Jiayang Zhang

Hang Du, Jiayang Zhang, Guoshun Nan et al.

Multi-image Interleaved Reasoning aims to improve Multi-modal Large Language Models (MLLMs) ability to jointly comprehend and reason across multiple images and their associated textual contexts, introducing unique challenges beyond single-image or non-interleaved multi-image tasks. While current multi-image benchmarks overlook interleaved textual contexts and neglect distinct relationships between individual images and their associated texts, enabling models to reason over multi-image interleaved data may significantly enhance their comprehension of complex scenes and better capture cross-modal correlations. To bridge this gap, we introduce a novel benchmark MIR, requiring joint reasoning over multiple images accompanied by interleaved textual contexts to accurately associate image regions with corresponding texts and logically connect information across images. To enhance MLLMs ability to comprehend multi-image interleaved data, we introduce reasoning steps for each instance within the benchmark and propose a stage-wise curriculum learning strategy. This strategy follows an "easy to hard" approach, progressively guiding models from simple to complex scenarios, thereby enhancing their ability to handle challenging tasks. Extensive experiments benchmarking multiple MLLMs demonstrate that our method significantly enhances models reasoning performance on MIR and other established benchmarks. We believe that MIR will encourage further research into multi-image interleaved reasoning, facilitating advancements in MLLMs capability to handle complex inter-modal tasks.

Wenrui Fan, L. M. Riza Rizky, Jiayang Zhang et al.

Neuropathic pain, affecting up to 10% of adults, remains difficult to treat due to limited therapeutic efficacy and tolerability. Although resting-state functional MRI (rs-fMRI) is a promising non-invasive measurement of brain biomarkers to predict drug response in therapeutic development, the complexity of fMRI demands machine learning models with substantial capacity. However, extreme data scarcity in neuropathic pain research limits the application of high-capacity models. To address the challenge of data scarcity, we propose FMM$_{TC}$, a Foundation-Model-boosted Multimodal learning framework for fMRI-based neuropathic pain drug response prediction, which leverages both internal multimodal information in pain-specific data and external knowledge from large pain-agnostic data. Specifically, to maximize the value of limited pain-specific data, FMM$_{TC}$ integrates complementary information from two rs-fMRI modalities: Time series and functional Connectivity. FMM$_{TC}$ is further boosted by an fMRI foundation model with its external knowledge from extensive pain-agnostic fMRI datasets enriching limited pain-specific information. Evaluations with an in-house dataset and a public dataset from OpenNeuro demonstrate FMM$_{TC}$'s superior representation ability, generalizability, and cross-dataset adaptability over existing unimodal fMRI models that only consider one of the rs-fMRI modalities. The ablation study validates the effectiveness of multimodal learning and foundation-model-powered external knowledge transfer in FMM$_{TC}$. An integrated gradient-based interpretation study explains how FMM$_{TC}$'s cross-dataset dynamic behaviors enhance its adaptability. In conclusion, FMM$_{TC}$ boosts clinical trials in neuropathic pain therapeutic development by accurately predicting drug responses to improve the participant stratification efficiency.