, and points to lexical support as a primary domain-adaptation issue for simplification.

Joongwon Chae, Zhenyu Wang, Lian Zhang et al.

Recent advances in multimodal models have demonstrated impressive capabilities in object recognition and scene understanding. However, these models often struggle with precise spatial localization - a critical capability for real-world applications. Inspired by how humans use grid-based references like chess boards and maps, we propose introducing explicit visual position encoding through a simple grid overlay approach. By adding a 9x9 black grid pattern onto input images, our method provides visual spatial guidance analogous to how positional encoding works in transformers, but in an explicit, visual form. Experiments on the COCO 2017 dataset demonstrate that our grid-based approach achieves significant improvements in localization accuracy, with a 107.4% increase in IoU (from 0.27 to 0.56) and a 194.4% improvement in GIoU (from 0.18 to 0.53) compared to baseline performance. Through attention visualization analysis, we show how this visual position encoding helps models better ground spatial relationships. Our method's simplicity and effectiveness make it particularly valuable for applications requiring accurate spatial reasoning, such as robotic manipulation, medical imaging, and autonomous navigation.

Zhicheng Du, Zhaotian Xie, Yan Tong et al.

This study constructs the LanguAge Model with Prompt EngineeRing (LAMPER) framework, designed to systematically evaluate the adaptability of pre-trained language models (PLMs) in accommodating diverse prompts and their integration in zero-shot time series (TS) classification. We deploy LAMPER in experimental assessments using 128 univariate TS datasets sourced from the UCR archive. Our findings indicate that the feature representation capacity of LAMPER is influenced by the maximum input token threshold imposed by PLMs.

Jiaming Deng, Zhenglin Chen, Minjiang Chen et al.

Mycoplasma pneumoniae pneumonia (MPP) poses significant diagnostic challenges in pediatric healthcare, especially in regions like China where it's prevalent. We introduce PneumoniaAPP, a mobile application leveraging deep learning techniques for rapid MPP detection. Our approach capitalizes on convolutional neural networks (CNNs) trained on a comprehensive dataset comprising 3345 chest X-ray (CXR) images, which includes 833 CXR images revealing MPP and additionally augmented with samples from a public dataset. The CNN model achieved an accuracy of 88.20% and an AUROC of 0.9218 across all classes, with a specific accuracy of 97.64% for the mycoplasma class, as demonstrated on the testing dataset. Furthermore, we integrated explainability techniques into PneumoniaAPP to aid respiratory physicians in lung opacity localization. Our contribution extends beyond existing research by targeting pediatric MPP, emphasizing the age group of 0-12 years, and prioritizing deployment on mobile devices. This work signifies a significant advancement in pediatric pneumonia diagnosis, offering a reliable and accessible tool to alleviate diagnostic burdens in healthcare settings.

Zhicheng Du, Zhaotian Xie, Huazhang Ying et al.

This study explores the ability of Image Captioning (IC) models to decode masked visual content sourced from diverse datasets. Our findings reveal the IC model's capability to generate captions from masked images, closely resembling the original content. Notably, even in the presence of masks, the model adeptly crafts descriptive textual information that goes beyond what is observable in the original image-generated captions. While the decoding performance of the IC model experiences a decline with an increase in the masked region's area, the model still performs well when important regions of the image are not masked at high coverage.

P. Bilha Githinji, Keming Zhao, Jiantao Wang et al.

Ocular conditions are a global concern and computational tools utilizing retinal fundus color photographs can aid in routine screening and management. Obtaining comprehensive and sufficiently sized datasets, however, is non-trivial for the intricate retinal fundus, which exhibits heterogeneities within pathologies, in addition to variations from demographics and acquisition. Moreover, retinal fundus datasets in the public space suffer fragmentation in the organization of data and definition of a healthy observation. We present Integrated Retinal Fundus Set (IRFundusSet), a dataset that consolidates, harmonizes and curates several public datasets, facilitating their consumption as a unified whole and with a consistent is_normal label. IRFundusSet comprises a Python package that automates harmonization and avails a dataset object in line with the PyTorch approach. Moreover, images are physically reviewed and a new is_normal label is annotated for a consistent definition of a healthy observation. Ten public datasets are initially considered with a total of 46064 images, of which 25406 are curated for a new is_normal label and 3515 are deemed healthy across the sources.

Zhicheng Du, Qingyang Shi, Jiasheng Lu et al.

The multimodal relevance metric is usually borrowed from the embedding ability of pretrained contrastive learning models for bimodal data, which is used to evaluate the correlation between cross-modal data (e.g., CLIP). However, the commonly used evaluation metrics are only suitable for the associated analysis between two modalities, which greatly limits the evaluation of multimodal similarity. Herein, we propose MAJORScore, a brand-new evaluation metric for the relevance of multiple modalities ($N$ modalities, $N\ge3$) via multimodal joint representation for the first time. The ability of multimodal joint representation to integrate multiple modalities into the same latent space can accurately represent different modalities at one scale, providing support for fair relevance scoring. Extensive experiments have shown that MAJORScore increases by 26.03%-64.29% for consistent modality and decreases by 13.28%-20.54% for inconsistence compared to existing methods. MAJORScore serves as a more reliable metric for evaluating similarity on large-scale multimodal datasets and multimodal model performance evaluation.

Boyuan Peng, Jiaju Chen, Yiwei Zhang et al.

The growing burden of myopia and retinal diseases necessitates more accessible and efficient eye screening solutions. This study presents a compact, dual-function optical device that integrates fundus photography and refractive error detection into a unified platform. The system features a coaxial optical design using dichroic mirrors to separate wavelength-dependent imaging paths, enabling simultaneous alignment of fundus and refraction modules. A Dense-U-Net-based algorithm with customized loss functions is employed for accurate pupil segmentation, facilitating automated alignment and focusing. Experimental evaluations demonstrate the system's capability to achieve high-precision pupil localization (EDE = 2.8 px, mIoU = 0.931) and reliable refractive estimation with a mean absolute error below 5%. Despite limitations due to commercial lens components, the proposed framework offers a promising solution for rapid, intelligent, and scalable ophthalmic screening, particularly suitable for community health settings.

Muhammad Akmal Raheem, Muhammad Ajwad Rahim, Ijaz Gul et al.

SARS-CoV-2, the highly contagious pathogen responsible for the COVID-19 pandemic, has persistent effects that begin four weeks after initial infection and last for an undetermined duration. These chronic effects are more harmful than acute ones. This review explores the long-term impact of the virus on various human organs, including the pulmonary, cardiovascular, neurological, reproductive, gastrointestinal, musculoskeletal, endocrine, and lymphoid systems, particularly in older adults. Regarding diagnosis, RT-PCR is the gold standard for detecting COVID-19, though it requires specialized equipment, skilled personnel, and considerable time to produce results. To address these limitations, artificial intelligence in imaging and microfluidics technologies offers promising alternatives for diagnosing COVID-19 efficiently. Pharmacological and non-pharmacological strategies are effective in mitigating the persistent impacts of COVID-19. These strategies enhance immunity in post-COVID-19 patients by reducing cytokine release syndrome, improving T cell response, and increasing the circulation of activated natural killer and CD8 T cells in blood and tissues. This, in turn, alleviates symptoms such as fever, nausea, fatigue, muscle weakness, and pain. Vaccines, including inactivated viral, live attenuated viral, protein subunit, viral vectored, mRNA, DNA, and nanoparticle vaccines, significantly reduce the adverse long-term effects of the virus. However, no vaccine has been reported to provide lifetime protection against COVID-19. Consequently, protective measures such as physical distancing, mask usage, and hand hygiene remain essential strategies. This review offers a comprehensive understanding of the persistent effects of COVID-19 on individuals of varying ages, along with insights into diagnosis, treatment, vaccination, and future preventative measures against the spread of SARS-CoV-2.

Wen Liang, Peipei Ran, Mengchao Bai et al.

Salient object detection (SOD) aims at finding the most salient objects in images and outputs pixel-level binary masks. Transformer-based methods achieve promising performance due to their global semantic understanding, crucial for identifying salient objects. However, these models tend to be large and require numerous training parameters. To better harness the potential of transformers for SOD, we propose a novel parameter-efficient fine-tuning method aimed at reducing the number of training parameters while enhancing the salient object detection capability. Our model, termed EXternal Prompt features Enhanced adapteR Tuning (ExPert), features an encoder-decoder structure with adapters and injectors interspersed between the layers of a frozen transformer encoder. The adapter modules adapt the pretrained backbone to SOD while the injector modules incorporate external prompt features to enhance the awareness of salient objects. Comprehensive experiments demonstrate the superiority of our method. Surpassing former state-of-the-art (SOTA) models across five SOD datasets, ExPert achieves 0.215 mean absolute error (MAE) in the ECSSD dataset with 80.2M trained parameters, 21% better than SelfReformer and 47% better than EGNet.

P. Bilha Githinji, Xi Yuan, Zhenglin Chen et al.

Realizing sufficient separability between the distributions of healthy and pathological samples is a critical obstacle for pathology detection convolutional models. Moreover, these models exhibit a bias for contrast-based images, with diminished performance on texture-based medical images. This study introduces the notion of a population-level context for pathology detection and employs a graph theoretic approach to model and incorporate it into the latent code of an autoencoder via a refinement module we term PopuSense. PopuSense seeks to capture additional intra-group variations inherent in biomedical data that a local or global context of the convolutional model might miss or smooth out. Proof-of-concept experiments on contrast-based and texture-based images, with minimal adaptation, encounter the existing preference for intensity-based input. Nevertheless, PopuSense demonstrates improved separability in contrast-based images, presenting an additional avenue for refining representations learned by a model.