Xinyu Huang

Haoyuan Chen, Chen Li, Xiaoyan Li et al.

In recent years, colorectal cancer has become one of the most significant diseases that endanger human health. Deep learning methods are increasingly important for the classification of colorectal histopathology images. However, existing approaches focus more on end-to-end automatic classification using computers rather than human-computer interaction. In this paper, we propose an IL-MCAM framework. It is based on attention mechanisms and interactive learning. The proposed IL-MCAM framework includes two stages: automatic learning (AL) and interactivity learning (IL). In the AL stage, a multi-channel attention mechanism model containing three different attention mechanism channels and convolutional neural networks is used to extract multi-channel features for classification. In the IL stage, the proposed IL-MCAM framework continuously adds misclassified images to the training set in an interactive approach, which improves the classification ability of the MCAM model. We carried out a comparison experiment on our dataset and an extended experiment on the HE-NCT-CRC-100K dataset to verify the performance of the proposed IL-MCAM framework, achieving classification accuracies of 98.98% and 99.77%, respectively. In addition, we conducted an ablation experiment and an interchangeability experiment to verify the ability and interchangeability of the three channels. The experimental results show that the proposed IL-MCAM framework has excellent performance in the colorectal histopathological image classification tasks.

Yuchao Zheng, Chen Li, Xiaomin Zhou et al.

Background: Breast cancer has the highest prevalence in women globally. The classification and diagnosis of breast cancer and its histopathological images have always been a hot spot of clinical concern. In Computer-Aided Diagnosis (CAD), traditional classification models mostly use a single network to extract features, which has significant limitations. On the other hand, many networks are trained and optimized on patient-level datasets, ignoring the application of lower-level data labels. Method: This paper proposes a deep ensemble model based on image-level labels for the binary classification of benign and malignant lesions of breast histopathological images. First, the BreaKHis dataset is randomly divided into a training, validation and test set. Then, data augmentation techniques are used to balance the number of benign and malignant samples. Thirdly, considering the performance of transfer learning and the complementarity between each network, VGG16, Xception, ResNet50, DenseNet201 are selected as the base classifiers. Result: In the ensemble network model with accuracy as the weight, the image-level binary classification achieves an accuracy of $98.90\%$. In order to verify the capabilities of our method, the latest Transformer and Multilayer Perception (MLP) models have been experimentally compared on the same dataset. Our model wins with a $5\%-20\%$ advantage, emphasizing the ensemble model's far-reaching significance in classification tasks. Conclusion: This research focuses on improving the model's classification performance with an ensemble algorithm. Transfer learning plays an essential role in small datasets, improving training speed and accuracy. Our model has outperformed many existing approaches in accuracy, providing a method for the field of auxiliary medical diagnosis.

Xinyu Huang, Youcai Zhang, Ying Cheng et al.

Vision-Language Pre-training (VLP) with large-scale image-text pairs has demonstrated superior performance in various fields. However, the image-text pairs co-occurrent on the Internet typically lack explicit alignment information, which is suboptimal for VLP. Existing methods proposed to adopt an off-the-shelf object detector to utilize additional image tag information. However, the object detector is time-consuming and can only identify the pre-defined object categories, limiting the model capacity. Inspired by the observation that the texts incorporate incomplete fine-grained image information, we introduce IDEA, which stands for increasing text diversity via online multi-label recognition for VLP. IDEA shows that multi-label learning with image tags extracted from the texts can be jointly optimized during VLP. Moreover, IDEA can identify valuable image tags online to provide more explicit textual supervision. Comprehensive experiments demonstrate that IDEA can significantly boost the performance on multiple downstream datasets with a small extra computational cost.

Shuojia Zou, Chen Li, Hongzan Sun et al.

The detection of tiny objects in microscopic videos is a problematic point, especially in large-scale experiments. For tiny objects (such as sperms) in microscopic videos, current detection methods face challenges in fuzzy, irregular, and precise positioning of objects. In contrast, we present a convolutional neural network for tiny object detection (TOD-CNN) with an underlying data set of high-quality sperm microscopic videos (111 videos, $>$ 278,000 annotated objects), and a graphical user interface (GUI) is designed to employ and test the proposed model effectively. TOD-CNN is highly accurate, achieving $85.60\%$ AP$_{50}$ in the task of real-time sperm detection in microscopic videos. To demonstrate the importance of sperm detection technology in sperm quality analysis, we carry out relevant sperm quality evaluation metrics and compare them with the diagnosis results from medical doctors.

Weiming Hu, Haoyuan Chen, Wanli Liu et al.

Gastric cancer is the fifth most common cancer in the world. At the same time, it is also the fourth most deadly cancer. Early detection of cancer exists as a guide for the treatment of gastric cancer. Nowadays, computer technology has advanced rapidly to assist physicians in the diagnosis of pathological pictures of gastric cancer. Ensemble learning is a way to improve the accuracy of algorithms, and finding multiple learning models with complementarity types is the basis of ensemble learning. The complementarity of sub-size pathology image classifiers when machine performance is insufficient is explored in this experimental platform. We choose seven classical machine learning classifiers and four deep learning classifiers for classification experiments on the GasHisSDB database. Among them, classical machine learning algorithms extract five different image virtual features to match multiple classifier algorithms. For deep learning, we choose three convolutional neural network classifiers. In addition, we also choose a novel Transformer-based classifier. The experimental platform, in which a large number of classical machine learning and deep learning methods are performed, demonstrates that there are differences in the performance of different classifiers on GasHisSDB. Classical machine learning models exist for classifiers that classify Abnormal categories very well, while classifiers that excel in classifying Normal categories also exist. Deep learning models also exist with multiple models that can be complementarity. Suitable classifiers are selected for ensemble learning, when machine performance is insufficient. This experimental platform demonstrates that multiple classifiers are indeed complementarity and can improve the efficiency of ensemble learning. This can better assist doctors in diagnosis, improve the detection of gastric cancer, and increase the cure rate.

Yuyan Li, Yuliang Guo, Zhixin Yan et al.

A well-known challenge in applying deep-learning methods to omnidirectional images is spherical distortion. In dense regression tasks such as depth estimation, where structural details are required, using a vanilla CNN layer on the distorted 360 image results in undesired information loss. In this paper, we propose a 360 monocular depth estimation pipeline, OmniFusion, to tackle the spherical distortion issue. Our pipeline transforms a 360 image into less-distorted perspective patches (i.e. tangent images) to obtain patch-wise predictions via CNN, and then merge the patch-wise results for final output. To handle the discrepancy between patch-wise predictions which is a major issue affecting the merging quality, we propose a new framework with the following key components. First, we propose a geometry-aware feature fusion mechanism that combines 3D geometric features with 2D image features to compensate for the patch-wise discrepancy. Second, we employ the self-attention-based transformer architecture to conduct a global aggregation of patch-wise information, which further improves the consistency. Last, we introduce an iterative depth refinement mechanism, to further refine the estimated depth based on the more accurate geometric features. Experiments show that our method greatly mitigates the distortion issue, and achieves state-of-the-art performances on several 360 monocular depth estimation benchmark datasets.

Haiqing Zhang, Chen Li, Shiliang Ai et al.

The gold standard for gastric cancer detection is gastric histopathological image analysis, but there are certain drawbacks in the existing histopathological detection and diagnosis. In this paper, based on the study of computer aided diagnosis system, graph based features are applied to gastric cancer histopathology microscopic image analysis, and a classifier is used to classify gastric cancer cells from benign cells. Firstly, image segmentation is performed, and after finding the region, cell nuclei are extracted using the k-means method, the minimum spanning tree (MST) is drawn, and graph based features of the MST are extracted. The graph based features are then put into the classifier for classification. In this study, different segmentation methods are compared in the tissue segmentation stage, among which are Level-Set, Otsu thresholding, watershed, SegNet, U-Net and Trans-U-Net segmentation; Graph based features, Red, Green, Blue features, Grey-Level Co-occurrence Matrix features, Histograms of Oriented Gradient features and Local Binary Patterns features are compared in the feature extraction stage; Radial Basis Function (RBF) Support Vector Machine (SVM), Linear SVM, Artificial Neural Network, Random Forests, k-NearestNeighbor, VGG16, and Inception-V3 are compared in the classifier stage. It is found that using U-Net to segment tissue areas, then extracting graph based features, and finally using RBF SVM classifier gives the optimal results with 94.29%.

Yunhao Ge, Hong-Xing Yu, Cheng Zhao et al. · stanford

A major challenge in monocular 3D object detection is the limited diversity and quantity of objects in real datasets. While augmenting real scenes with virtual objects holds promise to improve both the diversity and quantity of the objects, it remains elusive due to the lack of an effective 3D object insertion method in complex real captured scenes. In this work, we study augmenting complex real indoor scenes with virtual objects for monocular 3D object detection. The main challenge is to automatically identify plausible physical properties for virtual assets (e.g., locations, appearances, sizes, etc.) in cluttered real scenes. To address this challenge, we propose a physically plausible indoor 3D object insertion approach to automatically copy virtual objects and paste them into real scenes. The resulting objects in scenes have 3D bounding boxes with plausible physical locations and appearances. In particular, our method first identifies physically feasible locations and poses for the inserted objects to prevent collisions with the existing room layout. Subsequently, it estimates spatially-varying illumination for the insertion location, enabling the immersive blending of the virtual objects into the original scene with plausible appearances and cast shadows. We show that our augmentation method significantly improves existing monocular 3D object models and achieves state-of-the-art performance. For the first time, we demonstrate that a physically plausible 3D object insertion, serving as a generative data augmentation technique, can lead to significant improvements for discriminative downstream tasks such as monocular 3D object detection. Project website: https://gyhandy.github.io/3D-Copy-Paste/

Cheng Zhao, Su Sun, Ruoyu Wang et al.

Most 3D Gaussian Splatting (3D-GS) based methods for urban scenes initialize 3D Gaussians directly with 3D LiDAR points, which not only underutilizes LiDAR data capabilities but also overlooks the potential advantages of fusing LiDAR with camera data. In this paper, we design a novel tightly coupled LiDAR-Camera Gaussian Splatting (TCLC-GS) to fully leverage the combined strengths of both LiDAR and camera sensors, enabling rapid, high-quality 3D reconstruction and novel view RGB/depth synthesis. TCLC-GS designs a hybrid explicit (colorized 3D mesh) and implicit (hierarchical octree feature) 3D representation derived from LiDAR-camera data, to enrich the properties of 3D Gaussians for splatting. 3D Gaussian's properties are not only initialized in alignment with the 3D mesh which provides more completed 3D shape and color information, but are also endowed with broader contextual information through retrieved octree implicit features. During the Gaussian Splatting optimization process, the 3D mesh offers dense depth information as supervision, which enhances the training process by learning of a robust geometry. Comprehensive evaluations conducted on the Waymo Open Dataset and nuScenes Dataset validate our method's state-of-the-art (SOTA) performance. Utilizing a single NVIDIA RTX 3090 Ti, our method demonstrates fast training and achieves real-time RGB and depth rendering at 90 FPS in resolution of 1920x1280 (Waymo), and 120 FPS in resolution of 1600x900 (nuScenes) in urban scenarios.

Yuliang Guo, Abhinav Kumar, Cheng Zhao et al.

Monocular 3D reconstruction for categorical objects heavily relies on accurately perceiving each object's pose. While gradient-based optimization in a NeRF framework updates the initial pose, this paper highlights that scale-depth ambiguity in monocular object reconstruction causes failures when the initial pose deviates moderately from the true pose. Consequently, existing methods often depend on a third-party 3D object to provide an initial object pose, leading to increased complexity and generalization issues. To address these challenges, we present SUP-NeRF, a Streamlined Unification of object Pose estimation and NeRF-based object reconstruction. SUP-NeRF decouples the object's dimension estimation and pose refinement to resolve the scale-depth ambiguity, and introduces a camera-invariant projected-box representation that generalizes cross different domains. While using a dedicated pose estimator that smoothly integrates into an object-centric NeRF, SUP-NeRF is free from external 3D detectors. SUP-NeRF achieves state-of-the-art results in both reconstruction and pose estimation tasks on the nuScenes dataset. Furthermore, SUP-NeRF exhibits exceptional cross-dataset generalization on the KITTI and Waymo datasets, surpassing prior methods with up to 50\% reduction in rotation and translation error.

Weiming Hu, Chen Li, Xiaoyan Li et al.

Background and purpose: Colorectal cancer has become the third most common cancer worldwide, accounting for approximately 10% of cancer patients. Early detection of the disease is important for the treatment of colorectal cancer patients. Histopathological examination is the gold standard for screening colorectal cancer. However, the current lack of histopathological image datasets of colorectal cancer, especially enteroscope biopsies, hinders the accurate evaluation of computer-aided diagnosis techniques. Methods: A new publicly available Enteroscope Biopsy Histopathological H&E Image Dataset (EBHI) is published in this paper. To demonstrate the effectiveness of the EBHI dataset, we have utilized several machine learning, convolutional neural networks and novel transformer-based classifiers for experimentation and evaluation, using an image with a magnification of 200x. Results: Experimental results show that the deep learning method performs well on the EBHI dataset. Traditional machine learning methods achieve maximum accuracy of 76.02% and deep learning method achieves a maximum accuracy of 95.37%. Conclusion: To the best of our knowledge, EBHI is the first publicly available colorectal histopathology enteroscope biopsy dataset with four magnifications and five types of images of tumor differentiation stages, totaling 5532 images. We believe that EBHI could attract researchers to explore new classification algorithms for the automated diagnosis of colorectal cancer, which could help physicians and patients in clinical settings.

Jian Wu, Wanli Liu, Chen Li et al.

Image analysis technology is used to solve the inadvertences of artificial traditional methods in disease, wastewater treatment, environmental change monitoring analysis and convolutional neural networks (CNN) play an important role in microscopic image analysis. An important step in detection, tracking, monitoring, feature extraction, modeling and analysis is image segmentation, in which U-Net has increasingly applied in microscopic image segmentation. This paper comprehensively reviews the development history of U-Net, and analyzes various research results of various segmentation methods since the emergence of U-Net and conducts a comprehensive review of related papers. First, this paper has summarized the improved methods of U-Net and then listed the existing significance of image segmentation techniques and their improvements that has introduced over the years. Finally, focusing on the different improvement strategies of U-Net in different papers, the related work of each application target is reviewed according to detailed technical categories to facilitate future research. Researchers can clearly see the dynamics of transmission of technological development and keep up with future trends in this interdisciplinary field.

Yan Xia, Yang Zhang, Dingfu Zhou et al.

3D point cloud generation by the deep neural network from a single image has been attracting more and more researchers' attention. However, recently-proposed methods require the objects be captured with relatively clean backgrounds, fixed viewpoint, while this highly limits its application in the real environment. To overcome these drawbacks, we proposed to integrate the prior 3D shape knowledge into the network to guide the 3D generation. By taking additional 3D information, the proposed network can handle the 3D object generation from a single real image captured from any viewpoint and complex background. Specifically, giving a query image, we retrieve the nearest shape model from a pre-prepared 3D model database. Then, the image together with the retrieved shape model is fed into the proposed network to generate the fine-grained 3D point cloud. The effectiveness of our proposed framework has been verified on different kinds of datasets. Experimental results show that the proposed framework achieves state-of-the-art accuracy compared to other volumetric-based and point set generation methods. Furthermore, the proposed framework works well for real images in complex backgrounds with various view angles.

Qichuan Geng, Xinyu Huang, Zhong Zhou et al.

Confusing classes that are ubiquitous in real world often degrade performance for many vision related applications like object detection, classification, and segmentation. The confusion errors are not only caused by similar visual patterns but also amplified by various factors during the training of our designed models, such as reduced feature resolution in the encoding process or imbalanced data distributions. A large amount of deep learning based network structures has been proposed in recent years to deal with these individual factors and improve network performance. However, to our knowledge, no existing work in semantic image segmentation is designed to tackle confusion errors explicitly. In this paper, we present a novel and general network structure that reduces confusion errors in more direct manner and apply the network for semantic segmentation. There are two major contributions in our network structure: 1) We ensemble subnets with heterogeneous output spaces based on the discriminative confusing groups. The training for each subnet can distinguish confusing classes within the group without affecting unrelated classes outside the group. 2) We propose an improved cross-entropy loss function that maximizes the probability assigned to the correct class and penalizes the probabilities assigned to the confusing classes at the same time. Our network structure is a general structure and can be easily adapted to any other networks to further reduce confusion errors. Without any changes in the feature encoder and post-processing steps, our experiments demonstrate consistent and significant improvements on different baseline models on Cityscapes and PASCAL VOC datasets (e.g., 3.05% over ResNet-101 and 1.30% over ResNet-38).