Mark Jones

Leo van Iersel, Mark Jones, Mathias Weller

TREE CONTAINMENT is a central decision problem in mathematical phylogenetics, asking whether a given rooted phylogenetic tree is embeddable in ("displayed by") a given rooted phylogenetic network. While the problem is NP-complete for general networks, many algorithmic advances have relied on structural parameters that capture how "tree-like" a network is. In this paper we investigate TREE CONTAINMENT under the structural parameter scanwidth, a directed width measure generalizing popular parameters measuring tree-likeness of phylogenetic networks. We first present a parameterized algorithm that solves the problem in $O(4^{k + k\log{k}} n + nm^2)$ time, where $n$ and $m$ are the numbers of nodes and arcs in the network and $k$ is the width of a given tree-extension. Complementing this upper bound, we prove a matching lower bound under the Exponential-Time Hypothesis (ETH), showing that there is no algorithm for TREE CONTAINMENT that runs in $2^{o(c\log{c})} n^{O(1)}$ time, even on binary inputs, where $c$ is the directed cutwidth of the input network, which upper-bounds the scanwidth $k$.

Niels Holtgrefe, Leo van Iersel, Mark Jones

To measure the tree-likeness of a directed acyclic graph (DAG), a new width parameter that considers the directions of the arcs was recently introduced: scanwidth. We present the first algorithm that efficiently computes the exact scanwidth of general DAGs. For DAGs with one root and scanwidth $k$ it runs in $O(k \cdot n^k \cdot m)$ time. The algorithm also functions as an FPT algorithm with complexity $O(2^{4 \ell - 1} \cdot \ell \cdot n + n^2)$ for phylogenetic networks of level-$\ell$, a type of DAG used to depict evolutionary relationships among species. Our algorithm performs well in practice, being able to compute the scanwidth of synthetic networks up to 30 reticulations and 100 leaves within 500 seconds. Furthermore, we propose a heuristic that obtains an average practical approximation ratio of 1.5 on these networks. While we prove that the scanwidth is bounded from below by the treewidth of the underlying undirected graph, experiments suggest that for networks the parameters are close in practice.

Kin Quan, Ryutaro Tanno, Michael Duong et al.

Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas, rendering the identification of affected regions very difficult. Here we introduce a noise-robust method for automatically detecting the location of progressive airway dilatation given two profiles of the same airway acquired at different time points. We propose a probabilistic model of abrupt relative variations between profiles and perform inference via Reversible Jump Markov Chain Monte Carlo sampling. We demonstrate the efficacy of the proposed method on two datasets; (i) images of healthy airways with simulated dilatation; (ii) pairs of real images of IPF-affected airways acquired at 1 year intervals. Our model is able to detect the starting location of airway dilatation with an accuracy of 2.5mm on simulated data. The experiments on the IPF dataset display reasonable agreement with radiologists. We can compute a relative change in airway volume that may be useful for quantifying IPF disease progression. The code is available at https://github.com/quan14/Modelling_Airway_Geometry_as_Stock_Market_Data

Leo van Iersel, Mark Jones, Jannik Schestag et al.

We investigate parameterized algorithms for computing the average-tree phylogenetic diversity (APD) in rooted phylogenetic networks, studying the problem under different structural parameters that capture the deviation of a network from a tree. Our primary parameter is the scanwidth, a measure of the tree-likeness of a given directed acyclic graph. We show that a subset of taxa with maximum APD can be found in polynomial time in phylogenetic networks of scanwidth at most 2, but becomes NP-hard in networks of scanwidth 3. Further, we design an algorithm that computes the APD of a given set of taxa in O(2^sw n) time, where sw denotes the scanwidth and n the number of taxa in the input network. Finally, we give a linear-time algorithm for computing the APD of a given set of taxa if the network induced by these taxa is reticulation-visible. We generalize this algorithm to still run in polynomial time if each biconnected component of the induced network has only constantly many invisible reticulations.

Leo van Iersel, Mark Jones, Simone Linz et al.

A directed phylogenetic network is tree-child if every non-leaf vertex has a child that is not a reticulation. As a class of directed phylogenetic networks, tree-child networks are very useful from a computational perspective. For example, several computationally difficult problems in phylogenetics become tractable when restricted to tree-child networks. At the same time, the class itself is rich enough to contain quite complex networks. Furthermore, checking whether a directed network is tree-child can be done in polynomial time. In this paper, we seek a class of undirected phylogenetic networks that is rich and computationally useful in a similar way to the class tree-child directed networks. A natural class to consider for this role is the class of tree-child-orientable networks which contains all those undirected phylogenetic networks whose edges can be oriented to create a tree-child network. However, we show here that recognizing such networks is NP-hard, even for binary networks, and as such this class is inappropriate for this role. Towards finding a class of undirected networks that fills a similar role to directed tree-child networks, we propose new classes called $q$-cuttable networks, for any integer $q\geq 1$. We show that these classes have many of the desirable properties, similar to tree-child networks in the rooted case, including being recognizable in polynomial time, for all $q\geq 1$. Towards showing the computational usefulness of the class, we show that the NP-hard problem Tree Containment is polynomial-time solvable when restricted to $q$-cuttable networks with $q\geq 3$.

Jason Crampton, Naomi Farley, Gregory Gutin et al.

We may enforce an information flow policy by encrypting a protected resource and ensuring that only users authorized by the policy are able to decrypt the resource. In most schemes in the literature that use symmetric cryptographic primitives, each user is assigned a single secret and derives decryption keys using this secret and publicly available information. Recent work has challenged this approach by developing schemes, based on a chain partition of the information flow policy, that do not require public information for key derivation, the trade-off being that a user may need to be assigned more than one secret. In general, many different chain partitions exist for the same policy and, until now, it was not known how to compute an appropriate one. In this paper, we introduce the notion of a tree partition, of which chain partitions are a special case. We show how a tree partition may be used to define a cryptographic enforcement scheme and prove that such schemes can be instantiated in such a way as to preserve the strongest security properties known for cryptographic enforcement schemes. We establish a number of results linking the amount of secret material that needs to be distributed to users with a weighted acyclic graph derived from the tree partition. These results enable us to develop efficient algorithms for deriving tree and chain partitions that minimize the amount of secret material that needs to be distributed.

Jason Crampton, Andrei Gagarin, Gregory Gutin et al.

A workflow specification defines sets of steps and users. An authorization policy determines for each user a subset of steps the user is allowed to perform. Other security requirements, such as separation-of-duty, impose constraints on which subsets of users may perform certain subsets of steps. The \emph{workflow satisfiability problem} (WSP) is the problem of determining whether there exists an assignment of users to workflow steps that satisfies all such authorizations and constraints. An algorithm for solving WSP is important, both as a static analysis tool for workflow specifications, and for the construction of run-time reference monitors for workflow management systems. Given the computational difficulty of WSP, it is important, particularly for the second application, that such algorithms are as efficient as possible. We introduce class-independent constraints, enabling us to model scenarios where the set of users is partitioned into groups, and the identities of the user groups are irrelevant to the satisfaction of the constraint. We prove that solving WSP is fixed-parameter tractable (FPT) for this class of constraints and develop an FPT algorithm that is useful in practice. We compare the performance of the FPT algorithm with that of SAT4J (a pseudo-Boolean SAT solver) in computational experiments, which show that our algorithm significantly outperforms SAT4J for many instances of WSP. User-independent constraints, a large class of constraints including many practical ones, are a special case of class-independent constraints for which WSP was proved to be FPT (Cohen {\em et al.}, J. Artif. Intel. Res. 2014). Thus our results considerably extend our knowledge of the fixed-parameter tractability of WSP.

Jason Crampton, Naomi Farley, Gregory Gutin et al.

The simple security property in an information flow policy can be enforced by encrypting data objects and distributing an appropriate secret to each user. A user derives a suitable decryption key from the secret and publicly available information. A chain-based enforcement scheme provides an alternative method of cryptographic enforcement that does not require any public information, the trade-off being that a user may require more than one secret. For a given information flow policy, there will be many different possible chain-based enforcement schemes. In this paper, we provide a polynomial-time algorithm for selecting a chain-based scheme which uses the minimum possible number of keys. We also compute the number of secrets that will be required and establish an upper bound on the number of secrets required by any user.

Jason Crampton, Naomi Farley, Gregory Gutin et al.

Cryptographic access control has been studied for over 30 years and is now a mature research topic. When symmetric cryptographic primitives are used, each protected resource is encrypted and only authorized users should have access to the encryption key. By treating the keys themselves as protected resources, it is possible to develop schemes in which authorized keys are derived from the keys explicitly assigned to the user's possession and publicly available information. It has been generally assumed that each user would be assigned a single key from which all other authorized keys would be derived. Recent work has challenged this assumption by developing schemes that do not require public information, the trade-off being that a user may require more than one key. However, these new schemes, which require a chain partition of the partially ordered set on which the access control policy is based, have some disadvantages. In this paper we define the notion of a tree-based cryptographic enforcement scheme, which, like chain-based schemes, requires no public information. We establish that the strong security properties of chain-based schemes are preserved by tree-based schemes, and provide an efficient construction for deriving a tree-based enforcement scheme from a given policy that minimizes the number of keys required.