Ian Williams

Alan Dolhasz, Carlo Harvey, Ian Williams

Many tasks in computer vision are often calibrated and evaluated relative to human perception. In this paper, we propose to directly approximate the perceptual function performed by human observers completing a visual detection task. Specifically, we present a novel methodology for learning to detect image transformations visible to human observers through approximating perceptual thresholds. To do this, we carry out a subjective two-alternative forced-choice study to estimate perceptual thresholds of human observers detecting local exposure shifts in images. We then leverage transformation equivariant representation learning to overcome issues of limited perceptual data. This representation is then used to train a dense convolutional classifier capable of detecting local suprathreshold exposure shifts - a distortion common to image composites. In this context, our model can approximate perceptual thresholds with an average error of 0.1148 exposure stops between empirical and predicted thresholds. It can also be trained to detect a range of different local transformations.

Jonathan Shen, Patrick Nguyen, Yonghui Wu et al.

Lingvo is a Tensorflow framework offering a complete solution for collaborative deep learning research, with a particular focus towards sequence-to-sequence models. Lingvo models are composed of modular building blocks that are flexible and easily extensible, and experiment configurations are centralized and highly customizable. Distributed training and quantized inference are supported directly within the framework, and it contains existing implementations of a large number of utilities, helper functions, and the newest research ideas. Lingvo has been used in collaboration by dozens of researchers in more than 20 papers over the last two years. This document outlines the underlying design of Lingvo and serves as an introduction to the various pieces of the framework, while also offering examples of advanced features that showcase the capabilities of the framework.

Changwang Zhang, Shi Zhou, Elisabetta Groppelli et al.

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of some important computer worm outbreaks, to HIV-1 progression in vivo remains unknown. Here we present a new mathematical model that explicitly incorporates the ability of HIV-1 to use hybrid spreading mechanisms and evaluate the consequences for HIV-1 pathogenenesis. The model captures the major phases of the HIV-1 infection course of a cohort of treatment naive patients and also accurately predicts the results of the Short Pulse Anti-Retroviral Therapy at Seroconversion (SPARTAC) trial. Using this model we find that hybrid spreading is critical to seed and establish infection, and that cell-to-cell spread and increased CD4+ T cell activation are important for HIV-1 progression. Notably, the model predicts that cell-to-cell spread becomes increasingly effective as infection progresses and thus may present a considerable treatment barrier. Deriving predictions of various treatments' influence on HIV-1 progression highlights the importance of earlier intervention and suggests that treatments effectively targeting cell-to-cell HIV-1 spread can delay progression to AIDS. This study suggests that hybrid spreading is a fundamental feature of HIV infection, and provides the mathematical framework incorporating this feature with which to evaluate future therapeutic strategies.