Buwen Liang

Ruohao Guo, Xianghua Ying, Yaru Chen et al.

In this paper, we propose a new multi-modal task, termed audio-visual instance segmentation (AVIS), which aims to simultaneously identify, segment and track individual sounding object instances in audible videos. To facilitate this research, we introduce a high-quality benchmark named AVISeg, containing over 90K instance masks from 26 semantic categories in 926 long videos. Additionally, we propose a strong baseline model for this task. Our model first localizes sound source within each frame, and condenses object-specific contexts into concise tokens. Then it builds long-range audio-visual dependencies between these tokens using window-based attention, and tracks sounding objects among the entire video sequences. Extensive experiments reveal that our method performs best on AVISeg, surpassing the existing methods from related tasks. We further conduct the evaluation on several multi-modal large models. Unfortunately, they exhibits subpar performance on instance-level sound source localization and temporal perception. We expect that AVIS will inspire the community towards a more comprehensive multi-modal understanding. Dataset and code is available at https://github.com/ruohaoguo/avis.

Shiyi Liu, Buwen Liang, Yuetong Fang et al.

Recent advances in AI for science have highlighted the power of contrastive learning in bridging heterogeneous biological data modalities. Building on this paradigm, we propose HIPPO (HIerarchical Protein-Protein interaction prediction across Organisms), a hierarchical contrastive framework for protein-protein interaction(PPI) prediction, where protein sequences and their hierarchical attributes are aligned through multi-tiered biological representation matching. The proposed approach incorporates hierarchical contrastive loss functions that emulate the structured relationship among functional classes of proteins. The framework adaptively incorporates domain and family knowledge through a data-driven penalty mechanism, enforcing consistency between the learned embedding space and the intrinsic hierarchy of protein functions. Experiments on benchmark datasets demonstrate that HIPPO achieves state-of-the-art performance, outperforming existing methods and showing robustness in low-data regimes. Notably, the model demonstrates strong zero-shot transferability to other species without retraining, enabling reliable PPI prediction and functional inference even in less characterized or rare organisms where experimental data are limited. Further analysis reveals that hierarchical feature fusion is critical for capturing conserved interaction determinants, such as binding motifs and functional annotations. This work advances cross-species PPI prediction and provides a unified framework for interaction prediction in scenarios with sparse or imbalanced multi-species data.