Mohammad Rafayet Ali

Mohammad Rafayet Ali, Taylor Myers, Ellen Wagner et al.

One of the symptoms of Parkinson's disease (PD) is hypomimia or reduced facial expressions. In this paper, we present a digital biomarker for PD that utilizes the study of micro-expressions. We analyzed the facial action units (AU) from 1812 videos of 604 individuals (61 with PD and 543 without PD, mean age 63.9 yo, sd 7.8 ) collected online using a web-based tool (www.parktest.net). In these videos, participants were asked to make three facial expressions (a smiling, disgusted, and surprised face) followed by a neutral face. Using techniques from computer vision and machine learning, we objectively measured the variance of the facial muscle movements and used it to distinguish between individuals with and without PD. The prediction accuracy using the facial micro-expressions was comparable to those methodologies that utilize motor symptoms. Logistic regression analysis revealed that participants with PD had less variance in AU6 (cheek raiser), AU12 (lip corner puller), and AU4 (brow lowerer) than non-PD individuals. An automated classifier using Support Vector Machine was trained on the variances and achieved 95.6% accuracy. Using facial expressions as a biomarker for PD could be potentially transformative for patients in need of physical separation (e.g., due to COVID) or are immobile.

Mohammad Rafayet Ali, Taylan Sen, Benjamin Kane et al.

In this paper, we describe the iterative participatory design of SOPHIE, an online virtual patient for feedback-based practice of sensitive patient-physician conversations, and discuss an initial qualitative evaluation of the system by professional end users. The design of SOPHIE was motivated from a computational linguistic analysis of the transcripts of 383 patient-physician conversations from an essential office visit of late stage cancer patients with their oncologists. We developed methods for the automatic detection of two behavioral paradigms, lecturing and positive language usage patterns (sentiment trajectory of conversation), that are shown to be significantly associated with patient prognosis understanding. These automated metrics associated with effective communication were incorporated into SOPHIE, and a pilot user study identified that SOPHIE was favorably reviewed by a user group of practicing physicians.

Wasifur Rahman, Sangwu Lee, Md. Saiful Islam et al.

In this paper, we envision a web-based framework that can help anyone, anywhere around the world record a short speech task, and analyze the recorded data to screen for Parkinson's disease (PD). We collected data from 726 unique participants (262 PD, 38% female; 464 non-PD, 65% female; average age: 61) -- from all over the US and beyond. A small portion of the data was collected in a lab setting to compare quality. The participants were instructed to utter a popular pangram containing all the letters in the English alphabet "the quick brown fox jumps over the lazy dog..". We extracted both standard acoustic features (Mel Frequency Cepstral Coefficients (MFCC), jitter and shimmer variants) and deep learning based features from the speech data. Using these features, we trained several machine learning algorithms. We achieved 0.75 AUC (Area Under The Curve) performance on determining presence of self-reported Parkinson's disease by modeling the standard acoustic features through the XGBoost -- a gradient-boosted decision tree model. Further analysis reveal that the widely used MFCC features and a subset of previously validated dysphonia features designed for detecting Parkinson's from verbal phonation task (pronouncing 'ahh') contains the most distinct information. Our model performed equally well on data collected in controlled lab environment as well as 'in the wild' across different gender and age groups. Using this tool, we can collect data from almost anyone anywhere with a video/audio enabled device, contributing to equity and access in neurological care.

S. Zahra Razavi, Lenhart K. Schubert, Kimberly A. Van Orden et al.

We present some results concerning the dialogue behavior and inferred sentiment of a group of older adults interacting with a computer-based avatar. Our avatar is unique in its ability to hold natural dialogues on a wide range of everyday topics---27 topics in three groups, developed with the help of gerontologists. The three groups vary in ``degrees of intimacy", and as such in degrees of difficulty for the user. Each participant interacted with the avatar for 7-9 sessions over a period of 3-4 weeks; analysis of the dialogues reveals correlations such as greater verbosity for more difficult topics, increasing verbosity with successive sessions, especially for more difficult topics, stronger sentiment on topics concerned with life goals rather than routine activities, and stronger self-disclosure for more intimate topics. In addition to their intrinsic interest, these results also reflect positively on the sophistication of our dialogue system.

Minh Tran, Taylan Sen, Kurtis Haut et al.

Despite a revolution in the pervasiveness of video cameras in our daily lives, one of the most meaningful forms of nonverbal affective communication, interpersonal eye gaze, i.e. eye gaze relative to a conversation partner, is not available from common video. We introduce the Interpersonal-Calibrating Eye-gaze Encoder (ICE), which automatically extracts interpersonal gaze from video recordings without specialized hardware and without prior knowledge of participant locations. Leveraging the intuition that individuals spend a large portion of a conversation looking at each other enables the ICE dynamic clustering algorithm to extract interpersonal gaze. We validate ICE in both video chat using an objective metric with an infrared gaze tracker (F1=0.846, N=8), as well as in face-to-face communication with expert-rated evaluations of eye contact (r= 0.37, N=170). We then use ICE to analyze behavior in two different, yet important affective communication domains: interrogation-based deception detection, and communication skill assessment in speed dating. We find that honest witnesses break interpersonal gaze contact and look down more often than deceptive witnesses when answering questions (p=0.004, d=0.79). In predicting expert communication skill ratings in speed dating videos, we demonstrate that interpersonal gaze alone has more predictive power than facial expressions.

S. Zahra Razavi, Lenhart K. Schubert, Benjamin Kane et al.

We address the problem of designing a conversational avatar capable of a sequence of casual conversations with older adults. Users at risk of loneliness, social anxiety or a sense of ennui may benefit from practicing such conversations in private, at their convenience. We describe an automatic spoken dialogue manager for LISSA, an on-screen virtual agent that can keep older users involved in conversations over several sessions, each lasting 10-20 minutes. The idea behind LISSA is to improve users' communication skills by providing feedback on their non-verbal behavior at certain points in the course of the conversations. In this paper, we analyze the dialogues collected from the first session between LISSA and each of 8 participants. We examine the quality of the conversations by comparing the transcripts with those collected in a WOZ setting. LISSA's contributions to the conversations were judged by research assistants who rated the extent to which the contributions were "natural", "on track", "encouraging", "understanding", "relevant", and "polite". The results show that the automatic dialogue manager was able to handle conversation with the users smoothly and naturally.

Mohammad Rafayet Ali, Zahra Razavi, Abdullah Al Mamun et al.

We present the design of an online social skills development interface for teenagers with autism spectrum disorder (ASD). The interface is intended to enable private conversation practice anywhere, anytime using a web-browser. Users converse informally with a virtual agent, receiving feedback on nonverbal cues in real-time, and summary feedback. The prototype was developed in consultation with an expert UX designer, two psychologists, and a pediatrician. Using the data from 47 individuals, feedback and dialogue generation were automated using a hidden Markov model and a schema-driven dialogue manager capable of handling multi-topic conversations. We conducted a study with nine high-functioning ASD teenagers. Through a thematic analysis of post-experiment interviews, identified several key design considerations, notably: 1) Users should be fully briefed at the outset about the purpose and limitations of the system, to avoid unrealistic expectations. 2) An interface should incorporate positive acknowledgment of behavior change. 3) Realistic appearance of a virtual agent and responsiveness are important in engaging users. 4) Conversation personalization, for instance in prompting laconic users for more input and reciprocal questions, would help the teenagers engage for longer terms and increase the system's utility.