Lian Liu

Yuhao Huang, Xin Yang, Lian Liu et al.

The Segment Anything Model (SAM) is the first foundation model for general image segmentation. It has achieved impressive results on various natural image segmentation tasks. However, medical image segmentation (MIS) is more challenging because of the complex modalities, fine anatomical structures, uncertain and complex object boundaries, and wide-range object scales. To fully validate SAM's performance on medical data, we collected and sorted 53 open-source datasets and built a large medical segmentation dataset with 18 modalities, 84 objects, 125 object-modality paired targets, 1050K 2D images, and 6033K masks. We comprehensively analyzed different models and strategies on the so-called COSMOS 1050K dataset. Our findings mainly include the following: 1) SAM showed remarkable performance in some specific objects but was unstable, imperfect, or even totally failed in other situations. 2) SAM with the large ViT-H showed better overall performance than that with the small ViT-B. 3) SAM performed better with manual hints, especially box, than the Everything mode. 4) SAM could help human annotation with high labeling quality and less time. 5) SAM was sensitive to the randomness in the center point and tight box prompts, and may suffer from a serious performance drop. 6) SAM performed better than interactive methods with one or a few points, but will be outpaced as the number of points increases. 7) SAM's performance correlated to different factors, including boundary complexity, intensity differences, etc. 8) Finetuning the SAM on specific medical tasks could improve its average DICE performance by 4.39% and 6.68% for ViT-B and ViT-H, respectively. We hope that this comprehensive report can help researchers explore the potential of SAM applications in MIS, and guide how to appropriately use and develop SAM.

Lian Liu, Han Zhou, Jiongquan Chen et al.

Deep neural networks have been widely applied in dichotomous medical image segmentation (DMIS) of many anatomical structures in several modalities, achieving promising performance. However, existing networks tend to struggle with task-specific, heavy and complex designs to improve accuracy. They made little instructions to which feature channels would be more beneficial for segmentation, and that may be why the performance and universality of these segmentation models are hindered. In this study, we propose an instructive feature enhancement approach, namely IFE, to adaptively select feature channels with rich texture cues and strong discriminability to enhance raw features based on local curvature or global information entropy criteria. Being plug-and-play and applicable for diverse DMIS tasks, IFE encourages the model to focus on texture-rich features which are especially important for the ambiguous and challenging boundary identification, simultaneously achieving simplicity, universality, and certain interpretability. To evaluate the proposed IFE, we constructed the first large-scale DMIS dataset Cosmos55k, which contains 55,023 images from 7 modalities and 26 anatomical structures. Extensive experiments show that IFE can improve the performance of classic segmentation networks across different anatomies and modalities with only slight modifications. Code is available at https://github.com/yezi-66/IFE

Han Zhou, Dong Ni, Ao Chang et al.

Ultrasound (US) imaging is indispensable in clinical practice. To diagnose certain diseases, sonographers must observe corresponding dynamic anatomic structures to gather comprehensive information. However, the limited availability of specific US video cases causes teaching difficulties in identifying corresponding diseases, which potentially impacts the detection rate of such cases. The synthesis of US videos may represent a promising solution to this issue. Nevertheless, it is challenging to accurately animate the intricate motion of dynamic anatomic structures while preserving image fidelity. To address this, we present a novel online feature-decoupling framework called OnUVS for high-fidelity US video synthesis. Our highlights can be summarized by four aspects. First, we introduced anatomic information into keypoint learning through a weakly-supervised training strategy, resulting in improved preservation of anatomical integrity and motion while minimizing the labeling burden. Second, to better preserve the integrity and textural information of US images, we implemented a dual-decoder that decouples the content and textural features in the generator. Third, we adopted a multiple-feature discriminator to extract a comprehensive range of visual cues, thereby enhancing the sharpness and fine details of the generated videos. Fourth, we constrained the motion trajectories of keypoints during online learning to enhance the fluidity of generated videos. Our validation and user studies on in-house echocardiographic and pelvic floor US videos showed that OnUVS synthesizes US videos with high fidelity.

Zhongnuo Yan, Tong Han, Yuhao Huang et al.

Medical image segmentation aims to delineate the anatomical or pathological structures of interest, playing a crucial role in clinical diagnosis. A substantial amount of high-quality annotated data is crucial for constructing high-precision deep segmentation models. However, medical annotation is highly cumbersome and time-consuming, especially for medical videos or 3D volumes, due to the huge labeling space and poor inter-frame consistency. Recently, a fundamental task named Moving Object Segmentation (MOS) has made significant advancements in natural images. Its objective is to delineate moving objects from the background within image sequences, requiring only minimal annotations. In this paper, we propose the first foundation model, named iMOS, for MOS in medical images. Extensive experiments on a large multi-modal medical dataset validate the effectiveness of the proposed iMOS. Specifically, with the annotation of only a small number of images in the sequence, iMOS can achieve satisfactory tracking and segmentation performance of moving objects throughout the entire sequence in bi-directions. We hope that the proposed iMOS can help accelerate the annotation speed of experts, and boost the development of medical foundation models.

Zhongnuo Yan, Xin Yang, Mingyuan Luo et al.

Fine-grained spatio-temporal learning is crucial for freehand 3D ultrasound reconstruction. Previous works mainly resorted to the coarse-grained spatial features and the separated temporal dependency learning and struggles for fine-grained spatio-temporal learning. Mining spatio-temporal information in fine-grained scales is extremely challenging due to learning difficulties in long-range dependencies. In this context, we propose a novel method to exploit the long-range dependency management capabilities of the state space model (SSM) to address the above challenge. Our contribution is three-fold. First, we propose ReMamba, which mines multi-scale spatio-temporal information by devising a multi-directional SSM. Second, we propose an adaptive fusion strategy that introduces multiple inertial measurement units as auxiliary temporal information to enhance spatio-temporal perception. Last, we design an online alignment strategy that encodes the temporal information as pseudo labels for multi-modal alignment to further improve reconstruction performance. Extensive experimental validations on two large-scale datasets show remarkable improvement from our method over competitors.

Guanchen Li, Xiandong Zhao, Lian Liu et al.

Pre-trained language models (PLMs) are engineered to be robust in contextual understanding and exhibit outstanding performance in various natural language processing tasks. However, their considerable size incurs significant computational and storage costs. Modern pruning strategies employ one-shot techniques to compress PLMs without the need for retraining on task-specific or otherwise general data; however, these approaches often lead to an indispensable reduction in performance. In this paper, we propose SDS, a Sparse-Dense-Sparse pruning framework to enhance the performance of the pruned PLMs from a weight distribution optimization perspective. We outline the pruning process in three steps. Initially, we prune less critical connections in the model using conventional one-shot pruning methods. Next, we reconstruct a dense model featuring a pruning-friendly weight distribution by reactivating pruned connections with sparse regularization. Finally, we perform a second pruning round, yielding a superior pruned model compared to the initial pruning. Experimental results demonstrate that SDS outperforms the state-of-the-art pruning techniques SparseGPT and Wanda under an identical sparsity configuration. For instance, SDS reduces perplexity by 9.13 on Raw-Wikitext2 and improves accuracy by an average of 2.05% across multiple zero-shot benchmarks for OPT-125M with 2:4 sparsity.

Zhe Liu, Xiliang Zhu, Tong Han et al.

Mitral regurgitation (MR) is a serious heart valve disease. Early and accurate diagnosis of MR via ultrasound video is critical for timely clinical decision-making and surgical intervention. However, manual MR diagnosis heavily relies on the operator's experience, which may cause misdiagnosis and inter-observer variability. Since MR data is limited and has large intra-class variability, we propose an unsupervised out-of-distribution (OOD) detection method to identify MR rather than building a deep classifier. To our knowledge, we are the first to explore OOD in MR ultrasound videos. Our method consists of a feature extractor, a feature reconstruction model, and a residual accumulation amplification algorithm. The feature extractor obtains features from the video clips and feeds them into the feature reconstruction model to restore the original features. The residual accumulation amplification algorithm then iteratively performs noise feature reconstruction, amplifying the reconstructed error of OOD features. This algorithm is straightforward yet efficient and can seamlessly integrate as a plug-and-play component in reconstruction-based OOD detection methods. We validated the proposed method on a large ultrasound dataset containing 893 non-MR and 267 MR videos. Experimental results show that our OOD detection method can effectively identify MR samples.

Liguo Zhou, Yinglei Song, Yichao Gao et al.

Conducting real road testing for autonomous driving algorithms can be expensive and sometimes impractical, particularly for small startups and research institutes. Thus, simulation becomes an important method for evaluating these algorithms. However, the availability of free and open-source simulators is limited, and the installation and configuration process can be daunting for beginners and interdisciplinary researchers. We introduce an autonomous driving simulator with photorealistic scenes, meanwhile keeping a user-friendly workflow. The simulator is able to communicate with external algorithms through ROS2 or Socket.IO, making it compatible with existing software stacks. Furthermore, we implement a highly accurate vehicle dynamics model within the simulator to enhance the realism of the vehicle's physical effects. The simulator is able to serve various functions, including generating synthetic data and driving with machine learning-based algorithms. Moreover, we prioritize simplicity in the deployment process, ensuring that beginners find it approachable and user-friendly.

Yudong Pan, Yintao He, Tianhua Han et al.

To deploy large Mixture-of-Experts (MoE) models cost-effectively, offloading-based single-GPU heterogeneous inference is crucial. While GPU-CPU architectures that offload cold experts are constrained by host memory bandwidth, emerging GPU-NDP architectures utilize DIMM-NDP to offload non-hot experts. However, non-hot experts are not a homogeneous memory-bound group: a significant subset of warm experts exists is severely penalized by high GPU I/O latency yet can saturate NDP compute throughput, exposing a critical compute gap. We present TriMoE, a novel GPU-CPU-NDP architecture that fills this gap by synergistically leveraging AMX-enabled CPU to precisely map hot, warm, and cold experts onto their optimal compute units. We further introduce a bottleneck-aware expert scheduling policy and a prediction-driven dynamic relayout/rebalancing scheme. Experiments demonstrate that TriMoE achieves up to 2.83x speedup over state-of-the-art solutions.

Zhe Liu, Yuhao Huang, Lian Liu et al.

Color Doppler echocardiography is a crucial tool for diagnosing mitral regurgitation (MR). Recent studies have explored intelligent methods for MR diagnosis to minimize user dependence and improve accuracy. However, these approaches often fail to align with clinical workflow and may lead to suboptimal accuracy and interpretability. In this study, we introduce an automated MR diagnosis model (MReg) developed on the 4-chamber cardiac color Doppler echocardiography video (A4C-CDV). It follows comprehensive feature mining strategies to detect MR and assess its severity, considering clinical realities. Our contribution is threefold. First, we formulate the MR diagnosis as a regression task to capture the continuity and ordinal relationships between categories. Second, we design a feature selection and amplification mechanism to imitate the sonographer's diagnostic logic for accurate MR grading. Third, inspired by the Mixture-of-Experts concept, we introduce a feature summary module to extract the category-level features, enhancing the representational capacity for more accurate grading. We trained and evaluated our proposed MReg on a large in-house A4C-CDV dataset comprising 1868 cases with three graded regurgitation labels. Compared to other weakly supervised video anomaly detection and supervised classification methods, MReg demonstrated superior performance in MR diagnosis. Our code is available at: https://github.com/cskdstz/MReg.

Marcos V. Conde, Radu Timofte, Zihao Lu et al.

This paper reviews the NTIRE 2025 RAW Image Restoration and Super-Resolution Challenge, highlighting the proposed solutions and results. New methods for RAW Restoration and Super-Resolution could be essential in modern Image Signal Processing (ISP) pipelines, however, this problem is not as explored as in the RGB domain. The goal of this challenge is two fold, (i) restore RAW images with blur and noise degradations, (ii) upscale RAW Bayer images by 2x, considering unknown noise and blur. In the challenge, a total of 230 participants registered, and 45 submitted results during thee challenge period. This report presents the current state-of-the-art in RAW Restoration.

Jian Wang, Xin Yang, Xiaohong Jia et al.

Thyroid nodule classification and segmentation in ultrasound images are crucial for computer-aided diagnosis; however, they face limitations owing to insufficient labeled data. In this study, we proposed a multi-view contrastive self-supervised method to improve thyroid nodule classification and segmentation performance with limited manual labels. Our method aligns the transverse and longitudinal views of the same nodule, thereby enabling the model to focus more on the nodule area. We designed an adaptive loss function that eliminates the limitations of the paired data. Additionally, we adopted a two-stage pre-training to exploit the pre-training on ImageNet and thyroid ultrasound images. Extensive experiments were conducted on a large-scale dataset collected from multiple centers. The results showed that the proposed method significantly improves nodule classification and segmentation performance with limited manual labels and outperforms state-of-the-art self-supervised methods. The two-stage pre-training also significantly exceeded ImageNet pre-training.

Lian Liu, Haimeng Ren, Long Cheng et al.

Quantization is a widely-used compression technology to reduce the overhead of serving large language models (LLMs) on terminal devices and in cloud data centers. However, prevalent quantization methods, such as 8-bit weight-activation or 4-bit weight-only quantization, achieve limited performance improvements due to poor support for low-precision (e.g., 4-bit) activation. This work, for the first time, realizes practical W4A4KV4 serving for LLMs, fully utilizing the INT4 tensor cores on modern GPUs and reducing the memory bottleneck caused by the KV cache. Specifically, we propose a novel fine-grained mixed-precision quantization algorithm (FMPQ) that compresses most activations into 4-bit with negligible accuracy loss. To support mixed-precision matrix multiplication for W4A4 and W4A8, we develop a highly optimized W4Ax kernel. Our approach introduces a novel mixed-precision data layout to facilitate access and fast dequantization for activation and weight tensors, utilizing the GPU's software pipeline to hide the overhead of data loading and conversion. Additionally, we propose fine-grained streaming multiprocessor (SM) scheduling to achieve load balance across different SMs. We integrate the optimized W4Ax kernel into our inference framework, COMET, and provide efficient management to support popular LLMs such as LLaMA-3-70B. Extensive evaluations demonstrate that, when running LLaMA family models on a single A100-80G-SMX4, COMET achieves a kernel-level speedup of \textbf{$2.88\times$} over cuBLAS and a \textbf{$2.02 \times$} throughput improvement compared to TensorRT-LLM from an end-to-end framework perspective.

Linhua Kong, Dongxia Chang, Lian Liu et al.

Recently, 3D object detection algorithms based on radar and camera fusion have shown excellent performance, setting the stage for their application in autonomous driving perception tasks. Existing methods have focused on dealing with feature misalignment caused by the domain gap between radar and camera. However, existing methods either neglect inter-modal features interaction during alignment or fail to effectively align features at the same spatial location across modalities. To alleviate the above problems, we propose a new alignment model called Radar Camera Alignment (RCAlign). Specifically, we design a Dual-Route Alignment (DRA) module based on contrastive learning to align and fuse the features between radar and camera. Moreover, considering the sparsity of radar BEV features, a Radar Feature Enhancement (RFE) module is proposed to improve the densification of radar BEV features with the knowledge distillation loss. Experiments show RCAlign achieves a new state-of-the-art on the public nuScenes benchmark in radar camera fusion for 3D Object Detection. Furthermore, the RCAlign achieves a significant performance gain (4.3\% NDS and 8.4\% mAP) in real-time 3D detection compared to the latest state-of-the-art method (RCBEVDet).

Lian Liu, liguo Zhou

CNN-based face detection methods have achieved significant progress in recent years. In addition to the strong representation ability of CNN, post-processing methods are also very important for the performance of face detection. In general, the face detection method predicts several candidate bounding-boxes for one face. NMS is used to filter out inaccurate candidate boxes to get the most accurate box. The principle of NMS is to select the box with a higher score as the basic box and then delete the box which has a large overlapping area with the basic box but has a lower score. However, the current NMS method and its improved versions do not perform well when face image quality is poor or faces are in a cluster. In these situations, even after NMS filtering, there is often a face corresponding to multiple predicted boxes. To reduce this kind of negative result, in this paper, we propose a new NMS method that operates in the reverse order of other NMS methods. Our method performs well on low-quality and tiny face samples. Experiments demonstrate that our method is effective as a post-processor for different face detection methods.

Xi Long, Ying Cheng, Xiao Mu et al.

We present a summary of the domain adaptive cascade R-CNN method for mitosis detection of digital histopathology images. By comprehensive data augmentation and adapting existing popular detection architecture, our proposed method has achieved an F1 score of 0.7500 on the preliminary test set in MItosis DOmain Generalization (MIDOG) Challenge at MICCAI 2021.