Darko Štern

Anjany Sekuboyina, Malek E. Husseini, Amirhossein Bayat et al.

Vertebral labelling and segmentation are two fundamental tasks in an automated spine processing pipeline. Reliable and accurate processing of spine images is expected to benefit clinical decision-support systems for diagnosis, surgery planning, and population-based analysis on spine and bone health. However, designing automated algorithms for spine processing is challenging predominantly due to considerable variations in anatomy and acquisition protocols and due to a severe shortage of publicly available data. Addressing these limitations, the Large Scale Vertebrae Segmentation Challenge (VerSe) was organised in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2019 and 2020, with a call for algorithms towards labelling and segmentation of vertebrae. Two datasets containing a total of 374 multi-detector CT scans from 355 patients were prepared and 4505 vertebrae have individually been annotated at voxel-level by a human-machine hybrid algorithm (https://osf.io/nqjyw/, https://osf.io/t98fz/). A total of 25 algorithms were benchmarked on these datasets. In this work, we present the the results of this evaluation and further investigate the performance-variation at vertebra-level, scan-level, and at different fields-of-view. We also evaluate the generalisability of the approaches to an implicit domain shift in data by evaluating the top performing algorithms of one challenge iteration on data from the other iteration. The principal takeaway from VerSe: the performance of an algorithm in labelling and segmenting a spine scan hinges on its ability to correctly identify vertebrae in cases of rare anatomical variations. The content and code concerning VerSe can be accessed at: https://github.com/anjany/verse.

Stefan Eggenreich, Christian Payer, Martin Urschler et al.

Additionally to the extensive use in clinical medicine, biological age (BA) in legal medicine is used to assess unknown chronological age (CA) in applications where identification documents are not available. Automatic methods for age estimation proposed in the literature are predicting point estimates, which can be misleading without the quantification of predictive uncertainty. In our multi-factorial age estimation method from MRI data, we used the Variational Inference approach to estimate the uncertainty of a Bayesian CNN model. Distinguishing model uncertainty from data uncertainty, we interpreted data uncertainty as biological variation, i.e. the range of possible CA of subjects having the same BA.

Christian Payer, Darko Štern, Horst Bischof et al.

In many medical image analysis applications, often only a limited amount of training data is available, which makes training of convolutional neural networks (CNNs) challenging. In this work on anatomical landmark localization, we propose a CNN architecture that learns to split the localization task into two simpler sub-problems, reducing the need for large training datasets. Our fully convolutional SpatialConfiguration-Net (SCN) dedicates one component to locally accurate but ambiguous candidate predictions, while the other component improves robustness to ambiguities by incorporating the spatial configuration of landmarks. In our experimental evaluation, we show that the proposed SCN outperforms related methods in terms of landmark localization error on size-limited datasets.

Christian Payer, Darko Štern, Thomas Neff et al.

Different to semantic segmentation, instance segmentation assigns unique labels to each individual instance of the same class. In this work, we propose a novel recurrent fully convolutional network architecture for tracking such instance segmentations over time. The network architecture incorporates convolutional gated recurrent units (ConvGRU) into a stacked hourglass network to utilize temporal video information. Furthermore, we train the network with a novel embedding loss based on cosine similarities, such that the network predicts unique embeddings for every instance throughout videos. Afterwards, these embeddings are clustered among subsequent video frames to create the final tracked instance segmentations. We evaluate the recurrent hourglass network by segmenting left ventricles in MR videos of the heart, where it outperforms a network that does not incorporate video information. Furthermore, we show applicability of the cosine embedding loss for segmenting leaf instances on still images of plants. Finally, we evaluate the framework for instance segmentation and tracking on six datasets of the ISBI celltracking challenge, where it shows state-of-the-art performance.