Harsha Nori

LG
h-index27
24papers
7,315citations
Novelty49%
AI Score51

24 Papers

CLMar 22, 2023
Sparks of Artificial General Intelligence: Early experiments with GPT-4

Sébastien Bubeck, Varun Chandrasekaran, Ronen Eldan et al. · microsoft-research, uw

Artificial intelligence (AI) researchers have been developing and refining large language models (LLMs) that exhibit remarkable capabilities across a variety of domains and tasks, challenging our understanding of learning and cognition. The latest model developed by OpenAI, GPT-4, was trained using an unprecedented scale of compute and data. In this paper, we report on our investigation of an early version of GPT-4, when it was still in active development by OpenAI. We contend that (this early version of) GPT-4 is part of a new cohort of LLMs (along with ChatGPT and Google's PaLM for example) that exhibit more general intelligence than previous AI models. We discuss the rising capabilities and implications of these models. We demonstrate that, beyond its mastery of language, GPT-4 can solve novel and difficult tasks that span mathematics, coding, vision, medicine, law, psychology and more, without needing any special prompting. Moreover, in all of these tasks, GPT-4's performance is strikingly close to human-level performance, and often vastly surpasses prior models such as ChatGPT. Given the breadth and depth of GPT-4's capabilities, we believe that it could reasonably be viewed as an early (yet still incomplete) version of an artificial general intelligence (AGI) system. In our exploration of GPT-4, we put special emphasis on discovering its limitations, and we discuss the challenges ahead for advancing towards deeper and more comprehensive versions of AGI, including the possible need for pursuing a new paradigm that moves beyond next-word prediction. We conclude with reflections on societal influences of the recent technological leap and future research directions.

CLNov 28, 2023
Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine

Harsha Nori, Yin Tat Lee, Sheng Zhang et al. · microsoft-research

Generalist foundation models such as GPT-4 have displayed surprising capabilities in a wide variety of domains and tasks. Yet, there is a prevalent assumption that they cannot match specialist capabilities of fine-tuned models. For example, most explorations to date on medical competency benchmarks have leveraged domain-specific training, as exemplified by efforts on BioGPT and Med-PaLM. We build on a prior study of GPT-4's capabilities on medical challenge benchmarks in the absence of special training. Rather than using simple prompting to highlight the model's out-of-the-box capabilities, we perform a systematic exploration of prompt engineering. We find that prompting innovation can unlock deeper specialist capabilities and show that GPT-4 easily tops prior leading results for medical benchmarks. The prompting methods we explore are general purpose, and make no specific use of domain expertise, removing the need for expert-curated content. Our experimental design carefully controls for overfitting during the prompt engineering process. We introduce Medprompt, based on a composition of several prompting strategies. With Medprompt, GPT-4 achieves state-of-the-art results on all nine of the benchmark datasets in the MultiMedQA suite. The method outperforms leading specialist models such as Med-PaLM 2 by a significant margin with an order of magnitude fewer calls to the model. Steering GPT-4 with Medprompt achieves a 27% reduction in error rate on the MedQA dataset over the best methods to date achieved with specialist models and surpasses a score of 90% for the first time. Beyond medical problems, we show the power of Medprompt to generalize to other domains and provide evidence for the broad applicability of the approach via studies of the strategy on exams in electrical engineering, machine learning, philosophy, accounting, law, nursing, and clinical psychology.

LGJun 30, 2022
Interpretability, Then What? Editing Machine Learning Models to Reflect Human Knowledge and Values

Zijie J. Wang, Alex Kale, Harsha Nori et al. · gatech, microsoft-research

Machine learning (ML) interpretability techniques can reveal undesirable patterns in data that models exploit to make predictions--potentially causing harms once deployed. However, how to take action to address these patterns is not always clear. In a collaboration between ML and human-computer interaction researchers, physicians, and data scientists, we develop GAM Changer, the first interactive system to help domain experts and data scientists easily and responsibly edit Generalized Additive Models (GAMs) and fix problematic patterns. With novel interaction techniques, our tool puts interpretability into action--empowering users to analyze, validate, and align model behaviors with their knowledge and values. Physicians have started to use our tool to investigate and fix pneumonia and sepsis risk prediction models, and an evaluation with 7 data scientists working in diverse domains highlights that our tool is easy to use, meets their model editing needs, and fits into their current workflows. Built with modern web technologies, our tool runs locally in users' web browsers or computational notebooks, lowering the barrier to use. GAM Changer is available at the following public demo link: https://interpret.ml/gam-changer.

CLMar 20, 2023
Capabilities of GPT-4 on Medical Challenge Problems

Harsha Nori, Nicholas King, Scott Mayer McKinney et al.

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on medical competency examinations and benchmark datasets. GPT-4 is a general-purpose model that is not specialized for medical problems through training or engineered to solve clinical tasks. Our analysis covers two sets of official practice materials for the USMLE, a three-step examination program used to assess clinical competency and grant licensure in the United States. We also evaluate performance on the MultiMedQA suite of benchmark datasets. Beyond measuring model performance, experiments were conducted to investigate the influence of test questions containing both text and images on model performance, probe for memorization of content during training, and study probability calibration, which is of critical importance in high-stakes applications like medicine. Our results show that GPT-4, without any specialized prompt crafting, exceeds the passing score on USMLE by over 20 points and outperforms earlier general-purpose models (GPT-3.5) as well as models specifically fine-tuned on medical knowledge (Med-PaLM, a prompt-tuned version of Flan-PaLM 540B). In addition, GPT-4 is significantly better calibrated than GPT-3.5, demonstrating a much-improved ability to predict the likelihood that its answers are correct. We also explore the behavior of the model qualitatively through a case study that shows the ability of GPT-4 to explain medical reasoning, personalize explanations to students, and interactively craft new counterfactual scenarios around a medical case. Implications of the findings are discussed for potential uses of GPT-4 in medical education, assessment, and clinical practice, with appropriate attention to challenges of accuracy and safety.

HCApr 19, 2023
Supporting Human-AI Collaboration in Auditing LLMs with LLMs

Charvi Rastogi, Marco Tulio Ribeiro, Nicholas King et al. · microsoft-research, uw

Large language models are becoming increasingly pervasive and ubiquitous in society via deployment in sociotechnical systems. Yet these language models, be it for classification or generation, have been shown to be biased and behave irresponsibly, causing harm to people at scale. It is crucial to audit these language models rigorously. Existing auditing tools leverage either or both humans and AI to find failures. In this work, we draw upon literature in human-AI collaboration and sensemaking, and conduct interviews with research experts in safe and fair AI, to build upon the auditing tool: AdaTest (Ribeiro and Lundberg, 2022), which is powered by a generative large language model (LLM). Through the design process we highlight the importance of sensemaking and human-AI communication to leverage complementary strengths of humans and generative models in collaborative auditing. To evaluate the effectiveness of the augmented tool, AdaTest++, we conduct user studies with participants auditing two commercial language models: OpenAI's GPT-3 and Azure's sentiment analysis model. Qualitative analysis shows that AdaTest++ effectively leverages human strengths such as schematization, hypothesis formation and testing. Further, with our tool, participants identified a variety of failures modes, covering 26 different topics over 2 tasks, that have been shown before in formal audits and also those previously under-reported.

MLAug 2, 2023Code
LLMs Understand Glass-Box Models, Discover Surprises, and Suggest Repairs

Benjamin J. Lengerich, Sebastian Bordt, Harsha Nori et al.

We show that large language models (LLMs) are remarkably good at working with interpretable models that decompose complex outcomes into univariate graph-represented components. By adopting a hierarchical approach to reasoning, LLMs can provide comprehensive model-level summaries without ever requiring the entire model to fit in context. This approach enables LLMs to apply their extensive background knowledge to automate common tasks in data science such as detecting anomalies that contradict prior knowledge, describing potential reasons for the anomalies, and suggesting repairs that would remove the anomalies. We use multiple examples in healthcare to demonstrate the utility of these new capabilities of LLMs, with particular emphasis on Generalized Additive Models (GAMs). Finally, we present the package $\texttt{TalkToEBM}$ as an open-source LLM-GAM interface.

LGOct 16, 2023
Interpretable Predictive Models to Understand Risk Factors for Maternal and Fetal Outcomes

Tomas M. Bosschieter, Zifei Xu, Hui Lan et al.

Although most pregnancies result in a good outcome, complications are not uncommon and can be associated with serious implications for mothers and babies. Predictive modeling has the potential to improve outcomes through better understanding of risk factors, heightened surveillance for high risk patients, and more timely and appropriate interventions, thereby helping obstetricians deliver better care. We identify and study the most important risk factors for four types of pregnancy complications: (i) severe maternal morbidity, (ii) shoulder dystocia, (iii) preterm preeclampsia, and (iv) antepartum stillbirth. We use an Explainable Boosting Machine (EBM), a high-accuracy glass-box learning method, for prediction and identification of important risk factors. We undertake external validation and perform an extensive robustness analysis of the EBM models. EBMs match the accuracy of other black-box ML methods such as deep neural networks and random forests, and outperform logistic regression, while being more interpretable. EBMs prove to be robust. The interpretability of the EBM models reveals surprising insights into the features contributing to risk (e.g. maternal height is the second most important feature for shoulder dystocia) and may have potential for clinical application in the prediction and prevention of serious complications in pregnancy.

CLMar 4, 2024Code
Differentially Private Synthetic Data via Foundation Model APIs 2: Text

Chulin Xie, Zinan Lin, Arturs Backurs et al. · microsoft-research

Text data has become extremely valuable due to the emergence of machine learning algorithms that learn from it. A lot of high-quality text data generated in the real world is private and therefore cannot be shared or used freely due to privacy concerns. Generating synthetic replicas of private text data with a formal privacy guarantee, i.e., differential privacy (DP), offers a promising and scalable solution. However, existing methods necessitate DP finetuning of large language models (LLMs) on private data to generate DP synthetic data. This approach is not viable for proprietary LLMs (e.g., GPT-3.5) and also demands considerable computational resources for open-source LLMs. Lin et al. (2024) recently introduced the Private Evolution (PE) algorithm to generate DP synthetic images with only API access to diffusion models. In this work, we propose an augmented PE algorithm, named Aug-PE, that applies to the complex setting of text. We use API access to an LLM and generate DP synthetic text without any model training. We conduct comprehensive experiments on three benchmark datasets. Our results demonstrate that Aug-PE produces DP synthetic text that yields competitive utility with the SOTA DP finetuning baselines. This underscores the feasibility of relying solely on API access of LLMs to produce high-quality DP synthetic texts, thereby facilitating more accessible routes to privacy-preserving LLM applications. Our code and data are available at https://github.com/AI-secure/aug-pe.

HCMar 9
How people use Copilot for Health

Beatriz Costa-Gomes, Pavel Tolmachev, Eloise Taysom et al.

We analyze over 500,000 de-identified health-related conversations with Microsoft Copilot from January 2026 to characterize what people ask conversational AI about health. We develop a hierarchical intent taxonomy of 12 primary categories using privacy-preserving LLM-based classification validated against expert human annotation, and apply LLM-driven topic-clustering for prevalent themes within each intent. Using this taxonomy, we characterize the intents and topics behind health queries, identify who these queries are about, and analyze how usage varies by device and time of day. Five findings stand out. First, nearly one in five conversations involve personal symptom assessment or condition discussion, and even the dominant general information category (40%) is concentrated on specific treatments and conditions, suggesting that this is a lower bound on personal health intent. Second, one in seven of these personal health queries concern someone other than the user, such as a child, a parent, a partner, suggesting that conversational AI can be a caregiving tool, not just a personal one. Third, personal queries about symptoms and emotional health queries increase markedly in the evening and nighttime hours, when traditional healthcare is most limited. Fourth, usage diverges sharply by device: mobile concentrates on personal health concerns, while desktop is dominated by professional and academic work. Fifth, a substantial share of queries focuses on navigating healthcare systems such as finding providers, and understanding insurance, highlighting friction in the delivery of existing healthcare. These patterns have direct implications for platform-specific design, safety considerations, and the responsible development of health AI.

LGJul 12, 2022
Using Interpretable Machine Learning to Predict Maternal and Fetal Outcomes

Tomas M. Bosschieter, Zifei Xu, Hui Lan et al.

Most pregnancies and births result in a good outcome, but complications are not uncommon and when they do occur, they can be associated with serious implications for mothers and babies. Predictive modeling has the potential to improve outcomes through better understanding of risk factors, heightened surveillance, and more timely and appropriate interventions, thereby helping obstetricians deliver better care. For three types of complications we identify and study the most important risk factors using Explainable Boosting Machine (EBM), a glass box model, in order to gain intelligibility: (i) Severe Maternal Morbidity (SMM), (ii) shoulder dystocia, and (iii) preterm preeclampsia. While using the interpretability of EBM's to reveal surprising insights into the features contributing to risk, our experiments show EBMs match the accuracy of other black-box ML methods such as deep neural nets and random forests.

LGApr 9, 2024Code
Elephants Never Forget: Memorization and Learning of Tabular Data in Large Language Models

Sebastian Bordt, Harsha Nori, Vanessa Rodrigues et al.

While many have shown how Large Language Models (LLMs) can be applied to a diverse set of tasks, the critical issues of data contamination and memorization are often glossed over. In this work, we address this concern for tabular data. Specifically, we introduce a variety of different techniques to assess whether a language model has seen a tabular dataset during training. This investigation reveals that LLMs have memorized many popular tabular datasets verbatim. We then compare the few-shot learning performance of LLMs on datasets that were seen during training to the performance on datasets released after training. We find that LLMs perform better on datasets seen during training, indicating that memorization leads to overfitting. At the same time, LLMs show non-trivial performance on novel datasets and are surprisingly robust to data transformations. We then investigate the in-context statistical learning abilities of LLMs. While LLMs are significantly better than random at solving statistical classification problems, the sample efficiency of few-shot learning lags behind traditional statistical learning algorithms, especially as the dimension of the problem increases. This suggests that much of the observed few-shot performance on novel real-world datasets is due to the LLM's world knowledge. Overall, our results highlight the importance of testing whether an LLM has seen an evaluation dataset during pre-training. We release the https://github.com/interpretml/LLM-Tabular-Memorization-Checker Python package to test LLMs for memorization of tabular datasets.

LGMar 11, 2024Code
Elephants Never Forget: Testing Language Models for Memorization of Tabular Data

Sebastian Bordt, Harsha Nori, Rich Caruana

While many have shown how Large Language Models (LLMs) can be applied to a diverse set of tasks, the critical issues of data contamination and memorization are often glossed over. In this work, we address this concern for tabular data. Starting with simple qualitative tests for whether an LLM knows the names and values of features, we introduce a variety of different techniques to assess the degrees of contamination, including statistical tests for conditional distribution modeling and four tests that identify memorization. Our investigation reveals that LLMs are pre-trained on many popular tabular datasets. This exposure can lead to invalid performance evaluation on downstream tasks because the LLMs have, in effect, been fit to the test set. Interestingly, we also identify a regime where the language model reproduces important statistics of the data, but fails to reproduce the dataset verbatim. On these datasets, although seen during training, good performance on downstream tasks might not be due to overfitting. Our findings underscore the need for ensuring data integrity in machine learning tasks with LLMs. To facilitate future research, we release an open-source tool that can perform various tests for memorization \url{https://github.com/interpretml/LLM-Tabular-Memorization-Checker}.

CLJan 18, 2025Code
JSONSchemaBench: A Rigorous Benchmark of Structured Outputs for Language Models

Saibo Geng, Hudson Cooper, Michał Moskal et al.

Reliably generating structured outputs has become a critical capability for modern language model (LM) applications. Constrained decoding has emerged as the dominant technology across sectors for enforcing structured outputs during generation. Despite its growing adoption, little has been done with the systematic evaluation of the behaviors and performance of constrained decoding. Constrained decoding frameworks have standardized around JSON Schema as a structured data format, with most uses guaranteeing constraint compliance given a schema. However, there is poor understanding of the effectiveness of the methods in practice. We present an evaluation framework to assess constrained decoding approaches across three critical dimensions: efficiency in generating constraint-compliant outputs, coverage of diverse constraint types, and quality of the generated outputs. To facilitate this evaluation, we introduce JSONSchemaBench, a benchmark for constrained decoding comprising 10K real-world JSON schemas that encompass a wide range of constraints with varying complexity. We pair the benchmark with the existing official JSON Schema Test Suite and evaluate six state-of-the-art constrained decoding frameworks, including Guidance, Outlines, Llamacpp, XGrammar, OpenAI, and Gemini. Through extensive experiments, we gain insights into the capabilities and limitations of constrained decoding on structured generation with real-world JSON schemas. Our work provides actionable insights for improving constrained decoding frameworks and structured generation tasks, setting a new standard for evaluating constrained decoding and structured generation. We release JSONSchemaBench at https://github.com/guidance-ai/jsonschemabench

LGFeb 22, 2024Code
Data Science with LLMs and Interpretable Models

Sebastian Bordt, Ben Lengerich, Harsha Nori et al.

Recent years have seen important advances in the building of interpretable models, machine learning models that are designed to be easily understood by humans. In this work, we show that large language models (LLMs) are remarkably good at working with interpretable models, too. In particular, we show that LLMs can describe, interpret, and debug Generalized Additive Models (GAMs). Combining the flexibility of LLMs with the breadth of statistical patterns accurately described by GAMs enables dataset summarization, question answering, and model critique. LLMs can also improve the interaction between domain experts and interpretable models, and generate hypotheses about the underlying phenomenon. We release \url{https://github.com/interpretml/TalkToEBM} as an open-source LLM-GAM interface.

CVMay 24, 2023Code
Differentially Private Synthetic Data via Foundation Model APIs 1: Images

Zinan Lin, Sivakanth Gopi, Janardhan Kulkarni et al.

Generating differentially private (DP) synthetic data that closely resembles the original private data is a scalable way to mitigate privacy concerns in the current data-driven world. In contrast to current practices that train customized models for this task, we aim to generate DP Synthetic Data via APIs (DPSDA), where we treat foundation models as blackboxes and only utilize their inference APIs. Such API-based, training-free approaches are easier to deploy as exemplified by the recent surge in the number of API-based apps. These approaches can also leverage the power of large foundation models which are only accessible via their inference APIs. However, this comes with greater challenges due to strictly more restrictive model access and the need to protect privacy from the API provider. In this paper, we present a new framework called Private Evolution (PE) to solve this problem and show its initial promise on synthetic images. Surprisingly, PE can match or even outperform state-of-the-art (SOTA) methods without any model training. For example, on CIFAR10 (with ImageNet as the public data), we achieve FID <= 7.9 with privacy cost ε = 0.67, significantly improving the previous SOTA from ε = 32. We further demonstrate the promise of applying PE on large foundation models such as Stable Diffusion to tackle challenging private datasets with a small number of high-resolution images. The code and data are released at https://github.com/microsoft/DPSDA.

LGDec 6, 2021Code
GAM Changer: Editing Generalized Additive Models with Interactive Visualization

Zijie J. Wang, Alex Kale, Harsha Nori et al.

Recent strides in interpretable machine learning (ML) research reveal that models exploit undesirable patterns in the data to make predictions, which potentially causes harms in deployment. However, it is unclear how we can fix these models. We present our ongoing work, GAM Changer, an open-source interactive system to help data scientists and domain experts easily and responsibly edit their Generalized Additive Models (GAMs). With novel visualization techniques, our tool puts interpretability into action -- empowering human users to analyze, validate, and align model behaviors with their knowledge and values. Built using modern web technologies, our tool runs locally in users' computational notebooks or web browsers without requiring extra compute resources, lowering the barrier to creating more responsible ML models. GAM Changer is available at https://interpret.ml/gam-changer.

LGSep 19, 2019Code
InterpretML: A Unified Framework for Machine Learning Interpretability

Harsha Nori, Samuel Jenkins, Paul Koch et al.

InterpretML is an open-source Python package which exposes machine learning interpretability algorithms to practitioners and researchers. InterpretML exposes two types of interpretability - glassbox models, which are machine learning models designed for interpretability (ex: linear models, rule lists, generalized additive models), and blackbox explainability techniques for explaining existing systems (ex: Partial Dependence, LIME). The package enables practitioners to easily compare interpretability algorithms by exposing multiple methods under a unified API, and by having a built-in, extensible visualization platform. InterpretML also includes the first implementation of the Explainable Boosting Machine, a powerful, interpretable, glassbox model that can be as accurate as many blackbox models. The MIT licensed source code can be downloaded from github.com/microsoft/interpret.

LGNov 18, 2024
Steering Language Model Refusal with Sparse Autoencoders

Kyle O'Brien, David Majercak, Xavier Fernandes et al.

Responsible deployment of language models requires mechanisms for refusing unsafe prompts while preserving model performance. While most approaches modify model weights through additional training, we explore an alternative: steering model activations at inference time via amplifying sparse autoencoder (SAE) features that mediate refusal. This work uncovers a fundamental tension between SAE steering-based safety improvements and general model capabilities. While feature steering successfully improves robustness against both single-turn and challenging multi-turn jailbreak attempts, we discover that this comes at a previously underexplored cost -- systematic degradation of performance across multiple benchmark tasks, even on safe inputs with no apparent connection to refusal behavior. This suggests that features mediating refusal may be more deeply entangled with general language model capabilities than previously understood. Our findings reveal important open questions about the nature of safety-relevant features in language models and the feasibility of isolating them for targeted intervention. While SAE-based steering shows promise as a flexible approach to enhancing language model safety, our results highlight the critical need to understand and address the mechanisms behind these capability tradeoffs before such techniques can be practically deployed.

CLJun 27, 2025
Sequential Diagnosis with Language Models

Harsha Nori, Mayank Daswani, Christopher Kelly et al.

Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the complexity and nuance of evidence-based medicine in real-world settings. In clinical practice, physicians iteratively formulate and revise diagnostic hypotheses, adapting each subsequent question and test to what they've just learned, and weigh the evolving evidence before committing to a final diagnosis. To emulate this iterative process, we introduce the Sequential Diagnosis Benchmark, which transforms 304 diagnostically challenging New England Journal of Medicine clinicopathological conference (NEJM-CPC) cases into stepwise diagnostic encounters. A physician or AI begins with a short case abstract and must iteratively request additional details from a gatekeeper model that reveals findings only when explicitly queried. Performance is assessed not just by diagnostic accuracy but also by the cost of physician visits and tests performed. We also present the MAI Diagnostic Orchestrator (MAI-DxO), a model-agnostic orchestrator that simulates a panel of physicians, proposes likely differential diagnoses and strategically selects high-value, cost-effective tests. When paired with OpenAI's o3 model, MAI-DxO achieves 80% diagnostic accuracy--four times higher than the 20% average of generalist physicians. MAI-DxO also reduces diagnostic costs by 20% compared to physicians, and 70% compared to off-the-shelf o3. When configured for maximum accuracy, MAI-DxO achieves 85.5% accuracy. These performance gains with MAI-DxO generalize across models from the OpenAI, Gemini, Claude, Grok, DeepSeek, and Llama families. We highlight how AI systems, when guided to think iteratively and act judiciously, can advance diagnostic precision and cost-effectiveness in clinical care.

CLNov 6, 2024
From Medprompt to o1: Exploration of Run-Time Strategies for Medical Challenge Problems and Beyond

Harsha Nori, Naoto Usuyama, Nicholas King et al. · microsoft-research

Run-time steering strategies like Medprompt are valuable for guiding large language models (LLMs) to top performance on challenging tasks. Medprompt demonstrates that a general LLM can be focused to deliver state-of-the-art performance on specialized domains like medicine by using a prompt to elicit a run-time strategy involving chain of thought reasoning and ensembling. OpenAI's o1-preview model represents a new paradigm, where a model is designed to do run-time reasoning before generating final responses. We seek to understand the behavior of o1-preview on a diverse set of medical challenge problem benchmarks. Following on the Medprompt study with GPT-4, we systematically evaluate the o1-preview model across various medical benchmarks. Notably, even without prompting techniques, o1-preview largely outperforms the GPT-4 series with Medprompt. We further systematically study the efficacy of classic prompt engineering strategies, as represented by Medprompt, within the new paradigm of reasoning models. We found that few-shot prompting hinders o1's performance, suggesting that in-context learning may no longer be an effective steering approach for reasoning-native models. While ensembling remains viable, it is resource-intensive and requires careful cost-performance optimization. Our cost and accuracy analysis across run-time strategies reveals a Pareto frontier, with GPT-4o representing a more affordable option and o1-preview achieving state-of-the-art performance at higher cost. Although o1-preview offers top performance, GPT-4o with steering strategies like Medprompt retains value in specific contexts. Moreover, we note that the o1-preview model has reached near-saturation on many existing medical benchmarks, underscoring the need for new, challenging benchmarks. We close with reflections on general directions for inference-time computation with LLMs.

MLFeb 22, 2022
Differentially Private Estimation of Heterogeneous Causal Effects

Fengshi Niu, Harsha Nori, Brian Quistorff et al.

Estimating heterogeneous treatment effects in domains such as healthcare or social science often involves sensitive data where protecting privacy is important. We introduce a general meta-algorithm for estimating conditional average treatment effects (CATE) with differential privacy (DP) guarantees. Our meta-algorithm can work with simple, single-stage CATE estimators such as S-learner and more complex multi-stage estimators such as DR and R-learner. We perform a tight privacy analysis by taking advantage of sample splitting in our meta-algorithm and the parallel composition property of differential privacy. In this paper, we implement our approach using DP-EBMs as the base learner. DP-EBMs are interpretable, high-accuracy models with privacy guarantees, which allow us to directly observe the impact of DP noise on the learned causal model. Our experiments show that multi-stage CATE estimators incur larger accuracy loss than single-stage CATE or ATE estimators and that most of the accuracy loss from differential privacy is due to an increase in variance, not biased estimates of treatment effects.

LGJun 17, 2021
Accuracy, Interpretability, and Differential Privacy via Explainable Boosting

Harsha Nori, Rich Caruana, Zhiqi Bu et al.

We show that adding differential privacy to Explainable Boosting Machines (EBMs), a recent method for training interpretable ML models, yields state-of-the-art accuracy while protecting privacy. Our experiments on multiple classification and regression datasets show that DP-EBM models suffer surprisingly little accuracy loss even with strong differential privacy guarantees. In addition to high accuracy, two other benefits of applying DP to EBMs are: a) trained models provide exact global and local interpretability, which is often important in settings where differential privacy is needed; and b) the models can be edited after training without loss of privacy to correct errors which DP noise may have introduced.

CRJul 2, 2018
An Algorithmic Framework For Differentially Private Data Analysis on Trusted Processors

Joshua Allen, Bolin Ding, Janardhan Kulkarni et al.

Differential privacy has emerged as the main definition for private data analysis and machine learning. The {\em global} model of differential privacy, which assumes that users trust the data collector, provides strong privacy guarantees and introduces small errors in the output. In contrast, applications of differential privacy in commercial systems by Apple, Google, and Microsoft, use the {\em local model}. Here, users do not trust the data collector, and hence randomize their data before sending it to the data collector. Unfortunately, local model is too strong for several important applications and hence is limited in its applicability. In this work, we propose a framework based on trusted processors and a new definition of differential privacy called {\em Oblivious Differential Privacy}, which combines the best of both local and global models. The algorithms we design in this framework show interesting interplay of ideas from the streaming algorithms, oblivious algorithms, and differential privacy.

CRMar 24, 2018
Comparing Population Means under Local Differential Privacy: with Significance and Power

Bolin Ding, Harsha Nori, Paul Li et al.

A statistical hypothesis test determines whether a hypothesis should be rejected based on samples from populations. In particular, randomized controlled experiments (or A/B testing) that compare population means using, e.g., t-tests, have been widely deployed in technology companies to aid in making data-driven decisions. Samples used in these tests are collected from users and may contain sensitive information. Both the data collection and the testing process may compromise individuals' privacy. In this paper, we study how to conduct hypothesis tests to compare population means while preserving privacy. We use the notation of local differential privacy (LDP), which has recently emerged as the main tool to ensure each individual's privacy without the need of a trusted data collector. We propose LDP tests that inject noise into every user's data in the samples before collecting them (so users do not need to trust the data collector), and draw conclusions with bounded type-I (significance level) and type-II errors (1 - power). Our approaches can be extended to the scenario where some users require LDP while some are willing to provide exact data. We report experimental results on real-world datasets to verify the effectiveness of our approaches.