Patrick Philipp

Leonid Mill, David Wolff, Nele Gerrits et al.

Nanoparticles occur in various environments as a consequence of man-made processes, which raises concerns about their impact on the environment and human health. To allow for proper risk assessment, a precise and statistically relevant analysis of particle characteristics (such as e.g. size, shape and composition) is required that would greatly benefit from automated image analysis procedures. While deep learning shows impressive results in object detection tasks, its applicability is limited by the amount of representative, experimentally collected and manually annotated training data. Here, we present an elegant, flexible and versatile method to bypass this costly and tedious data acquisition process. We show that using a rendering software allows to generate realistic, synthetic training data to train a state-of-the art deep neural network. Using this approach, we derive a segmentation accuracy that is comparable to man-made annotations for toxicologically relevant metal-oxide nanoparticle ensembles which we chose as examples. Our study paves the way towards the use of deep learning for automated, high-throughput particle detection in a variety of imaging techniques such as microscopies and spectroscopies, for a wide variety of studies and applications, including the detection of plastic micro- and nanoparticles.

Maria Maleshkova, Patrick Philipp, York Sure-Vetter et al.

The past few years have been marked by an increased use of sensor technologies, abundant availability of mobile devices, and growing popularity of wearables, which enable the direct integration of their data as part of rich client applications. Despite the potential and added value that such aggregate applications bring, the implementations are usually custom solutions for particular use cases and do not support easy integration of further devices. To this end, the vision of the Web of Things (WoT) is to leverage Web standards in order to interconnect all types of devices and real-world objects, and thus to make them a part of the World Wide Web (WWW) and provide overall interoperability. In this context we introduce Smart Web Services (SmartWS) that not only provide remote access to resources and functionalities, by relying on standard communication protocols, but also encapsulate `intelligence'. Smartness features can include, for instance, context-based adaptation, cognition, inference and rules that implement autonomous decision logic in order to realize services that automatically perform tasks on behalf of the users, without requiring their explicit involvement. In this paper, we present the key characteristics of SmartWS, and introduce a reference implementation framework. Furthermore, we describe a specific use case for implementing SmartWS in the medical domain and specify a maturity model for determining the quality and usability of SmartWS.