John Xiang

John Xiang, Rohith Ravindranath, Sophia Y. Wang

We evaluated whether a glaucoma risk assessment (GRA) model trained on All of Us national data can identify patients at high probability of glaucoma using only systemic electronic health records (EHR) at an independent institution. In this cross-sectional study, 20,636 Stanford patients seen from November 2013 to January 2024 were included (15% with glaucoma). A pretrained GRA model was fine-tuned on the Stanford cohort and tested on a held-out set using demographics, systemic diagnoses, medications, laboratory results, and physical examination measurements as inputs. The best model achieved AUROC 0.883 and PPV 0.657. Calibration was consistent with clinical risk: the highest prediction decile showed the greatest glaucoma diagnosis rate (65.7%) and treatment rate (57.0%). Performance improved with more trainable layers up to 15 and with additional data. An EHR-only GRA model may enable scalable and accessible pre-screening without specialized imaging.

Qijing Huang, Ameer Haj-Ali, William Moses et al.

The performance of the code a compiler generates depends on the order in which it applies the optimization passes. Choosing a good order--often referred to as the phase-ordering problem, is an NP-hard problem. As a result, existing solutions rely on a variety of heuristics. In this paper, we evaluate a new technique to address the phase-ordering problem: deep reinforcement learning. To this end, we implement AutoPhase: a framework that takes a program and uses deep reinforcement learning to find a sequence of compilation passes that minimizes its execution time. Without loss of generality, we construct this framework in the context of the LLVM compiler toolchain and target high-level synthesis programs. We use random forests to quantify the correlation between the effectiveness of a given pass and the program's features. This helps us reduce the search space by avoiding phase orderings that are unlikely to improve the performance of a given program. We compare the performance of AutoPhase to state-of-the-art algorithms that address the phase-ordering problem. In our evaluation, we show that AutoPhase improves circuit performance by 28% when compared to using the -O3 compiler flag, and achieves competitive results compared to the state-of-the-art solutions, while requiring fewer samples. Furthermore, unlike existing state-of-the-art solutions, our deep reinforcement learning solution shows promising result in generalizing to real benchmarks and 12,874 different randomly generated programs, after training on a hundred randomly generated programs.

Ameer Haj-Ali, Qijing Huang, William Moses et al.

The performance of the code generated by a compiler depends on the order in which the optimization passes are applied. In high-level synthesis, the quality of the generated circuit relates directly to the code generated by the front-end compiler. Choosing a good order--often referred to as the phase-ordering problem--is an NP-hard problem. In this paper, we evaluate a new technique to address the phase-ordering problem: deep reinforcement learning. We implement a framework in the context of the LLVM compiler to optimize the ordering for HLS programs and compare the performance of deep reinforcement learning to state-of-the-art algorithms that address the phase-ordering problem. Overall, our framework runs one to two orders of magnitude faster than these algorithms, and achieves a 16% improvement in circuit performance over the -O3 compiler flag.