Daniel Lai

Jiabei Cheng, Zhen-Qun Yang, Jiannong Cao et al.

In the educational domain, identifying students at risk of dropping out is essential for allowing educators to intervene effectively, improving both academic outcomes and overall student well-being. Data in educational settings often originate from diverse sources, such as assignments, grades, and attendance records. However, most existing research relies on online learning data and just extracting the quantitative features. While quantification eases processing, it also leads to a significant loss of original information. Moreover, current models primarily identify students with consistently poor performance through simple and discrete behavioural patterns, failing to capture the complex continuity and non-linear changes in student behaviour. We have developed an innovative prediction model, Multimodal- ChangePoint Detection (MCPD), utilizing the textual teacher remark data and numerical grade data from middle schools. Our model achieves a highly integrated and intelligent analysis by using independent encoders to process two data types, fusing the encoded feature. The model further refines its analysis by leveraging a changepoint detection module to pinpoint crucial behavioral changes, which are integrated as dynamic weights through a simple attention mechanism. Experimental validations indicate that our model achieves an accuracy range of 70- 75%, with an average outperforming baseline algorithms by approximately 5-10%. Additionally, our algorithm demonstrates a certain degree of transferability, maintaining high accuracy when adjusted and retrained with different definitions of at-risk, proving its broad applicability.

Kevin Lam, William Daniels, J Maxwell Douglas et al.

Cancer is a genetic disorder whose clonal evolution can be monitored by tracking noisy genome-wide copy number variants. We introduce the Copy Number Stochastic Block Model (CN-SBM), a probabilistic framework that jointly clusters samples and genomic regions based on discrete copy number states using a bipartite categorical block model. Unlike models relying on Gaussian or Poisson assumptions, CN-SBM respects the discrete nature of CNV calls and captures subpopulation-specific patterns through block-wise structure. Using a two-stage approach, CN-SBM decomposes CNV data into primary and residual components, enabling detection of both large-scale chromosomal alterations and finer aberrations. We derive a scalable variational inference algorithm for application to large cohorts and high-resolution data. Benchmarks on simulated and real datasets show improved model fit over existing methods. Applied to TCGA low-grade glioma data, CN-SBM reveals clinically relevant subtypes and structured residual variation, aiding patient stratification in survival analysis. These results establish CN-SBM as an interpretable, scalable framework for CNV analysis with direct relevance for tumor heterogeneity and prognosis.