Vitor Santos Costa

Finn Kuusisto, Vitor Santos Costa, Zhonggang Hou et al.

There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell cultures, suffer from challenges related to time, cost, and applicability to human physiology. We previously demonstrated success employing machine learning to predict developmental neurotoxicity using gene expression data collected from human 3D tissue models exposed to various compounds. The 3D model is biologically similar to developing neural structures, but its complexity necessitates extensive expertise and effort to employ. By instead focusing solely on constructing an assay of developmental neurotoxicity, we propose that a simpler 2D tissue model may prove sufficient. We thus compare the accuracy of predictive models trained on data from a 2D tissue model with those trained on data from a 3D tissue model, and find the 2D model to be substantially more accurate. Furthermore, we find the 2D model to be more robust under stringent gene set selection, whereas the 3D model suffers substantial accuracy degradation. While both approaches have advantages and disadvantages, we propose that our described 2D approach could be a valuable tool for decision makers when prioritizing neurotoxicity screening.

Elena Bellodi, Evelina Lamma, Fabrizio Riguzzi et al.

Lifted inference has been proposed for various probabilistic logical frameworks in order to compute the probability of queries in a time that depends on the size of the domains of the random variables rather than the number of instances. Even if various authors have underlined its importance for probabilistic logic programming (PLP), lifted inference has been applied up to now only to relational languages outside of logic programming. In this paper we adapt Generalized Counting First Order Variable Elimination (GC-FOVE) to the problem of computing the probability of queries to probabilistic logic programs under the distribution semantics. In particular, we extend the Prolog Factor Language (PFL) to include two new types of factors that are needed for representing ProbLog programs. These factors take into account the existing causal independence relationships among random variables and are managed by the extension to variable elimination proposed by Zhang and Poole for dealing with convergent variables and heterogeneous factors. Two new operators are added to GC-FOVE for treating heterogeneous factors. The resulting algorithm, called LP$^2$ for Lifted Probabilistic Logic Programming, has been implemented by modifying the PFL implementation of GC-FOVE and tested on three benchmarks for lifted inference. A comparison with PITA and ProbLog2 shows the potential of the approach.

Vitor Santos Costa, David Page, Maleeha Qazi et al.

We present CLP(BN), a novel approach that aims at expressing Bayesian networks through the constraint logic programming framework. Arguably, an important limitation of traditional Bayesian networks is that they are propositional, and thus cannot represent relations between multiple similar objects in multiple contexts. Several researchers have thus proposed first-order languages to describe such networks. Namely, one very successful example of this approach are the Probabilistic Relational Models (PRMs), that combine Bayesian networks with relational database technology. The key difficulty that we had to address when designing CLP(cal{BN}) is that logic based representations use ground terms to denote objects. With probabilitic data, we need to be able to uniquely represent an object whose value we are not sure about. We use {sl Skolem functions} as unique new symbols that uniquely represent objects with unknown value. The semantics of CLP(cal{BN}) programs then naturally follow from the general framework of constraint logic programming, as applied to a specific domain where we have probabilistic data. This paper introduces and defines CLP(cal{BN}), and it describes an implementation and initial experiments. The paper also shows how CLP(cal{BN}) relates to Probabilistic Relational Models (PRMs), Ngo and Haddawys Probabilistic Logic Programs, AND Kersting AND De Raedts Bayesian Logic Programs.

Jesse Davis, Vitor Santos Costa, Peggy Peissig et al.

Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs but is less adept at handling their inherent latent structure, such as connections between related medications or diseases. One way to capture the latent structure is via a relational clustering of objects. We propose a novel approach that, instead of pre-clustering the objects, performs a demand-driven clustering during learning. We evaluate our algorithm on three real-world tasks where the goal is to use EMRs to predict whether a patient will have an adverse reaction to a medication. We find that our approach is more accurate than performing no clustering, pre-clustering, and using expert-constructed medical heterarchies.

Kendrick Boyd, Vitor Santos Costa, Jesse Davis et al.

Precision-recall (PR) curves and the areas under them are widely used to summarize machine learning results, especially for data sets exhibiting class skew. They are often used analogously to ROC curves and the area under ROC curves. It is known that PR curves vary as class skew changes. What was not recognized before this paper is that there is a region of PR space that is completely unachievable, and the size of this region depends only on the skew. This paper precisely characterizes the size of that region and discusses its implications for empirical evaluation methodology in machine learning.