Sen Song

Guan Wang, Sijie Cheng, Xianyuan Zhan et al. · tsinghua

Nowadays, open-source large language models like LLaMA have emerged. Recent developments have incorporated supervised fine-tuning (SFT) and reinforcement learning fine-tuning (RLFT) to align these models with human goals. However, SFT methods treat all training data with mixed quality equally, while RLFT methods require high-quality pairwise or ranking-based preference data. In this study, we present a novel framework, named OpenChat, to advance open-source language models with mixed-quality data. Specifically, we consider the general SFT training data, consisting of a small amount of expert data mixed with a large proportion of sub-optimal data, without any preference labels. We propose the C(onditioned)-RLFT, which regards different data sources as coarse-grained reward labels and learns a class-conditioned policy to leverage complementary data quality information. Interestingly, the optimal policy in C-RLFT can be easily solved through single-stage, RL-free supervised learning, which is lightweight and avoids costly human preference labeling. Through extensive experiments on three standard benchmarks, our openchat-13b fine-tuned with C-RLFT achieves the highest average performance among all 13b open-source language models. Moreover, we use AGIEval to validate the model generalization performance, in which only openchat-13b surpasses the base model. Finally, we conduct a series of analyses to shed light on the effectiveness and robustness of OpenChat. Our code, data, and models are publicly available at https://github.com/imoneoi/openchat and https://huggingface.co/openchat.

Zhiyuan Ma, Zeyuan Li, Zihao Qiu et al.

In real-world applications of noninvasive electroencephalography (EEG), specialized decoders often show limited generalizability across diverse tasks under subject-independent settings. One central challenge is that task-relevant EEG signals often follow different temporal organization patterns across tasks, while many existing methods rely on task-tailored architectural designs that introduce task-specific temporal inductive biases. This mismatch makes it difficult to adapt temporal modeling across tasks without changing the model configuration. To address these challenges, we propose DSAINet, an efficient dual-scale attentive interaction network for general EEG decoding. Specifically, DSAINet constructs shared spatiotemporal token representations from raw EEG signals and models diverse temporal dynamics through parallel convolutional branches at fine and coarse scales. The resulting representations are then adaptively refined by intra-branch attention to emphasize salient scale-specific patterns and by inter-branch attention to integrate task-relevant features across scales, followed by adaptive token aggregation to yield a compact representation for prediction. Extensive experiments on five downstream EEG decoding tasks across ten public datasets show that DSAINet consistently outperforms 13 representative baselines under strict subject-independent evaluation. Notably, this performance is achieved using the same architecture hyperparameters across datasets. Moreover, DSAINet achieves a favorable accuracy-efficiency trade-off with only about 77K trainable parameters and provides interpretable neurophysiological insights. The code is publicly available at https://github.com/zy0929/DSAINet.

Zhe Huang, Peng Wang, Yan Zheng et al.

Product bundling boosts e-commerce revenue by recommending complementary item combinations. However, existing methods face two critical challenges: (1) collaborative filtering approaches struggle with cold-start items owing to dependency on historical interactions, and (2) LLMs lack inherent capability to model interactive graph directly. To bridge this gap, we propose a dual-enhancement method that integrates interactive graph learning and LLM-based semantic understanding for product bundling. Our method introduces a graph-to-text paradigm, which leverages a Dynamic Concept Binding Mechanism (DCBM) to translate graph structures into natural language prompts. The DCBM plays a critical role in aligning domain-specific entities with LLM tokenization, enabling effective comprehension of combinatorial constraints. Experiments on three benchmarks (POG, POG_dense, Steam) demonstrate 6.3%-26.5% improvements over state-of-the-art baselines.

Hengshuai Yao, Xing Chen, Ahmed Murtadha et al.

We introduce Focus, a method that learns which token pairs matter rather than approximating all of them. Learnable centroids assign tokens to groups; distant attention is restricted to same-group pairs while local attention operates at full resolution. Because all model weights stay frozen, Focus is purely additive: centroid-only training (as few as 148K parameters) improves domain perplexity with zero degradation on downstream benchmarks--from 124M to 70B parameters, across five attention architectures. No existing efficient attention method achieves this in the retrofit setting. At 124M, Focus surpasses full attention (30.3 vs 31.4 PPL); trained from scratch at 7B scale (2B tokens), Focus again beats full attention (13.82 vs 13.89 PPL). At inference, restricting each token to its top-k highest-scoring groups discretizes the soft routing into a hard sparsity pattern, yielding 2x speedup while beating the pretrained baseline (41.3 vs 42.8 PPL); decomposing this pattern into two standard FlashAttention calls reaches 8.6x wall-clock speedup at 1M tokens with no custom kernels. Unlike LoRA, centroid routing preserves alignment: instruction-tuned models retain TruthfulQA scores after adaptation, while LoRA degrades at every learning rate and rank. Sinkhorn normalization enforces balanced groups as a hard constraint, and the resulting groups discover interpretable linguistic categories without supervision.

Yukun Yan, Sen Song

There has been a growing academic interest in the recognition of nested named entities in many domains. We tackle the task with a novel local hypergraph-based method: We first propose start token candidates and generate corresponding queries with their surrounding context, then use a query-based sequence labeling module to form a local hypergraph for each candidate. An end token estimator is used to correct the hypergraphs and get the final predictions. Compared to span-based approaches, our method is free of the high computation cost of span sampling and the risk of losing long entities. Sequential prediction makes it easier to leverage information in word order inside nested structures, and richer representations are built with a local hypergraph. Experiments show that our proposed method outperforms all the previous hypergraph-based and sequence labeling approaches with large margins on all four nested datasets. It achieves a new state-of-the-art F1 score on the ACE 2004 dataset and competitive F1 scores with previous state-of-the-art methods on three other nested NER datasets: ACE 2005, GENIA, and KBP 2017.

Xiaobin Wong, Zhonghua Zhao, Haoran Guo et al.

EEG-based neural decoding models often fail to generalize across acquisition sites due to structured, site-dependent biases implicitly exploited during training. We reformulate cross-site clinical EEG learning as a bias-factorized generalization problem, in which domain shifts arise from multiple interacting sources. We identify three fundamental bias factors and propose a general training framework that mitigates their influence through data standardization and representation-level constraints. We construct a standardized multi-site EEG benchmark for Major Depressive Disorder and introduce CRCC, a two-stage training paradigm combining encoder-decoder pretraining with joint fine-tuning via cross-subject/site contrastive learning and site-adversarial optimization. CRCC consistently outperforms state-of-the-art baselines and achieves a 10.7 percentage-point improvement in balanced accuracy under strict zero-shot site transfer, demonstrating robust generalization to unseen environments.

Jinhao Li, Yuhao Sun, Zhiyuan Ma et al.

Recurrent spiking neural networks (RSNNs) are a promising substrate for energy-efficient control policies, but training them for high-dimensional, long-horizon reinforcement learning remains challenging. Population-based, gradient-free optimization circumvents backpropagation through non-differentiable spike dynamics by estimating gradients. However, with finite populations, high variance of these estimates can induce harmful and overly aggressive update steps. Inspired by trust-region methods in reinforcement learning that constrain policy updates in distribution space, we propose \textbf{Signal-Adaptive Trust Regions (SATR)}, a distributional update rule that constrains relative change by bounding KL divergence normalized by an estimated signal energy. SATR automatically expands the trust region under strong signals and contracts it when updates are noise-dominated. We instantiate SATR for Bernoulli connectivity distributions, which have shown strong empirical performance for RSNN optimization. Across a suite of high-dimensional continuous-control benchmarks, SATR improves stability under limited populations and reaches competitive returns against strong baselines including PPO-LSTM. In addition, to make SATR practical at scale, we introduce a bitset implementation for binary spiking and binary weights, substantially reducing wall-clock training time and enabling fast RSNN policy search.

Guan Wang, Jin Li, Yuhao Sun et al.

Reasoning, the process of devising and executing complex goal-oriented action sequences, remains a critical challenge in AI. Current large language models (LLMs) primarily employ Chain-of-Thought (CoT) techniques, which suffer from brittle task decomposition, extensive data requirements, and high latency. Inspired by the hierarchical and multi-timescale processing in the human brain, we propose the Hierarchical Reasoning Model (HRM), a novel recurrent architecture that attains significant computational depth while maintaining both training stability and efficiency. HRM executes sequential reasoning tasks in a single forward pass without explicit supervision of the intermediate process, through two interdependent recurrent modules: a high-level module responsible for slow, abstract planning, and a low-level module handling rapid, detailed computations. With only 27 million parameters, HRM achieves exceptional performance on complex reasoning tasks using only 1000 training samples. The model operates without pre-training or CoT data, yet achieves nearly perfect performance on challenging tasks including complex Sudoku puzzles and optimal path finding in large mazes. Furthermore, HRM outperforms much larger models with significantly longer context windows on the Abstraction and Reasoning Corpus (ARC), a key benchmark for measuring artificial general intelligence capabilities. These results underscore HRM's potential as a transformative advancement toward universal computation and general-purpose reasoning systems.

Junjie Fang, Likai Tang, Hongzhe Bi et al. · tencent-ai

Long-context processing is a critical ability that constrains the applicability of large language models (LLMs). Although there exist various methods devoted to enhancing the long-context processing ability of LLMs, they are developed in an isolated manner and lack systematic analysis and integration of their strengths, hindering further developments. In this paper, we introduce UniMem, a Unified framework that reformulates existing long-context methods from the view of Memory augmentation of LLMs. Distinguished by its four core dimensions-Memory Management, Memory Writing, Memory Reading, and Memory Injection, UniMem empowers researchers to conduct systematic exploration of long-context methods. We re-formulate 16 existing methods based on UniMem and analyze four representative methods: Transformer-XL, Memorizing Transformer, RMT, and Longformer into equivalent UniMem forms to reveal their design principles and strengths. Based on these analyses, we propose UniMix, an innovative approach that integrates the strengths of these algorithms. Experimental results show that UniMix achieves superior performance in handling long contexts with significantly lower perplexity than baselines.

Jialiang Wu, Yi Shen, Sijia Liu et al.

Despite their impressive capacities, Large language models (LLMs) often struggle with the hallucination issue of generating inaccurate or fabricated content even when they possess correct knowledge. In this paper, we extend the exploration of the correlation between hidden-state prediction changes and output factuality into a deeper, token-wise level. Based on the insights , we propose cross-layer Entropy eNhanced Decoding (END), a decoding method that mitigates hallucinations without requiring extra training. END leverages inner probability changes across layers to individually quantify the factual knowledge required for each candidate token, and adjusts the final predicting distribution to prioritize tokens with higher factuality. Experiments on both hallucination and QA benchmarks demonstrate that END significantly enhances the truthfulness and informativeness of generated content while maintaining robust QA accuracy. Moreover, our work provides a deeper perspective on understanding the correlations between inherent knowledge and output factuality.

Xinke Shen, Lingyi Tao, Xuyang Chen et al.

Neural representations induced by naturalistic stimuli offer insights into how humans respond to stimuli in daily life. Understanding neural mechanisms underlying naturalistic stimuli processing hinges on the precise identification and extraction of the shared neural patterns that are consistently present across individuals. Targeting the Electroencephalogram (EEG) technique, known for its rich spatial and temporal information, this study presents a framework for Contrastive Learning of Shared SpatioTemporal EEG Representations across individuals (CL-SSTER). CL-SSTER utilizes contrastive learning to maximize the similarity of EEG representations across individuals for identical stimuli, contrasting with those for varied stimuli. The network employed spatial and temporal convolutions to simultaneously learn the spatial and temporal patterns inherent in EEG. The versatility of CL-SSTER was demonstrated on three EEG datasets, including a synthetic dataset, a natural speech comprehension EEG dataset, and an emotional video watching EEG dataset. CL-SSTER attained the highest inter-subject correlation (ISC) values compared to the state-of-the-art ISC methods. The latent representations generated by CL-SSTER exhibited reliable spatiotemporal EEG patterns, which can be explained by properties of the naturalistic stimuli. CL-SSTER serves as an interpretable and scalable framework for the identification of inter-subject shared neural representations in naturalistic neuroscience.

Chenghao Yue, Zhiyuan Ma, Zhongye Xia et al.

Electroencephalography (EEG) provides a non-invasive window into brain activity, offering high temporal resolution crucial for understanding and interacting with neural processes through brain-computer interfaces (BCIs). Current dual-stream neural networks for EEG often process temporal and spatial features independently through parallel branches, delaying their integration until a final, late-stage fusion. This design inherently leads to an "information silo" problem, precluding intermediate cross-stream refinement and hindering spatial-temporal decompositions essential for full feature utilization. We propose LI-DSN, a layer-wise interactive dual-stream network that facilitates progressive, cross-stream communication at each layer, thereby overcoming the limitations of late-fusion paradigms. LI-DSN introduces a novel Temporal-Spatial Integration Attention (TSIA) mechanism, which constructs a Spatial Affinity Correlation Matrix (SACM) to capture inter-electrode spatial structural relationships and a Temporal Channel Aggregation Matrix (TCAM) to integrate cosine-gated temporal dynamics under spatial guidance. Furthermore, we employ an adaptive fusion strategy with learnable channel weights to optimize the integration of dual-stream features. Extensive experiments across eight diverse EEG datasets, encompassing motor imagery (MI) classification, emotion recognition, and steady-state visual evoked potentials (SSVEP), consistently demonstrate that LI-DSN significantly outperforms 13 state-of-the-art (SOTA) baseline models, showcasing its superior robustness and decoding performance. The code will be publicized after acceptance.

Yongjian Li, HaoCheng Chu, Yukun Yan et al.

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access broader knowledge sources, yet factual inconsistencies persist due to noise in retrieved documents-even with advanced retrieval methods. We demonstrate that enhancing generative models' capacity to process noisy content is equally critical for robust performance. In this paper, we present KARE-RAG (Knowledge-Aware Refinement and Enhancement for RAG), which improves knowledge utilization through three key innovations: (1) structured knowledge representations that facilitate error detection during training, (2) Dense Direct Preference Optimization (DDPO)-a refined training objective that prioritizes correction of critical errors, and (3) a contrastive data generation pipeline that maintains semantic consistency while rectifying factual inaccuracies. Experiments show our method significantly enhances standard RAG pipelines across model scales, improving both in-domain and out-of-domain task performance without compromising general capabilities. Notably, these gains are achieved with modest training data, suggesting data-efficient optimization is possible through targeted learning strategies. Our findings establish a new direction for RAG improvement: by improving how models learn to process retrieved content, we can enhance performance across diverse inference paradigms. All data and code will be publicly available on Github.

Jiyi Wang, Likai Tang, Huimiao Chen et al.

Replay is a powerful strategy to promote learning in artificial intelligence and the brain. However, the conditions to generate it and its functional advantages have not been fully recognized. In this study, we develop a modular reinforcement learning model that could generate replay. We prove that replay generated in this way helps complete the task. We also analyze the information contained in the representation and provide a mechanism for how replay makes a difference. Our design avoids complex assumptions and enables replay to emerge naturally within a task-optimized paradigm. Our model also reproduces key phenomena observed in biological agents. This research explores the structural biases in modular ANN to generate replay and its potential utility in developing efficient RL.

Xianggen Liu, Pengyong Li, Fandong Meng et al.

Optimization of discrete structures aims at generating a new structure with the better property given an existing one, which is a fundamental problem in machine learning. Different from the continuous optimization, the realistic applications of discrete optimization (e.g., text generation) are very challenging due to the complex and long-range constraints, including both syntax and semantics, in discrete structures. In this work, we present SAGS, a novel Simulated Annealing framework for Graph and Sequence optimization. The key idea is to integrate powerful neural networks into metaheuristics (e.g., simulated annealing, SA) to restrict the search space in discrete optimization. We start by defining a sophisticated objective function, involving the property of interest and pre-defined constraints (e.g., grammar validity). SAGS searches from the discrete space towards this objective by performing a sequence of local edits, where deep generative neural networks propose the editing content and thus can control the quality of editing. We evaluate SAGS on paraphrase generation and molecule generation for sequence optimization and graph optimization, respectively. Extensive results show that our approach achieves state-of-the-art performance compared with existing paraphrase generation methods in terms of both automatic and human evaluations. Further, SAGS also significantly outperforms all the previous methods in molecule generation.

Xinke Shen, Xianggen Liu, Xin Hu et al.

EEG signals have been reported to be informative and reliable for emotion recognition in recent years. However, the inter-subject variability of emotion-related EEG signals still poses a great challenge for the practical applications of EEG-based emotion recognition. Inspired by recent neuroscience studies on inter-subject correlation, we proposed a Contrastive Learning method for Inter-Subject Alignment (CLISA) to tackle the cross-subject emotion recognition problem. Contrastive learning was employed to minimize the inter-subject differences by maximizing the similarity in EEG signal representations across subjects when they received the same emotional stimuli in contrast to different ones. Specifically, a convolutional neural network was applied to learn inter-subject aligned spatiotemporal representations from EEG time series in contrastive learning. The aligned representations were subsequently used to extract differential entropy features for emotion classification. CLISA achieved state-of-the-art cross-subject emotion recognition performance on our THU-EP dataset with 80 subjects and the publicly available SEED dataset with 15 subjects. It could generalize to unseen subjects or unseen emotional stimuli in testing. Furthermore, the spatiotemporal representations learned by CLISA could provide insights into the neural mechanisms of human emotion processing.

Pengyong Li, Jun Wang, Yixuan Qiao et al.

How to produce expressive molecular representations is a fundamental challenge in AI-driven drug discovery. Graph neural network (GNN) has emerged as a powerful technique for modeling molecular data. However, previous supervised approaches usually suffer from the scarcity of labeled data and have poor generalization capability. Here, we proposed a novel Molecular Pre-training Graph-based deep learning framework, named MPG, that leans molecular representations from large-scale unlabeled molecules. In MPG, we proposed a powerful MolGNet model and an effective self-supervised strategy for pre-training the model at both the node and graph-level. After pre-training on 11 million unlabeled molecules, we revealed that MolGNet can capture valuable chemistry insights to produce interpretable representation. The pre-trained MolGNet can be fine-tuned with just one additional output layer to create state-of-the-art models for a wide range of drug discovery tasks, including molecular properties prediction, drug-drug interaction, and drug-target interaction, involving 13 benchmark datasets. Our work demonstrates that MPG is promising to become a novel approach in the drug discovery pipeline.

Xianggen Liu, Yunan Luo, Sen Song et al.

Modeling the effects of mutations on the binding affinity plays a crucial role in protein engineering and drug design. In this study, we develop a novel deep learning based framework, named GraphPPI, to predict the binding affinity changes upon mutations based on the features provided by a graph neural network (GNN). In particular, GraphPPI first employs a well-designed pre-training scheme to enforce the GNN to capture the features that are predictive of the effects of mutations on binding affinity in an unsupervised manner and then integrates these graphical features with gradient-boosting trees to perform the prediction. Experiments showed that, without any annotated signals, GraphPPI can capture meaningful patterns of the protein structures. Also, GraphPPI achieved new state-of-the-art performance in predicting the binding affinity changes upon both single- and multi-point mutations on five benchmark datasets. In-depth analyses also showed GraphPPI can accurately estimate the effects of mutations on the binding affinity between SARS-CoV-2 and its neutralizing antibodies. These results have established GraphPPI as a powerful and useful computational tool in the studies of protein design.

Yujie Wu, Rong Zhao, Jun Zhu et al.

Two main routes of learning methods exist at present including error-driven global learning and neuroscience-oriented local learning. Integrating them into one network may provide complementary learning capabilities for versatile learning scenarios. At the same time, neuromorphic computing holds great promise, but still needs plenty of useful algorithms and algorithm-hardware co-designs for exploiting the advantages. Here, we report a neuromorphic hybrid learning model by introducing a brain-inspired meta-learning paradigm and a differentiable spiking model incorporating neuronal dynamics and synaptic plasticity. It can meta-learn local plasticity and receive top-down supervision information for multiscale synergic learning. We demonstrate the advantages of this model in multiple different tasks, including few-shot learning, continual learning, and fault-tolerance learning in neuromorphic vision sensors. It achieves significantly higher performance than single-learning methods, and shows promise in empowering neuromorphic applications revolution. We further implemented the hybrid model in the Tianjic neuromorphic platform by exploiting algorithm-hardware co-designs and proved that the model can fully utilize neuromorphic many-core architecture to develop hybrid computation paradigm.

Xianggen Liu, Lili Mou, Fandong Meng et al.

Unsupervised paraphrase generation is a promising and important research topic in natural language processing. We propose UPSA, a novel approach that accomplishes Unsupervised Paraphrasing by Simulated Annealing. We model paraphrase generation as an optimization problem and propose a sophisticated objective function, involving semantic similarity, expression diversity, and language fluency of paraphrases. Then, UPSA searches the sentence space towards this objective by performing a sequence of local editing. Our method is unsupervised and does not require parallel corpora for training, so it could be easily applied to different domains. We evaluate our approach on a variety of benchmark datasets, namely, Quora, Wikianswers, MSCOCO, and Twitter. Extensive results show that UPSA achieves the state-of-the-art performance compared with previous unsupervised methods in terms of both automatic and human evaluations. Further, our approach outperforms most existing domain-adapted supervised models, showing the generalizability of UPSA.

Yukun Yan, Daqi Zheng, Zhengdong Lu et al.

Structural information is important in natural language understanding. Although some current neural net-based models have a limited ability to take local syntactic information, they fail to use high-level and large-scale structures of documents. This information is valuable for text understanding since it contains the author's strategy to express information, in building an effective representation and forming appropriate output modes. We propose a neural net-based model, Zooming Network, capable of representing and leveraging text structure of long document and developing its own analyzing rhythm to extract critical information. Generally, ZN consists of an encoding neural net that can build a hierarchical representation of a document, and an interpreting neural model that can read the information at multi-levels and issuing labeling actions through a policy-net. Our model is trained with a hybrid paradigm of supervised learning (distinguishing right and wrong decision) and reinforcement learning (determining the goodness among multiple right paths). We applied the proposed model to long text sequence labeling tasks, with performance exceeding baseline model (biLSTM-crf) by 10 F1-measure.

Xianggen Liu, Lili Mou, Haotian Cui et al.

In early years, text classification is typically accomplished by feature-based machine learning models; recently, deep neural networks, as a powerful learning machine, make it possible to work with raw input as the text stands. However, exiting end-to-end neural networks lack explicit interpretation of the prediction. In this paper, we propose a novel framework, JUMPER, inspired by the cognitive process of text reading, that models text classification as a sequential decision process. Basically, JUMPER is a neural system that scans a piece of text sequentially and makes classification decisions at the time it wishes. Both the classification result and when to make the classification are part of the decision process, which is controlled by a policy network and trained with reinforcement learning. Experimental results show that a properly trained JUMPER has the following properties: (1) It can make decisions whenever the evidence is enough, therefore reducing total text reading by 30-40% and often finding the key rationale of prediction. (2) It achieves classification accuracy better than or comparable to state-of-the-art models in several benchmark and industrial datasets.

Fangzhou Liao, Ming Liang, Zhe Li et al.

Automatic diagnosing lung cancer from Computed Tomography (CT) scans involves two steps: detect all suspicious lesions (pulmonary nodules) and evaluate the whole-lung/pulmonary malignancy. Currently, there are many studies about the first step, but few about the second step. Since the existence of nodule does not definitely indicate cancer, and the morphology of nodule has a complicated relationship with cancer, the diagnosis of lung cancer demands careful investigations on every suspicious nodule and integration of information of all nodules. We propose a 3D deep neural network to solve this problem. The model consists of two modules. The first one is a 3D region proposal network for nodule detection, which outputs all suspicious nodules for a subject. The second one selects the top five nodules based on the detection confidence, evaluates their cancer probabilities and combines them with a leaky noisy-or gate to obtain the probability of lung cancer for the subject. The two modules share the same backbone network, a modified U-net. The over-fitting caused by the shortage of training data is alleviated by training the two modules alternately. The proposed model won the first place in the Data Science Bowl 2017 competition. The code has been made publicly available.

Yukun Yan, Daqi Zheng, Zhengdong Lu et al.

We propose scale-free Identifier Network(sfIN), a novel model for event identification in documents. In general, sfIN first encodes a document into multi-scale memory stacks, then extracts special events via conducting multi-scale actions, which can be considered as a special type of sequence labelling. The design of large scale actions makes it more efficient processing a long document. The whole model is trained with both supervised learning and reinforcement learning.

Fangzhou Liao, Xi Chen, Xiaolin Hu et al.

Segmenting human left ventricle (LV) in magnetic resonance imaging (MRI) images and calculating its volume are important for diagnosing cardiac diseases. In 2016, Kaggle organized a competition to estimate the volume of LV from MRI images. The dataset consisted of a large number of cases, but only provided systole and diastole volumes as labels. We designed a system based on neural networks to solve this problem. It began with a detector combined with a neural network classifier for detecting regions of interest (ROIs) containing LV chambers. Then a deep neural network named hypercolumns fully convolutional network was used to segment LV in ROIs. The 2D segmentation results were integrated across different images to estimate the volume. With ground-truth volume labels, this model was trained end-to-end. To improve the result, an additional dataset with only segmentation label was used. The model was trained alternately on these two datasets with different types of teaching signals. We also proposed a variance estimation method for the final prediction. Our algorithm ranked the 4th on the test set in this competition.

Zhaofei Yu, David Kappel, Robert Legenstein et al.

Synaptic plasticity is implemented and controlled through over thousand different types of molecules in the postsynaptic density and presynaptic boutons that assume a staggering array of different states through phosporylation and other mechanisms. One of the most prominent molecule in the postsynaptic density is CaMKII, that is described in molecular biology as a "memory molecule" that can integrate through auto-phosporylation Ca-influx signals on a relatively large time scale of dozens of seconds. The functional impact of this memory mechanism is largely unknown. We show that the experimental data on the specific role of CaMKII activation in dopamine-gated spine consolidation suggest a general functional role in speeding up reward-guided search for network configurations that maximize reward expectation. Our theoretical analysis shows that stochastic search could in principle even attain optimal network configurations by emulating one of the most well-known nonlinear optimization methods, simulated annealing. But this optimization is usually impeded by slowness of stochastic search at a given temperature. We propose that CaMKII contributes a momentum term that substantially speeds up this search. In particular, it allows the network to overcome saddle points of the fitness function. The resulting improved stochastic policy search can be understood on a more abstract level as Hamiltonian sampling, which is known to be one of the most efficient stochastic search methods.

Qian Wang, Jiaxing Zhang, Sen Song et al.

Attentional Neural Network is a new framework that integrates top-down cognitive bias and bottom-up feature extraction in one coherent architecture. The top-down influence is especially effective when dealing with high noise or difficult segmentation problems. Our system is modular and extensible. It is also easy to train and cheap to run, and yet can accommodate complex behaviors. We obtain classification accuracy better than or competitive with state of art results on the MNIST variation dataset, and successfully disentangle overlaid digits with high success rates. We view such a general purpose framework as an essential foundation for a larger system emulating the cognitive abilities of the whole brain.