Arunkumar Kannan

Arunkumar Kannan, Yanbo Zhang, Han Liu et al.

While automated diagnosis systems have achieved remarkable success in computed tomography (CT)-based lung cancer screening, their development remains limited by the scarcity of diverse, annotated pulmonary nodule datasets. Diffusion-based generative models offer a promising strategy for data synthesis; however, many existing conditional approaches primarily optimize spatial reconstruction losses, which encourage voxel-wise similarity but may inadequately constrain lesion-level intensity distributions. As a result, these methods may produce over-smoothed texture profiles and underrepresent the distinct attenuation characteristics of different nodule subtypes, including solid, part-solid, and ground-glass nodules. To address this challenge, we propose a controllable latent diffusion model that synthesizes pulmonary nodules within full 3D CT volumes while accurately modeling nodule-specific intensity distributions. Specifically, rather than relying solely on spatial losses, we introduce a histogram-based regularization term that constrains voxel intensity distributions during the generative process. The model combines subtype, spatial mask, and Hounsfield unit (HU) histogram conditioning with the differentiable feature-space histogram regularization term to better align lesion-level intensity distributions, improving the visual plausibility and subtype consistency of synthesized nodules. Extensive experiments on lung CT data demonstrate that our framework achieves strong visual realism, validated through both quantitative metrics and a visual Turing test. Furthermore, when used for data augmentation, the generated nodules improve performance in downstream clinical tasks, particularly for underrepresented nodule subtypes, and show a potential benefit for subtype-informed malignancy classification.

Arunkumar Kannan, Martin A. Lindquist, Brian Caffo

Recent advances in deep learning have made it possible to predict phenotypic measures directly from functional magnetic resonance imaging (fMRI) brain volumes, sparking significant interest in the neuroimaging community. However, existing approaches, primarily based on convolutional neural networks or transformer architectures, often struggle to model the complex relationships inherent in fMRI data, limited by their inability to capture long-range spatial and temporal dependencies. To overcome these shortcomings, we introduce BrainMT, a novel hybrid framework designed to efficiently learn and integrate long-range spatiotemporal attributes in fMRI data. Our framework operates in two stages: (1) a bidirectional Mamba block with a temporal-first scanning mechanism to capture global temporal interactions in a computationally efficient manner; and (2) a transformer block leveraging self-attention to model global spatial relationships across the deep features processed by the Mamba block. Extensive experiments on two large-scale public datasets, UKBioBank and the Human Connectome Project, demonstrate that BrainMT achieves state-of-the-art performance on both classification (sex prediction) and regression (cognitive intelligence prediction) tasks, outperforming existing methods by a significant margin. Our code and implementation details will be made publicly available at this https://github.com/arunkumar-kannan/BrainMT-fMRI

Basudha Pal, Arunkumar Kannan, Ram Prabhakar Kathirvel et al.

Diffusion models have achieved great progress in face generation. However, these models amplify the bias in the generation process, leading to an imbalance in distribution of sensitive attributes such as age, gender and race. This paper proposes a novel solution to this problem by balancing the facial attributes of the generated images. We mitigate the bias by localizing the means of the facial attributes in the latent space of the diffusion model using Gaussian mixture models (GMM). Our motivation for choosing GMMs over other clustering frameworks comes from the flexible latent structure of diffusion model. Since each sampling step in diffusion models follows a Gaussian distribution, we show that fitting a GMM model helps us to localize the subspace responsible for generating a specific attribute. Furthermore, our method does not require retraining, we instead localize the subspace on-the-fly and mitigate the bias for generating a fair dataset. We evaluate our approach on multiple face attribute datasets to demonstrate the effectiveness of our approach. Our results demonstrate that our approach leads to a more fair data generation in terms of representational fairness while preserving the quality of generated samples.