Antonio M. G. Pinheiro

Rafael Rodrigues, Susana Quijano-Roy, Robert-Yves Carlier et al.

Magnetic Resonance Imaging (MRI) is a non-invasive tool for the clinical assessment of low-prevalence neuromuscular disorders. Automated diagnosis methods might reduce the need for biopsies and provide valuable information on disease follow-up. In this paper, three methods are proposed to classify target muscles in Collagen VI-related myopathy cases, based on their degree of involvement, notably a Convolutional Neural Network, a Fully Connected Network to classify texture features, and a hybrid method combining the two feature sets. The proposed methods were evaluated on axial T1-weighted Turbo Spin-Echo MRI from 26 subjects, including Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy patients at different evolution stages. The hybrid model achieved the best cross-validation results, with a global accuracy of 93.8%, and F-scores of 0.99, 0.82, and 0.95, for healthy, mild and moderate/severe cases, respectively.

Rafael Rodrigues, Antonio M. G. Pinheiro

Segmentation of skeletal muscles in Magnetic Resonance Images (MRI) is essential for the study of muscle physiology and diagnosis of muscular pathologies. However, manual segmentation of large MRI volumes is a time-consuming task. The state-of-the-art on algorithms for muscle segmentation in MRI is still not very extensive and is somewhat database-dependent. In this paper, an automated segmentation method based on AdaBoost classification of local texture features is presented. The texture descriptor consists of the Histogram of Oriented Gradients (HOG), Wavelet-based features, and a set of statistical measures computed from both the original and the Laplacian of Gaussian filtering of the grayscale MRI. The classifier performance suggests that texture analysis may be a helpful tool for designing a generalized and automated MRI muscle segmentation framework. Furthermore, an atlas-based approach to individual muscle segmentation is also described in this paper. The atlas is obtained by overlaying the muscle segmentation ground truth, provided by a radiologist, after image alignment using an appropriate affine transformation. Then, it is used to define the muscle labels upon the AdaBoost binary segmentation. The developed atlas method provides reasonable results when an accurate muscle tissue segmentation was obtained.