Jacob Young

Hannah Schieber, Jacob Young, Tobias Langlotz et al.

Advancements in 3D rendering like Gaussian Splatting (GS) allow novel view synthesis and real-time rendering in virtual reality (VR). However, GS-created 3D environments are often difficult to edit. For scene enhancement or to incorporate 3D assets, segmenting Gaussians by class is essential. Existing segmentation approaches are typically limited to certain types of scenes, e.g., ''circular'' scenes, to determine clear object boundaries. However, this method is ineffective when removing large objects in non-''circling'' scenes such as large outdoor scenes. We propose Semantics-Controlled GS (SCGS), a segmentation-driven GS approach, enabling the separation of large scene parts in uncontrolled, natural environments. SCGS allows scene editing and the extraction of scene parts for VR. Additionally, we introduce a challenging outdoor dataset, overcoming the ''circling'' setup. We outperform the state-of-the-art in visual quality on our dataset and in segmentation quality on the 3D-OVS dataset. We conducted an exploratory user study, comparing a 360-video, plain GS, and SCGS in VR with a fixed viewpoint. In our subsequent main study, users were allowed to move freely, evaluating plain GS and SCGS. Our main study results show that participants clearly prefer SCGS over plain GS. We overall present an innovative approach that surpasses the state-of-the-art both technically and in user experience.

Felix Tripier, Woo Chang Chung, Jacob Young et al.

We propose a fault-tolerant quantum computer architecture for trapped-ion devices, which we call the walking cat architecture. Our blueprint includes a compiler, a detailed description of all the quantum error-correction protocols, a micro-architecture, a sufficiently fast decoder, and thorough simulations. The backbone of the architecture is a cat factory, producing cat states distributed throughout the machine, which are consumed to perform logical operations. The walking cat architecture is based entirely on a modern quantum error-correction approach called low-density parity-check (LDPC) codes. We identify promising instances of the walking cat architecture, such as (1) a simple architecture based on a single LDPC code, (2) a fast architecture based on fast logical gates relying on a [[70, 6, 9]] code, equipped with Clifford-frame tracking for any 6-qubit Clifford gate, and (3) a dense architecture based on a [[102, 22, 9]]] code encoding 22 logical qubits per memory block. Our dense architecture provides a design with 110 logical qubits executing about one million T gates per day using only 2,514 physical qubits. We estimate that the quantum Hamiltonian simulation of a Heisenberg model on 100 sites can be executed within one month with 10,000 physical qubits, including all shots required to achieve chemical accuracy, suggesting that such a device could enter the regime of classically intractable physics simulations. Our design relies on hardware components that have been experimentally demonstrated on small devices. We emphasize simplicity over hypothetical performance to facilitate the practical realization of this machine. Based on this approach, we believe that a fault-tolerant quantum computer with hundreds of logical qubits capable of running millions of logical gates can be built in the near term, providing a platform to explore a broad range of applications.

Xinhai Hou, Akhil Kondepudi, Cheng Jiang et al.

The importance of rapid and accurate histologic analysis of surgical tissue in the operating room has been recognized for over a century. Our standard-of-care intraoperative pathology workflow is based on light microscopy and H\&E histology, which is slow, resource-intensive, and lacks real-time digital imaging capabilities. Here, we present an emerging and innovative method for intraoperative histologic analysis, called Intelligent Histology, that integrates artificial intelligence (AI) with stimulated Raman histology (SRH). SRH is a rapid, label-free, digital imaging method for real-time microscopic tumor tissue analysis. SRH generates high-resolution digital images of surgical specimens within seconds, enabling AI-driven tumor histologic analysis, molecular classification, and tumor infiltration detection. We review the scientific background, clinical translation, and future applications of intelligent histology in tumor neurosurgery. We focus on the major scientific and clinical studies that have demonstrated the transformative potential of intelligent histology across multiple neurosurgical specialties, including neurosurgical oncology, skull base, spine oncology, pediatric tumors, and periperal nerve tumors. Future directions include the development of AI foundation models through multi-institutional datasets, incorporating clinical and radiologic data for multimodal learning, and predicting patient outcomes. Intelligent histology represents a transformative intraoperative workflow that can reinvent real-time tumor analysis for 21st century neurosurgery.