Bing Yang

Zhan Chen, Sicheng Li, Bing Yang et al.

Graph convolutional networks have been widely used for skeleton-based action recognition due to their excellent modeling ability of non-Euclidean data. As the graph convolution is a local operation, it can only utilize the short-range joint dependencies and short-term trajectory but fails to directly model the distant joints relations and long-range temporal information that are vital to distinguishing various actions. To solve this problem, we present a multi-scale spatial graph convolution (MS-GC) module and a multi-scale temporal graph convolution (MT-GC) module to enrich the receptive field of the model in spatial and temporal dimensions. Concretely, the MS-GC and MT-GC modules decompose the corresponding local graph convolution into a set of sub-graph convolution, forming a hierarchical residual architecture. Without introducing additional parameters, the features will be processed with a series of sub-graph convolutions, and each node could complete multiple spatial and temporal aggregations with its neighborhoods. The final equivalent receptive field is accordingly enlarged, which is capable of capturing both short- and long-range dependencies in spatial and temporal domains. By coupling these two modules as a basic block, we further propose a multi-scale spatial temporal graph convolutional network (MST-GCN), which stacks multiple blocks to learn effective motion representations for action recognition. The proposed MST-GCN achieves remarkable performance on three challenging benchmark datasets, NTU RGB+D, NTU-120 RGB+D and Kinetics-Skeleton, for skeleton-based action recognition.

Yining Wang, Xumeng Gong, Shaochuan Li et al.

In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function. Therefore, antibody structure prediction from its sequence alone has always been a highly valuable problem for de novo antibody design. AlphaFold2, a breakthrough in the field of structural biology, provides a solution to predict protein structure based on protein sequences and computationally expensive coevolutionary multiple sequence alignments (MSAs). However, the computational efficiency and undesirable prediction accuracy of antibodies, especially on the complementarity-determining regions (CDRs) of antibodies limit their applications in the industrially high-throughput drug design. To learn an informative representation of antibodies, we employed a deep antibody language model (ALM) on curated sequences from the observed antibody space database via a transformer model. We also developed a novel model named xTrimoABFold to predict antibody structure from antibody sequence based on the pretrained ALM as well as efficient evoformers and structural modules. The model was trained end-to-end on the antibody structures in PDB by minimizing the ensemble loss of domain-specific focal loss on CDR and the frame-aligned point loss. xTrimoABFold outperforms AlphaFold2 and other protein language model based SOTAs, e.g., OmegaFold, HelixFold-Single, and IgFold with a large significant margin (30+\% improvement on RMSD) while performing 151 times faster than AlphaFold2. To the best of our knowledge, xTrimoABFold achieved state-of-the-art antibody structure prediction. Its improvement in both accuracy and efficiency makes it a valuable tool for de novo antibody design and could make further improvements in immuno-theory.

Shuwei Zhou, Christian Haeffner, Shuancheng Wang et al.

Physics-informed neural networks have been widely applied to solid mechanics problems. However, balancing the governing partial differential equations and boundary conditions remains challenging, particularly in fracture mechanics, where accurate predictions strongly depend on refined sampling near crack tips. To overcome these limitations, a Kolosov-Muskhelishvili informed neural network with Williams enrichment is developed in this study. Benefiting from the holomorphic representation, the governing equations are satisfied by construction, and only boundary points are required for training. Across a series of benchmark problems, the Kolosov-Muskhelishvili informed neural network shows excellent agreement with analytical and finite element method references, achieving average relative errors below 1\% and $R^2$ above 0.99 for both mode I and mode II loadings. Furthermore, three crack propagation criteria (maximum tangential stress, maximum energy release rate, and principle of local symmetry) are integrated into the framework using a transfer learning strategy to predict crack propagation directions. The predicted paths are nearly identical across all criteria, and the transfer learning strategy reduces the required training time by more than 70\%. Overall, the developed framework provides a unified, mesh-free, and physically consistent approach for accurate and efficient crack propagation analysis.

Zhifei Li, Lifan Chen, Jiali Yi et al.

Knowledge Tracing (KT) aims to dynamically model a student's mastery of knowledge concepts based on their historical learning interactions. Most current methods rely on single-point estimates, which cannot distinguish true ability from outburst or carelessness, creating ambiguity in judging mastery. To address this issue, we propose a Knowledge Mastery-State Disambiguation for Knowledge Tracing model (KeenKT), which represents a student's knowledge state at each interaction using a Normal-Inverse-Gaussian (NIG) distribution, thereby capturing the fluctuations in student learning behaviors. Furthermore, we design an NIG-distance-based attention mechanism to model the dynamic evolution of the knowledge state. In addition, we introduce a diffusion-based denoising reconstruction loss and a distributional contrastive learning loss to enhance the model's robustness. Extensive experiments on six public datasets demonstrate that KeenKT outperforms SOTA KT models in terms of prediction accuracy and sensitivity to behavioral fluctuations. The proposed method yields the maximum AUC improvement of 5.85% and the maximum ACC improvement of 6.89%.

Zhifei Li, Yiran Wang, Chenyi Xiong et al.

Visual Question Answering (VQA) requires models to reason over multimodal information, combining visual and textual data. With the development of continual learning, significant progress has been made in retaining knowledge and adapting to new information in the VQA domain. However, current methods often struggle with balancing knowledge retention, adaptation, and robust feature representation. To address these challenges, we propose a novel framework with adaptive memory allocation and global noise filtering called MacVQA for visual question answering. MacVQA fuses visual and question information while filtering noise to ensure robust representations, and employs prototype-based memory allocation to optimize feature quality and memory usage. These designs enable MacVQA to balance knowledge acquisition, retention, and compositional generalization in continual VQA learning. Experiments on ten continual VQA tasks show that MacVQA outperforms existing baselines, achieving 43.38% average accuracy and 2.32% average forgetting on standard tasks, and 42.53% average accuracy and 3.60% average forgetting on novel composition tasks.

Xin Liao, Bing Yang, Cai Yu

The integrity of Water Quality Data (WQD) is critical in environmental monitoring for scientific decision-making and ecological protection. However, water quality monitoring systems are often challenged by large amounts of missing data due to unavoidable problems such as sensor failures and communication delays, which further lead to water quality data becoming High-Dimensional and Sparse (HDS). Traditional data imputation methods are difficult to depict the potential dynamics and fail to capture the deep data features, resulting in unsatisfactory imputation performance. To effectively address the above issues, this paper proposes a Nonlinear Low-rank Representation model (NLR) with Convolutional Neural Networks (CNN) for imputing missing WQD, which utilizes CNNs to implement two ideas: a) fusing temporal features to model the temporal dependence of data between time slots, and b) Extracting nonlinear interactions and local patterns to mine higher-order relationships features and achieve deep fusion of multidimensional information. Experimental studies on three real water quality datasets demonstrate that the proposed model significantly outperforms existing state-of-the-art data imputation models in terms of estimation accuracy. It provides an effective approach for handling water quality monitoring data in complex dynamic environments.

Xin Liao, Bing Yang, Tan Dongli et al.

The monitoring of water quality is a crucial part of environmental protection, and a large number of monitors are widely deployed to monitor water quality. Due to unavoidable factors such as data acquisition breakdowns, sensors and communication failures, water quality monitoring data suffers from missing values over time, resulting in High-Dimensional and Sparse (HDS) Water Quality Data (WQD). The simple and rough filling of the missing values leads to inaccurate results and affects the implementation of relevant measures. Therefore, this paper proposes a Causal convolutional Low-rank Representation (CLR) model for imputing missing WQD to improve the completeness of the WQD, which employs a two-fold idea: a) applying causal convolutional operation to consider the temporal dependence of the low-rank representation, thus incorporating temporal information to improve the imputation accuracy; and b) implementing a hyperparameters adaptation scheme to automatically adjust the best hyperparameters during model training, thereby reducing the tedious manual adjustment of hyper-parameters. Experimental studies on three real-world water quality datasets demonstrate that the proposed CLR model is superior to some of the existing state-of-the-art imputation models in terms of imputation accuracy and time cost, as well as indicating that the proposed model provides more reliable decision support for environmental monitoring.

Qian Liu, Lan Wang, Bing Yang et al.

Water quality data can supply a substantial decision support for water resources utilization and pollution prevention. However, there are numerous missing values in water quality data due to inescapable factors like sensor failure, thereby leading to biased result for hydrological analysis and failing to support environmental governance decision accurately. A Latent Factorization of Tensors (LFT) with Stochastic Gradient Descent (SGD) proves to be an efficient imputation method. However, a standard SGD-based LFT model commonly surfers from the slow convergence that impairs its efficiency. To tackle this issue, this paper proposes a Fast Latent Factorization of Tensors (FLFT) model. It constructs an adjusted instance error into SGD via leveraging a nonlinear PID controller to incorporates the past, current and future information of prediction error for improving convergence rate. Comparing with state-of-art models in real world datasets, the results of experiment indicate that the FLFT model achieves a better convergence rate and higher accuracy.

Yutong Xie, Bing Yang, Qingbiao Guan et al.

Medical image segmentation plays an important role in computer-aided diagnosis. Attention mechanisms that distinguish important parts from irrelevant parts have been widely used in medical image segmentation tasks. This paper systematically reviews the basic principles of attention mechanisms and their applications in medical image segmentation. First, we review the basic concepts of attention mechanism and formulation. Second, we surveyed over 300 articles related to medical image segmentation, and divided them into two groups based on their attention mechanisms, non-Transformer attention and Transformer attention. In each group, we deeply analyze the attention mechanisms from three aspects based on the current literature work, i.e., the principle of the mechanism (what to use), implementation methods (how to use), and application tasks (where to use). We also thoroughly analyzed the advantages and limitations of their applications to different tasks. Finally, we summarize the current state of research and shortcomings in the field, and discuss the potential challenges in the future, including task specificity, robustness, standard evaluation, etc. We hope that this review can showcase the overall research context of traditional and Transformer attention methods, provide a clear reference for subsequent research, and inspire more advanced attention research, not only in medical image segmentation, but also in other image analysis scenarios.

Bing Yang, Hong Liu, Xiaofei Li

Multiple moving sound source localization in real-world scenarios remains a challenging issue due to interaction between sources, time-varying trajectories, distorted spatial cues, etc. In this work, we propose to use deep learning techniques to learn competing and time-varying direct-path phase differences for localizing multiple moving sound sources. A causal convolutional recurrent neural network is designed to extract the direct-path phase difference sequence from signals of each microphone pair. To avoid the assignment ambiguity and the problem of uncertain output-dimension encountered when simultaneously predicting multiple targets, the learning target is designed in a weighted sum format, which encodes source activity in the weight and direct-path phase differences in the summed value. The learned direct-path phase differences for all microphone pairs can be directly used to construct the spatial spectrum according to the formulation of steered response power (SRP). This deep neural network (DNN) based SRP method is referred to as SRP-DNN. The locations of sources are estimated by iteratively detecting and removing the dominant source from the spatial spectrum, in which way the interaction between sources is reduced. Experimental results on both simulated and real-world data show the superiority of the proposed method in the presence of noise and reverberation.

Bing Yang, Hong Liu, Xiaofei Li

Direct-path relative transfer function (DP-RTF) refers to the ratio between the direct-path acoustic transfer functions of two microphone channels. Though DP-RTF fully encodes the sound spatial cues and serves as a reliable localization feature, it is often erroneously estimated in the presence of noise and reverberation. This paper proposes to learn DP-RTF with deep neural networks for robust binaural sound source localization. A DP-RTF learning network is designed to regress the binaural sensor signals to a real-valued representation of DP-RTF. It consists of a branched convolutional neural network module to separately extract the inter-channel magnitude and phase patterns, and a convolutional recurrent neural network module for joint feature learning. To better explore the speech spectra to aid the DP-RTF estimation, a monaural speech enhancement network is used to recover the direct-path spectrograms from the noisy ones. The enhanced spectrograms are stacked onto the noisy spectrograms to act as the input of the DP-RTF learning network. We train one unique DP-RTF learning network using many different binaural arrays to enable the generalization of DP-RTF learning across arrays. This way avoids time-consuming training data collection and network retraining for a new array, which is very useful in practical application. Experimental results on both simulated and real-world data show the effectiveness of the proposed method for direction of arrival (DOA) estimation in the noisy and reverberant environment, and a good generalization ability to unseen binaural arrays.

Tianyang Zhang, Huazhu Fu, Yitian Zhao et al.

Generative Adversarial Networks (GANs) have the capability of synthesizing images, which have been successfully applied to medical image synthesis tasks. However, most of existing methods merely consider the global contextual information and ignore the fine foreground structures, e.g., vessel, skeleton, which may contain diagnostic indicators for medical image analysis. Inspired by human painting procedure, which is composed of stroking and color rendering steps, we propose a Sketching-rendering Unconditional Generative Adversarial Network (SkrGAN) to introduce a sketch prior constraint to guide the medical image generation. In our SkrGAN, a sketch guidance module is utilized to generate a high quality structural sketch from random noise, then a color render mapping is used to embed the sketch-based representations and resemble the background appearances. Experimental results show that the proposed SkrGAN achieves the state-of-the-art results in synthesizing images for various image modalities, including retinal color fundus, X-Ray, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). In addition, we also show that the performances of medical image segmentation method have been improved by using our synthesized images as data augmentation.