Zhihao Zhan

Fang Sun, Zhihao Zhan, Hongyu Guo et al.

Designing molecules that bind to specific target proteins is a fundamental task in drug discovery. Recent models leverage geometric constraints to generate ligand molecules that bind cohesively with specific protein pockets. However, these models cannot effectively generate 3D molecules with 2D skeletal curtailments and property constraints, which are pivotal to drug potency and development. To tackle this challenge, we propose GraphVF, a variational flow-based framework that combines 2D topology and 3D geometry, for controllable generation of binding 3D molecules. Empirically, our method achieves state-of-the-art binding affinity and realistic sub-structural layouts for protein-specific generation. In particular, GraphVF represents the first controllable geometry-aware, protein-specific molecule generation method, which can generate binding 3D molecules with tailored sub-structures and physio-chemical properties. Our code is available at https://github.com/Franco-Solis/GraphVF-code.

Jianan Zhao, Xixian Liu, Zhihao Zhan et al.

Long-context DNA models are limited by token-mixing cost and by how compression allocates representational budget across the genome. Existing approaches operate close to base-pair resolution, apply fixed downsampling, or learn content-dependent chunks without an explicit genomic budget, making long-context pretraining expensive and difficult to control. We introduce GeneZip, a region-aware DNA compression framework that combines H-Net-style dynamic routing with a Region-Aware Ratio (RAR) objective and bounded routing. GeneZip uses static gene-structure annotations during compression training to specify region-wise base-pairs-per-token (BPT) targets; at inference time, it compresses raw unseen DNA without annotations. GeneZip provides three main benefits. First, it is effective: GeneZip variants achieve the best validation PPL among encoder-based compressors, with GeneZip-70M operating at 137.6 BPT, and across four reproducible DNALongBench tasks--contact map prediction, eQTL prediction, enhancer-target gene prediction, and transcription-initiation signal prediction--GeneZip obtains the best average rank among compared sequence models. Second, it is redundancy-aware: a post-hoc RepeatMasker/TRF analysis shows that, without repeat supervision, GeneZip assigns higher local BPT to TE-derived interspersed repeats and tandem repeats, two major classes of repetitive DNA sequence redundancy. Third, it is efficient: by reducing the effective token-mixing length, GeneZip enables longer-context and larger-capacity pretraining, including 128K-context and 636M-parameter variants on a single A100 80GB GPU, and fine-tunes the eQTL task 50.4x faster than JanusDNA (50 vs. 2520 minutes). These results establish GeneZip as an effective, redundancy-aware, and efficient compression interface for long-context DNA modeling.

Xinyu Yuan, Zhihao Zhan, Zuobai Zhang et al.

Transcriptome foundation models TFMs hold great promises of deciphering the transcriptomic language that dictate diverse cell functions by self-supervised learning on large-scale single-cell gene expression data, and ultimately unraveling the complex mechanisms of human diseases. However, current TFMs treat cells as independent samples and ignore the taxonomic relationships between cell types, which are available in cell ontology graphs. We argue that effectively leveraging this ontology information during the TFM pre-training can improve learning biologically meaningful gene co-expression patterns while preserving TFM as a general purpose foundation model for downstream zero-shot and fine-tuning tasks. To this end, we present single cell, Cell-ontology guided TFM scCello. We introduce cell-type coherence loss and ontology alignment loss, which are minimized along with the masked gene expression prediction loss during the pre-training. The novel loss component guide scCello to learn the cell-type-specific representation and the structural relation between cell types from the cell ontology graph, respectively. We pre-trained scCello on 22 million cells from CellxGene database leveraging their cell-type labels mapped to the cell ontology graph from Open Biological and Biomedical Ontology Foundry. Our TFM demonstrates competitive generalization and transferability performance over the existing TFMs on biologically important tasks including identifying novel cell types of unseen cells, prediction of cell-type-specific marker genes, and cancer drug responses.

Zhihao Zhan, Le Tao, Shaobin Li et al.

Accurate terrain perception is essential for terrain-following flight of agricultural unmanned aerial vehicles (UAVs), yet remains challenging in real-world farmland due to occlusions, complex terrain geometry, and environmental disturbances. Millimeter-wave (mmWave) radar is a promising sensing modality for this task due to its robustness to adverse conditions; however, existing UAV-mounted radar systems rely on fixed field of view (FoV) and terrain extraction methods designed for dense LiDAR data, leading to incomplete and unreliable terrain estimation. To address these limitations, we present a low-cost rotating mmWave radar-enabled terrain perception framework for agricultural UAVs operating in complex farmland environments. Specifically, a mechanically rotating sensing design is introduced to enlarge spatial coverage and improve terrain observability beyond the limitations of fixed-view radar under dynamic low-altitude flight. Building upon this sensing capability, we further design a pose-consistent terrain reconstruction pipeline tailored for sparse, noisy, and partially observable radar data, enabling reliable ground extraction and continuous terrain surface estimation in challenging agricultural scenarios. The complete system is deployed on a real agricultural UAV platform and comprehensively evaluated through extensive field experiments. Experimental results demonstrate improved terrain coverage and estimation accuracy, achieving an F1 score of 94.42 for ground segmentation, while the closest rival only achieves 90.48. Thus, leading to more robust terrain following flight.

Tianle Zhang, Zhihao Yuan, Dafeng Chi et al.

Robotic autonomy in open-world environments is fundamentally limited by insufficient data diversity and poor cross-embodiment generalization. Existing robotic datasets are often limited in scale and task coverage, while relatively large differences across robot embodiments impede effective behavior knowledge transfer. To address these challenges, we propose JoyAI-RA, a vision-language-action (VLA) embodied foundation model tailored for generalizable robotic manipulation. JoyAI-RA presents a multi-source multi-level pretraining framework that integrates web data, large-scale egocentric human manipulation videos, simulation-generated trajectories, and real-robot data. Through training on heterogeneous multi-source data with explicit action-space unification, JoyAI-RA effectively bridges embodiment gaps, particularly between human manipulation and robotic control, thereby enhancing cross-embodiment behavior learning. JoyAI-RA outperforms state-of-the-art methods in both simulation and real-world benchmarks, especially on diverse tasks with generalization demands.

Zhihao Zhan, Yuhao Chen, Jiaying Zhou et al.

Vision-Language-Action (VLA) models have demonstrated impressive capabilities in generalized robotic control; however, they remain notoriously brittle to linguistic perturbations. We identify a critical ``modality collapse'' phenomenon where strong visual priors overwhelm sparse linguistic signals, causing agents to overfit to specific instruction phrasings while ignoring the underlying semantic intent. To address this, we propose \textbf{Residual Semantic Steering (RSS)}, a probabilistic framework that disentangles physical affordance from semantic execution. RSS introduces two theoretical innovations: (1) \textbf{Monte Carlo Syntactic Integration}, which approximates the true semantic posterior via dense, LLM-driven distributional expansion, and (2) \textbf{Residual Affordance Steering}, a dual-stream decoding mechanism that explicitly isolates the causal influence of language by subtracting the visual affordance prior. Theoretical analysis suggests that RSS effectively maximizes the mutual information between action and intent while suppressing visual distractors. Empirical results across diverse manipulation benchmarks demonstrate that RSS achieves state-of-the-art robustness, maintaining performance even under adversarial linguistic perturbations.

Jiaying Zhou, Zhihao Zhan, Ruifeng Zhai et al.

Vision--Language--Action (VLA) policies have shown strong progress in mapping language instructions and visual observations to robotic actions, yet their reliability degrades in cluttered scenes with distractors. By analyzing failure cases, we find that many errors do not arise from infeasible motions, but from instance-level grounding failures: the policy often produces a plausible grasp trajectory that lands slightly off-target or even on the wrong object instance. To address this issue, we propose TAG (Target-Agnostic Guidance), a simple inference-time guidance mechanism that explicitly reduces distractor- and appearance-induced bias in VLA policies. Inspired by classifier-free guidance (CFG), TAG contrasts policy predictions under the original observation and an object-erased observation, and uses their difference as a residual steering signal that strengthens the influence of object evidence in the decision process. TAG does not require modifying the policy architecture and can be integrated with existing VLA policies with minimal training and inference changes. We evaluate TAG on standard manipulation benchmarks, including LIBERO, LIBERO-Plus, and VLABench, where it consistently improves robustness under clutter and reduces near-miss and wrong-object executions.

Zhengyi Xu, Yuhang Ming, Zhihao Zhan et al.

Multi-modal cross-view place recognition remains a fundamental challenge in computer vision and robotics due to the severe viewpoint, modality, and spatial-structure discrepancies between ground observations and aerial references. To address this challenge, we present MAG-VLAQ, a foundation-model-enhanced query aggregation framework for multi-modal aerial-ground cross-view place recognition. Specifically, our approach leverages pre-trained foundation models to extract dense visual tokens from both ground and aerial images, as well as expressive geometric tokens from ground LiDAR observations. These heterogeneous tokens are then projected into a shared embedding space for cross-modal alignment and fusion. As our main contribution, we propose ODE-conditioned VLAQ, which tightly couples neural ordinary differential equations (ODE)-based RGB-LiDAR fusion with vectors of locally aggregated queries (VLAQ). In this design, the VLAQ query centers are dynamically adapted according to the fused multi-modal state. This mechanism allows the final global descriptor to preserve globally learned retrieval prototypes while remaining responsive to scene-specific visual and geometric evidence, significantly improving aerial-ground matching. Extensive experiments on KITTI360-AG and nuScenes-AG validate the effectiveness of our proposed MAG-VLAQ. Notably, on KITTI360-AG, our MAG-VLAQ nearly doubles the state-of-the-art performance, achieving 61.1 Recall@1 in the satellite setting, compared with 34.5 from the closest competing approach.

Zhihao Zhan

This note presents a concise mathematical formulation of tightly-coupled LiDAR-Inertial Odometry within an iterated error-state Kalman filter framework using a VoxelMap representation. Rather than proposing a new algorithm, it provides a clear and self-contained derivation that unifies the geometric modeling and probabilistic state estimation through consistent notation and explicit formulations. The document is intended to serve both as a technical reference and as an accessible entry point for a foundational understanding of the system architecture and estimation principles.

Likui Zhang, Tao Tang, Zhihao Zhan et al.

Recent advances in Visual-Language-Action (VLA) models have shown promising potential for robotic manipulation tasks. However, real-world robotic tasks often involve long-horizon, multi-step problem-solving and require generalization for continual skill acquisition, extending beyond single actions or skills. These challenges present significant barriers for existing VLA models, which use monolithic action decoders trained on aggregated data, resulting in poor scalability. To address these challenges, we propose AtomicVLA, a unified planning-and-execution framework that jointly generates task-level plans, atomic skill abstractions, and fine-grained actions. AtomicVLA constructs a scalable atomic skill library through a Skill-Guided Mixture-of-Experts (SG-MoE), where each expert specializes in mastering generic yet precise atomic skills. Furthermore, we introduce a flexible routing encoder that automatically assigns dedicated atomic experts to new skills, enabling continual learning. We validate our approach through extensive experiments. In simulation, AtomicVLA outperforms $π_{0}$ by 2.4\% on LIBERO, 10\% on LIBERO-LONG, and outperforms $π_{0}$ and $π_{0.5}$ by 0.22 and 0.25 in average task length on CALVIN. Additionally, our AtomicVLA consistently surpasses baselines by 18.3\% and 21\% in real-world long-horizon tasks and continual learning. These results highlight the effectiveness of atomic skill abstraction and dynamic expert composition for long-horizon and lifelong robotic tasks. The project page is \href{https://zhanglk9.github.io/atomicvla-web/}{here}.

Zhihao Zhan, Jianan Zhao, Zhaocheng Zhu et al.

Efficient long-context modeling remains a critical challenge for natural language processing (NLP), as the time complexity of the predominant Transformer architecture scales quadratically with the sequence length. While state-space models (SSMs) offer alternative sub-quadratic solutions, they struggle to capture long-range dependencies effectively. In this work, we focus on analyzing and improving the long-context modeling capabilities of SSMs. We show that the widely used synthetic task, associative recall, which requires a model to recall a value associated with a single key without context, insufficiently represents the complexities of real-world long-context modeling. To address this limitation, we extend the associative recall to a novel synthetic task, \emph{joint recall}, which requires a model to recall the value associated with a key given in a specified context. Theoretically, we prove that SSMs do not have the expressiveness to solve multi-query joint recall in sub-quadratic time complexity. To resolve this issue, we propose a solution based on integrating SSMs with Context-Dependent Sparse Attention (CDSA), which has the expressiveness to solve multi-query joint recall with sub-quadratic computation. To bridge the gap between theoretical analysis and real-world applications, we propose locality-sensitive Hashing Attention with sparse Key Selection (HAX), which instantiates the theoretical solution and is further tailored to natural language domains. Extensive experiments on both synthetic and real-world long-context benchmarks show that HAX consistently outperforms SSM baselines and SSMs integrated with context-independent sparse attention (CISA).

Qian Wang, Zhihao Zhan, Jialei He et al.

Highly accurate geometric precision and dense image features characterize True Digital Orthophoto Maps (TDOMs), which are in great demand for applications such as urban planning, infrastructure management, and environmental monitoring.Traditional TDOM generation methods need sophisticated processes, such as Digital Surface Models (DSM) and occlusion detection, which are computationally expensive and prone to errors.This work presents an alternative technique rooted in 2D Gaussian Splatting (2DGS), free of explicit DSM and occlusion detection. With depth map generation, spatial information for every pixel within the TDOM is retrieved and can reconstruct the scene with high precision. Divide-and-conquer strategy achieves excellent GS training and rendering with high-resolution TDOMs at a lower resource cost, which preserves higher quality of rendering on complex terrain and thin structure without a decrease in efficiency. Experimental results demonstrate the efficiency of large-scale scene reconstruction and high-precision terrain modeling. This approach provides accurate spatial data, which assists users in better planning and decision-making based on maps.

Wang Pang, Zhihao Zhan, Xiang Zhu et al.

Most motion deblurring algorithms rely on spatial-domain convolution models, which struggle with the complex, non-linear blur arising from camera shake and object motion. In contrast, we propose a novel single-image deblurring approach that treats motion blur as a temporal averaging phenomenon. Our core innovation lies in leveraging a pre-trained video diffusion transformer model to capture diverse motion dynamics within a latent space. It sidesteps explicit kernel estimation and effectively accommodates diverse motion patterns. We implement the algorithm within a diffusion-based inverse problem framework. Empirical results on synthetic and real-world datasets demonstrate that our method outperforms existing techniques in deblurring complex motion blur scenarios. This work paves the way for utilizing powerful video diffusion models to address single-image deblurring challenges.

Hanyu Zhu, Zhihao Zhan, Yuhang Ming et al.

One of the central challenges in visual place recognition (VPR) is learning a robust global representation that remains discriminative under large viewpoint changes, illumination variations, and severe domain shifts. While visual foundation models (VFMs) provide strong local features, most existing methods rely on a single model, overlooking the complementary cues offered by different VFMs. However, exploiting such complementary information inevitably alters token distributions, which challenges the stability of existing query-based global aggregation schemes. To address these challenges, we propose DC-VLAQ, a representation-centric framework that integrates the fusion of complementary VFMs and robust global aggregation. Specifically, we first introduce a lightweight residual-guided complementary fusion that anchors representations in the DINOv2 feature space while injecting complementary semantics from CLIP through a learned residual correction. In addition, we propose the Vector of Local Aggregated Queries (VLAQ), a query--residual global aggregation scheme that encodes local tokens by their residual responses to learnable queries, resulting in improved stability and the preservation of fine-grained discriminative cues. Extensive experiments on standard VPR benchmarks, including Pitts30k, Tokyo24/7, MSLS, Nordland, SPED, and AmsterTime, demonstrate that DC-VLAQ consistently outperforms strong baselines and achieves state-of-the-art performance, particularly under challenging domain shifts and long-term appearance changes.

Zhihao Zhan, Jiaying Zhou, Likui Zhang et al.

Vision-Language-Action (VLA) models offer a unified framework for robotic manipulation by integrating visual perception, language understanding, and control generation. Yet existing VLA models still struggle to generalize across diverse tasks, scenes, and camera viewpoints, and often produce coarse or unstable actions. We introduce E0, a continuized discrete diffusion framework that formulates action generation as iterative denoising over quantized action tokens. Compared with continuous diffusion policies, E0 offers two key advantages: (1) discrete action tokens align naturally with the symbolic structure of pretrained VLM/VLA backbones, enabling stronger semantic conditioning; and 2. discrete diffusion matches the true quantized nature of real-world robot control-whose hardware constraints (e.g., encoder resolution, control frequency, actuation latency) inherently discretize continuous signals-and therefore benefits from a Bayes-optimal denoiser that models the correct discrete action distribution, leading to stronger generalization. Compared with discrete autoregressive and mask-based discrete diffusion models, E0 supports a significantly larger and finer-grained action vocabulary and avoids the distributional mismatch introduced by masking-based corruptions-yielding more accurate fine-grained action control. We further introduce a spherical viewpoint perturbation augmentation method to improve robustness to camera shifts without additional data. Experiments on LIBERO, VLABench, and ManiSkill show that E0 achieves state-of-the-art performance across 14 diverse environments, outperforming strong baselines by 10.7% on average. Real-world evaluation on a Franka arm confirms that E0 delivers precise, robust, and transferable manipulation, establishing discrete diffusion as a promising direction for generalizable VLA policy learning.

Zhihao Zhan, Wang Pang, Xiang Zhu et al.

In this work, we rethink the approach to video super-resolution by introducing a method based on the Diffusion Posterior Sampling framework, combined with an unconditional video diffusion transformer operating in latent space. The video generation model, a diffusion transformer, functions as a space-time model. We argue that a powerful model, which learns the physics of the real world, can easily handle various kinds of motion patterns as prior knowledge, thus eliminating the need for explicit estimation of optical flows or motion parameters for pixel alignment. Furthermore, a single instance of the proposed video diffusion transformer model can adapt to different sampling conditions without re-training. Empirical results on synthetic and real-world datasets illustrate the feasibility of diffusion-based, alignment-free video super-resolution.

Jialei He, Zhihao Zhan, Zhituo Tu et al.

Rapid generation of large-scale orthoimages from Unmanned Aerial Vehicles (UAVs) has been a long-standing focus of research in the field of aerial mapping. A multi-sensor UAV system, integrating the Global Positioning System (GPS), Inertial Measurement Unit (IMU), 4D millimeter-wave radar and camera, can provide an effective solution to this problem. In this paper, we utilize multi-sensor data to overcome the limitations of conventional orthoimage generation methods in terms of temporal performance, system robustness, and geographic reference accuracy. A prior-pose-optimized feature matching method is introduced to enhance matching speed and accuracy, reducing the number of required features and providing precise references for the Structure from Motion (SfM) process. The proposed method exhibits robustness in low-texture scenes like farmlands, where feature matching is difficult. Experiments show that our approach achieves accurate feature matching orthoimage generation in a short time. The proposed drone system effectively aids in farmland detection and management.