Joie Yeahuay Wu

Yi Ren Fung, Ziqiang Guan, Ritesh Kumar et al.

In recent years, many papers have reported state-of-the-art performance on Alzheimer's Disease classification with MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset using convolutional neural networks. However, we discover that when we split that data into training and testing sets at the subject level, we are not able to obtain similar performance, bringing the validity of many of the previous studies into question. Furthermore, we point out that previous works use different subsets of the ADNI data, making comparison across similar works tricky. In this study, we present the results of three splitting methods, discuss the motivations behind their validity, and report our results using all of the available subjects.

Surya Teja Devarakonda, Joie Yeahuay Wu, Yi Ren Fung et al.

Computational models that forecast the progression of Alzheimer's disease at the patient level are extremely useful tools for identifying high risk cohorts for early intervention and treatment planning. The state-of-the-art work in this area proposes models that forecast by using latent representations extracted from the longitudinal data across multiple modalities, including volumetric information extracted from medical scans and demographic info. These models incorporate the time horizon, which is the amount of time between the last recorded visit and the future visit, by directly concatenating a representation of it to the data latent representation. In this paper, we present a model which generates a sequence of latent representations of the patient status across the time horizon, providing more informative modeling of the temporal relationships between the patient's history and future visits. Our proposed model outperforms the baseline in terms of forecasting accuracy and F1 score with the added benefit of robustly handling missing visits.