Wei Xie

Wei Xie, Yang Wang, Steven M. Boker et al.

Safeguarding privacy in machine learning is highly desirable, especially in collaborative studies across many organizations. Privacy-preserving distributed machine learning (based on cryptography) is popular to solve the problem. However, existing cryptographic protocols still incur excess computational overhead. Here, we make a novel observation that this is partially due to naive adoption of mainstream numerical optimization (e.g., Newton method) and failing to tailor for secure computing. This work presents a contrasting perspective: customizing numerical optimization specifically for secure settings. We propose a seemingly less-favorable optimization method that can in fact significantly accelerate privacy-preserving logistic regression. Leveraging this new method, we propose two new secure protocols for conducting logistic regression in a privacy-preserving and distributed manner. Extensive theoretical and empirical evaluations prove the competitive performance of our two secure proposals while without compromising accuracy or privacy: with speedup up to 2.3x and 8.1x, respectively, over state-of-the-art; and even faster as data scales up. Such drastic speedup is on top of and in addition to performance improvements from existing (and future) state-of-the-art cryptography. Our work provides a new way towards efficient and practical privacy-preserving logistic regression for large-scale studies which are common for modern science.

Ru-Ze Liang, Wei Xie, Weizhi Li et al.

In this paper, we propose a novel learning framework for the problem of domain transfer learning. We map the data of two domains to one single common space, and learn a classifier in this common space. Then we adapt the common classifier to the two domains by adding two adaptive functions to it respectively. In the common space, the target domain data points are weighted and matched to the target domain in term of distributions. The weighting terms of source domain data points and the target domain classification responses are also regularized by the local reconstruction coefficients. The novel transfer learning framework is evaluated over some benchmark cross-domain data sets, and it outperforms the existing state-of-the-art transfer learning methods.

Wenfa Li, Hongzhe Liu, Peng Yang et al.

As one of the most popular statistical and machine learning models, logistic regression with regularization has found wide adoption in biomedicine, social sciences, information technology, and so on. These domains often involve data of human subjects that are contingent upon strict privacy regulations. Increasing concerns over data privacy make it more and more difficult to coordinate and conduct large-scale collaborative studies, which typically rely on cross-institution data sharing and joint analysis. Our work here focuses on safeguarding regularized logistic regression, a widely-used machine learning model in various disciplines while at the same time has not been investigated from a data security and privacy perspective. We consider a common use scenario of multi-institution collaborative studies, such as in the form of research consortia or networks as widely seen in genetics, epidemiology, social sciences, etc. To make our privacy-enhancing solution practical, we demonstrate a non-conventional and computationally efficient method leveraging distributing computing and strong cryptography to provide comprehensive protection over individual-level and summary data. Extensive empirical evaluation on several studies validated the privacy guarantees, efficiency and scalability of our proposal. We also discuss the practical implications of our solution for large-scale studies and applications from various disciplines, including genetic and biomedical studies, smart grid, network analysis, etc.