Jiawei Sun

Kexin Huang, Xiangyang Liu, Qianyu Guo et al.

The widespread adoption of large language models (LLMs) across various regions underscores the urgent need to evaluate their alignment with human values. Current benchmarks, however, fall short of effectively uncovering safety vulnerabilities in LLMs. Despite numerous models achieving high scores and 'topping the chart' in these evaluations, there is still a significant gap in LLMs' deeper alignment with human values and achieving genuine harmlessness. To this end, this paper proposes a value alignment benchmark named Flames, which encompasses both common harmlessness principles and a unique morality dimension that integrates specific Chinese values such as harmony. Accordingly, we carefully design adversarial prompts that incorporate complex scenarios and jailbreaking methods, mostly with implicit malice. By prompting 17 mainstream LLMs, we obtain model responses and rigorously annotate them for detailed evaluation. Our findings indicate that all the evaluated LLMs demonstrate relatively poor performance on Flames, particularly in the safety and fairness dimensions. We also develop a lightweight specified scorer capable of scoring LLMs across multiple dimensions to efficiently evaluate new models on the benchmark. The complexity of Flames has far exceeded existing benchmarks, setting a new challenge for contemporary LLMs and highlighting the need for further alignment of LLMs. Our benchmark is publicly available at https://github.com/AIFlames/Flames.

Jiahui Li, Jiawei Sun, Zixiang Ren et al.

Recent perception-free end-to-end (E2E) autonomous driving methods bypass explicit perception outputs by compressing dense image patch tokens into compact scene tokens for downstream trajectory generation and scoring. While these scene tokens form a compact visual bottleneck for the planner, they receive supervision solely from the planning objective, providing limited constraints on the encoded visual information. To address this limitation, we introduce Neural Token Reconstruction (NTR), a representation learning framework to directly constrain the compact scene-token bottleneck in perception-free driving. NTR introduces a self-distillation masked latent reconstruction objective that reconstructs masked patch-level latent features using only compact scene tokens as reconstruction memory. This forces reconstruction gradients to pass exclusively through the scene-token bottleneck, encouraging scene tokens to preserve richer and less redundant visual representations for planning. We further introduce semantic priors derived from foundation-model annotations as a weak semantic interface biasing reconstruction targets toward driving-related structures without introducing explicit perception heads. All auxiliary reconstruction components are removed at inference time, leaving the deployed planner unchanged. NTR achieves state-of-the-art performance on three public autonomous driving benchmarks, including 8.0461 RFS on Waymo E2E and 94.1 PDMS / 90.9 EPDMS on NavSim1&2. The learned scene tokens exhibit lower pairwise redundancy and higher effective rank, indicating that effective bottleneck supervision improves both compact visual representation learning and planning performance.

Xianghao Zhan, Jiawei Sun, Yuzhe Liu et al.

Machine learning head models (MLHMs) are developed to estimate brain deformation for early detection of traumatic brain injury (TBI). However, the overfitting to simulated impacts and the lack of generalizability caused by distributional shift of different head impact datasets hinders the broad clinical applications of current MLHMs. We propose brain deformation estimators that integrates unsupervised domain adaptation with a deep neural network to predict whole-brain maximum principal strain (MPS) and MPS rate (MPSR). With 12,780 simulated head impacts, we performed unsupervised domain adaptation on on-field head impacts from 302 college football (CF) impacts and 457 mixed martial arts (MMA) impacts using domain regularized component analysis (DRCA) and cycle-GAN-based methods. The new model improved the MPS/MPSR estimation accuracy, with the DRCA method significantly outperforming other domain adaptation methods in prediction accuracy (p<0.001): MPS RMSE: 0.027 (CF) and 0.037 (MMA); MPSR RMSE: 7.159 (CF) and 13.022 (MMA). On another two hold-out test sets with 195 college football impacts and 260 boxing impacts, the DRCA model significantly outperformed the baseline model without domain adaptation in MPS and MPSR estimation accuracy (p<0.001). The DRCA domain adaptation reduces the MPS/MPSR estimation error to be well below TBI thresholds, enabling accurate brain deformation estimation to detect TBI in future clinical applications.

Jiawei Sun, Ruoxin Chen, Jie Li et al.

Graph Contrastive Learning (GCL) has shown promising performance in graph representation learning (GRL) without the supervision of manual annotations. GCL can generate graph-level embeddings by maximizing the Mutual Information (MI) between different augmented views of the same graph (positive pairs). However, the GCL is limited by dimensional collapse, i.e., embedding vectors only occupy a low-dimensional subspace. In this paper, we show that the smoothing effect of the graph pooling and the implicit regularization of the graph convolution are two causes of the dimensional collapse in GCL. To mitigate the above issue, we propose a non-maximum removal graph contrastive learning approach (nmrGCL), which removes "prominent'' dimensions (i.e., contribute most in similarity measurement) for positive pair in the pre-text task. Comprehensive experiments on various benchmark datasets are conducted to demonstrate the effectiveness of nmrGCL, and the results show that our model outperforms the state-of-the-art methods. Source code will be made publicly available.

Zhaxizhuoma Zhaxizhuoma, Pengan Chen, Ziniu Wu et al.

This paper presents AlignBot, a novel framework designed to optimize VLM-powered customized task planning for household robots by effectively aligning with user reminders. In domestic settings, aligning task planning with user reminders poses significant challenges due to the limited quantity, diversity, and multimodal nature of the reminders. To address these challenges, AlignBot employs a fine-tuned LLaVA-7B model, functioning as an adapter for GPT-4o. This adapter model internalizes diverse forms of user reminders-such as personalized preferences, corrective guidance, and contextual assistance-into structured instruction-formatted cues that prompt GPT-4o in generating customized task plans. Additionally, AlignBot integrates a dynamic retrieval mechanism that selects task-relevant historical successes as prompts for GPT-4o, further enhancing task planning accuracy. To validate the effectiveness of AlignBot, experiments are conducted in real-world household environments, which are constructed within the laboratory to replicate typical household settings. A multimodal dataset with over 1,500 entries derived from volunteer reminders is used for training and evaluation. The results demonstrate that AlignBot significantly improves customized task planning, outperforming existing LLM- and VLM-powered planners by interpreting and aligning with user reminders, achieving 86.8% success rate compared to the vanilla GPT-4o baseline at 21.6%, reflecting a 65% improvement and over four times greater effectiveness. Supplementary materials are available at: https://yding25.com/AlignBot/

Shuo Sun, Zekai Gu, Tianchen Sun et al.

Realistic and diverse traffic scenarios in large quantities are crucial for the development and validation of autonomous driving systems. However, owing to numerous difficulties in the data collection process and the reliance on intensive annotations, real-world datasets lack sufficient quantity and diversity to support the increasing demand for data. This work introduces DriveSceneGen, a data-driven driving scenario generation method that learns from the real-world driving dataset and generates entire dynamic driving scenarios from scratch. DriveSceneGen is able to generate novel driving scenarios that align with real-world data distributions with high fidelity and diversity. Experimental results on 5k generated scenarios highlight the generation quality, diversity, and scalability compared to real-world datasets. To the best of our knowledge, DriveSceneGen is the first method that generates novel driving scenarios involving both static map elements and dynamic traffic participants from scratch.

Zhaoqing Chen, Jiawei Sun, Xibin Yang et al.

Lensless fiber endomicroscope is an emerging tool for in-vivo microscopic imaging, where quantitative phase imaging (QPI) can be utilized as a label-free method to enhance image contrast. However, existing single-shot phase reconstruction methods through lensless fiber endomicroscope typically perform well on simple images but struggle with complex microscopic structures. Here, we propose a speckle-conditioned diffusion model (SpecDiffusion), which reconstructs phase images directly from speckles captured at the detection side of a multi-core fiber (MCF). Unlike conventional neural networks, SpecDiffusion employs iterative phase denoising steps for speckle-driven phase reconstruction. The iteration scheme allows SpecDiffusion to break down the phase reconstruction process into multiple steps, gradually building up to the final phase image. This attribute alleviates the computation challenge at each step and enables the reconstruction of rich details in complex microscopic images. To validate its efficacy, we build an optical system to capture speckles from MCF and construct a dataset consisting of 100,000 paired images. SpecDiffusion provides high-fidelity phase reconstruction results and shows powerful generalization capacity for unseen objects, such as test charts and biological tissues, reducing the average mean absolute error of the reconstructed tissue images by 7 times. Furthermore, the reconstructed tissue images using SpecDiffusion shows higher accuracy in zero-shot cell segmentation tasks compared to the conventional method, demonstrating the potential for further cell morphology analysis through the learning-based lensless fiber endomicroscope. SpecDiffusion offers a precise and generalized method to phase reconstruction through scattering media, including MCFs, opening new perspective in lensless fiber endomicroscopic imaging.

Jiawei Sun, Bin Zhao, Dong Wang et al.

Quantitative phase imaging (QPI) through multi-core fibers (MCFs) has been an emerging in vivo label-free endoscopic imaging modality with minimal invasiveness. However, the computational demands of conventional iterative phase retrieval algorithms have limited their real-time imaging potential. We demonstrate a learning-based MCF phase imaging method, that significantly reduced the phase reconstruction time to 5.5 ms, enabling video-rate imaging at 181 fps. Moreover, we introduce an innovative optical system that automatically generated the first open-source dataset tailored for MCF phase imaging, comprising 50,176 paired speckle and phase images. Our trained deep neural network (DNN) demonstrates robust phase reconstruction performance in experiments with a mean fidelity of up to 99.8\%. Such an efficient fiber phase imaging approach can broaden the applications of QPI in hard-to-reach areas.

Yunfan Gao, Yun Xiong, Xinyu Gao et al.

Large Language Models (LLMs) showcase impressive capabilities but encounter challenges like hallucination, outdated knowledge, and non-transparent, untraceable reasoning processes. Retrieval-Augmented Generation (RAG) has emerged as a promising solution by incorporating knowledge from external databases. This enhances the accuracy and credibility of the generation, particularly for knowledge-intensive tasks, and allows for continuous knowledge updates and integration of domain-specific information. RAG synergistically merges LLMs' intrinsic knowledge with the vast, dynamic repositories of external databases. This comprehensive review paper offers a detailed examination of the progression of RAG paradigms, encompassing the Naive RAG, the Advanced RAG, and the Modular RAG. It meticulously scrutinizes the tripartite foundation of RAG frameworks, which includes the retrieval, the generation and the augmentation techniques. The paper highlights the state-of-the-art technologies embedded in each of these critical components, providing a profound understanding of the advancements in RAG systems. Furthermore, this paper introduces up-to-date evaluation framework and benchmark. At the end, this article delineates the challenges currently faced and points out prospective avenues for research and development.

Sijie Ji, Xinzhe Zheng, Jiawei Sun et al.

Mental health disorders are among the most prevalent diseases worldwide, affecting nearly one in four people. Despite their widespread impact, the intervention rate remains below 25%, largely due to the significant cooperation required from patients for both diagnosis and intervention. The core issue behind this low treatment rate is stigma, which discourages over half of those affected from seeking help. This paper presents MindGuard, an accessible, stigma-free, and professional mobile mental healthcare system designed to provide mental health first aid. The heart of MindGuard is an innovative edge LLM, equipped with professional mental health knowledge, that seamlessly integrates objective mobile sensor data with subjective Ecological Momentary Assessment records to deliver personalized screening and intervention conversations. We conduct a broad evaluation of MindGuard using open datasets spanning four years and real-world deployment across various mobile devices involving 20 subjects for two weeks. Remarkably, MindGuard achieves results comparable to GPT-4 and outperforms its counterpart with more than 10 times the model size. We believe that MindGuard paves the way for mobile LLM applications, potentially revolutionizing mental healthcare practices by substituting self-reporting and intervention conversations with passive, integrated monitoring within daily life, thus ensuring accessible and stigma-free mental health support.

Ao Li, Jiawei Sun, Le Dong et al.

Real-world exposure correction is fundamentally challenged by spatially non-uniform degradations, where diverse exposure errors frequently coexist within a single image. However, existing exposure correction methods are still largely developed under a predominantly uniform assumption. Architecturally, they typically rely on globally aggregated modulation signals that capture only the overall exposure trend. From the optimization perspective, conventional reconstruction losses are usually derived under a shared global scale, thus overlooking the spatially varying correction demands across regions. To address these limitations, we propose a new exposure correction paradigm explicitly designed for spatial non-uniformity. Specifically, we introduce a Spatial Signal Encoder to predict spatially adaptive modulation weights, which are used to guide multiple look-up tables for image transformation, together with an HSL-based compensation module for improved color fidelity. Beyond the architectural design, we propose an uncertainty-inspired non-uniform loss that dynamically allocates the optimization focus based on local restoration uncertainties, better matching the heterogeneous nature of real-world exposure errors. Extensive experiments demonstrate that our method achieves superior qualitative and quantitative performance compared with state-of-the-art methods. Code is available at https://github.com/FALALAS/rethinkingEC.

Rao Fu, Jie Yang, Jiawei Sun et al.

Fine-grained 3D shape retrieval aims to retrieve 3D shapes similar to a query shape in a repository with models belonging to the same class, which requires shape descriptors to be capable of representing detailed geometric information to discriminate shapes with globally similar structures. Moreover, 3D objects can be placed with arbitrary position and orientation in real-world applications, which further requires shape descriptors to be robust to rigid transformations. The shape descriptions used in existing 3D shape retrieval systems fail to meet the above two criteria. In this paper, we introduce a novel deep architecture, RISA-Net, which learns rotation invariant 3D shape descriptors that are capable of encoding fine-grained geometric information and structural information, and thus achieve accurate results on the task of fine-grained 3D object retrieval. RISA-Net extracts a set of compact and detailed geometric features part-wisely and discriminatively estimates the contribution of each semantic part to shape representation. Furthermore, our method is able to learn the importance of geometric and structural information of all the parts when generating the final compact latent feature of a 3D shape for fine-grained retrieval. We also build and publish a new 3D shape dataset with sub-class labels for validating the performance of fine-grained 3D shape retrieval methods. Qualitative and quantitative experiments show that our RISA-Net outperforms state-of-the-art methods on the fine-grained object retrieval task, demonstrating its capability in geometric detail extraction. The code and dataset are available at: https://github.com/IGLICT/RisaNET.

Jiawei Sun, Bin Yang, Nektarios Koukourakis et al.

Optical tomography has emerged as a non-invasive imaging method, providing three-dimensional insights into subcellular structures and thereby enabling a deeper understanding of cellular functions, interactions, and processes. Conventional optical tomography methods are constrained by a limited illumination scanning range, leading to anisotropic resolution and incomplete imaging of cellular structures. To overcome this problem, we employ a compact multi-core fibre-optic cell rotator system that facilitates precise optical manipulation of cells within a microfluidic chip, achieving full-angle projection tomography with isotropic resolution. Moreover, we demonstrate an AI-driven tomographic reconstruction workflow, which can be a paradigm shift from conventional computational methods, often demanding manual processing, to a fully autonomous process. The performance of the proposed cell rotation tomography approach is validated through the three-dimensional reconstruction of cell phantoms and HL60 human cancer cells. The versatility of this learning-based tomographic reconstruction workflow paves the way for its broad application across diverse tomographic imaging modalities, including but not limited to flow cytometry tomography and acoustic rotation tomography. Therefore, this AI-driven approach can propel advancements in cell biology, aiding in the inception of pioneering therapeutics, and augmenting early-stage cancer diagnostics.

Jiyue Jiang, Pengan Chen, Jiuming Wang et al.

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of these LLMs. However, current benchmarks can hardly evaluate the performance of these models across diverse tasks effectively. In this paper, we introduce a comprehensive prompting-based benchmarking framework, termed Bio-benchmark, which includes 30 key bioinformatics tasks covering areas such as proteins, RNA, drugs, electronic health records, and traditional Chinese medicine. Using this benchmark, we evaluate six mainstream LLMs, including GPT-4o and Llama-3.1-70b, etc., using 0-shot and few-shot Chain-of-Thought (CoT) settings without fine-tuning to reveal their intrinsic capabilities. To improve the efficiency of our evaluations, we demonstrate BioFinder, a new tool for extracting answers from LLM responses, which increases extraction accuracy by round 30% compared to existing methods. Our benchmark results show the biological tasks suitable for current LLMs and identify specific areas requiring enhancement. Furthermore, we propose targeted prompt engineering strategies for optimizing LLM performance in these contexts. Based on these findings, we provide recommendations for the development of more robust LLMs tailored for various biological applications. This work offers a comprehensive evaluation framework and robust tools to support the application of LLMs in bioinformatics.

Xinzhe Zheng, Sijie Ji, Jiawei Sun et al.

Mental health risk is a critical global public health challenge, necessitating innovative and reliable assessment methods. With the development of large language models (LLMs), they stand out to be a promising tool for explainable mental health care applications. Nevertheless, existing approaches predominantly rely on subjective textual mental records, which can be distorted by inherent mental uncertainties, leading to inconsistent and unreliable predictions. To address these limitations, this paper introduces ProMind-LLM. We investigate an innovative approach integrating objective behavior data as complementary information alongside subjective mental records for robust mental health risk assessment. Specifically, ProMind-LLM incorporates a comprehensive pipeline that includes domain-specific pretraining to tailor the LLM for mental health contexts, a self-refine mechanism to optimize the processing of numerical behavioral data, and causal chain-of-thought reasoning to enhance the reliability and interpretability of its predictions. Evaluations of two real-world datasets, PMData and Globem, demonstrate the effectiveness of our proposed methods, achieving substantial improvements over general LLMs. We anticipate that ProMind-LLM will pave the way for more dependable, interpretable, and scalable mental health case solutions.

Yibo Cui, Liang Xie, Yu Zhao et al.

Vision-Language Navigation (VLN) enables intelligent agents to navigate environments by integrating visual perception and natural language instructions, yet faces significant challenges due to the scarcity of fine-grained cross-modal alignment annotations. Existing datasets primarily focus on global instruction-trajectory matching, neglecting sub-instruction-level and entity-level alignments critical for accurate navigation action decision-making. To address this limitation, we propose FCA-NIG, a generative framework that automatically constructs navigation instructions with dual-level fine-grained cross-modal annotations. In this framework, an augmented trajectory is first divided into sub-trajectories, which are then processed through GLIP-based landmark detection, crafted instruction construction, OFA-Speaker based R2R-like instruction generation, and CLIP-powered entity selection, generating sub-instruction-trajectory pairs with entity-landmark annotations. Finally, these sub-pairs are aggregated to form a complete instruction-trajectory pair. The framework generates the FCA-R2R dataset, the first large-scale augmentation dataset featuring precise sub-instruction-sub-trajectory and entity-landmark alignments. Extensive experiments demonstrate that training with FCA-R2R significantly improves the performance of multiple state-of-the-art VLN agents, including SF, EnvDrop, RecBERT, and HAMT. Incorporating sub-instruction-trajectory alignment enhances agents' state awareness and decision accuracy, while entity-landmark alignment further boosts navigation performance and generalization. These results highlight the effectiveness of FCA-NIG in generating high-quality, scalable training data without manual annotation, advancing fine-grained cross-modal learning in complex navigation tasks.

Jiahui Li, Tianle Shen, Zekai Gu et al.

Motion prediction is a challenging problem in autonomous driving as it demands the system to comprehend stochastic dynamics and the multi-modal nature of real-world agent interactions. Diffusion models have recently risen to prominence, and have proven particularly effective in pedestrian motion prediction tasks. However, the significant time consumption and sensitivity to noise have limited the real-time predictive capability of diffusion models. In response to these impediments, we propose a novel diffusion-based, acceleratable framework that adeptly predicts future trajectories of agents with enhanced resistance to noise. The core idea of our model is to learn a coarse-grained prior distribution of trajectory, which can skip a large number of denoise steps. This advancement not only boosts sampling efficiency but also maintains the fidelity of prediction accuracy. Our method meets the rigorous real-time operational standards essential for autonomous vehicles, enabling prompt trajectory generation that is vital for secure and efficient navigation. Through extensive experiments, our method speeds up the inference time to 136ms compared to standard diffusion model, and achieves significant improvement in multi-agent motion prediction on the Argoverse 1 motion forecasting dataset.

Haojun Jiang, Jiawei Sun, Jie Li et al.

Graph representation learning (GRL) makes considerable progress recently, which encodes graphs with topological structures into low-dimensional embeddings. Meanwhile, the time-consuming and costly process of annotating graph labels manually prompts the growth of self-supervised learning (SSL) techniques. As a dominant approach of SSL, Contrastive learning (CL) learns discriminative representations by differentiating between positive and negative samples. However, when applied to graph data, it overemphasizes global patterns while neglecting local structures. To tackle the above issue, we propose \underline{Local}-aware \underline{G}raph \underline{C}ontrastive \underline{L}earning (\textbf{\methnametrim}), a self-supervised learning framework that supplementarily captures local graph information with masking-based modeling compared with vanilla contrastive learning. Extensive experiments validate the superiority of \methname against state-of-the-art methods, demonstrating its promise as a comprehensive graph representation learner.

Jiawei Sun, Hongkang Li, Meng Wang

Jumping connections enable Graph Convolutional Networks (GCNs) to overcome over-smoothing, while graph sparsification reduces computational demands by selecting a sub-matrix of the graph adjacency matrix during neighborhood aggregation. Learning GCNs with graph sparsification has shown empirical success across various applications, but a theoretical understanding of the generalization guarantees remains limited, with existing analyses ignoring either graph sparsification or jumping connections. This paper presents the first learning dynamics and generalization analysis of GCNs with jumping connections using graph sparsification. Our analysis demonstrates that the generalization accuracy of the learned model closely approximates the highest achievable accuracy within a broad class of target functions dependent on the proposed sparse effective adjacency matrix $A^*$. Thus, graph sparsification maintains generalization performance when $A^*$ preserves the essential edges that support meaningful message propagation. We reveal that jumping connections lead to different sparsification requirements across layers. In a two-hidden-layer GCN, the generalization is more affected by the sparsified matrix deviations from $A^*$ of the first layer than the second layer. To the best of our knowledge, this marks the first theoretical characterization of jumping connections' role in sparsification requirements. We validate our theoretical results on benchmark datasets in deep GCNs.

Shuo Sun, Yimin Zhao, Christina Dao Wen Lee et al.

As the field progresses toward Artificial General Intelligence (AGI), there is a pressing need for more comprehensive and insightful evaluation frameworks that go beyond aggregate performance metrics. This paper introduces a unified rating system that jointly models the difficulty of individual test cases and the competency of AI models (or humans) across vision, language, and action domains. Unlike existing metrics that focus solely on models, our approach allows for fine-grained, difficulty-aware evaluations through competitive interactions between models and tasks, capturing both the long-tail distribution of real-world challenges and the competency gap between current models and full task mastery. We validate the generalizability and robustness of our system through extensive experiments on multiple established datasets and models across distinct AGI domains. The resulting rating distributions offer novel perspectives and interpretable insights into task difficulty, model progression, and the outstanding challenges that remain on the path to achieving full AGI task mastery.

Jiawei Sun, Jiachen Wu, Nektarios Koukourakis et al.

The generation of tailored light with multi-core fiber (MCF) lensless microendoscopes is widely used in biomedicine. However, the computer-generated holograms (CGHs) used for such applications are typically generated by iterative algorithms, which demand high computation effort, limiting advanced applications like in vivo optogenetic stimulation and fiber-optic cell manipulation. The random and discrete distribution of the fiber cores induces strong spatial aliasing to the CGHs, hence, an approach that can rapidly generate tailored CGHs for MCFs is highly demanded. We demonstrate a novel phase encoder deep neural network (CoreNet), which can generate accurate tailored CGHs for MCFs at a near video-rate. Simulations show that CoreNet can speed up the computation time by two magnitudes and increase the fidelity of the generated light field compared to the conventional CGH techniques. For the first time, real-time generated tailored CGHs are on-the-fly loaded to the phase-only SLM for dynamic light fields generation through the MCF microendoscope in experiments. This paves the avenue for real-time cell rotation and several further applications that require real-time high-fidelity light delivery in biomedicine.

Spyridon Bakas, Mauricio Reyes, Andras Jakab et al.

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset.

Zhaodong Chen, Lei Deng, Guoqi Li et al.

Deep Neural Networks (DNNs) thrive in recent years in which Batch Normalization (BN) plays an indispensable role. However, it has been observed that BN is costly due to the reduction operations. In this paper, we propose alleviating this problem through sampling only a small fraction of data for normalization at each iteration. Specifically, we model it as a statistical sampling problem and identify that by sampling less correlated data, we can largely reduce the requirement of the number of data for statistics estimation in BN, which directly simplifies the reduction operations. Based on this conclusion, we propose two sampling strategies, "Batch Sampling" (randomly select several samples from each batch) and "Feature Sampling" (randomly select a small patch from each feature map of all samples), that take both computational efficiency and sample correlation into consideration. Furthermore, we introduce an extremely simple variant of BN, termed as Virtual Dataset Normalization (VDN), that can normalize the activations well with few synthetical random samples. All the proposed methods are evaluated on various datasets and networks, where an overall training speedup by up to 20% on GPU is practically achieved without the support of any specialized libraries, and the loss on accuracy and convergence rate are negligible. Finally, we extend our work to the "micro-batch normalization" problem and yield comparable performance with existing approaches at the case of tiny batch size.