Yiming Liao

Yiming Liao, Zeno Franco, Jose Eduardo Lizarraga Mazaba et al.

Hallucinations in medical large language models (LLMs) pose serious risks for clinical decision support, particularly when models must reason over complex electronic health records (EHRs). However, existing benchmarks often lack a realistic clinical context and provide limited insight into how hallucinations can be mitigated in practice. We introduce Med-HEAL, a framework for systematically identifying, analyzing, and mitigating hallucinations in medical LLMs using clinically grounded data. Building on the EHRNoteQA benchmark derived from MIMIC-IV discharge summaries, we construct a hallucination dataset by evaluating BioMistral-7B on open-ended clinical question answering tasks. Model outputs are labeled through a dual evaluation pipeline that combines LLM-as-a-Judge assessment (GPT-4o) with human auditing by medical student reviewers, producing correctness judgments and annotations of reasoning errors via a custom web-based evaluation system. We then leverage this dataset to investigate mitigation strategies: a self-critique pipeline, in which the test model reviews its own answers to detect potential errors and regenerates responses for flagged cases, and retrieval-augmented in-context learning (RA-ICL), which exposes the model to hallucinated and corrected examples. Experiments across five open-source LLMs-BioMistral, Llama-3.1, DeepSeek, Qwen2.5, and Qwen3, show that the self-critique strategy improves accuracy for three of five models (p < 0.05) without requiring parameter updates. Med-HEAL provides both a reusable hallucination dataset and a practical framework for studying and mitigating hallucinations in medical LLMs, supporting safer deployment of AI systems in clinical environments. Our code and data are publicly available at https://github.com/yimingliao-blad/med-heal.git.

Yiming Liao, Yiheng Li, Ning Jiang et al.

Accurate computational prediction of T cell receptor (TCR) antigen specificity would transform the study of T cell biology and enable scalable immune engineering, yet existing models lack sufficient sensitivity and specificity for broad applications. A major limitation is the absence of rigorously defined, unseen benchmark datasets that allow unbiased evaluation of model performance and generalizability. Here, we describe two complementary classes of datasets that meet this criterion and argue that they provide both a robust framework for model assessment and a foundation for next-generation TCR-antigen prediction algorithm development.

Thanh Tran, Kyumin Lee, Yiming Liao et al.

Following recent successes in exploiting both latent factor and word embedding models in recommendation, we propose a novel Regularized Multi-Embedding (RME) based recommendation model that simultaneously encapsulates the following ideas via decomposition: (1) which items a user likes, (2) which two users co-like the same items, (3) which two items users often co-liked, and (4) which two items users often co-disliked. In experimental validation, the RME outperforms competing state-of-the-art models in both explicit and implicit feedback datasets, significantly improving Recall@5 by 5.9~7.0%, NDCG@20 by 4.3~5.6%, and MAP@10 by 7.9~8.9%. In addition, under the cold-start scenario for users with the lowest number of interactions, against the competing models, the RME outperforms NDCG@5 by 20.2% and 29.4% in MovieLens-10M and MovieLens-20M datasets, respectively. Our datasets and source code are available at: https://github.com/thanhdtran/RME.git.