Jianxiang An

Sijing Li, Zhongwei Qiu, Jiang Liu et al.

Accurate tumor analysis is central to clinical radiology and precision oncology, where early detection, reliable lesion characterization, and pathology-level risk assessment guide diagnosis and treatment planning. Chain-of-Thought (CoT) reasoning is particularly important in this setting because it enables step-by-step interpretation from imaging findings to clinical impressions and pathology conclusions, improving traceability and reducing diagnostic errors. Here, we target the clinical tumor analysis task and build a large-scale benchmark that operationalizes a multimodal reasoning pipeline, spanning findings, impressions, and pathology predictions. We curate TumorCoT, a large-scale dataset of 1.5M CoT-labeled VQA instructions paired with 3D CT scans, with step-aligned rationales and cross-modal alignments along the trajectory from findings to impression to pathology, enabling evaluation of both answer accuracy and reasoning consistency. We further propose TumorChain, a multimodal interleaved reasoning framework that tightly couples 3D imaging encoders, clinical text understanding, and organ-level vision-language alignment. Through cross-modal alignment and iterative interleaved causal reasoning, TumorChain grounds visual evidence, aggregates conclusions, and issues pathology predictions after multiple rounds of self-refinement, improving traceability and reducing hallucination risk. Experiments show consistent improvements over strong baselines in lesion detection, impression generation, and pathology classification, and demonstrate strong generalization on the DeepTumorVQA benchmark. These results highlight the potential of multimodal reasoning for reliable and interpretable tumor analysis in clinical practice. Detailed information about our project can be found on our project homepage at https://github.com/ZJU4HealthCare/TumorChain.

Yang Dai, Jianxiang An, Tianwei Lin et al.

Multimodal Large Language Models (MLLMs) have achieved success across various domains. However, their applicability tends to degrade when confronted with different types of data inputs, especially for MLLMs that have been fine-tuned for specific tasks. Despite its importance, the study of knowledge sharing among domain-specific MLLMs--such as those trained for mathematics or code--remains largely underexplored. To address the fragmentation of knowledge across domain-specialized MLLMs, we propose a unified parameter integration framework that enables modular composition of expert capabilities. Our method is grounded in a novel Compatibility-Aware Parameter Splicing (CAPS) strategy, which leverages both local functional attribution and global information-theoretic signals to guide selective parameter fusion. By extending this mechanism to the low-rank adaptation layer granularity, we ensure efficient integration with minimal inference overhead. Furthermore, we introduce a domain compatibility scoring mechanism that quantifies inter-expert alignment at the activation level and correlates with downstream task utility. This principled fusion protocol allows the final model to synergize heterogeneous expertise while preserving structural modularity. Extensive evaluations across diverse multimodal benchmarks validate the effectiveness of our framework, offering a scalable path toward compositional, domain-adaptive MLLMs.

Haoyu Zheng, Wenqiao Zhang, Zheqi Lv et al.

Diffusion-based text-to-image (T2I) models have demonstrated remarkable results in global video editing tasks. However, their focus is primarily on global video modifications, and achieving desired attribute-specific changes remains a challenging task, specifically in multi-attribute editing (MAE) in video. Contemporary video editing approaches either require extensive fine-tuning or rely on additional networks (such as ControlNet) for modeling multi-object appearances, yet they remain in their infancy, offering only coarse-grained MAE solutions. In this paper, we present MAKIMA, a tuning-free MAE framework built upon pretrained T2I models for open-domain video editing. Our approach preserves video structure and appearance information by incorporating attention maps and features from the inversion process during denoising. To facilitate precise editing of multiple attributes, we introduce mask-guided attention modulation, enhancing correlations between spatially corresponding tokens and suppressing cross-attribute interference in both self-attention and cross-attention layers. To balance video frame generation quality and efficiency, we implement consistent feature propagation, which generates frame sequences by editing keyframes and propagating their features throughout the sequence. Extensive experiments demonstrate that MAKIMA outperforms existing baselines in open-domain multi-attribute video editing tasks, achieving superior results in both editing accuracy and temporal consistency while maintaining computational efficiency.