Lourdes Peña‐Castillo

Ali Amelia, Lourdes Pena-Castillo, Hamid Usefi

Genome-Wide Association Studies (GWAS) help identify genetic variations in people with diseases such as Parkinson's disease (PD), which are less common in those without the disease. Thus, GWAS data can be used to identify genetic variations associated with the disease. Feature selection and machine learning approaches can be used to analyze GWAS data and identify potential disease biomarkers. However, GWAS studies have technical variations that affect the reproducibility of identified biomarkers, such as differences in genotyping platforms and selection criteria for individuals to be genotyped. To address this issue, we collected five GWAS datasets from the database of Genotypes and Phenotypes (dbGaP) and explored several data integration strategies. We evaluated the agreement among different strategies in terms of the Single Nucleotide Polymorphisms (SNPs) that were identified as potential PD biomarkers. Our results showed a low concordance of biomarkers discovered using different datasets or integration strategies. However, we identified fifty SNPs that were identified at least twice, which could potentially serve as novel PD biomarkers. These SNPs are indirectly linked to PD in the literature but have not been directly associated with PD before. These findings open up new potential avenues of investigation.

Aiur Nanzatov, Lourdes Peña-Castillo, Oscar Meruvia-Pastor

Two-factor authentication (2FA) has become widely adopted as an efficient and secure way to validate someone's identity online. Two-factor authentication is difficult in virtual reality (VR) because users are usually wearing a head-mounted display (HMD) which does not allow them to see their real-world surroundings. We present NRXR-ID, a technique to implement two-factor authentication while using extended reality systems and smartphones. The proposed method allows users to complete an authentication challenge using their smartphones without removing their HMD. We performed a user study where we explored four types of challenges for users, including a novel checkers-style challenge. Users responded to these challenges under three different configurations, including a technique that uses the smartphone to support gaze-based selection without the use of VR controllers. A 4X3 within-subjects design allowed us to study all the variations proposed. We collected performance metrics and performed user experience questionnaires to collect subjective impressions from 30 participants. Results suggest that the checkers-style visual matching challenge was the most appropriate option, followed by entering a digital PIN challenge submitted via the smartphone and answered within the VR environment.

Hanieh Marvi Khorasani, Hamid Usefi, Lourdes Peña-Castillo

Ulcerative colitis (UC) is one of the most common forms of inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. Diagnosis of UC is based on clinical symptoms, and then confirmed based on endoscopic, histologic and laboratory findings. Feature selection and machine learning have been previously used for creating models to facilitate the diagnosis of certain diseases. In this work, we used a recently developed feature selection algorithm (DRPT) combined with a support vector machine (SVM) classifier to generate a model to discriminate between healthy subjects and subjects with UC based on the expression values of 32 genes in colon samples. We validated our model with an independent gene expression dataset of colonic samples from subjects in active and inactive periods of UC. Our model perfectly detected all active cases and had an average precision of 0.62 in the inactive cases. Compared with results reported in previous studies and a model generated by a recently published software for biomarker discovery using machine learning (BioDiscML), our final model for detecting UC shows better performance in terms of average precision.